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The map label for this gene is htpX [H]

Identifier: 158317985

GI number: 158317985

Start: 7581681

End: 7583330

Strand: Reverse

Name: htpX [H]

Synonym: Franean1_6245

Alternate gene names: 158317985

Gene position: 7583330-7581681 (Counterclockwise)

Preceding gene: 158317988

Following gene: 158317979

Centisome position: 84.43

GC content: 72.97

Gene sequence:

>1650_bases
ATGACGGGTTACGTCTGGCGGCGTTCGTCGGCCGCCTTGTCGGTGCTGGGCGGTGTACTGATCCTGGCCTGCTGGCTGCT
GACCGTCTTCACACCGGTGCCGGTCCTTGTGCCGGTGGCCGTCGTGACCGGCCTCGCCGTCCTGCAGTACCTGGTGGGGC
CGCGGGTCGTGGAGTGGCTGGCCCCAGCCCGAGAGCTGGAGCGTGGCGCCGACGGATATCTCAGCGACGAGCCGGTTGCC
GCGATCGTCGCCCGGCAGTGCCGGAACGCCGGCATTCCGCTGGTCCGGCTCGGCATCGTCGAGGACGGTGACCCCAACGC
GTTCACCTTCGGCCGGACCAGGCGGGACGCGCGTATCTGGATTTCCCGCGGGCTGCTCGACCGGCTCAACGACCGCGAGG
TCGAGGCGGTGGTCGCACACGAAATCGGGCACATCAGGAATCGGGACTTCGCCGTGATGACGGCGCTGTGCGTGGTGCCG
GCCCTCATGTACTACGCGGCGGCCGGCGCGCGCAGCAGCGACCAGTCCGGGGACAACGACCCGGTCAGGCTGATCGGGTC
CGCCGCCTACCTGCTCTCCGAGCTGGCGCTGCTCAGCTTCTCGCGCGCTCGCGAGCTGGGGGCCGACCACGCTTCCTGCG
TGATGACCGGGGACGGCGACGCGCTGTGCTCCGCCCTCGTCAAGATTGTGTACGGGATGGGGGAGCGGGATCAGGATCTC
GCCGCCCGCGTCCACGCGCTGCGGGAGAACGACGAGAAGGGAGCGGCCCGTCGGCTGGCTCGCCGGGAGAGCAGGGTCCG
GGCAGTCGGTGCCCTCGGTATCGCCAGCAGCGGCTCGGCGCCGTCCGTCGGCCTGATCGGCCCGGAGCTGCCCCCCGAGC
GTCTCGTGCGGGCGTTGCGCTGGGAGGTCACCAGCCCCTGGGCGCGCTGGCTGGAGATCTGCTCCACCCATCCCCTCGTC
TCGACCCGGATCGCCGCGCTGGAGGCGAGCGGCCTGCCCGGTGCGCCCCGGCAGTGGCGGGGAGCCCGGGCCGCGGCGCG
CGGGAGCGCCGGCGAGCGGGTCCGGGCCCGCGGCCAGTTCCTGGTGGAGCTGCCCGTGTACTTCGGTGGCTGGATCTGCC
TGGGTGCCGCGCTGATCCTCGCCCGCCGTGGGCCCGACCACTACGACCTGGGCTTCCTCGCCGGACTGGTGACGGCCGCC
GGTGCGCTGCTGCTGATCCGCGCGGGCCTGCGGGCACCGCTGGGCACTCCGGAGCCGGTCGGACGGCTCACCGACCTGCT
CGACCGGCTCGACGCCGGGCCACTCGGCGCGATACCGGTCAGCCTGCGCGGGACGATCGTGGGCCGGGGCGGGTTCGTGA
CCTCGCCCGACCTCGTCCTCGCGGACGCCAGCGGGACGGTGCCCGTCGTGTACCGCCACCCGGCGCCGGGAGGAGGGATC
CTGTTCGCGCTGACCCGGGCCCAGTCCTTCGTCGGAGACGAGGTGGTGGTGACCGGGTGGTATCTGCGCGCGCCCCATCC
GTACGTCGAACTGCGCACCGTCAGCGGCGCCGAGGCCGGGACCGTCCGGTGCTGGCTTTTCGCCGCACGCTATCTGCTGT
CCGCCGCGGTGCTCCTCGCCGGAGCCCTGCTGTTCGTGTACGCCCCCTGA

Upstream 100 bases:

>100_bases
GCAGCATGCGACGAGGCTATCCTCCGGCAGCCGGGAACGGTTTTGGATAACTTGGTCCGGGTTGTATGGCTGCTTGTCTG
GCCGATTCGGGGGGCGGGGC

Downstream 100 bases:

>100_bases
GCCCGATCCTCAACCCGGCCTTGGTGGGGGTGAGGATGATGCGCCGCGACAGCGGATGTCTCGACGGACGTCAGCGGGAC
AGTCCGGTCGCGCGCAGCGG

Product: peptidase M48 Ste24p

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTGYVWRRSSAALSVLGGVLILACWLLTVFTPVPVLVPVAVVTGLAVLQYLVGPRVVEWLAPARELERGADGYLSDEPVA
AIVARQCRNAGIPLVRLGIVEDGDPNAFTFGRTRRDARIWISRGLLDRLNDREVEAVVAHEIGHIRNRDFAVMTALCVVP
ALMYYAAAGARSSDQSGDNDPVRLIGSAAYLLSELALLSFSRARELGADHASCVMTGDGDALCSALVKIVYGMGERDQDL
AARVHALRENDEKGAARRLARRESRVRAVGALGIASSGSAPSVGLIGPELPPERLVRALRWEVTSPWARWLEICSTHPLV
STRIAALEASGLPGAPRQWRGARAAARGSAGERVRARGQFLVELPVYFGGWICLGAALILARRGPDHYDLGFLAGLVTAA
GALLLIRAGLRAPLGTPEPVGRLTDLLDRLDAGPLGAIPVSLRGTIVGRGGFVTSPDLVLADASGTVPVVYRHPAPGGGI
LFALTRAQSFVGDEVVVTGWYLRAPHPYVELRTVSGAEAGTVRCWLFAARYLLSAAVLLAGALLFVYAP

Sequences:

>Translated_549_residues
MTGYVWRRSSAALSVLGGVLILACWLLTVFTPVPVLVPVAVVTGLAVLQYLVGPRVVEWLAPARELERGADGYLSDEPVA
AIVARQCRNAGIPLVRLGIVEDGDPNAFTFGRTRRDARIWISRGLLDRLNDREVEAVVAHEIGHIRNRDFAVMTALCVVP
ALMYYAAAGARSSDQSGDNDPVRLIGSAAYLLSELALLSFSRARELGADHASCVMTGDGDALCSALVKIVYGMGERDQDL
AARVHALRENDEKGAARRLARRESRVRAVGALGIASSGSAPSVGLIGPELPPERLVRALRWEVTSPWARWLEICSTHPLV
STRIAALEASGLPGAPRQWRGARAAARGSAGERVRARGQFLVELPVYFGGWICLGAALILARRGPDHYDLGFLAGLVTAA
GALLLIRAGLRAPLGTPEPVGRLTDLLDRLDAGPLGAIPVSLRGTIVGRGGFVTSPDLVLADASGTVPVVYRHPAPGGGI
LFALTRAQSFVGDEVVVTGWYLRAPHPYVELRTVSGAEAGTVRCWLFAARYLLSAAVLLAGALLFVYAP
>Mature_548_residues
TGYVWRRSSAALSVLGGVLILACWLLTVFTPVPVLVPVAVVTGLAVLQYLVGPRVVEWLAPARELERGADGYLSDEPVAA
IVARQCRNAGIPLVRLGIVEDGDPNAFTFGRTRRDARIWISRGLLDRLNDREVEAVVAHEIGHIRNRDFAVMTALCVVPA
LMYYAAAGARSSDQSGDNDPVRLIGSAAYLLSELALLSFSRARELGADHASCVMTGDGDALCSALVKIVYGMGERDQDLA
ARVHALRENDEKGAARRLARRESRVRAVGALGIASSGSAPSVGLIGPELPPERLVRALRWEVTSPWARWLEICSTHPLVS
TRIAALEASGLPGAPRQWRGARAAARGSAGERVRARGQFLVELPVYFGGWICLGAALILARRGPDHYDLGFLAGLVTAAG
ALLLIRAGLRAPLGTPEPVGRLTDLLDRLDAGPLGAIPVSLRGTIVGRGGFVTSPDLVLADASGTVPVVYRHPAPGGGIL
FALTRAQSFVGDEVVVTGWYLRAPHPYVELRTVSGAEAGTVRCWLFAARYLLSAAVLLAGALLFVYAP

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=153, Percent_Identity=32.0261437908497, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 58375; Mature: 58244

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYVWRRSSAALSVLGGVLILACWLLTVFTPVPVLVPVAVVTGLAVLQYLVGPRVVEWL
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APARELERGADGYLSDEPVAAIVARQCRNAGIPLVRLGIVEDGDPNAFTFGRTRRDARIW
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEECCCCCCCHHHH
ISRGLLDRLNDREVEAVVAHEIGHIRNRDFAVMTALCVVPALMYYAAAGARSSDQSGDND
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PVRLIGSAAYLLSELALLSFSRARELGADHASCVMTGDGDALCSALVKIVYGMGERDQDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHH
AARVHALRENDEKGAARRLARRESRVRAVGALGIASSGSAPSVGLIGPELPPERLVRALR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHH
WEVTSPWARWLEICSTHPLVSTRIAALEASGLPGAPRQWRGARAAARGSAGERVRARGQF
HCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHCCCHHHHCCCCCHHHHHCCCE
LVELPVYFGGWICLGAALILARRGPDHYDLGFLAGLVTAAGALLLIRAGLRAPLGTPEPV
EEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
GRLTDLLDRLDAGPLGAIPVSLRGTIVGRGGFVTSPDLVLADASGTVPVVYRHPAPGGGI
HHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCE
LFALTRAQSFVGDEVVVTGWYLRAPHPYVELRTVSGAEAGTVRCWLFAARYLLSAAVLLA
EEEEHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
GALLFVYAP
HHHHHEECC
>Mature Secondary Structure 
TGYVWRRSSAALSVLGGVLILACWLLTVFTPVPVLVPVAVVTGLAVLQYLVGPRVVEWL
CCCEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APARELERGADGYLSDEPVAAIVARQCRNAGIPLVRLGIVEDGDPNAFTFGRTRRDARIW
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEECCCCCCCHHHH
ISRGLLDRLNDREVEAVVAHEIGHIRNRDFAVMTALCVVPALMYYAAAGARSSDQSGDND
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PVRLIGSAAYLLSELALLSFSRARELGADHASCVMTGDGDALCSALVKIVYGMGERDQDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHH
AARVHALRENDEKGAARRLARRESRVRAVGALGIASSGSAPSVGLIGPELPPERLVRALR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHH
WEVTSPWARWLEICSTHPLVSTRIAALEASGLPGAPRQWRGARAAARGSAGERVRARGQF
HCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHCCCHHHHCCCCCHHHHHCCCE
LVELPVYFGGWICLGAALILARRGPDHYDLGFLAGLVTAAGALLLIRAGLRAPLGTPEPV
EEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
GRLTDLLDRLDAGPLGAIPVSLRGTIVGRGGFVTSPDLVLADASGTVPVVYRHPAPGGGI
HHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCE
LFALTRAQSFVGDEVVVTGWYLRAPHPYVELRTVSGAEAGTVRCWLFAARYLLSAAVLLA
EEEEHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
GALLFVYAP
HHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]