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The map label for this gene is bioH [H]

Identifier: 158317336

GI number: 158317336

Start: 6771709

End: 6772689

Strand: Reverse

Name: bioH [H]

Synonym: Franean1_5586

Alternate gene names: 158317336

Gene position: 6772689-6771709 (Counterclockwise)

Preceding gene: 158317338

Following gene: 158317335

Centisome position: 75.4

GC content: 72.68

Gene sequence:

>981_bases
ATGGCCGATCTGCCGAACATCAACAGCACGCTGGACGCCGAAGAGCACAACCACGACCACGACCAGGCTTACGAACGCGA
CGACTACGACGAGTTCGGGCTGCTCCACGAGAACGCCGAGGAGCTGGGCATCCCCTATCAGGGCCGGCCGGACGTCACCC
GCGGCCACGTGGAGGTCGAACCCGGGCGGCGGTTGAGCCACATCCGATGGGGGACGGCCGACCCGGAGATCGTGTTCCTG
CACGGCGGCGGTCAGAACGCCCATACCTGGGACTCGGTCGCGCTGGCCCTCGGCCGGCCCGCGATCGCCTTCGACCTGCC
CGGTCACGGCCGGTCGTTCCGGCGTCCGGACCGGAACTACGGCCCGTGGGCGAGCGGCACGGCGGTGGCGACGGCGCTAG
GTGAGCTGGCGCCGAACGCGGCGGTCATCGTCGGCATGTCCCTCGGGGGCGCCACCACCATCCACCTCGCCGCGACCCGG
CCCGACCTGTGCCGGCGCGCGGTCATCGTGGACGTCACCCCCCAGTCTGCCGACCGGAGCCGGGCGATGAACACCGCGGA
GCGCGGCGCGGTGGCGCTGGTCGGCGGCCAGCCCACCTACGACTCGTTCGAGCAGATGGCCGACGCGGCGGTCCGGCTCA
GCCCGAACCGGCCGGCCTCGGGCGTCCGCCGCGGCGTGCGGCACAACGCCTACCAGCGCGCCGACGGCCGGTGGGTGTGG
CGCTACGACCTGGGCGGCCCCAGCGCGACGACCGAGGTGACCGGCATGGACAGCCTGTGGGAGGAGGTGGACACGATCAT
CGTCCCGCTACTGCTCGTGCGCGGGGCGCTGTCCCGGTTCGTCCATGATGACGACGTCGAGCAGTTCCGCCTCCGTCTGC
CGGCGCTGCGCTCCGTCGTGGTGGACGGCGCCGGCCACGCGGTGCAGAGCGACCGCCCGCACGAGCTCGTCCGCCTGATC
CGGGAGTTCGCCTTCGCCTAG

Upstream 100 bases:

>100_bases
CGCGCCGATGGGTCCTACATTCTCCCTTGACGATCCGTCGGCCGCCGCGTCGGGCGGTGCCGGGCGGTCGAACAGGCGGT
GACGAGAGCGAGGCGGGATC

Downstream 100 bases:

>100_bases
CGCGCCGGTGATTCCGACCGCGGGCCGGCGCGGTGCCGGCCCCTGCGCTGGCGCGGCGCCGGCAGGCGGGCCGGGAGTGC
GGGGGACCGTCGCGGGTAGC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Biotin synthesis protein BioH [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MADLPNINSTLDAEEHNHDHDQAYERDDYDEFGLLHENAEELGIPYQGRPDVTRGHVEVEPGRRLSHIRWGTADPEIVFL
HGGGQNAHTWDSVALALGRPAIAFDLPGHGRSFRRPDRNYGPWASGTAVATALGELAPNAAVIVGMSLGGATTIHLAATR
PDLCRRAVIVDVTPQSADRSRAMNTAERGAVALVGGQPTYDSFEQMADAAVRLSPNRPASGVRRGVRHNAYQRADGRWVW
RYDLGGPSATTEVTGMDSLWEEVDTIIVPLLLVRGALSRFVHDDDVEQFRLRLPALRSVVVDGAGHAVQSDRPHELVRLI
REFAFA

Sequences:

>Translated_326_residues
MADLPNINSTLDAEEHNHDHDQAYERDDYDEFGLLHENAEELGIPYQGRPDVTRGHVEVEPGRRLSHIRWGTADPEIVFL
HGGGQNAHTWDSVALALGRPAIAFDLPGHGRSFRRPDRNYGPWASGTAVATALGELAPNAAVIVGMSLGGATTIHLAATR
PDLCRRAVIVDVTPQSADRSRAMNTAERGAVALVGGQPTYDSFEQMADAAVRLSPNRPASGVRRGVRHNAYQRADGRWVW
RYDLGGPSATTEVTGMDSLWEEVDTIIVPLLLVRGALSRFVHDDDVEQFRLRLPALRSVVVDGAGHAVQSDRPHELVRLI
REFAFA
>Mature_325_residues
ADLPNINSTLDAEEHNHDHDQAYERDDYDEFGLLHENAEELGIPYQGRPDVTRGHVEVEPGRRLSHIRWGTADPEIVFLH
GGGQNAHTWDSVALALGRPAIAFDLPGHGRSFRRPDRNYGPWASGTAVATALGELAPNAAVIVGMSLGGATTIHLAATRP
DLCRRAVIVDVTPQSADRSRAMNTAERGAVALVGGQPTYDSFEQMADAAVRLSPNRPASGVRRGVRHNAYQRADGRWVWR
YDLGGPSATTEVTGMDSLWEEVDTIIVPLLLVRGALSRFVHDDDVEQFRLRLPALRSVVVDGAGHAVQSDRPHELVRLIR
EFAFA

Specific function: Shows carboxylesterase activity with a preference for short chain fatty acid esters (acyl chain length of up to 6 carbons). Also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family [H]

Homologues:

Organism=Homo sapiens, GI23200008, Length=257, Percent_Identity=29.5719844357977, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI23200012, Length=257, Percent_Identity=29.5719844357977, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR010076 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 35704; Mature: 35573

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLPNINSTLDAEEHNHDHDQAYERDDYDEFGLLHENAEELGIPYQGRPDVTRGHVEVE
CCCCCCCCCCCCCHHCCCCHHHHHCCCCCHHHCCHHCCHHHHCCCCCCCCCCCCCEEEEC
PGRRLSHIRWGTADPEIVFLHGGGQNAHTWDSVALALGRPAIAFDLPGHGRSFRRPDRNY
CCCCCCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
GPWASGTAVATALGELAPNAAVIVGMSLGGATTIHLAATRPDLCRRAVIVDVTPQSADRS
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCHHHHCCEEEEEECCCCCHHH
RAMNTAERGAVALVGGQPTYDSFEQMADAAVRLSPNRPASGVRRGVRHNAYQRADGRWVW
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCEEE
RYDLGGPSATTEVTGMDSLWEEVDTIIVPLLLVRGALSRFVHDDDVEQFRLRLPALRSVV
EEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VDGAGHAVQSDRPHELVRLIREFAFA
HCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADLPNINSTLDAEEHNHDHDQAYERDDYDEFGLLHENAEELGIPYQGRPDVTRGHVEVE
CCCCCCCCCCCCHHCCCCHHHHHCCCCCHHHCCHHCCHHHHCCCCCCCCCCCCCEEEEC
PGRRLSHIRWGTADPEIVFLHGGGQNAHTWDSVALALGRPAIAFDLPGHGRSFRRPDRNY
CCCCCCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
GPWASGTAVATALGELAPNAAVIVGMSLGGATTIHLAATRPDLCRRAVIVDVTPQSADRS
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCHHHHCCEEEEEECCCCCHHH
RAMNTAERGAVALVGGQPTYDSFEQMADAAVRLSPNRPASGVRRGVRHNAYQRADGRWVW
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCEEE
RYDLGGPSATTEVTGMDSLWEEVDTIIVPLLLVRGALSRFVHDDDVEQFRLRLPALRSVV
EEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VDGAGHAVQSDRPHELVRLIREFAFA
HCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA