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The map label for this gene is arlS [H]

Identifier: 158318243

GI number: 158318243

Start: 7915410

End: 7916882

Strand: Direct

Name: arlS [H]

Synonym: Franean1_6508

Alternate gene names: 158318243

Gene position: 7915410-7916882 (Clockwise)

Preceding gene: 158318242

Following gene: 158318244

Centisome position: 88.12

GC content: 76.04

Gene sequence:

>1473_bases
ATGACGCTTCGCCTGAAGCTCATGCTCGGCCTGGTGGCGTTGACCGCCACCGGCCTCATCCTGACAATCGTCGCGACGGT
CGTCGCCCTGCGCGGCTACCTCGTCGACCGCGTCGACGTCCGACTGCGGGCCGTCGAGCAGGTCACCCGGCTGCCGCTGG
CCGCGGTGCTGGCCGGGGCGCCCACGGGCAGCCGGCCCGTGCTGGAGCGGGCGATCGCGCCCACCGACTACGTGGTGGAG
GCCCGCCGGACCGACGGCGAAATCCTACGGGTAGCGGGTCCGGCGGACCGTTCCCAACCACTGCTCGCCGAGATCGCCAC
GGGGAAGGCCACCGGGGAGACCACGGGGACGACCGCGCCGCCGGCCGACGGCACCCCGTTCACCGTGACCCACAGTGGCG
AGCGGTACCGCGCGGTGCTCGACCACGTCCCCGGCGGCGAGGTGCTGATCGCCCAGCCGCTGGCGACCGTCCGGGACACC
CTGCGCCGGCTGGTCGTCGCAGCGGCGGTCGCGGCGCTGGTCATGCTCGCCGCCATCGCCACGCTGGCCTGGCTGCTGCT
CACCCGCGGCCTGCGCCCGCTGCGCGTCGTCGCGAGCACCGCGTCCGCGATCGCCGCCGGCGACCTGTCCCGCCGGGTGC
CGGAGGGCCCGCCGCGCTCGGAGACCGGGCAGCTCAGCCGGGCGCTGAACATCATGCTCGGCCAGATCCAGGCCGCCTTC
ACCGCCCGGGTCGCCTCCCAGAACAACCTGCGCCGCTTCGCCGCCGACGCCTCGCACGAGCTGCGCACGCCGCTGACCTC
GATCCGCGGCTACGTCGACCTGCTGCGCGCCGGGATGGTCCCGCCGGCCGAGACCGACGACACCCTGCGGCGGGTGGCCG
AGGAGACCGCCCGCATGCAGACCCTCGTCGACGACCTCCTCTACCTCGCGCACCTCGACGAGCTGCGCCCCCGCGACCGG
GTGGTGGACGTCGACCTGGTCACGATCGCCGAGGACGCGGCGGCGAACCTGCGGGCCGTCGACCCCGGCCGCCCGGTCAC
CGTCGAGGTCGAGGCCGGTCCCGAGGCCGGCCGGCACGTCCTCGGCGATCCGGACGCGCTGCGCCAGCTGCTGGGCAACC
TGCTGACGAACGCCCGCGTGCACACCCCCGCGGGCACCACGGTGACCGTTCGGGTCACCGGATGGGACGCGGCCACCCCG
GCCCAGGACCGCGCGGCCGTCCTGGCGGTCGAGGACGGCGGGCCCGGCATGCCGCCGGAGGTCGCGCGGCACGTCTTCGA
CCGGTTCTACCGGGCGGCCGGAAGCAGGGCCCGGGGCCGCTCCGGCAGCGGCCTCGGGCTGTCGATCGTCGCGGCCACGG
CGGCCGCGCACGGCGGCCGCGCCGAGGTGAGCAGCACCCCCGAGGGGGGCACGACCTTCCGGGTGTACCTGCCCGGGGGC
GTTTCCGACCAGACCCCCGCTGACCTGGCCTGA

Upstream 100 bases:

>100_bases
CCCAGCGCGGCTTCGGCTACGCCCTGCGCGCCCCCGCCCCCGCCCCCGCGCCCGCCCCCGCGCCCGCCGCCGGCCCCGGC
GCCGCGCCCGAGCACTCCCG

Downstream 100 bases:

>100_bases
CCTGCCACGGACGGCCCGTCCCGGCCCGCCGGAAAGGGGCGGAAAGGGCGATCCGGACGAAGTCGCCGGCTGGCCCTGGG
CGGCGCACCCGGGTCGACGT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTLRLKLMLGLVALTATGLILTIVATVVALRGYLVDRVDVRLRAVEQVTRLPLAAVLAGAPTGSRPVLERAIAPTDYVVE
ARRTDGEILRVAGPADRSQPLLAEIATGKATGETTGTTAPPADGTPFTVTHSGERYRAVLDHVPGGEVLIAQPLATVRDT
LRRLVVAAAVAALVMLAAIATLAWLLLTRGLRPLRVVASTASAIAAGDLSRRVPEGPPRSETGQLSRALNIMLGQIQAAF
TARVASQNNLRRFAADASHELRTPLTSIRGYVDLLRAGMVPPAETDDTLRRVAEETARMQTLVDDLLYLAHLDELRPRDR
VVDVDLVTIAEDAAANLRAVDPGRPVTVEVEAGPEAGRHVLGDPDALRQLLGNLLTNARVHTPAGTTVTVRVTGWDAATP
AQDRAAVLAVEDGGPGMPPEVARHVFDRFYRAAGSRARGRSGSGLGLSIVAATAAAHGGRAEVSSTPEGGTTFRVYLPGG
VSDQTPADLA

Sequences:

>Translated_490_residues
MTLRLKLMLGLVALTATGLILTIVATVVALRGYLVDRVDVRLRAVEQVTRLPLAAVLAGAPTGSRPVLERAIAPTDYVVE
ARRTDGEILRVAGPADRSQPLLAEIATGKATGETTGTTAPPADGTPFTVTHSGERYRAVLDHVPGGEVLIAQPLATVRDT
LRRLVVAAAVAALVMLAAIATLAWLLLTRGLRPLRVVASTASAIAAGDLSRRVPEGPPRSETGQLSRALNIMLGQIQAAF
TARVASQNNLRRFAADASHELRTPLTSIRGYVDLLRAGMVPPAETDDTLRRVAEETARMQTLVDDLLYLAHLDELRPRDR
VVDVDLVTIAEDAAANLRAVDPGRPVTVEVEAGPEAGRHVLGDPDALRQLLGNLLTNARVHTPAGTTVTVRVTGWDAATP
AQDRAAVLAVEDGGPGMPPEVARHVFDRFYRAAGSRARGRSGSGLGLSIVAATAAAHGGRAEVSSTPEGGTTFRVYLPGG
VSDQTPADLA
>Mature_489_residues
TLRLKLMLGLVALTATGLILTIVATVVALRGYLVDRVDVRLRAVEQVTRLPLAAVLAGAPTGSRPVLERAIAPTDYVVEA
RRTDGEILRVAGPADRSQPLLAEIATGKATGETTGTTAPPADGTPFTVTHSGERYRAVLDHVPGGEVLIAQPLATVRDTL
RRLVVAAAVAALVMLAAIATLAWLLLTRGLRPLRVVASTASAIAAGDLSRRVPEGPPRSETGQLSRALNIMLGQIQAAFT
ARVASQNNLRRFAADASHELRTPLTSIRGYVDLLRAGMVPPAETDDTLRRVAEETARMQTLVDDLLYLAHLDELRPRDRV
VDVDLVTIAEDAAANLRAVDPGRPVTVEVEAGPEAGRHVLGDPDALRQLLGNLLTNARVHTPAGTTVTVRVTGWDAATPA
QDRAAVLAVEDGGPGMPPEVARHVFDRFYRAAGSRARGRSGSGLGLSIVAATAAAHGGRAEVSSTPEGGTTFRVYLPGGV
SDQTPADLA

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=338, Percent_Identity=32.2485207100592, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786600, Length=288, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=31.5972222222222, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788279, Length=345, Percent_Identity=26.3768115942029, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1790346, Length=293, Percent_Identity=29.6928327645051, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=248, Percent_Identity=31.4516129032258, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1787894, Length=322, Percent_Identity=26.7080745341615, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789403, Length=345, Percent_Identity=28.4057971014493, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=27.3529411764706, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=31.8367346938775, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788713, Length=271, Percent_Identity=26.9372693726937, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=314, Percent_Identity=28.343949044586, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=371, Percent_Identity=23.1805929919137, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=28.695652173913, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790300, Length=260, Percent_Identity=31.1538461538462, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790551, Length=231, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51468; Mature: 51336

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLKLMLGLVALTATGLILTIVATVVALRGYLVDRVDVRLRAVEQVTRLPLAAVLAGA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
PTGSRPVLERAIAPTDYVVEARRTDGEILRVAGPADRSQPLLAEIATGKATGETTGTTAP
CCCCCHHHHHHCCCCHHEEEEECCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCC
PADGTPFTVTHSGERYRAVLDHVPGGEVLIAQPLATVRDTLRRLVVAAAVAALVMLAAIA
CCCCCCEEEECCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLAWLLLTRGLRPLRVVASTASAIAAGDLSRRVPEGPPRSETGQLSRALNIMLGQIQAAF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TARVASQNNLRRFAADASHELRTPLTSIRGYVDLLRAGMVPPAETDDTLRRVAEETARMQ
HHHHHHHCHHHHHHHCCCHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TLVDDLLYLAHLDELRPRDRVVDVDLVTIAEDAAANLRAVDPGRPVTVEVEAGPEAGRHV
HHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHCCCCEECCCCCCEEEEEECCCCCCCCC
LGDPDALRQLLGNLLTNARVHTPAGTTVTVRVTGWDAATPAQDRAAVLAVEDGGPGMPPE
CCCHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCHH
VARHVFDRFYRAAGSRARGRSGSGLGLSIVAATAAAHGGRAEVSSTPEGGTTFRVYLPGG
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
VSDQTPADLA
CCCCCCCCCC
>Mature Secondary Structure 
TLRLKLMLGLVALTATGLILTIVATVVALRGYLVDRVDVRLRAVEQVTRLPLAAVLAGA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
PTGSRPVLERAIAPTDYVVEARRTDGEILRVAGPADRSQPLLAEIATGKATGETTGTTAP
CCCCCHHHHHHCCCCHHEEEEECCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCC
PADGTPFTVTHSGERYRAVLDHVPGGEVLIAQPLATVRDTLRRLVVAAAVAALVMLAAIA
CCCCCCEEEECCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLAWLLLTRGLRPLRVVASTASAIAAGDLSRRVPEGPPRSETGQLSRALNIMLGQIQAAF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TARVASQNNLRRFAADASHELRTPLTSIRGYVDLLRAGMVPPAETDDTLRRVAEETARMQ
HHHHHHHCHHHHHHHCCCHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TLVDDLLYLAHLDELRPRDRVVDVDLVTIAEDAAANLRAVDPGRPVTVEVEAGPEAGRHV
HHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHCCCCEECCCCCCEEEEEECCCCCCCCC
LGDPDALRQLLGNLLTNARVHTPAGTTVTVRVTGWDAATPAQDRAAVLAVEDGGPGMPPE
CCCHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCHH
VARHVFDRFYRAAGSRARGRSGSGLGLSIVAATAAAHGGRAEVSSTPEGGTTFRVYLPGG
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
VSDQTPADLA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA