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The map label for this gene is acbB [H]

Identifier: 158318028

GI number: 158318028

Start: 7637310

End: 7638338

Strand: Direct

Name: acbB [H]

Synonym: Franean1_6288

Alternate gene names: 158318028

Gene position: 7637310-7638338 (Clockwise)

Preceding gene: 158318027

Following gene: 158318029

Centisome position: 85.03

GC content: 68.9

Gene sequence:

>1029_bases
ATGAGGCTGCGGAATGTTCTGGTGACGGGAGGAGCCGGATTCATCGGCTCCCACCTCGTCGTCCGTCTGATCAGCAACCC
GACGGTCGAAAAGGTGACGGTGCTGGACGCCCTCACCTACGCCGGCCACCGCGACAACCTCGCCCCTGTCGCCGCCTCAC
CGAAGCTGGAGTTCGTCGAGGGCAACATCCTCGACGCCGACCTGCTCGCCAGCCTGATGGACGGGCAGGACGGTGTGGCG
CACTTAGCCGCCGAATCCCACGTCGACCGGTCATTCCTGGAGGCCGGGAACTTCCTGCTCACCAACGTGCTCGGCACCCA
GCGGGTCCTGGACGCCGCCCTGGCCGCCGGGGTCCGGCGGATCGTGCACGTGTCCACCGACGAGGTGTACGGGTCGTGGC
CGTCGGGGGCTGCGACCGAGGTCGATCCGGTCCGACCCACCTTCCCCTATTCGGCTTCCAAGGCCGCCAGCGACCTGGCC
ACCCTCGCCCACTTCCGCTCCTACGGCACCCCGGTGTCGGTGACCCGGTCGTCGAACTGCTACGGGCCCGCCCAGCATCC
CGAGAAGATCATCCCGCTGTTCGTGACCCGGCTGCTCCAGGGCCTGGAGGTCAGCCTGCACGGCCACGGCCAGCACCTGC
GGAACTGGTTGCATGTGGAGGACAACTGCGCCGGGATCGAGTTGGTGCTGCGTGGCGGCCAGCCCGGTGAGATCTACAAC
CTCGGCGGCGGCACCGACCTGACCACCCACCAGCTCACCGCGCTGCTGCTGGAGCTGTGCGGCGCGGACTGGTCGGCCGT
GTCGTATGTGCCCGACCGGACGGCCAACGACTACCGGTACAGCATGGACTCCTCCAAGGCCATGAGCGTCCTGGGCTACC
GGCCGGTCAGGGGTCTGCGGGAGAGCCTGGTCGAGACCGTCCAGTGGTACCGCGACCACCCCGACCGGTGGGGGCCCGGC
ACCCGCAACGCCGCCGCCCCGCTCGCCCAGGTTGAAGTCTCCACGCTGACCACTACCGCGCATGAGTGA

Upstream 100 bases:

>100_bases
CGGGCCTGTCGTTCCTGCTGTCCGACGGCGACACCGCCGCGCCCACCCTCGGCCAGGCCCGCGACGCCGGCCTGCTGCCC
GCCTACCTCGGAGGAGAGCC

Downstream 100 bases:

>100_bases
GCCGCTCTCGCCGCGGCGGGTGTTGGTAACCGGGGTCGGTGCGGCGCCGGGCCTTCAGACCGCCCGCGCCCTGCTGAAGC
GGGGCTGCGAGGTGGTCGCG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MRLRNVLVTGGAGFIGSHLVVRLISNPTVEKVTVLDALTYAGHRDNLAPVAASPKLEFVEGNILDADLLASLMDGQDGVA
HLAAESHVDRSFLEAGNFLLTNVLGTQRVLDAALAAGVRRIVHVSTDEVYGSWPSGAATEVDPVRPTFPYSASKAASDLA
TLAHFRSYGTPVSVTRSSNCYGPAQHPEKIIPLFVTRLLQGLEVSLHGHGQHLRNWLHVEDNCAGIELVLRGGQPGEIYN
LGGGTDLTTHQLTALLLELCGADWSAVSYVPDRTANDYRYSMDSSKAMSVLGYRPVRGLRESLVETVQWYRDHPDRWGPG
TRNAAAPLAQVEVSTLTTTAHE

Sequences:

>Translated_342_residues
MRLRNVLVTGGAGFIGSHLVVRLISNPTVEKVTVLDALTYAGHRDNLAPVAASPKLEFVEGNILDADLLASLMDGQDGVA
HLAAESHVDRSFLEAGNFLLTNVLGTQRVLDAALAAGVRRIVHVSTDEVYGSWPSGAATEVDPVRPTFPYSASKAASDLA
TLAHFRSYGTPVSVTRSSNCYGPAQHPEKIIPLFVTRLLQGLEVSLHGHGQHLRNWLHVEDNCAGIELVLRGGQPGEIYN
LGGGTDLTTHQLTALLLELCGADWSAVSYVPDRTANDYRYSMDSSKAMSVLGYRPVRGLRESLVETVQWYRDHPDRWGPG
TRNAAAPLAQVEVSTLTTTAHE
>Mature_342_residues
MRLRNVLVTGGAGFIGSHLVVRLISNPTVEKVTVLDALTYAGHRDNLAPVAASPKLEFVEGNILDADLLASLMDGQDGVA
HLAAESHVDRSFLEAGNFLLTNVLGTQRVLDAALAAGVRRIVHVSTDEVYGSWPSGAATEVDPVRPTFPYSASKAASDLA
TLAHFRSYGTPVSVTRSSNCYGPAQHPEKIIPLFVTRLLQGLEVSLHGHGQHLRNWLHVEDNCAGIELVLRGGQPGEIYN
LGGGTDLTTHQLTALLLELCGADWSAVSYVPDRTANDYRYSMDSSKAMSVLGYRPVRGLRESLVETVQWYRDHPDRWGPG
TRNAAAPLAQVEVSTLTTTAHE

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=324, Percent_Identity=38.8888888888889, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=26.984126984127, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI48994969, Length=339, Percent_Identity=40.4129793510324, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1788353, Length=334, Percent_Identity=39.8203592814371, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1788366, Length=343, Percent_Identity=25.9475218658892, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17568069, Length=322, Percent_Identity=32.9192546583851, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI115532424, Length=319, Percent_Identity=31.974921630094, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17539532, Length=333, Percent_Identity=23.4234234234234, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21356223, Length=316, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19923002, Length=351, Percent_Identity=24.7863247863248, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 36893; Mature: 36893

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRNVLVTGGAGFIGSHLVVRLISNPTVEKVTVLDALTYAGHRDNLAPVAASPKLEFVE
CCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
GNILDADLLASLMDGQDGVAHLAAESHVDRSFLEAGNFLLTNVLGTQRVLDAALAAGVRR
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IVHVSTDEVYGSWPSGAATEVDPVRPTFPYSASKAASDLATLAHFRSYGTPVSVTRSSNC
HHEECCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCC
YGPAQHPEKIIPLFVTRLLQGLEVSLHGHGQHLRNWLHVEDNCAGIELVLRGGQPGEIYN
CCCCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHCCCCCCCCEEEEEEECCCCCCEEE
LGGGTDLTTHQLTALLLELCGADWSAVSYVPDRTANDYRYSMDSSKAMSVLGYRPVRGLR
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCHHHHHHHCCCHHHHHH
ESLVETVQWYRDHPDRWGPGTRNAAAPLAQVEVSTLTTTAHE
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEHHHHCCCCCC
>Mature Secondary Structure
MRLRNVLVTGGAGFIGSHLVVRLISNPTVEKVTVLDALTYAGHRDNLAPVAASPKLEFVE
CCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
GNILDADLLASLMDGQDGVAHLAAESHVDRSFLEAGNFLLTNVLGTQRVLDAALAAGVRR
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IVHVSTDEVYGSWPSGAATEVDPVRPTFPYSASKAASDLATLAHFRSYGTPVSVTRSSNC
HHEECCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCC
YGPAQHPEKIIPLFVTRLLQGLEVSLHGHGQHLRNWLHVEDNCAGIELVLRGGQPGEIYN
CCCCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHCCCCCCCCEEEEEEECCCCCCEEE
LGGGTDLTTHQLTALLLELCGADWSAVSYVPDRTANDYRYSMDSSKAMSVLGYRPVRGLR
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCHHHHHHHCCCHHHHHH
ESLVETVQWYRDHPDRWGPGTRNAAAPLAQVEVSTLTTTAHE
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]