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The map label for this gene is nuoM [H]

Identifier: 158317824

GI number: 158317824

Start: 7403644

End: 7405203

Strand: Reverse

Name: nuoM [H]

Synonym: Franean1_6082

Alternate gene names: 158317824

Gene position: 7405203-7403644 (Counterclockwise)

Preceding gene: 158317825

Following gene: 158317823

Centisome position: 82.44

GC content: 68.27

Gene sequence:

>1560_bases
GTGAGCACAGCCCCCTGGCTGACGATCATGCTGATCGTCCCCGCGGTCGGTTCGCTGGTCGTCGCGTCGCTGCCGCGCCG
GCACGGCACGCTCGCCAAGCAACTCGCGCTCGTGGTATCGCTGGCGGTTCTGGTGCTCGCGGTGCTGGCCACCGCCGCCT
ACGACCCGGACAAGGCCGGCTTCCAGTTCGGCCAGTCCTATGACTGGATCAAGGAGTTCGGCGTCTCCTACTCGGTGGGC
GCCGACGGCATCTCGCTGGTGCTGATGCTGCTCGCCGCGCTGCTCGTCCCGGTGGTCGTGCTGTCCTCCTGGGACGAGGC
GGAAGAGGGGCGGCGTTCCGTCCCCGCGTTCTTCGCGCTGCTGCTGGCGCTGGAGACGGGCATGGTCGGGGTGTTCGCCG
CCACCGACGTGTTCCTCTTCTATGTCTTCTTCGAGGCCATGCTCATCCCGATGTACTTCCTCATCGGGAGCTACGGGCCG
GTCGAGGAGAAGGCACAGCGCTCCTACGCGGCGGTGAAGTTCCTGCTCTACAGCCTGTTCGGCGGGCTGCTGATGCTCGC
CGCGGTGATCGGCCTGTACGTGGTCTCCGCCGACCAGCTCGGCACGGGCACGTTCGACTTCGCCACCCTGCGCCAGCTGG
AGATCACCCCGGGCGTGCAGAAGCTGCTCTTCCTCGGCTTCTTCATCGCCTTCGCCATCAAGGCGCCGCTGTTTCCCTTC
CACACCTGGCTGCCCGACGCCGGCGCGCAGTCGCCGACCGGCGGCGCCGTCCTGCTCGTCGGGGTGCTGGACAAGGTCGG
CACCTTCGGCCTGATCCGGTACTGCATCCCGCTGTTCCCGGACGCCGCCGAGTACTTCGCGCCGATGGTGCTGGCCCTGG
CGGTGATCGGCATCTTCTACGGCGCCCTGCTGGCCATCGGCCAGCGGGACATGAAACGGCTGGTCGCCTACACCTCGCTG
GCGCACTTCGGGTTCATAGCGCTGGGGACCTTCGCCTTCACCTCGCAGGCCGGCACGGGCGCCGTGCTCTACATGGTCAA
CCACGGCCTGTCGACGGGGCTGCTGTTCGTGGTGGTCGGCTTCCTGGTGGCCCGCCGGGGCAGCCGGGACGTCAGCGCCT
ACGGCGGCATGGCCCAGGTGACGCCGATCCTCGCCGGGGTCTTCCTGATCGCCGGCCTGTCCTCGCTGGCCCTGCCGGGT
ACGAACAGCTTCGTCAGCGAGTTCCTGGTGCTGGTCGGCACGTTCACCGAGTACCGGGCGCTGGCGATCGTCGCGACCTG
CGGGATCGTGCTCGCCGCGATCTACATCCTGTACCTGTACCAGCGCACGATGACCGGTCCGGTCAAGGACGAGAAGATGC
GTCTCATCAAGGACCTCAGCGTGCGGGAGCGGGTGGTGGTCGCGCCGATGGTCGCGCTGATCATCGGGCTCGGGGTGTAC
CCCAAGCCGCTGCTCGACATCATCACGCCCACGGTGACCGCCACGTTCGCGGACATCGGGAAGTCTGACCCGGCGCCGAC
GGCCCCGGTGGCCGCGCCGGAATCCGGAGGCCATTCGTGA

Upstream 100 bases:

>100_bases
CGACGCACCCAGACCGGCTTCGTCCGGTCCTACGCACTGTCGATGTTGGGAGGTACCGTCCTCGTGGTCGGTGCTCTGCT
GCTCACCAGGGCCGGCTGAC

Downstream 100 bases:

>100_bases
GCGCCGCAACGACTGTGCTGGCGCAGGGCGCCGCGCAGAAGATCACACCGCCGTCGATCGAGTACTCGTCCCTCAGCCCG
ATGCTCATCCTGTTCGGCGT

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MSTAPWLTIMLIVPAVGSLVVASLPRRHGTLAKQLALVVSLAVLVLAVLATAAYDPDKAGFQFGQSYDWIKEFGVSYSVG
ADGISLVLMLLAALLVPVVVLSSWDEAEEGRRSVPAFFALLLALETGMVGVFAATDVFLFYVFFEAMLIPMYFLIGSYGP
VEEKAQRSYAAVKFLLYSLFGGLLMLAAVIGLYVVSADQLGTGTFDFATLRQLEITPGVQKLLFLGFFIAFAIKAPLFPF
HTWLPDAGAQSPTGGAVLLVGVLDKVGTFGLIRYCIPLFPDAAEYFAPMVLALAVIGIFYGALLAIGQRDMKRLVAYTSL
AHFGFIALGTFAFTSQAGTGAVLYMVNHGLSTGLLFVVVGFLVARRGSRDVSAYGGMAQVTPILAGVFLIAGLSSLALPG
TNSFVSEFLVLVGTFTEYRALAIVATCGIVLAAIYILYLYQRTMTGPVKDEKMRLIKDLSVRERVVVAPMVALIIGLGVY
PKPLLDIITPTVTATFADIGKSDPAPTAPVAAPESGGHS

Sequences:

>Translated_519_residues
MSTAPWLTIMLIVPAVGSLVVASLPRRHGTLAKQLALVVSLAVLVLAVLATAAYDPDKAGFQFGQSYDWIKEFGVSYSVG
ADGISLVLMLLAALLVPVVVLSSWDEAEEGRRSVPAFFALLLALETGMVGVFAATDVFLFYVFFEAMLIPMYFLIGSYGP
VEEKAQRSYAAVKFLLYSLFGGLLMLAAVIGLYVVSADQLGTGTFDFATLRQLEITPGVQKLLFLGFFIAFAIKAPLFPF
HTWLPDAGAQSPTGGAVLLVGVLDKVGTFGLIRYCIPLFPDAAEYFAPMVLALAVIGIFYGALLAIGQRDMKRLVAYTSL
AHFGFIALGTFAFTSQAGTGAVLYMVNHGLSTGLLFVVVGFLVARRGSRDVSAYGGMAQVTPILAGVFLIAGLSSLALPG
TNSFVSEFLVLVGTFTEYRALAIVATCGIVLAAIYILYLYQRTMTGPVKDEKMRLIKDLSVRERVVVAPMVALIIGLGVY
PKPLLDIITPTVTATFADIGKSDPAPTAPVAAPESGGHS
>Mature_518_residues
STAPWLTIMLIVPAVGSLVVASLPRRHGTLAKQLALVVSLAVLVLAVLATAAYDPDKAGFQFGQSYDWIKEFGVSYSVGA
DGISLVLMLLAALLVPVVVLSSWDEAEEGRRSVPAFFALLLALETGMVGVFAATDVFLFYVFFEAMLIPMYFLIGSYGPV
EEKAQRSYAAVKFLLYSLFGGLLMLAAVIGLYVVSADQLGTGTFDFATLRQLEITPGVQKLLFLGFFIAFAIKAPLFPFH
TWLPDAGAQSPTGGAVLLVGVLDKVGTFGLIRYCIPLFPDAAEYFAPMVLALAVIGIFYGALLAIGQRDMKRLVAYTSLA
HFGFIALGTFAFTSQAGTGAVLYMVNHGLSTGLLFVVVGFLVARRGSRDVSAYGGMAQVTPILAGVFLIAGLSSLALPGT
NSFVSEFLVLVGTFTEYRALAIVATCGIVLAAIYILYLYQRTMTGPVKDEKMRLIKDLSVRERVVVAPMVALIIGLGVYP
KPLLDIITPTVTATFADIGKSDPAPTAPVAAPESGGHS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=374, Percent_Identity=30.4812834224599, Blast_Score=166, Evalue=7e-41,
Organism=Escherichia coli, GI1788613, Length=491, Percent_Identity=38.4928716904277, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1788827, Length=309, Percent_Identity=28.1553398058252, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1788831, Length=299, Percent_Identity=30.1003344481605, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788829, Length=414, Percent_Identity=28.9855072463768, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693160, Length=407, Percent_Identity=25.7985257985258, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788614, Length=452, Percent_Identity=24.7787610619469, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI2367154, Length=235, Percent_Identity=28.0851063829787, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55138; Mature: 55007

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAPWLTIMLIVPAVGSLVVASLPRRHGTLAKQLALVVSLAVLVLAVLATAAYDPDKAG
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FQFGQSYDWIKEFGVSYSVGADGISLVLMLLAALLVPVVVLSSWDEAEEGRRSVPAFFAL
HHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LLALETGMVGVFAATDVFLFYVFFEAMLIPMYFLIGSYGPVEEKAQRSYAAVKFLLYSLF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
GGLLMLAAVIGLYVVSADQLGTGTFDFATLRQLEITPGVQKLLFLGFFIAFAIKAPLFPF
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHH
HTWLPDAGAQSPTGGAVLLVGVLDKVGTFGLIRYCIPLFPDAAEYFAPMVLALAVIGIFY
HHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GALLAIGQRDMKRLVAYTSLAHFGFIALGTFAFTSQAGTGAVLYMVNHGLSTGLLFVVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
FLVARRGSRDVSAYGGMAQVTPILAGVFLIAGLSSLALPGTNSFVSEFLVLVGTFTEYRA
HHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LAIVATCGIVLAAIYILYLYQRTMTGPVKDEKMRLIKDLSVRERVVVAPMVALIIGLGVY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PKPLLDIITPTVTATFADIGKSDPAPTAPVAAPESGGHS
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STAPWLTIMLIVPAVGSLVVASLPRRHGTLAKQLALVVSLAVLVLAVLATAAYDPDKAG
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH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CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]