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The map label for this gene is shc [H]

Identifier: 158317461

GI number: 158317461

Start: 6932639

End: 6934825

Strand: Reverse

Name: shc [H]

Synonym: Franean1_5713

Alternate gene names: 158317461

Gene position: 6934825-6932639 (Counterclockwise)

Preceding gene: 158317462

Following gene: 158317460

Centisome position: 77.21

GC content: 72.52

Gene sequence:

>2187_bases
ATGAGCCTGACCTCGGACCAGTCCTCGGCTGCCCCGACGGCCGCGGCGCAGAGCCCGAAGATCCCGAACCCGTCGGTGGC
ACGGCCGTCGGCGGACGCCGGGTCCTTCGAGACCGCCGGCGCAGTGCGAACCGACTCGGTGTCGATCGACTCGGTGTCGA
CCGGCACGCCGGTCGACCCGGTGGTGGGCGCGATGCGCCGTGGCCGCGACCATCTGCTCTCCCTGCAGGCTGAGGAGGGC
TGGTGGAAGGGCGAGCTGGAGACCAACGTCACCATGGACGCCGAGGACCTCATGCTTCGGCAGTTCCTCGGCATCCTGAC
CCCGTCGACGGCCACTGAGACCGGACGCTGGATCCGTTCCCAACAGCTCTCCGACGGCGGCTGGGCTACCTTCTACGGCG
GCCCGTCCGACCTTTCGACCACCATCGAGGCCTACGTCGCGCTGCGGCTCGCCGGGGACGACCCGGACGCCCCGCACATG
CGCTCCGCCGCCGAGTGGGTGCGCTCCGCGGGCGGCATCGCCGCCTCCCGGGTGTTCACCCGGATCTGGCTGGCGCTGTT
CGGCGAGTGGTCCTGGGACGACGTCCCGGTGCTGCCGGCGGAGATGACCTTCCTTCCGCCGTGGTTCCCGTTGAACATCT
ACGACTTCGCCTGCTGGGCCCGCCAGACCGTGGTGGCGCTGACGATCGTCGGTTCGCTGCGGCCGGTGCGCTCGTTCGGG
TTCACCCTGGACGAACTGCGTGTCCAGGCGCCCAAGGCGACGAAGGCGCCGCTGCGGAGCTGGGCCGGCGCGTTCGAGCG
GCTCGATTCCGTGCTGCACCGCTACGAGAAGCGGCCCTTCCAGCCGCTGCGCCGGCTCGCGCTGCGCCGCGCCGCCGAAT
GGGTGATCGCCCGCCAGGAGGCGGACGGCTGCTGGGGCGGCATCCAGCCGCCGATGGTGTACTCGATCATGGCCCTGCAT
CTCATGGGCTACCCCCTGAACCACCCGGTGATCTCGATGGCGTTCCGCGCCCTCGACCGGTTCACGATCCGCGAGGAGAC
ACCGGAGGGCACGGTGCGCCGTATCGAGGCGTGCCAGTCGCCGGTCTGGGACACGGCGCTGGCCGTCGTCGCGCTCGCGG
ACGCCGGTCTGGGCGGTGACCACCCGGCTATGGTCCGGGCCGGTCGCTGGCTCGCCGACGAGGAGGTGCGCGTCGCCGGT
GACTGGGCGGTGCGCCGTCCCACCCTCGCGCCGGGCGGCTGGGCGTTCGAGTTCGACAACGACTTCTACCCGGACGTCGA
CGACACCGCCGAGGTGGTCATCGCCATCCGCCGCCTGCTCGGCGACGGTCACGGCCCGGTGGACCACTCCGACGGCTCCG
GCCCCGGCTCGGCCGCGGCCACCGCGGCCTCCGCCGCGGCGGAGGCCGCGGTGGCCGCGGCCGGCACGATCGCCGCCGCG
GATCCGGAGCTCGCCGCCCGGCTGCGCGCCGCCGCGGAGCGGGGCGTCGACTGGTCGGTGGGCATGCGCTCGTCGAACGG
TGCCTGGGCGGCGTTCGACGCCGACAACGTGCGCACCCTGGTCAGGAAGATCCCATTCTGCGACTTCGGCGAGGTGGTCG
ACCCACCGTCGGCGGACGTCACCGCGCACATGGTCGAGATGCTCGCCCTGCTGGGTCGCTCCGACCACCCGATCACCCAG
CGCGGGGTCCGCTGGCTGCTGGACAACCAGGAGGCCGGCGGGTCGTGGTTCGGTCGCTGGGGCGTGAACCACGTCTACGG
CACCGGCGCGGTCGTGCCCGCGCTGATCTCCGCGGGTGTAGACGCGGAGCACCCGGCGATCGTCTCCTCGATGCACTGGC
TCGTCGAGCACCAGACGCCGGAGGGCGGCTGGGGCGAGGACCTGCGCTCCTACCGCGACGACGAGTGGATCGGGCGCGGC
GAGCCGACGGCCTCGCAGACCGCCTGGGCGCTGCTGGCGCTGCTGGCCGCCGAACCGGCGTCCGGGACCGCCGAGTGGGA
GGCGGTCGAACGCGGCGTGCGCTGGCTCTGCGACACCCAGCGCCCCGACGGCACCTGGGACGAGCCGCAGTTCACCGGCA
CGGGCTTCCCCTGGGACTTCTCCATCAACTATCACCTGTACCGGCTGGTCTTTCCCGTGACGGCACTCGGTCGGTACGTG
ACCCTCACCGGCAGGTCGACGTCATGA

Upstream 100 bases:

>100_bases
GAACGAGATCGCTGAGGGGGAGCGAGGTGGCAGTACCCGCCCGCCGGTCGCCCGGCGGTCATCCGCACGACCAGTACATA
TACGACGAGGGGAGTCGTCG

Downstream 100 bases:

>100_bases
GCATCCCGGCAACAGACAACGGGGGCGACGCCGACCACGGCGGTTCGCCCACCGTTACCCCGCGCGACGCCACGGCGCCG
AGCCTCGGACCGCCGGGCTT

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MSLTSDQSSAAPTAAAQSPKIPNPSVARPSADAGSFETAGAVRTDSVSIDSVSTGTPVDPVVGAMRRGRDHLLSLQAEEG
WWKGELETNVTMDAEDLMLRQFLGILTPSTATETGRWIRSQQLSDGGWATFYGGPSDLSTTIEAYVALRLAGDDPDAPHM
RSAAEWVRSAGGIAASRVFTRIWLALFGEWSWDDVPVLPAEMTFLPPWFPLNIYDFACWARQTVVALTIVGSLRPVRSFG
FTLDELRVQAPKATKAPLRSWAGAFERLDSVLHRYEKRPFQPLRRLALRRAAEWVIARQEADGCWGGIQPPMVYSIMALH
LMGYPLNHPVISMAFRALDRFTIREETPEGTVRRIEACQSPVWDTALAVVALADAGLGGDHPAMVRAGRWLADEEVRVAG
DWAVRRPTLAPGGWAFEFDNDFYPDVDDTAEVVIAIRRLLGDGHGPVDHSDGSGPGSAAATAASAAAEAAVAAAGTIAAA
DPELAARLRAAAERGVDWSVGMRSSNGAWAAFDADNVRTLVRKIPFCDFGEVVDPPSADVTAHMVEMLALLGRSDHPITQ
RGVRWLLDNQEAGGSWFGRWGVNHVYGTGAVVPALISAGVDAEHPAIVSSMHWLVEHQTPEGGWGEDLRSYRDDEWIGRG
EPTASQTAWALLALLAAEPASGTAEWEAVERGVRWLCDTQRPDGTWDEPQFTGTGFPWDFSINYHLYRLVFPVTALGRYV
TLTGRSTS

Sequences:

>Translated_728_residues
MSLTSDQSSAAPTAAAQSPKIPNPSVARPSADAGSFETAGAVRTDSVSIDSVSTGTPVDPVVGAMRRGRDHLLSLQAEEG
WWKGELETNVTMDAEDLMLRQFLGILTPSTATETGRWIRSQQLSDGGWATFYGGPSDLSTTIEAYVALRLAGDDPDAPHM
RSAAEWVRSAGGIAASRVFTRIWLALFGEWSWDDVPVLPAEMTFLPPWFPLNIYDFACWARQTVVALTIVGSLRPVRSFG
FTLDELRVQAPKATKAPLRSWAGAFERLDSVLHRYEKRPFQPLRRLALRRAAEWVIARQEADGCWGGIQPPMVYSIMALH
LMGYPLNHPVISMAFRALDRFTIREETPEGTVRRIEACQSPVWDTALAVVALADAGLGGDHPAMVRAGRWLADEEVRVAG
DWAVRRPTLAPGGWAFEFDNDFYPDVDDTAEVVIAIRRLLGDGHGPVDHSDGSGPGSAAATAASAAAEAAVAAAGTIAAA
DPELAARLRAAAERGVDWSVGMRSSNGAWAAFDADNVRTLVRKIPFCDFGEVVDPPSADVTAHMVEMLALLGRSDHPITQ
RGVRWLLDNQEAGGSWFGRWGVNHVYGTGAVVPALISAGVDAEHPAIVSSMHWLVEHQTPEGGWGEDLRSYRDDEWIGRG
EPTASQTAWALLALLAAEPASGTAEWEAVERGVRWLCDTQRPDGTWDEPQFTGTGFPWDFSINYHLYRLVFPVTALGRYV
TLTGRSTS
>Mature_727_residues
SLTSDQSSAAPTAAAQSPKIPNPSVARPSADAGSFETAGAVRTDSVSIDSVSTGTPVDPVVGAMRRGRDHLLSLQAEEGW
WKGELETNVTMDAEDLMLRQFLGILTPSTATETGRWIRSQQLSDGGWATFYGGPSDLSTTIEAYVALRLAGDDPDAPHMR
SAAEWVRSAGGIAASRVFTRIWLALFGEWSWDDVPVLPAEMTFLPPWFPLNIYDFACWARQTVVALTIVGSLRPVRSFGF
TLDELRVQAPKATKAPLRSWAGAFERLDSVLHRYEKRPFQPLRRLALRRAAEWVIARQEADGCWGGIQPPMVYSIMALHL
MGYPLNHPVISMAFRALDRFTIREETPEGTVRRIEACQSPVWDTALAVVALADAGLGGDHPAMVRAGRWLADEEVRVAGD
WAVRRPTLAPGGWAFEFDNDFYPDVDDTAEVVIAIRRLLGDGHGPVDHSDGSGPGSAAATAASAAAEAAVAAAGTIAAAD
PELAARLRAAAERGVDWSVGMRSSNGAWAAFDADNVRTLVRKIPFCDFGEVVDPPSADVTAHMVEMLALLGRSDHPITQR
GVRWLLDNQEAGGSWFGRWGVNHVYGTGAVVPALISAGVDAEHPAIVSSMHWLVEHQTPEGGWGEDLRSYRDDEWIGRGE
PTASQTAWALLALLAAEPASGTAEWEAVERGVRWLCDTQRPDGTWDEPQFTGTGFPWDFSINYHLYRLVFPVTALGRYVT
LTGRSTS

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=694, Percent_Identity=25.0720461095101, Blast_Score=146, Evalue=8e-35,
Organism=Homo sapiens, GI47933397, Length=694, Percent_Identity=25.0720461095101, Blast_Score=146, Evalue=8e-35,
Organism=Homo sapiens, GI224177558, Length=689, Percent_Identity=24.8185776487663, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI224177556, Length=694, Percent_Identity=24.3515850144092, Blast_Score=126, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6321863, Length=632, Percent_Identity=23.5759493670886, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 79018; Mature: 78887

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTSDQSSAAPTAAAQSPKIPNPSVARPSADAGSFETAGAVRTDSVSIDSVSTGTPVDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCEEECCCCCCCCHHH
VVGAMRRGRDHLLSLQAEEGWWKGELETNVTMDAEDLMLRQFLGILTPSTATETGRWIRS
HHHHHHCCCHHEEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHH
QQLSDGGWATFYGGPSDLSTTIEAYVALRLAGDDPDAPHMRSAAEWVRSAGGIAASRVFT
HCCCCCCEEEECCCCHHHHHHHEEHEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
RIWLALFGEWSWDDVPVLPAEMTFLPPWFPLNIYDFACWARQTVVALTIVGSLRPVRSFG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEHHHHCCCHHHHHC
FTLDELRVQAPKATKAPLRSWAGAFERLDSVLHRYEKRPFQPLRRLALRRAAEWVIARQE
CCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
ADGCWGGIQPPMVYSIMALHLMGYPLNHPVISMAFRALDRFTIREETPEGTVRRIEACQS
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
PVWDTALAVVALADAGLGGDHPAMVRAGRWLADEEVRVAGDWAVRRPTLAPGGWAFEFDN
CHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEECCHHCCCCCCCCCCEEEECCC
DFYPDVDDTAEVVIAIRRLLGDGHGPVDHSDGSGPGSAAATAASAAAEAAVAAAGTIAAA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
DPELAARLRAAAERGVDWSVGMRSSNGAWAAFDADNVRTLVRKIPFCDFGEVVDPPSADV
CHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCHH
TAHMVEMLALLGRSDHPITQRGVRWLLDNQEAGGSWFGRWGVNHVYGTGAVVPALISAGV
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCCC
DAEHPAIVSSMHWLVEHQTPEGGWGEDLRSYRDDEWIGRGEPTASQTAWALLALLAAEPA
CCCCCHHHHHHHHHHEECCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
SGTAEWEAVERGVRWLCDTQRPDGTWDEPQFTGTGFPWDFSINYHLYRLVFPVTALGRYV
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCEE
TLTGRSTS
EEECCCCC
>Mature Secondary Structure 
SLTSDQSSAAPTAAAQSPKIPNPSVARPSADAGSFETAGAVRTDSVSIDSVSTGTPVDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCEEECCCCCCCCHHH
VVGAMRRGRDHLLSLQAEEGWWKGELETNVTMDAEDLMLRQFLGILTPSTATETGRWIRS
HHHHHHCCCHHEEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHH
QQLSDGGWATFYGGPSDLSTTIEAYVALRLAGDDPDAPHMRSAAEWVRSAGGIAASRVFT
HCCCCCCEEEECCCCHHHHHHHEEHEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
RIWLALFGEWSWDDVPVLPAEMTFLPPWFPLNIYDFACWARQTVVALTIVGSLRPVRSFG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEHHHHCCCHHHHHC
FTLDELRVQAPKATKAPLRSWAGAFERLDSVLHRYEKRPFQPLRRLALRRAAEWVIARQE
CCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
ADGCWGGIQPPMVYSIMALHLMGYPLNHPVISMAFRALDRFTIREETPEGTVRRIEACQS
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
PVWDTALAVVALADAGLGGDHPAMVRAGRWLADEEVRVAGDWAVRRPTLAPGGWAFEFDN
CHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEECCHHCCCCCCCCCCEEEECCC
DFYPDVDDTAEVVIAIRRLLGDGHGPVDHSDGSGPGSAAATAASAAAEAAVAAAGTIAAA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
DPELAARLRAAAERGVDWSVGMRSSNGAWAAFDADNVRTLVRKIPFCDFGEVVDPPSADV
CHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCHH
TAHMVEMLALLGRSDHPITQRGVRWLLDNQEAGGSWFGRWGVNHVYGTGAVVPALISAGV
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCCC
DAEHPAIVSSMHWLVEHQTPEGGWGEDLRSYRDDEWIGRGEPTASQTAWALLALLAAEPA
CCCCCHHHHHHHHHHEECCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
SGTAEWEAVERGVRWLCDTQRPDGTWDEPQFTGTGFPWDFSINYHLYRLVFPVTALGRYV
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCEE
TLTGRSTS
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]