Click here to switch to the map view.

The map label for this gene is mprA [H]

Identifier: 158318242

GI number: 158318242

Start: 7914601

End: 7915413

Strand: Direct

Name: mprA [H]

Synonym: Franean1_6507

Alternate gene names: 158318242

Gene position: 7914601-7915413 (Clockwise)

Preceding gene: 158318240

Following gene: 158318243

Centisome position: 88.12

GC content: 74.78

Gene sequence:

>813_bases
ATGAGGGACGCATCGCGGCCACCGCGGTTCGGCGAGGACGCCGCCACGCCGCCACGGGCCCCCCGGGTCCTGGTCGTCGA
CGACGAGCCCAACATCGTCGACCTCGTCCGGATGGCGTTGCGCTTCCACGGCTTCGACGTCGTCACGGCGGCCACCGGCC
AGGAGGCGCTCACCCGAGCCGCCGCCGACCAGCCCGACCTGCTGATCCTGGACGTCATGCTGCCCGACGCCGACGGGTTC
GAGGTGTGCCGGCGGCTACGCGCGGACGGGGCGGAGGTCGCCGTCGTCTACCTCACGGCCCGCGACGCGCACCGGGACAA
GATCACCGGTCTCACCTACGGCGGCGACGACTACATCACCAAGCCGTTCGCCGTCGAGGAGCTGATCGCGCGGGTGCGGG
CGGTGCTGCGCCGGACCCGCCGTCCCGCACCGGAGCCGTCGCCCGCGCCGGGCCTGCTCACCTACGCCGACGTCGAGCTC
GACCCGGACGCCCACCTGGTACGCCGGGCGGACCAGCCGGTCGAGCTCTCCCCCACCGAGTTCTCCCTGCTGCGCTACTT
CCTGCACAACCCGAACCGGGTGCTCTCCCGCGCCCAGATCCTGGCCGCGGTGTGGGACCGCGACTTTGACGGCGAACCGA
CCGTCGTCGACCAGTACGTCAGCTACCTGCGGCGCAAGCTCGGCCAGCACGGGCCGCCGCTCATCCACACCCAGCGCGGC
TTCGGCTACGCCCTGCGCGCCCCCGCCCCCGCCCCCGCGCCCGCCCCCGCGCCCGCCGCCGGCCCCGGCGCCGCGCCCGA
GCACTCCCGATGA

Upstream 100 bases:

>100_bases
CGTTCCTCTCATGTCGTGCGGGTTTCCTCAGGGCACGCCGCGCCTCCGCCCGCCCCGCCGGGGCGCGTGCCCGGACGCCG
GCTGTTCGAGGATGGGTGAG

Downstream 100 bases:

>100_bases
CGCTTCGCCTGAAGCTCATGCTCGGCCTGGTGGCGTTGACCGCCACCGGCCTCATCCTGACAATCGTCGCGACGGTCGTC
GCCCTGCGCGGCTACCTCGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MRDASRPPRFGEDAATPPRAPRVLVVDDEPNIVDLVRMALRFHGFDVVTAATGQEALTRAAADQPDLLILDVMLPDADGF
EVCRRLRADGAEVAVVYLTARDAHRDKITGLTYGGDDYITKPFAVEELIARVRAVLRRTRRPAPEPSPAPGLLTYADVEL
DPDAHLVRRADQPVELSPTEFSLLRYFLHNPNRVLSRAQILAAVWDRDFDGEPTVVDQYVSYLRRKLGQHGPPLIHTQRG
FGYALRAPAPAPAPAPAPAAGPGAAPEHSR

Sequences:

>Translated_270_residues
MRDASRPPRFGEDAATPPRAPRVLVVDDEPNIVDLVRMALRFHGFDVVTAATGQEALTRAAADQPDLLILDVMLPDADGF
EVCRRLRADGAEVAVVYLTARDAHRDKITGLTYGGDDYITKPFAVEELIARVRAVLRRTRRPAPEPSPAPGLLTYADVEL
DPDAHLVRRADQPVELSPTEFSLLRYFLHNPNRVLSRAQILAAVWDRDFDGEPTVVDQYVSYLRRKLGQHGPPLIHTQRG
FGYALRAPAPAPAPAPAPAAGPGAAPEHSR
>Mature_270_residues
MRDASRPPRFGEDAATPPRAPRVLVVDDEPNIVDLVRMALRFHGFDVVTAATGQEALTRAAADQPDLLILDVMLPDADGF
EVCRRLRADGAEVAVVYLTARDAHRDKITGLTYGGDDYITKPFAVEELIARVRAVLRRTRRPAPEPSPAPGLLTYADVEL
DPDAHLVRRADQPVELSPTEFSLLRYFLHNPNRVLSRAQILAAVWDRDFDGEPTVVDQYVSYLRRKLGQHGPPLIHTQRG
FGYALRAPAPAPAPAPAPAAGPGAAPEHSR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=38.5964912280702, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=40.0881057268723, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=41.0714285714286, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=36.4035087719298, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=37.4449339207048, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=32.15859030837, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=32.6271186440678, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=31.7391304347826, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=30.9734513274336, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.5964125560538, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.8777292576419, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.6943231441048, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=118, Percent_Identity=33.0508474576271, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29594; Mature: 29594

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDASRPPRFGEDAATPPRAPRVLVVDDEPNIVDLVRMALRFHGFDVVTAATGQEALTRA
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHH
AADQPDLLILDVMLPDADGFEVCRRLRADGAEVAVVYLTARDAHRDKITGLTYGGDDYIT
HCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCC
KPFAVEELIARVRAVLRRTRRPAPEPSPAPGLLTYADVELDPDAHLVRRADQPVELSPTE
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCHHHHHCCCCCCCCCCHH
FSLLRYFLHNPNRVLSRAQILAAVWDRDFDGEPTVVDQYVSYLRRKLGQHGPPLIHTQRG
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCC
FGYALRAPAPAPAPAPAPAAGPGAAPEHSR
CCEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDASRPPRFGEDAATPPRAPRVLVVDDEPNIVDLVRMALRFHGFDVVTAATGQEALTRA
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHH
AADQPDLLILDVMLPDADGFEVCRRLRADGAEVAVVYLTARDAHRDKITGLTYGGDDYIT
HCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCC
KPFAVEELIARVRAVLRRTRRPAPEPSPAPGLLTYADVELDPDAHLVRRADQPVELSPTE
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCHHHHHCCCCCCCCCCHH
FSLLRYFLHNPNRVLSRAQILAAVWDRDFDGEPTVVDQYVSYLRRKLGQHGPPLIHTQRG
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCC
FGYALRAPAPAPAPAPAPAAGPGAAPEHSR
CCEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA