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The map label for this gene is drrB [H]

Identifier: 158317990

GI number: 158317990

Start: 7590450

End: 7591307

Strand: Reverse

Name: drrB [H]

Synonym: Franean1_6250

Alternate gene names: 158317990

Gene position: 7591307-7590450 (Counterclockwise)

Preceding gene: 158317991

Following gene: 158317988

Centisome position: 84.52

GC content: 67.95

Gene sequence:

>858_bases
ATGAACACCCTCGTAGCCGAACCGTCCGCCGCCCGCCCGCGATCGGCGCCAGCCGTCGACCCGGCCGCAGCCGTAGCCCG
CACGCGCGCCCGCCCCGGGCTGGGCGACACTTTCAACCAGACCTTCGCGATGGCGTGGCGGGCGCTGAAGAAGATGCGCC
GCAACCCGGAGCAGTTCTTCGACGTGGCGCTGCAGCCTCTGCTGTTCACCGCGATGTTCGCCTACGTGTTCGGTGGCGCG
ATCTCCGGTGACGTCGACAGCTACCTGCCGTTGCTGATTCCCGGCATCGTCGCCCAGACCGTGCTCACCACCTGCATGGC
CACCGGGGTGCAGATGCGGGAGGACATGGACAAGGGCGTCTTCGACCGGTTCCGGTCGTTGCCGATGTCCCGGATCGCGC
CGCTCGCCGGGCCGATGATGGCGGATCTGATCCGCTACCTGATCGCGGCGGTGCTGACCTATCTGATGGGCCTGCTGCTC
GGCTACCGGCCGGGCGGCGGTGTGCTCGGTGTTGTCGGTGCCGTCGTGCTCGCGGTCTTCACCGGCTGGGCGCTCGCGTG
GGCGTTCACCTGGATCGGCACACTGGCCCGCAGCGCCCGCAGCGTGCAGGGGATCTCGATGATGATCCTCTTCCCGCTCA
CCTTCCTTTCCAACGCCTTCGTGCCGGCGGACACGCTGCCGGGCTGGCTGGAGTCCTTCACCAAGATCAACCCGGTGTCG
CACCTGGTCTCCGGAACCCGCGACCTCGCCAACAACGGCGTGATCACCGGGCAGGTCGGCTGGACGCTGCTCGCCGGCCT
CTGCGTGATCGTGATCTTCATGCCGCTGTCGGTCATCAGCTACAAGCGGCACCTCTAG

Upstream 100 bases:

>100_bases
GCACCGGCACCGGGGACGGCACGGGCACCGCCGGCCCGGCCGGCGCCGTCCCCGGCCAGGACACGAACAGCCCCGACAAG
CCCGTCATGGAGAAGGCCCG

Downstream 100 bases:

>100_bases
CCGTGAATGCGGTGCCCCCACCCGATGGGCGGGCGACGCCCGGACGGCGTCCTGCCCGGTCAACTGCCCGGCCAGCCATC
CAGCCATCCAGTCAGGCGTT

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNTLVAEPSAARPRSAPAVDPAAAVARTRARPGLGDTFNQTFAMAWRALKKMRRNPEQFFDVALQPLLFTAMFAYVFGGA
ISGDVDSYLPLLIPGIVAQTVLTTCMATGVQMREDMDKGVFDRFRSLPMSRIAPLAGPMMADLIRYLIAAVLTYLMGLLL
GYRPGGGVLGVVGAVVLAVFTGWALAWAFTWIGTLARSARSVQGISMMILFPLTFLSNAFVPADTLPGWLESFTKINPVS
HLVSGTRDLANNGVITGQVGWTLLAGLCVIVIFMPLSVISYKRHL

Sequences:

>Translated_285_residues
MNTLVAEPSAARPRSAPAVDPAAAVARTRARPGLGDTFNQTFAMAWRALKKMRRNPEQFFDVALQPLLFTAMFAYVFGGA
ISGDVDSYLPLLIPGIVAQTVLTTCMATGVQMREDMDKGVFDRFRSLPMSRIAPLAGPMMADLIRYLIAAVLTYLMGLLL
GYRPGGGVLGVVGAVVLAVFTGWALAWAFTWIGTLARSARSVQGISMMILFPLTFLSNAFVPADTLPGWLESFTKINPVS
HLVSGTRDLANNGVITGQVGWTLLAGLCVIVIFMPLSVISYKRHL
>Mature_285_residues
MNTLVAEPSAARPRSAPAVDPAAAVARTRARPGLGDTFNQTFAMAWRALKKMRRNPEQFFDVALQPLLFTAMFAYVFGGA
ISGDVDSYLPLLIPGIVAQTVLTTCMATGVQMREDMDKGVFDRFRSLPMSRIAPLAGPMMADLIRYLIAAVLTYLMGLLL
GYRPGGGVLGVVGAVVLAVFTGWALAWAFTWIGTLARSARSVQGISMMILFPLTFLSNAFVPADTLPGWLESFTKINPVS
HLVSGTRDLANNGVITGQVGWTLLAGLCVIVIFMPLSVISYKRHL

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 30729; Mature: 30729

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]