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The map label for this gene is nuoL [H]

Identifier: 158317825

GI number: 158317825

Start: 7405205

End: 7407193

Strand: Reverse

Name: nuoL [H]

Synonym: Franean1_6083

Alternate gene names: 158317825

Gene position: 7407193-7405205 (Counterclockwise)

Preceding gene: 158317826

Following gene: 158317824

Centisome position: 82.47

GC content: 69.18

Gene sequence:

>1989_bases
ATGAGCGCCGGAGGGGCCGCCATCCTCGCGGCCGACGAGCACGGTGGCGCGGCCGTGCACTACGCCGCCGCGTCCGGGGC
GTTCTCGCTGACCTGGCTGCTCATCGCGCTTCCGCTGGCCGGGGCGGCCGTTCTCCTGCTCGGCGGGCGGCGTACCGACC
GGTGGGGCCACCTGCTCGGCACGCTGACCGCGGCCGCATCCTTCGTCGTCGGCCTGGTCCTGTTCTTCGGGCTGCTCGAC
CGCTCCGGTGACGACCGGGCCGTCTCCCAGCACCTCTACAGCTGGATCCCGGTCAACGGCTTCCAGGTGGACGTCGGCCT
GCTGTTCGACCAGCTCTCCGCGGTCTTCGTGCTGCTGATCACCGGTGTGGGCACGCTGATCCACATCTACTCGATCGGCT
ACATGTCGCACGACCCGGGCCGGCGGCGCTTCTTCGCCTACATGAACCTGTTCCTGGCGTCGATGCTGCTGCTGGTGCTG
GGCAACAACTTCCTGGTGCTCTACGGTGGCTGGGAGCTGGTCGGCCTCTCGTCCTTCCTGCTCATCAAGTTCTGGGAGTA
CAAGCCGGCCGCGGCCACCGCCGCGAACAAGGCCTTCTACATGAACCGGGTCGGCGACGTCGGTCTCGCACTCGCGATCA
TGTTCATGTTCGCCACCGTCGGCAGCACGAACTACGACTCGGTGTTCGGTGCCGCCGCCGCGGACGTCATCGGCTACGGC
ACCATCACCGCGATGGCGCTCCTGCTCCTGCTCGGCGCCTGCGGCAAGTCCGGTCAGTTCCCGCTGCAGGCCTGGCTCCC
GGACGCCATGGAGGGCCCGACCCCGATCTCGGCGCTCATCCACGCCGCGACCATGGTCACCGCCGGTGTGTACCTGATCG
TCCGGGCTGCCCCGATCTTCGACCAGACGCAGGCCGCGCGGACCGTCGTCCTGATCATCGGCGCGGTCACGATCCTCATT
GGATGCGTCATCGGCTGCGCCTACGACGACATCAAGAAGGTCCTGGCCTACTCGACGGTCAGCCAGATCGGCTACATGTT
CCTCGCCGTCGGGCTCGGCCCGGCCGGGTACGCGCTGGGCATCATGCACCTGCTCGCGCACGGCTTCTTCAAGGCCGGCC
TGTTCCTCGGCTCCGGCTCGGTCATCCACGCGATGGACGGCGAGCAGGACATGCGCAGGCACGGCGGGCTGTGGCGGCAC
ATGCCGGTCACCTGGGTCACCTTCGGCCTCGGCTATCTGGCGATCATCGGTTTCCCGGGCCTGTCCGGGTTCTTCACCAA
GGACCGCATCATCGAGACGGCGCTGGCCAAGGGTGGCACCAGCGGCTACATCTACGGTGGCGTGGCGCTGCTCGGTGCCG
GGATCACCGCCTTCTACATGACCCGGCTGTTCCTGATGACCTTCCACGGCAAGGCGCGCTGGGAGCACGACGGGCCGAAG
GCCAAGCACCCGCACGAGTCGCCGGCGACAATGACCGGCCCGATGATGCTGCTGGCCGTCGGCTCGGTCTTCGCCGGTGG
GCTGTTCGTCCTCGGCAGCTCGATGCAGGACTGGCTCGCCCCGGTGGTGGGCGAACACGGCGAGGCGCACCACGACATCT
CGCCCGCGGTCGTCACCGCGCTGGTGCTGGTCGTCTCCGCCGGCGGGTTCGCCGGTGCCTACCTGCGCTACCAGCTCCGC
CCGGTCGAGGCCGTCGCCCGGCCGGACGCCGAGGTCAGCGTGGTGACCGTCGCCGCGCGCCACGACCTCTACGCGAACAC
CTTCAACGAGGTCGTCGCCATGCGGCCGGGGCAGTACCTGACCCGCTTCCTGGTCTGGGCGGACAACGTCGGCATCGACG
GCTTCGTGCGCGGGAGCGCCGCCGCCGTGGGCGGGCTGTCCGGCCGGCTGCGACGCACCCAGACCGGCTTCGTCCGGTCC
TACGCACTGTCGATGTTGGGAGGTACCGTCCTCGTGGTCGGTGCTCTGCTGCTCACCAGGGCCGGCTGA

