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The map label for this gene is cya1 [H]

Identifier: 158318175

GI number: 158318175

Start: 7831104

End: 7832495

Strand: Direct

Name: cya1 [H]

Synonym: Franean1_6440

Alternate gene names: 158318175

Gene position: 7831104-7832495 (Clockwise)

Preceding gene: 158318172

Following gene: 158318176

Centisome position: 87.19

GC content: 75.57

Gene sequence:

>1392_bases
GTGCTGCTCGCCGACGACAACCTGATCGTCCGGGAGGGCGTGCGGGCGCTGCTCTCCCGCGTCGCCGACATCGCGGTCAT
CGGTGTCGCCGCTGACCACGACGAGCTGGTCCGCGCCGCCGCGCGGCTGCGCCCCAGGGTCGTCGTCACCGACATCCGGA
TGCCGCCGGACTTCACCGACGAGGGGGTCCGGGCGGCCCAGCGCATCCGGGCGGCGAGCCCGGCGACAGGCATCGTGCTG
CTCTCCCAGTACGACGAGCCCGACTACGCGATCACACTGCTGCGTGACGGCCTGTCCGGCTACGCCTACCTGCTCAAGGA
GCGGGTCGCCGACCCCGACCTGCTGGCGCGCGCCATCCGCGAGGTCGCCGGCGGCGGCTCCATGCTGGACCCGGACATCG
TCGCCGCGGTGATAACGCCCGTCCGCGAGGCCGGGACGCTGACCCGCGAGCAGGAGGAGCTGCTGCGCGACGTCGCCCAC
GGGCGCCCCGTGGCCGCCATCGCCGCCGACCACGGCGACACCCCGGCCGCCGTCAACGCGGCGATCGACGCGCTGCTGCT
GCGGCTCGCGCAGGGCGCGAGCTCGGGCCAGGCCGGCGCGCTGCGCCGCCTGCGCATGCTGCACGAGGCGCTGATGAAGC
GTGAGGAACAGGACGTCGCCCTGACCAGGCTGCTCCCCAGCGGCCTGGCGCAGAAGCTGCGCGACGATGCCACCGCCGCG
AGCCGCGCCGAACGCCTTGATGTCACCGTGCTCATGTCGGACGTCCGCGGCTACTCGGGCATCGCGCAGCGCACCGACCC
GATGGTGCTGGCGCACCAGCTCGACGAGCACCGCCGGGAGATGAACGCGGCGATCCTCGCCGAGGGCGGCACCGTCCTGC
AGTACGCCGGGGACGCGGTGATCGCTGTCTTCGGCGCGCCGGACCCGACCAGTGACCACCGCGAGCGTGCGGTGCGCGCC
GCGGCCGCGATGCACCGGCGCCAACGCGGCCTGGACGAGCGGTGGACCAGGCGCCGGCTGGAGCCGTTCGGGCTGGGCAT
CGGGGTCTCCACCGGCGAGGTCGCGGCGGCCCTGCTGGGCTGCGACGCGCACCGGGAGTACACGCTGGTCGGGGACACGA
TGAACCTCGCGCAGCGGCTCCAGGCGATGGCGGAGGCGGGTGTCACGATCGTGAGCGCCGCGACCGCGGCGGCGCTGCCC
GCCGACGTCGTCGTCCCCCTCGACCCGCGGCCGGTGAAGGGACGGGTCGGGGACGTCCGGGCCTACCGCGTCATCGCCGG
CGGCGCCTCCGCCCCCATCCCCGTCCCCACTCCCGTCGTTCCGGCGCCTGCCCTCACCGCGCCGGTCCCGCGGCCGCGCC
GCCGCCGTCTGCTGGCCCGCTCCGCCGCCTGA

Upstream 100 bases:

>100_bases
AGCCATGGCGCGCAACGGCACGGCGGGCGACACCACACCAGGCCACAAAACAGGCAGCCACCGACCAACGGACGTGACCG
GGAGCACCGGAGCGATCACC

Downstream 100 bases:

>100_bases
GCGGCGGGCACGAGCCCCGCCCCGATGGAAAATGGGCCCCGGAACGCAGGCCGGGGCCGCCGGGGAGATCCCCGGCTGAT
CGGGAGGGTCGTGATGACCG

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLLADDNLIVREGVRALLSRVADIAVIGVAADHDELVRAAARLRPRVVVTDIRMPPDFTDEGVRAAQRIRAASPATGIVL
LSQYDEPDYAITLLRDGLSGYAYLLKERVADPDLLARAIREVAGGGSMLDPDIVAAVITPVREAGTLTREQEELLRDVAH
GRPVAAIAADHGDTPAAVNAAIDALLLRLAQGASSGQAGALRRLRMLHEALMKREEQDVALTRLLPSGLAQKLRDDATAA
SRAERLDVTVLMSDVRGYSGIAQRTDPMVLAHQLDEHRREMNAAILAEGGTVLQYAGDAVIAVFGAPDPTSDHRERAVRA
AAAMHRRQRGLDERWTRRRLEPFGLGIGVSTGEVAAALLGCDAHREYTLVGDTMNLAQRLQAMAEAGVTIVSAATAAALP
ADVVVPLDPRPVKGRVGDVRAYRVIAGGASAPIPVPTPVVPAPALTAPVPRPRRRRLLARSAA

Sequences:

>Translated_463_residues
MLLADDNLIVREGVRALLSRVADIAVIGVAADHDELVRAAARLRPRVVVTDIRMPPDFTDEGVRAAQRIRAASPATGIVL
LSQYDEPDYAITLLRDGLSGYAYLLKERVADPDLLARAIREVAGGGSMLDPDIVAAVITPVREAGTLTREQEELLRDVAH
GRPVAAIAADHGDTPAAVNAAIDALLLRLAQGASSGQAGALRRLRMLHEALMKREEQDVALTRLLPSGLAQKLRDDATAA
SRAERLDVTVLMSDVRGYSGIAQRTDPMVLAHQLDEHRREMNAAILAEGGTVLQYAGDAVIAVFGAPDPTSDHRERAVRA
AAAMHRRQRGLDERWTRRRLEPFGLGIGVSTGEVAAALLGCDAHREYTLVGDTMNLAQRLQAMAEAGVTIVSAATAAALP
ADVVVPLDPRPVKGRVGDVRAYRVIAGGASAPIPVPTPVVPAPALTAPVPRPRRRRLLARSAA
>Mature_463_residues
MLLADDNLIVREGVRALLSRVADIAVIGVAADHDELVRAAARLRPRVVVTDIRMPPDFTDEGVRAAQRIRAASPATGIVL
LSQYDEPDYAITLLRDGLSGYAYLLKERVADPDLLARAIREVAGGGSMLDPDIVAAVITPVREAGTLTREQEELLRDVAH
GRPVAAIAADHGDTPAAVNAAIDALLLRLAQGASSGQAGALRRLRMLHEALMKREEQDVALTRLLPSGLAQKLRDDATAA
SRAERLDVTVLMSDVRGYSGIAQRTDPMVLAHQLDEHRREMNAAILAEGGTVLQYAGDAVIAVFGAPDPTSDHRERAVRA
AAAMHRRQRGLDERWTRRRLEPFGLGIGVSTGEVAAALLGCDAHREYTLVGDTMNLAQRLQAMAEAGVTIVSAATAAALP
ADVVVPLDPRPVKGRVGDVRAYRVIAGGASAPIPVPTPVVPAPALTAPVPRPRRRRLLARSAA

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=255, Percent_Identity=28.6274509803922, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4580422, Length=252, Percent_Identity=28.1746031746032, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17561810, Length=225, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983004, Length=182, Percent_Identity=26.3736263736264, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=215, Percent_Identity=27.4418604651163, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86564713, Length=217, Percent_Identity=24.8847926267281, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=202, Percent_Identity=26.7326732673267, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=202, Percent_Identity=26.7326732673267, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508769, Length=209, Percent_Identity=28.2296650717703, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI212659371, Length=211, Percent_Identity=26.0663507109005, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161078020, Length=235, Percent_Identity=30.2127659574468, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330470, Length=282, Percent_Identity=26.241134751773, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330468, Length=282, Percent_Identity=26.241134751773, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62484477, Length=213, Percent_Identity=28.6384976525822, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62484298, Length=213, Percent_Identity=28.6384976525822, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116008008, Length=213, Percent_Identity=28.6384976525822, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281366459, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281366457, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281366455, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI56292422, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI56292424, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24666940, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 49300; Mature: 49300

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLADDNLIVREGVRALLSRVADIAVIGVAADHDELVRAAARLRPRVVVTDIRMPPDFTD
CEECCCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCH
EGVRAAQRIRAASPATGIVLLSQYDEPDYAITLLRDGLSGYAYLLKERVADPDLLARAIR
HHHHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHCHHHHHHHHHHHCCCHHHHHHHHH
EVAGGGSMLDPDIVAAVITPVREAGTLTREQEELLRDVAHGRPVAAIAADHGDTPAAVNA
HHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
AIDALLLRLAQGASSGQAGALRRLRMLHEALMKREEQDVALTRLLPSGLAQKLRDDATAA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRAERLDVTVLMSDVRGYSGIAQRTDPMVLAHQLDEHRREMNAAILAEGGTVLQYAGDAV
HHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHCCEEEECCCEEEEECCCEE
IAVFGAPDPTSDHRERAVRAAAAMHRRQRGLDERWTRRRLEPFGLGIGVSTGEVAAALLG
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
CDAHREYTLVGDTMNLAQRLQAMAEAGVTIVSAATAAALPADVVVPLDPRPVKGRVGDVR
CCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCEEEECCCCCCCCCCCCEE
AYRVIAGGASAPIPVPTPVVPAPALTAPVPRPRRRRLLARSAA
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLLADDNLIVREGVRALLSRVADIAVIGVAADHDELVRAAARLRPRVVVTDIRMPPDFTD
CEECCCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCH
EGVRAAQRIRAASPATGIVLLSQYDEPDYAITLLRDGLSGYAYLLKERVADPDLLARAIR
HHHHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHCHHHHHHHHHHHCCCHHHHHHHHH
EVAGGGSMLDPDIVAAVITPVREAGTLTREQEELLRDVAHGRPVAAIAADHGDTPAAVNA
HHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
AIDALLLRLAQGASSGQAGALRRLRMLHEALMKREEQDVALTRLLPSGLAQKLRDDATAA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRAERLDVTVLMSDVRGYSGIAQRTDPMVLAHQLDEHRREMNAAILAEGGTVLQYAGDAV
HHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHCCEEEECCCEEEEECCCEE
IAVFGAPDPTSDHRERAVRAAAAMHRRQRGLDERWTRRRLEPFGLGIGVSTGEVAAALLG
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
CDAHREYTLVGDTMNLAQRLQAMAEAGVTIVSAATAAALPADVVVPLDPRPVKGRVGDVR
CCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCEEEECCCCCCCCCCCCEE
AYRVIAGGASAPIPVPTPVVPAPALTAPVPRPRRRRLLARSAA
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]