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The map label for this gene is nuoN

Identifier: 158317823

GI number: 158317823

Start: 7402070

End: 7403647

Strand: Reverse

Name: nuoN

Synonym: Franean1_6081

Alternate gene names: 158317823

Gene position: 7403647-7402070 (Counterclockwise)

Preceding gene: 158317824

Following gene: 158317822

Centisome position: 82.43

GC content: 70.53

Gene sequence:

>1578_bases
GTGAGCGCCGCAACGACTGTGCTGGCGCAGGGCGCCGCGCAGAAGATCACACCGCCGTCGATCGAGTACTCGTCCCTCAG
CCCGATGCTCATCCTGTTCGGCGTCGCGCTGGCCGGGGTCCTCGTCGACGCCTTCGCCCCGCCGAAGGCCCGGCGGGTGC
TCCAGCCGCTGCTGGCCGGGGCGGGGTTCATCGGCGCGTTCGTCGCGGTGGTGCTCCTGCACGCCCACCGCCAGGTGCTC
GCCGCCGGCGCGGTGGCCATCGACGGGCCGACGCTGTTCCTGCAGGGCACCATCCTGGTGTTCGCGCTGCTGTCGGTGCT
GCTGGTCGCCGAGCGCCGGCTGGACTCCTCCGGCGGCGCGCTCGTCGCCTCCGCCGCGGTCGTCCCCGGCTCGCGCGGCT
CCACCGCGCAGCGCACCTCGCCGGACGTGCAGACCGAGGCGTATCCGCTGATGGTCTTCTCGGTCAGCGGCATGCTGCTC
TTCGTCGCCTCGAACAACCTGCTGGTCATGTTCGTGGCGCTGGAGATCCTCTCGCTGCCGCTGTACCTGCTGTGCGGGCT
GGCGCGGCGCCGGCGGCTGCTGTCGCAGGAAGCCGCGATGAAGTACTTCCTGCTCGGGGCGTTCTCGTCCGCGTTCTTCC
TGTACGGCGTCGCGTTCGCCTACGGCTACGCTGGCAGCGTCGAGCTCGGCCGGGTCGCCGACGCGGTCGGCACGGTCGGC
CAGAACGACACCTACCTCTACCTGTCGCTCGCGCTGCTCGGCGTCGGCCTGTTCTTCAAGATCGGTGCCGCCCCGTTCCA
CTCCTGGACGCCGGACGTCTACCAGGGCGCGCCGACACCGATCACCGCCTTCATGGCGGCCGGGACGAAGGTCGCCGCTT
TCGGGGCGCTGCTGCGTGTCTTCTACGTGGCCTTCGGCGGCATGCGCTGGGACTGGCGGCCGGTGATCTGGGCTGTGGCG
ATCCTCACCATGGTCGTCGGCGCGGTGCTCGCGCTCACCCAGCGTGACATCAAGCGGATGCTCGCGTACTCCGCGGTCGC
CCACGCCGGCTTCCTGCTCGTCGGGATGGCCGGCTCGAACATCGACGGCCTGCGCGGCGCCATGTTCTACCTGGTGACCT
ACGGCTTCACCACGATCGCGGCGTTCGCGGTGGTCTCCCTGGTCCGCACCGGCGACGGCGAGGCCAGCGACCTCTCCCAG
TGGCAGGGCCTGGGCCGGACGTCGCCGCTGCTGGCAGGCACGTTCGCCTTCCTACTGCTCGCGCTCGCCGGCATCCCGCT
GACCAGCGGGTTCACCGGGAAGTTCGCGGTCTTCCAGGCGGCGATCGCCGGTGACGCCACCCCGCTGGTGGTCGTGGCCC
TGGTGTGCAGCGCGATCGCGGCGTTCTTCTACGTCCGGGTCATCGTGCTGATGTTCTTCTCCGAGCCGCTCGCCGACGGG
CCGGTCGTTGTCACCCGGCCGACTCTTACCTTCGCTACGGTGGGTATAGGTGCACTCATGACCCTGCTGTTGGGCGTGGC
GCCGCAGCCGCTTCTCGACCTGGCGACCACCGCGGCGACCTCCGGCTTCGTACGCTGA