Upstream 100 bases:

>100_bases
CGGACGACACTGCAGTGACGCTTTGCGCAACAGGGGCGGCGCAGCCCGGACCACCTCCGGTGGCCCTGGCGCTGGCGCAC
GTACCCGGAACCGGACCGCG

Downstream 100 bases:

>100_bases
CGTGAGCACAGCCCCCTGGCTGACGATCATGCTGATCGTCCCCGCGGTCGGTTCGCTGGTCGTCGCGTCGCTGCCGCGCC
GGCACGGCACGCTCGCCAAG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MSAGGAAILAADEHGGAAVHYAAASGAFSLTWLLIALPLAGAAVLLLGGRRTDRWGHLLGTLTAAASFVVGLVLFFGLLD
RSGDDRAVSQHLYSWIPVNGFQVDVGLLFDQLSAVFVLLITGVGTLIHIYSIGYMSHDPGRRRFFAYMNLFLASMLLLVL
GNNFLVLYGGWELVGLSSFLLIKFWEYKPAAATAANKAFYMNRVGDVGLALAIMFMFATVGSTNYDSVFGAAAADVIGYG
TITAMALLLLLGACGKSGQFPLQAWLPDAMEGPTPISALIHAATMVTAGVYLIVRAAPIFDQTQAARTVVLIIGAVTILI
GCVIGCAYDDIKKVLAYSTVSQIGYMFLAVGLGPAGYALGIMHLLAHGFFKAGLFLGSGSVIHAMDGEQDMRRHGGLWRH
MPVTWVTFGLGYLAIIGFPGLSGFFTKDRIIETALAKGGTSGYIYGGVALLGAGITAFYMTRLFLMTFHGKARWEHDGPK
AKHPHESPATMTGPMMLLAVGSVFAGGLFVLGSSMQDWLAPVVGEHGEAHHDISPAVVTALVLVVSAGGFAGAYLRYQLR
PVEAVARPDAEVSVVTVAARHDLYANTFNEVVAMRPGQYLTRFLVWADNVGIDGFVRGSAAAVGGLSGRLRRTQTGFVRS
YALSMLGGTVLVVGALLLTRAG

Sequences:

>Translated_662_residues
MSAGGAAILAADEHGGAAVHYAAASGAFSLTWLLIALPLAGAAVLLLGGRRTDRWGHLLGTLTAAASFVVGLVLFFGLLD
RSGDDRAVSQHLYSWIPVNGFQVDVGLLFDQLSAVFVLLITGVGTLIHIYSIGYMSHDPGRRRFFAYMNLFLASMLLLVL
GNNFLVLYGGWELVGLSSFLLIKFWEYKPAAATAANKAFYMNRVGDVGLALAIMFMFATVGSTNYDSVFGAAAADVIGYG
TITAMALLLLLGACGKSGQFPLQAWLPDAMEGPTPISALIHAATMVTAGVYLIVRAAPIFDQTQAARTVVLIIGAVTILI
GCVIGCAYDDIKKVLAYSTVSQIGYMFLAVGLGPAGYALGIMHLLAHGFFKAGLFLGSGSVIHAMDGEQDMRRHGGLWRH
MPVTWVTFGLGYLAIIGFPGLSGFFTKDRIIETALAKGGTSGYIYGGVALLGAGITAFYMTRLFLMTFHGKARWEHDGPK
AKHPHESPATMTGPMMLLAVGSVFAGGLFVLGSSMQDWLAPVVGEHGEAHHDISPAVVTALVLVVSAGGFAGAYLRYQLR
PVEAVARPDAEVSVVTVAARHDLYANTFNEVVAMRPGQYLTRFLVWADNVGIDGFVRGSAAAVGGLSGRLRRTQTGFVRS
YALSMLGGTVLVVGALLLTRAG
>Mature_661_residues
SAGGAAILAADEHGGAAVHYAAASGAFSLTWLLIALPLAGAAVLLLGGRRTDRWGHLLGTLTAAASFVVGLVLFFGLLDR
SGDDRAVSQHLYSWIPVNGFQVDVGLLFDQLSAVFVLLITGVGTLIHIYSIGYMSHDPGRRRFFAYMNLFLASMLLLVLG
NNFLVLYGGWELVGLSSFLLIKFWEYKPAAATAANKAFYMNRVGDVGLALAIMFMFATVGSTNYDSVFGAAAADVIGYGT
ITAMALLLLLGACGKSGQFPLQAWLPDAMEGPTPISALIHAATMVTAGVYLIVRAAPIFDQTQAARTVVLIIGAVTILIG
CVIGCAYDDIKKVLAYSTVSQIGYMFLAVGLGPAGYALGIMHLLAHGFFKAGLFLGSGSVIHAMDGEQDMRRHGGLWRHM
PVTWVTFGLGYLAIIGFPGLSGFFTKDRIIETALAKGGTSGYIYGGVALLGAGITAFYMTRLFLMTFHGKARWEHDGPKA
KHPHESPATMTGPMMLLAVGSVFAGGLFVLGSSMQDWLAPVVGEHGEAHHDISPAVVTALVLVVSAGGFAGAYLRYQLRP
VEAVARPDAEVSVVTVAARHDLYANTFNEVVAMRPGQYLTRFLVWADNVGIDGFVRGSAAAVGGLSGRLRRTQTGFVRSY
ALSMLGGTVLVVGALLLTRAG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=466, Percent_Identity=36.6952789699571, Blast_Score=285, Evalue=1e-76,
Organism=Escherichia coli, GI1788614, Length=485, Percent_Identity=43.298969072165, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1788829, Length=408, Percent_Identity=33.578431372549, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1788827, Length=471, Percent_Identity=31.2101910828025, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=30.4597701149425, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788613, Length=399, Percent_Identity=27.0676691729323, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI2367154, Length=218, Percent_Identity=29.3577981651376, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI145693160, Length=366, Percent_Identity=23.4972677595628, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 69932; Mature: 69800

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGGAAILAADEHGGAAVHYAAASGAFSLTWLLIALPLAGAAVLLLGGRRTDRWGHLLG
CCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
TLTAAASFVVGLVLFFGLLDRSGDDRAVSQHLYSWIPVNGFQVDVGLLFDQLSAVFVLLI
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
TGVGTLIHIYSIGYMSHDPGRRRFFAYMNLFLASMLLLVLGNNFLVLYGGWELVGLSSFL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
LIKFWEYKPAAATAANKAFYMNRVGDVGLALAIMFMFATVGSTNYDSVFGAAAADVIGYG
HHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TITAMALLLLLGACGKSGQFPLQAWLPDAMEGPTPISALIHAATMVTAGVYLIVRAAPIF
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCC
DQTQAARTVVLIIGAVTILIGCVIGCAYDDIKKVLAYSTVSQIGYMFLAVGLGPAGYALG
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IMHLLAHGFFKAGLFLGSGSVIHAMDGEQDMRRHGGLWRHMPVTWVTFGLGYLAIIGFPG
HHHHHHHHHHHHHEEECCCCEEEECCCHHHHHHCCCCEECCCHHHHHHHHHHHHHHCCCC
LSGFFTKDRIIETALAKGGTSGYIYGGVALLGAGITAFYMTRLFLMTFHGKARWEHDGPK
CCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AKHPHESPATMTGPMMLLAVGSVFAGGLFVLGSSMQDWLAPVVGEHGEAHHDISPAVVTA
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
LVLVVSAGGFAGAYLRYQLRPVEAVARPDAEVSVVTVAARHDLYANTFNEVVAMRPGQYL
HHHHHHCCCCCCEEEEEEECHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCHHHH
TRFLVWADNVGIDGFVRGSAAAVGGLSGRLRRTQTGFVRSYALSMLGGTVLVVGALLLTR
HHHHHHCCCCCCCCEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
AG
CC
>Mature Secondary Structure 
SAGGAAILAADEHGGAAVHYAAASGAFSLTWLLIALPLAGAAVLLLGGRRTDRWGHLLG
CCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
TLTAAASFVVGLVLFFGLLDRSGDDRAVSQHLYSWIPVNGFQVDVGLLFDQLSAVFVLLI
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
TGVGTLIHIYSIGYMSHDPGRRRFFAYMNLFLASMLLLVLGNNFLVLYGGWELVGLSSFL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
LIKFWEYKPAAATAANKAFYMNRVGDVGLALAIMFMFATVGSTNYDSVFGAAAADVIGYG
HHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TITAMALLLLLGACGKSGQFPLQAWLPDAMEGPTPISALIHAATMVTAGVYLIVRAAPIF
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCC
DQTQAARTVVLIIGAVTILIGCVIGCAYDDIKKVLAYSTVSQIGYMFLAVGLGPAGYALG
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IMHLLAHGFFKAGLFLGSGSVIHAMDGEQDMRRHGGLWRHMPVTWVTFGLGYLAIIGFPG
HHHHHHHHHHHHHEEECCCCEEEECCCHHHHHHCCCCEECCCHHHHHHHHHHHHHHCCCC
LSGFFTKDRIIETALAKGGTSGYIYGGVALLGAGITAFYMTRLFLMTFHGKARWEHDGPK
CCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AKHPHESPATMTGPMMLLAVGSVFAGGLFVLGSSMQDWLAPVVGEHGEAHHDISPAVVTA
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
LVLVVSAGGFAGAYLRYQLRPVEAVARPDAEVSVVTVAARHDLYANTFNEVVAMRPGQYL
HHHHHHCCCCCCEEEEEEECHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCHHHH
TRFLVWADNVGIDGFVRGSAAAVGGLSGRLRRTQTGFVRSYALSMLGGTVLVVGALLLTR
HHHHHHCCCCCCCCEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]