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The map label for this gene is yqjQ [H]

Identifier: 158317466

GI number: 158317466

Start: 6940338

End: 6941168

Strand: Reverse

Name: yqjQ [H]

Synonym: Franean1_5718

Alternate gene names: 158317466

Gene position: 6941168-6940338 (Counterclockwise)

Preceding gene: 158317467

Following gene: 158317465

Centisome position: 77.28

GC content: 71.84

Gene sequence:

>831_bases
GTGAACACTCGGCCCCGCGCAGCCGCCCGCGAGGGGAACCTGACCGTCGTATCCAGCGGTGCGCGATCCGCCTCGCCGGG
GGGATGGCCGCCACGGACAGCCGTGGTGACCGGAGCCAGCTCCGGCATCGGCCGGGAGGCGGCGCTCCTGCTCGCCGACC
AGAACTGCCGATCGCTCCTGGTCGGGCGGAACGGCCCGGCCCTGGACGAGGTGGCAGCCGCTACGCAGGGCCATCGGATC
GCCGTGGACCTCGCACGTCCCGGCTCCGAGGTCACGGTGGCCTCTCGCGCCTCGGAGCTGCTCGGCGACGTGGATCTGGT
GATCTGCTCGGCGGGCCTGGGCGCCGCGGGGCCGTTCGACGTGATGCCCCCGTCTGCCATCAACGATCTCGTCGCCGTGA
ACATCCTGGCCCCGATGATGCTGGTCCGGGCGATGCTGCCGGCGATGCTCGACCGGGGGGAGGGGCGAATCCTCCTGGTC
GGCAGTGTCGCCGGCGCGCTGGGTGTGCGAGGCGAGGTCGTGTACTCGGCGACGAAGGCGGCGATGGTGGGCTTCGCCGA
CGCGCTTCGTTCCGAAGTAGCCGGACGCGGCATCAGCGTGACGTTGTGTTTACCGGGAGTGGTCGACACCCCCTTCTTTC
ACCGGCGTGGCGCACCGTATGTGCGCCGGTGGCCGCGTCCCATCCCGGCCGGTCTGGTGGCGCAGCGCATGATCGCTGCC
GCCGGTCGGGGAGACGCCGAAGTATGGGTGCCACGGTGGTTGTCCGCGGCCGCGCGCGTGCACGGCGCGGCTCCTTCTCT
GTACCGCCGCCTGGCCGGTGTCTTCGGATGA

Upstream 100 bases:

>100_bases
GCCGATGGTGGAGGGCGACATAAACGGAAGCAGTAGGTGACGTGAAACCTGTGCCGGAACGGGACCACGGGGGGGACCGT
GTGACCCGAGGTGGTGGGCC

Downstream 100 bases:

>100_bases
GCCCGAGGCCGGCCCAGGAGGTGAGTGAGCAGGTCGACTACTGAGTCGCCGCCGGTGGCACCCCCACCGGCGGCGAGGCG
GCAGCCGCGGCGCGGCCCGT

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNTRPRAAAREGNLTVVSSGARSASPGGWPPRTAVVTGASSGIGREAALLLADQNCRSLLVGRNGPALDEVAAATQGHRI
AVDLARPGSEVTVASRASELLGDVDLVICSAGLGAAGPFDVMPPSAINDLVAVNILAPMMLVRAMLPAMLDRGEGRILLV
GSVAGALGVRGEVVYSATKAAMVGFADALRSEVAGRGISVTLCLPGVVDTPFFHRRGAPYVRRWPRPIPAGLVAQRMIAA
AGRGDAEVWVPRWLSAAARVHGAAPSLYRRLAGVFG

Sequences:

>Translated_276_residues
MNTRPRAAAREGNLTVVSSGARSASPGGWPPRTAVVTGASSGIGREAALLLADQNCRSLLVGRNGPALDEVAAATQGHRI
AVDLARPGSEVTVASRASELLGDVDLVICSAGLGAAGPFDVMPPSAINDLVAVNILAPMMLVRAMLPAMLDRGEGRILLV
GSVAGALGVRGEVVYSATKAAMVGFADALRSEVAGRGISVTLCLPGVVDTPFFHRRGAPYVRRWPRPIPAGLVAQRMIAA
AGRGDAEVWVPRWLSAAARVHGAAPSLYRRLAGVFG
>Mature_276_residues
MNTRPRAAAREGNLTVVSSGARSASPGGWPPRTAVVTGASSGIGREAALLLADQNCRSLLVGRNGPALDEVAAATQGHRI
AVDLARPGSEVTVASRASELLGDVDLVICSAGLGAAGPFDVMPPSAINDLVAVNILAPMMLVRAMLPAMLDRGEGRILLV
GSVAGALGVRGEVVYSATKAAMVGFADALRSEVAGRGISVTLCLPGVVDTPFFHRRGAPYVRRWPRPIPAGLVAQRMIAA
AGRGDAEVWVPRWLSAAARVHGAAPSLYRRLAGVFG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=214, Percent_Identity=34.1121495327103, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI20149619, Length=259, Percent_Identity=28.957528957529, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7657478, Length=188, Percent_Identity=33.5106382978723, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI210032110, Length=242, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI157739938, Length=187, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI142976729, Length=186, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI223718074, Length=194, Percent_Identity=32.9896907216495, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI40254992, Length=206, Percent_Identity=29.6116504854369, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5031737, Length=192, Percent_Identity=31.25, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI32455239, Length=194, Percent_Identity=29.8969072164948, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI5031765, Length=194, Percent_Identity=29.8969072164948, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=31.0160427807487, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI40807363, Length=245, Percent_Identity=26.530612244898, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI7705855, Length=197, Percent_Identity=30.4568527918782, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI226371731, Length=199, Percent_Identity=30.6532663316583, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7706318, Length=212, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI32483357, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1787335, Length=209, Percent_Identity=30.1435406698565, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786701, Length=185, Percent_Identity=33.5135135135135, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=192, Percent_Identity=32.8125, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787820, Length=183, Percent_Identity=28.9617486338798, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787526, Length=184, Percent_Identity=33.1521739130435, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=230, Percent_Identity=30.4347826086957, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17564282, Length=213, Percent_Identity=29.1079812206573, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=35.7894736842105, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193203115, Length=227, Percent_Identity=28.1938325991189, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=191, Percent_Identity=33.5078534031414, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=232, Percent_Identity=24.5689655172414, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=205, Percent_Identity=28.2926829268293, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25152911, Length=209, Percent_Identity=30.622009569378, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=206, Percent_Identity=28.1553398058252, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=229, Percent_Identity=26.6375545851528, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=243, Percent_Identity=27.1604938271605, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=28.8770053475936, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21358495, Length=192, Percent_Identity=32.2916666666667, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24584744, Length=194, Percent_Identity=33.5051546391753, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574402, Length=193, Percent_Identity=33.6787564766839, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581726, Length=136, Percent_Identity=33.0882352941176, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=194, Percent_Identity=30.4123711340206, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640492, Length=256, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161076933, Length=192, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584748, Length=192, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355631, Length=173, Percent_Identity=28.3236994219653, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356301, Length=200, Percent_Identity=28, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510726, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI23397609, Length=189, Percent_Identity=30.1587301587302, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28571526, Length=195, Percent_Identity=28.2051282051282, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649181, Length=261, Percent_Identity=26.8199233716475, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28393; Mature: 28393

Theoretical pI: Translated: 11.24; Mature: 11.24

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRPRAAAREGNLTVVSSGARSASPGGWPPRTAVVTGASSGIGREAALLLADQNCRSLL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCEEE
VGRNGPALDEVAAATQGHRIAVDLARPGSEVTVASRASELLGDVDLVICSAGLGAAGPFD
ECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHCCHHEEEEECCCCCCCCCC
VMPPSAINDLVAVNILAPMMLVRAMLPAMLDRGEGRILLVGSVAGALGVRGEVVYSATKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCEEHHHHHH
AMVGFADALRSEVAGRGISVTLCLPGVVDTPFFHRRGAPYVRRWPRPIPAGLVAQRMIAA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHCCCCCHHHHCCCCCCHHHHHHHHHHH
AGRGDAEVWVPRWLSAAARVHGAAPSLYRRLAGVFG
CCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNTRPRAAAREGNLTVVSSGARSASPGGWPPRTAVVTGASSGIGREAALLLADQNCRSLL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCEEE
VGRNGPALDEVAAATQGHRIAVDLARPGSEVTVASRASELLGDVDLVICSAGLGAAGPFD
ECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHCCHHEEEEECCCCCCCCCC
VMPPSAINDLVAVNILAPMMLVRAMLPAMLDRGEGRILLVGSVAGALGVRGEVVYSATKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCEEHHHHHH
AMVGFADALRSEVAGRGISVTLCLPGVVDTPFFHRRGAPYVRRWPRPIPAGLVAQRMIAA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHCCCCCHHHHCCCCCCHHHHHHHHHHH
AGRGDAEVWVPRWLSAAARVHGAAPSLYRRLAGVFG
CCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]