Upstream 100 bases:

>100_bases
ACATCATCACGCCCACGGTGACCGCCACGTTCGCGGACATCGGGAAGTCTGACCCGGCGCCGACGGCCCCGGTGGCCGCG
CCGGAATCCGGAGGCCATTC

Downstream 100 bases:

>100_bases
TGGCGGTATGAGCGCTATCGGGCTGGAAGTGATGGGGATCAGGGCCGACCCTGATCTCGAGAAGTCGATGCGGGTCGGGC
TCGCCGCGGTCGAGGAGATG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSAATTVLAQGAAQKITPPSIEYSSLSPMLILFGVALAGVLVDAFAPPKARRVLQPLLAGAGFIGAFVAVVLLHAHRQVL
AAGAVAIDGPTLFLQGTILVFALLSVLLVAERRLDSSGGALVASAAVVPGSRGSTAQRTSPDVQTEAYPLMVFSVSGMLL
FVASNNLLVMFVALEILSLPLYLLCGLARRRRLLSQEAAMKYFLLGAFSSAFFLYGVAFAYGYAGSVELGRVADAVGTVG
QNDTYLYLSLALLGVGLFFKIGAAPFHSWTPDVYQGAPTPITAFMAAGTKVAAFGALLRVFYVAFGGMRWDWRPVIWAVA
ILTMVVGAVLALTQRDIKRMLAYSAVAHAGFLLVGMAGSNIDGLRGAMFYLVTYGFTTIAAFAVVSLVRTGDGEASDLSQ
WQGLGRTSPLLAGTFAFLLLALAGIPLTSGFTGKFAVFQAAIAGDATPLVVVALVCSAIAAFFYVRVIVLMFFSEPLADG
PVVVTRPTLTFATVGIGALMTLLLGVAPQPLLDLATTAATSGFVR

Sequences:

>Translated_525_residues
MSAATTVLAQGAAQKITPPSIEYSSLSPMLILFGVALAGVLVDAFAPPKARRVLQPLLAGAGFIGAFVAVVLLHAHRQVL
AAGAVAIDGPTLFLQGTILVFALLSVLLVAERRLDSSGGALVASAAVVPGSRGSTAQRTSPDVQTEAYPLMVFSVSGMLL
FVASNNLLVMFVALEILSLPLYLLCGLARRRRLLSQEAAMKYFLLGAFSSAFFLYGVAFAYGYAGSVELGRVADAVGTVG
QNDTYLYLSLALLGVGLFFKIGAAPFHSWTPDVYQGAPTPITAFMAAGTKVAAFGALLRVFYVAFGGMRWDWRPVIWAVA
ILTMVVGAVLALTQRDIKRMLAYSAVAHAGFLLVGMAGSNIDGLRGAMFYLVTYGFTTIAAFAVVSLVRTGDGEASDLSQ
WQGLGRTSPLLAGTFAFLLLALAGIPLTSGFTGKFAVFQAAIAGDATPLVVVALVCSAIAAFFYVRVIVLMFFSEPLADG
PVVVTRPTLTFATVGIGALMTLLLGVAPQPLLDLATTAATSGFVR
>Mature_524_residues
SAATTVLAQGAAQKITPPSIEYSSLSPMLILFGVALAGVLVDAFAPPKARRVLQPLLAGAGFIGAFVAVVLLHAHRQVLA
AGAVAIDGPTLFLQGTILVFALLSVLLVAERRLDSSGGALVASAAVVPGSRGSTAQRTSPDVQTEAYPLMVFSVSGMLLF
VASNNLLVMFVALEILSLPLYLLCGLARRRRLLSQEAAMKYFLLGAFSSAFFLYGVAFAYGYAGSVELGRVADAVGTVGQ
NDTYLYLSLALLGVGLFFKIGAAPFHSWTPDVYQGAPTPITAFMAAGTKVAAFGALLRVFYVAFGGMRWDWRPVIWAVAI
LTMVVGAVLALTQRDIKRMLAYSAVAHAGFLLVGMAGSNIDGLRGAMFYLVTYGFTTIAAFAVVSLVRTGDGEASDLSQW
QGLGRTSPLLAGTFAFLLLALAGIPLTSGFTGKFAVFQAAIAGDATPLVVVALVCSAIAAFFYVRVIVLMFFSEPLADGP
VVVTRPTLTFATVGIGALMTLLLGVAPQPLLDLATTAATSGFVR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831117, Length=345, Percent_Identity=23.768115942029, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI251831108, Length=291, Percent_Identity=23.3676975945017, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI145693160, Length=383, Percent_Identity=36.0313315926893, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1788831, Length=392, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788614, Length=326, Percent_Identity=27.3006134969325, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788827, Length=303, Percent_Identity=26.4026402640264, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788613, Length=279, Percent_Identity=24.3727598566308, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788829, Length=192, Percent_Identity=30.7291666666667, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_FRASN (A8LC88)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001510331.1
- GeneID:   5674402
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_6081
- HOGENOM:   HBG747830
- OMA:   LMFFSEP
- ProtClustDB:   PRK05777
- BioCyc:   FSP1855:FRANEAN1_6081-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 54762; Mature: 54631

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ab76d1c)-; HASH(0x1f9632d4)-; HASH(0x212b6428)-; HASH(0x212ec7cc)-; HASH(0x20b06728)-; HASH(0x211c221c)-; HASH(0x21d4badc)-; HASH(0x219d0684)-; HASH(0x21e5d1d8)-; HASH(0x2197ebc8)-; HASH(0x217aa280)-; HASH(0x21a231e4)-; HASH(0x210f1e68)-; HASH(0x20ddd58c)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAATTVLAQGAAQKITPPSIEYSSLSPMLILFGVALAGVLVDAFAPPKARRVLQPLLAG
CCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
AGFIGAFVAVVLLHAHRQVLAAGAVAIDGPTLFLQGTILVFALLSVLLVAERRLDSSGGA
CCHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LVASAAVVPGSRGSTAQRTSPDVQTEAYPLMVFSVSGMLLFVASNNLLVMFVALEILSLP
EEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHH
LYLLCGLARRRRLLSQEAAMKYFLLGAFSSAFFLYGVAFAYGYAGSVELGRVADAVGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QNDTYLYLSLALLGVGLFFKIGAAPFHSWTPDVYQGAPTPITAFMAAGTKVAAFGALLRV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHCCCHHHHHHHHHHH
FYVAFGGMRWDWRPVIWAVAILTMVVGAVLALTQRDIKRMLAYSAVAHAGFLLVGMAGSN
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCC
IDGLRGAMFYLVTYGFTTIAAFAVVSLVRTGDGEASDLSQWQGLGRTSPLLAGTFAFLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
ALAGIPLTSGFTGKFAVFQAAIAGDATPLVVVALVCSAIAAFFYVRVIVLMFFSEPLADG
HHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVVVTRPTLTFATVGIGALMTLLLGVAPQPLLDLATTAATSGFVR
CEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
SAATTVLAQGAAQKITPPSIEYSSLSPMLILFGVALAGVLVDAFAPPKARRVLQPLLAG
CCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
AGFIGAFVAVVLLHAHRQVLAAGAVAIDGPTLFLQGTILVFALLSVLLVAERRLDSSGGA
CCHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LVASAAVVPGSRGSTAQRTSPDVQTEAYPLMVFSVSGMLLFVASNNLLVMFVALEILSLP
EEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHH
LYLLCGLARRRRLLSQEAAMKYFLLGAFSSAFFLYGVAFAYGYAGSVELGRVADAVGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QNDTYLYLSLALLGVGLFFKIGAAPFHSWTPDVYQGAPTPITAFMAAGTKVAAFGALLRV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHCCCHHHHHHHHHHH
FYVAFGGMRWDWRPVIWAVAILTMVVGAVLALTQRDIKRMLAYSAVAHAGFLLVGMAGSN
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCC
IDGLRGAMFYLVTYGFTTIAAFAVVSLVRTGDGEASDLSQWQGLGRTSPLLAGTFAFLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
ALAGIPLTSGFTGKFAVFQAAIAGDATPLVVVALVCSAIAAFFYVRVIVLMFFSEPLADG
HHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVVVTRPTLTFATVGIGALMTLLLGVAPQPLLDLATTAATSGFVR
CEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA