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The map label for this gene is pncB1 [H]

Identifier: 158317407

GI number: 158317407

Start: 6869407

End: 6870828

Strand: Reverse

Name: pncB1 [H]

Synonym: Franean1_5658

Alternate gene names: 158317407

Gene position: 6870828-6869407 (Counterclockwise)

Preceding gene: 158317416

Following gene: 158317406

Centisome position: 76.5

GC content: 74.75

Gene sequence:

>1422_bases
GTGGTGCACCGGAAGCCTGTCGTCCCTACCCTGTTCCGGATGTCCACGGCGCTTCTGACCGATCACTACGAGTTGACCAT
GCTGCGGGCGGCTCTGCGCTCCGGCGCGGCCGAACGCAGAGCGGTCTTCGAGGTCTTCACCCGGTCCCTGCCCGCCGGCC
GTCGCTTCGGAGTCATGGCCGGCACCGGGCGCCTGCTCGCCGCGCTCGCCGACTTCCGGTTCGGCCCGGCCGAGATCGAC
CACCTGTCCGCGACCGGCGTCGTGGATCCCGACACGGCCGACTGGCTGGCCTCCTACCAGTTCCGCGGCGACGTCGACGG
GTTCGCCGAGGGCGAGCCCTTCCTGCCCGACACCCCCGTCCTCGTGGTGGAGGGCACGTTCGCCGAGTGCGTCCTGCTGG
AGACCCTCGTCCTGTCGGTGCTCAACCACGACAGCGCCATCGCCGCCGCCGGCAGCCGCATGGTCGCCGCCGCCGGCGAC
CGGCCGTGCATAGAGATGGGTGGCCGGCGCACCCACGAGCAGGCCGCGGTCGCCGCCGCGCGGGCCGCCTACCTCGTCGG
CTTCACCGCGACGTCCAACCTGGAGGCGGCGCGCCGCTACGGCGTGCCCAGCGCAGGCACGAGCGCGCACGCCTTCACCC
TCGCGCACCACGACGAGGCGGCGGCGTTCGCGGCCCAGGTCGCGGCACTCGGCGCCGGCACGACCCTGCTGGTGGACACC
TACGACATCCCGACCGGGATCGCCAACGCCGTGGCCGCGGCGGGCAGCGAGCTCGGGGCGATCCGCATCGACAGCGGGGA
CCTCGCCGGCGGCGCCCGGGCGGCCCGCACCCAGCTCGACCAGCTCGGCGCCGAGTCCACCCGGATCATCGTCACCGGCG
ACCTCGACGAGCACTCGATCGCCCGCCTGGCCTCGGCCCCCGTCGACGGCTACGGCGTGGGCACCAGCCTGGTGACCGGG
TCGGGCGCACCCACCGCCGGCTTCGTCTACAAACTCGTCGAGGTTGACGGTGAGCCGGTCGTCAAGACTTCTGTGGGCAA
GCGCAGCCGCGGCGGGCGCAAGGACGTCCTGCGCCGCCTGGGCCCGAACGGACTGGCCGTCGCCGACCTGGTCATCCCCA
GAGCACCCCTCGACCGCTCCGCCGCCCCGCGGCCCGCCGGCGGTGCGTCCGCTGCCCGCGTACCTGGCGGAGAGGCGCTG
GACGGGGCTGTGGGGCGCCGGGACCGCCATCTCCTCGTCCCCCTGATGCGCGGCGGCCAGCTCGTCGCGGACACGCTCGT
CGGCGCGGCCGGAGTCGCCCGGGCCCGGGAGCACCACCGGCTCGCCCTGGAGTCCCTACCGGCCGGCGCGCGCGAGGTCT
CCTTCGGACGTCCATGCCTGCCGGTCGTGGTCGCAGCGGCGGAGCCGCGGACCTCCTTCTGA

Upstream 100 bases:

>100_bases
CGCGCACGTTCCTGCCCGTCACGTGCCGCCACCCGCCCCCGCGACCGCCGCCACCCGGGCCGCGACCGGCCACCCGCCGC
GGCCCGCGGGTTCGTCCGAT

Downstream 100 bases:

>100_bases
CCGGTGAAGCCGCGGGCACCGCGGACAGGGGCGCGCCGGCACGCCTGTCGGGAAGAGGGGTGCCGGCGCGGGTGCCGGGG
CGGACGGCCAGACTTGACCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MVHRKPVVPTLFRMSTALLTDHYELTMLRAALRSGAAERRAVFEVFTRSLPAGRRFGVMAGTGRLLAALADFRFGPAEID
HLSATGVVDPDTADWLASYQFRGDVDGFAEGEPFLPDTPVLVVEGTFAECVLLETLVLSVLNHDSAIAAAGSRMVAAAGD
RPCIEMGGRRTHEQAAVAAARAAYLVGFTATSNLEAARRYGVPSAGTSAHAFTLAHHDEAAAFAAQVAALGAGTTLLVDT
YDIPTGIANAVAAAGSELGAIRIDSGDLAGGARAARTQLDQLGAESTRIIVTGDLDEHSIARLASAPVDGYGVGTSLVTG
SGAPTAGFVYKLVEVDGEPVVKTSVGKRSRGGRKDVLRRLGPNGLAVADLVIPRAPLDRSAAPRPAGGASAARVPGGEAL
DGAVGRRDRHLLVPLMRGGQLVADTLVGAAGVARAREHHRLALESLPAGAREVSFGRPCLPVVVAAAEPRTSF

Sequences:

>Translated_473_residues
MVHRKPVVPTLFRMSTALLTDHYELTMLRAALRSGAAERRAVFEVFTRSLPAGRRFGVMAGTGRLLAALADFRFGPAEID
HLSATGVVDPDTADWLASYQFRGDVDGFAEGEPFLPDTPVLVVEGTFAECVLLETLVLSVLNHDSAIAAAGSRMVAAAGD
RPCIEMGGRRTHEQAAVAAARAAYLVGFTATSNLEAARRYGVPSAGTSAHAFTLAHHDEAAAFAAQVAALGAGTTLLVDT
YDIPTGIANAVAAAGSELGAIRIDSGDLAGGARAARTQLDQLGAESTRIIVTGDLDEHSIARLASAPVDGYGVGTSLVTG
SGAPTAGFVYKLVEVDGEPVVKTSVGKRSRGGRKDVLRRLGPNGLAVADLVIPRAPLDRSAAPRPAGGASAARVPGGEAL
DGAVGRRDRHLLVPLMRGGQLVADTLVGAAGVARAREHHRLALESLPAGAREVSFGRPCLPVVVAAAEPRTSF
>Mature_473_residues
MVHRKPVVPTLFRMSTALLTDHYELTMLRAALRSGAAERRAVFEVFTRSLPAGRRFGVMAGTGRLLAALADFRFGPAEID
HLSATGVVDPDTADWLASYQFRGDVDGFAEGEPFLPDTPVLVVEGTFAECVLLETLVLSVLNHDSAIAAAGSRMVAAAGD
RPCIEMGGRRTHEQAAVAAARAAYLVGFTATSNLEAARRYGVPSAGTSAHAFTLAHHDEAAAFAAQVAALGAGTTLLVDT
YDIPTGIANAVAAAGSELGAIRIDSGDLAGGARAARTQLDQLGAESTRIIVTGDLDEHSIARLASAPVDGYGVGTSLVTG
SGAPTAGFVYKLVEVDGEPVVKTSVGKRSRGGRKDVLRRLGPNGLAVADLVIPRAPLDRSAAPRPAGGASAARVPGGEAL
DGAVGRRDRHLLVPLMRGGQLVADTLVGAAGVARAREHHRLALESLPAGAREVSFGRPCLPVVVAAAEPRTSF

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=425, Percent_Identity=32.2352941176471, Blast_Score=146, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71997947, Length=441, Percent_Identity=30.1587301587302, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71997952, Length=441, Percent_Identity=30.1587301587302, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71997955, Length=205, Percent_Identity=33.1707317073171, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24581587, Length=452, Percent_Identity=30.3097345132743, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI161076680, Length=201, Percent_Identity=31.8407960199005, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581595, Length=201, Percent_Identity=31.8407960199005, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574709, Length=201, Percent_Identity=31.8407960199005, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581593, Length=201, Percent_Identity=31.8407960199005, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581591, Length=201, Percent_Identity=31.8407960199005, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 48846; Mature: 48846

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHRKPVVPTLFRMSTALLTDHYELTMLRAALRSGAAERRAVFEVFTRSLPAGRRFGVMA
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEE
GTGRLLAALADFRFGPAEIDHLSATGVVDPDTADWLASYQFRGDVDGFAEGEPFLPDTPV
CCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCE
LVVEGTFAECVLLETLVLSVLNHDSAIAAAGSRMVAAAGDRPCIEMGGRRTHEQAAVAAA
EEEECCHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHH
RAAYLVGFTATSNLEAARRYGVPSAGTSAHAFTLAHHDEAAAFAAQVAALGAGTTLLVDT
HHHEEEEEECCCCHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEEC
YDIPTGIANAVAAAGSELGAIRIDSGDLAGGARAARTQLDQLGAESTRIIVTGDLDEHSI
CCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHH
ARLASAPVDGYGVGTSLVTGSGAPTAGFVYKLVEVDGEPVVKTSVGKRSRGGRKDVLRRL
HHHHCCCCCCCCCCCCEEECCCCCCHHHEEEEEECCCCCEEEECCCCCCCCCHHHHHHHH
GPNGLAVADLVIPRAPLDRSAAPRPAGGASAARVPGGEALDGAVGRRDRHLLVPLMRGGQ
CCCCCEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
LVADTLVGAAGVARAREHHRLALESLPAGAREVSFGRPCLPVVVAAAEPRTSF
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCC
>Mature Secondary Structure
MVHRKPVVPTLFRMSTALLTDHYELTMLRAALRSGAAERRAVFEVFTRSLPAGRRFGVMA
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEE
GTGRLLAALADFRFGPAEIDHLSATGVVDPDTADWLASYQFRGDVDGFAEGEPFLPDTPV
CCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCE
LVVEGTFAECVLLETLVLSVLNHDSAIAAAGSRMVAAAGDRPCIEMGGRRTHEQAAVAAA
EEEECCHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHH
RAAYLVGFTATSNLEAARRYGVPSAGTSAHAFTLAHHDEAAAFAAQVAALGAGTTLLVDT
HHHEEEEEECCCCHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEEC
YDIPTGIANAVAAAGSELGAIRIDSGDLAGGARAARTQLDQLGAESTRIIVTGDLDEHSI
CCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHH
ARLASAPVDGYGVGTSLVTGSGAPTAGFVYKLVEVDGEPVVKTSVGKRSRGGRKDVLRRL
HHHHCCCCCCCCCCCCEEECCCCCCHHHEEEEEECCCCCEEEECCCCCCCCCHHHHHHHH
GPNGLAVADLVIPRAPLDRSAAPRPAGGASAARVPGGEALDGAVGRRDRHLLVPLMRGGQ
CCCCCEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
LVADTLVGAAGVARAREHHRLALESLPAGAREVSFGRPCLPVVVAAAEPRTSF
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]