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The map label for this gene is manA [H]

Identifier: 158317605

GI number: 158317605

Start: 7109857

End: 7111146

Strand: Direct

Name: manA [H]

Synonym: Franean1_5861

Alternate gene names: 158317605

Gene position: 7109857-7111146 (Clockwise)

Preceding gene: 158317604

Following gene: 158317611

Centisome position: 79.16

GC content: 76.28

Gene sequence:

>1290_bases
GTGACCATCGGGGAGACCACACCAGCCAACACCGGGACGTCCGTTCGGAGGTGGGACGCGCGGACCGGCCGACCGGCGGG
CGCGCCACGCGGGGCACCACCGCCGCGTGCCCCGGTCCGCATCCTGGAGCTGCACGGCCGGGCACAGCGCTACGCCTGGG
GCTCGCCGACCGCGATACCCGACCTCCTGGACGTCCCGTCCGACGGGGAGCCCGTCGCCGAGCTGTGGCTGGGCACCCAC
CCCCAGGCCCCGGCCGAGGTCGTGGGCACCGGAACCTCAGGTCGGCGGCCGGCCGCCGACCTCGTCGGCGAGCTGCCCTT
CCTGCTGAAGGTGCTCGCCGCCGACAAGGCCCTGTCGCTGCAGGTCCACCCGAACGTCGAGCAGGCACGCGCCGGCTTCG
ACGCCGAGCAGGCCGCAGGGATCACTCCCGACGACCCGCGCCGCCGCTACCGGGACCGCAACCACAAGCCCGAGCTGATC
GTGGCCCTGACGCCGTTCCGGGCCCTCGCCGGCATCCGGGCGCCCGGCGCCACCCTCGCGATCGCGCGCGGGCTCGGCCA
TCCCGGTCTGATCGCCGCGTTCGCGCCCCTGGCGACCGATCCGGCCGGCGGCGCCACCCAGGTGCTGCGCAGCCTGCTGA
CACTCCCCCCGCAGGCCGGCGAGGAGCTGGCCGCCGGGGTGGTCGCCGCCGCCGAGCGGGTCTCCCCCGACGCGGACGAG
CAGTTGCGTCGCGCGGCCGAGCTCGTCCTGCTGCTCGCCGAGACCCACCCCGGGGACGTCGGCATCGCCGCGGCGCTGCT
GCTCAACGACGTCACGCTGCGCCCCGGCGAGGGCCTGTTCCAGCCGGCGCGGCTGCTGCACGCCTACGTCCAGGGCGTCG
GGATCGAGATCATGGCCACGTCGGACAACGTCCTGCGCGGCGGGCTCACCCCGAAGCACATCGACGTCGACGAGCTGCTG
CGGATCCTCGACCCGCGCCCCACCAGCGCTCCGGTACTCACCCCGCGCCCGCTGGCGACCGGCCCCGGCGGCCAGCTGCG
GGCCTGGGATGTGCCGGTGGACGACTTCGTCCTGCGCGAGGCTGTCTGCGCCGGTGGCAGCGTGGCGGTGCCCGACACGT
CCGTGCTGCTGGCGGTGGAGGGCAGCGTCGAGGTCGCGGGCACGGACCTGGCGGGCTCGCCGCTGGCGCCGATGACCCTG
CGCCGCGGCGGCTCGGCCCTGGTGACCGGCCCGGCAGCCCTGACACTCACCGGCACGGGACGGGTCTTCGCCGCGGGCTC
CCGCGTCTGA

Upstream 100 bases:

>100_bases
GGCCATGGCTGGGGCGACGACGAGGAGTAGGGCCCACCACGAGAGCCACCCGACGGGCTCAGAGCCGCTCACGACCGCCG
ACGCGGGGACGGAGACACGT

Downstream 100 bases:

>100_bases
GCCCGGCCAGACAGAGAGCACACGCAGACCACTACACCTTCGTTTGGCCTGGGCGGGTGCCGCTCACCAGGCGACGCGCG
GATCGGCCAGCGACGCCGGA

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTIGETTPANTGTSVRRWDARTGRPAGAPRGAPPPRAPVRILELHGRAQRYAWGSPTAIPDLLDVPSDGEPVAELWLGTH
PQAPAEVVGTGTSGRRPAADLVGELPFLLKVLAADKALSLQVHPNVEQARAGFDAEQAAGITPDDPRRRYRDRNHKPELI
VALTPFRALAGIRAPGATLAIARGLGHPGLIAAFAPLATDPAGGATQVLRSLLTLPPQAGEELAAGVVAAAERVSPDADE
QLRRAAELVLLLAETHPGDVGIAAALLLNDVTLRPGEGLFQPARLLHAYVQGVGIEIMATSDNVLRGGLTPKHIDVDELL
RILDPRPTSAPVLTPRPLATGPGGQLRAWDVPVDDFVLREAVCAGGSVAVPDTSVLLAVEGSVEVAGTDLAGSPLAPMTL
RRGGSALVTGPAALTLTGTGRVFAAGSRV

Sequences:

>Translated_429_residues
MTIGETTPANTGTSVRRWDARTGRPAGAPRGAPPPRAPVRILELHGRAQRYAWGSPTAIPDLLDVPSDGEPVAELWLGTH
PQAPAEVVGTGTSGRRPAADLVGELPFLLKVLAADKALSLQVHPNVEQARAGFDAEQAAGITPDDPRRRYRDRNHKPELI
VALTPFRALAGIRAPGATLAIARGLGHPGLIAAFAPLATDPAGGATQVLRSLLTLPPQAGEELAAGVVAAAERVSPDADE
QLRRAAELVLLLAETHPGDVGIAAALLLNDVTLRPGEGLFQPARLLHAYVQGVGIEIMATSDNVLRGGLTPKHIDVDELL
RILDPRPTSAPVLTPRPLATGPGGQLRAWDVPVDDFVLREAVCAGGSVAVPDTSVLLAVEGSVEVAGTDLAGSPLAPMTL
RRGGSALVTGPAALTLTGTGRVFAAGSRV
>Mature_428_residues
TIGETTPANTGTSVRRWDARTGRPAGAPRGAPPPRAPVRILELHGRAQRYAWGSPTAIPDLLDVPSDGEPVAELWLGTHP
QAPAEVVGTGTSGRRPAADLVGELPFLLKVLAADKALSLQVHPNVEQARAGFDAEQAAGITPDDPRRRYRDRNHKPELIV
ALTPFRALAGIRAPGATLAIARGLGHPGLIAAFAPLATDPAGGATQVLRSLLTLPPQAGEELAAGVVAAAERVSPDADEQ
LRRAAELVLLLAETHPGDVGIAAALLLNDVTLRPGEGLFQPARLLHAYVQGVGIEIMATSDNVLRGGLTPKHIDVDELLR
ILDPRPTSAPVLTPRPLATGPGGQLRAWDVPVDDFVLREAVCAGGSVAVPDTSVLLAVEGSVEVAGTDLAGSPLAPMTLR
RGGSALVTGPAALTLTGTGRVFAAGSRV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=419, Percent_Identity=30.3102625298329, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1787899, Length=402, Percent_Identity=36.5671641791045, Blast_Score=204, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71997620, Length=404, Percent_Identity=30.4455445544554, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17557650, Length=332, Percent_Identity=29.8192771084337, Blast_Score=134, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320839, Length=367, Percent_Identity=28.6103542234332, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21356061, Length=335, Percent_Identity=31.9402985074627, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 44350; Mature: 44219

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00965 PMI_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGETTPANTGTSVRRWDARTGRPAGAPRGAPPPRAPVRILELHGRAQRYAWGSPTAIP
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCCC
DLLDVPSDGEPVAELWLGTHPQAPAEVVGTGTSGRRPAADLVGELPFLLKVLAADKALSL
HHHCCCCCCCHHHHHHCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
QVHPNVEQARAGFDAEQAAGITPDDPRRRYRDRNHKPELIVALTPFRALAGIRAPGATLA
EECCCHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHHCCCCCCHHHH
IARGLGHPGLIAAFAPLATDPAGGATQVLRSLLTLPPQAGEELAAGVVAAAERVSPDADE
HHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHH
QLRRAAELVLLLAETHPGDVGIAAALLLNDVTLRPGEGLFQPARLLHAYVQGVGIEIMAT
HHHHHHHHEEEEECCCCCCHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHCCCEEEEEC
SDNVLRGGLTPKHIDVDELLRILDPRPTSAPVLTPRPLATGPGGQLRAWDVPVDDFVLRE
CCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
AVCAGGSVAVPDTSVLLAVEGSVEVAGTDLAGSPLAPMTLRRGGSALVTGPAALTLTGTG
HHHCCCCEECCCCEEEEEECCCEEEECCCCCCCCCCCHHHHCCCCEEEECCEEEEEECCC
RVFAAGSRV
EEEECCCCC
>Mature Secondary Structure 
TIGETTPANTGTSVRRWDARTGRPAGAPRGAPPPRAPVRILELHGRAQRYAWGSPTAIP
CCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCCC
DLLDVPSDGEPVAELWLGTHPQAPAEVVGTGTSGRRPAADLVGELPFLLKVLAADKALSL
HHHCCCCCCCHHHHHHCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
QVHPNVEQARAGFDAEQAAGITPDDPRRRYRDRNHKPELIVALTPFRALAGIRAPGATLA
EECCCHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHHCCCCCCHHHH
IARGLGHPGLIAAFAPLATDPAGGATQVLRSLLTLPPQAGEELAAGVVAAAERVSPDADE
HHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHH
QLRRAAELVLLLAETHPGDVGIAAALLLNDVTLRPGEGLFQPARLLHAYVQGVGIEIMAT
HHHHHHHHEEEEECCCCCCHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHCCCEEEEEC
SDNVLRGGLTPKHIDVDELLRILDPRPTSAPVLTPRPLATGPGGQLRAWDVPVDDFVLRE
CCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
AVCAGGSVAVPDTSVLLAVEGSVEVAGTDLAGSPLAPMTLRRGGSALVTGPAALTLTGTG
HHHCCCCEECCCCEEEEEECCCEEEECCCCCCCCCCCHHHHCCCCEEEECCEEEEEECCC
RVFAAGSRV
EEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]