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The map label for this gene is lon [H]

Identifier: 158317261

GI number: 158317261

Start: 6672688

End: 6675195

Strand: Direct

Name: lon [H]

Synonym: Franean1_5508

Alternate gene names: 158317261

Gene position: 6672688-6675195 (Clockwise)

Preceding gene: 158317255

Following gene: 158317262

Centisome position: 74.29

GC content: 74.8

Gene sequence:

>2508_bases
ATGTCACACACCAGGCTCCTCCCGCTGCTGCCGCTGGACGACGCGGTCGTCCTGCCCGGCATGGTGGTTCCGCTCGACCT
GTCGGACGCCGGGACCCGCGCCGCCGTGGACGCGGCCCGCGGCGGCAGGCCCGACTCCACACCCGACGCCAGGGCGCCGG
GCATCTCCAGCCGCTCCTTCCAGCGCACCGCCGAGATCCTGCTCGTCCCCCGGGTGGACGGCGACCTCGCCGACATGGGC
GTCCTCGCCGTCGTCGACCAGATCGGCCGGCTGCCGAACGGCGGGACGGCCGCGCTCGTGCGGGCCGTGTCCCGCGCCCG
GGTCGGCACCGCCCCCACGCCGCCCGGCGCCGCCGACGCCGGTGTCGTGTGGGCGGAGGCGACCCCTGTCGAGCCGGTCC
TCCCGGCCGGCTTCACCGGCACGATCAGCGCGACGGCGACCGCGGGCGCGCCGGGCGCCACCGGCGACCCCGACGGCCCG
ACCGCCCGGCTGGTCGAGCTCGCCCGCGAGTACCGCACGCTGGTGACCGGGGTGCTGCGCGCCCGCGGGGTCGGCCAGGT
CGCCGACACCGTCGAGGCGATCGAGAACCCCGACACGCTGGCCGACACCGCCGGCTACTCGTCCTACCTGTCGACCGCGC
AGAAGCTGGAGCTGCTGCGCACCGTCGACGTGACCGCCCGGCTGGAGCTGCTCGTCCCGTGGACTCGGGAGCACGCCGCC
GAGGTCGACGTGGCCGAGACCATCCGGCGCGACGTCCAGGAGGGCGTCGACCGCCAGCAGCGGGAGTTCCTGCTGCGCCG
TCAGCTGGAGGCCGTCCGCAAGGAACTGGCCGAGCTGGACGGGTCACCCGCGTCCTCCGAACAGGAGGACTACCGGGCCC
GGGTCGAGGCCGCCGACCTGCCGGAGAAGGTCCGCGCCGCGGCGCTCAAGGAGGTCGACAAGCTGGAGCGGACGGCCGAG
TCCTCCCCCGAGGTCGGTTGGATCCGCACCTGGCTGGACACCGTCCTGGAGCTGCCGTGGAACGAGCACGCCGAGGACAC
CTACGACATCGCCTCGGCGCGGGCCGTGCTGGACGCCGACCACGCCGGGCTCAGCGACGTCAAGGACCGGATCGTCGAGT
ACCTGGCGGTCCGCCGCCGGCGGGCCGACGCCGGGCTCGGGGTCGTCGGTGGGCGCCGCAGCGGCGCGGTGCTCGCGCTT
GCCGGGCCGCCCGGGGTCGGCAAGACCTCGCTGGGCGAGTCCGTGGCCCGCGCCATGGGCCGCCGGTTCGCCCGGGTGGC
GCTCGGCGGCGTCCGCGACGAGGCGGAGATCCGCGGCCACCGGCGCACCTACGTCGGTGCGCAGCCCGGTCGCATCGTGC
GGGCGATCCGCGAGGCCGGCTCGATGAACCCGGTGATCCTGCTCGACGAGGTCGACAAGGTCGGCTCCGACTACCGCGGG
GACCCGACGGCGGCGCTGCTCGAGGTGCTGGACCCGGCGCAGAACCACACCTTCCGCGACCACTACCTGGAGGTCGAGCT
CGACCTGTCGGACGTGTTGTTCCTGGCCACCGCGAACGTGCTGGAGTCCATCCCGGCGCCGCTGCTGGACCGGATGGAGC
TGATCCTGCTCGACGGCTACACCGAGGAGGAGAAGGTCACCATCGCCCGCGACCACCTGCTCCCGCGCCAGCTCGAGCGG
GCCGGGCTGACCCCCGACGACGTCACCGTGGACGACGCGGCGCTGCGGCTGCTGGCCGGCGAGTACACCCGCGAGGCCGG
CGTGCGTGACCTGGAGCGGGCGACCGCCCGGGTGCTGCGCAAGGTCGTCGCGAAGGTCGCACTGGACGAGACCGCCCTGC
CGGTCACGATCGGCGCCGGCGATCTGGCCGGATACCTCGGACGGCCGCGGCACACCCCGGAGTCGGCGGAGCGCACCGCG
CTGCCGGGGGTGGCGACCGGGCTCGCGGTCACAGGGGCCGGCGGGGACGTCCTGTTCGTCGAGGCGTCACTGGCCGACCC
GGAGACCGGGGCCAGCGGAGTGACGCTGACCGGGCAGCTCGGCGACGTCATGAAGGAGTCGGCGCAGATCGCGCTGTCCT
ACCTGCGCTCGCGCGGGGTGGAGCTCGAACTGCCGGTCGGCGACCTGCGTGACCGCGGGGTGCACATCCACGTCCCGGCG
GGCGCGGTGCCCAAGGACGGGCCGAGCGCCGGGGTCACGATGACCACCGCGCTGGCATCCCTGCTCTCCGGGCGCCCGGT
GCGCGCGGACGTGGCGATGACCGGCGAGGTCTCGCTGACCGGTCGGGTGCTACCCATAGGTGGGGTCAAGCAGAAGTTGC
TCGCCGCGCACCGCGCCGGCATCGCAACGGTGCTCCTGCCGGCGCGCAACGGCCCGGACCTTGACGACGTCCCGGCAGCG
GTCCGCGAGGCGCTGACCGTGCACCTGGTTGCGGACGTCCGCGAAGTGCTTGAGCTGGCGCTGGAACCGGCCTTCGACAC
GACGCACACCCACGCCGTGGCGGCCTGA

Upstream 100 bases:

>100_bases
GGCGATCAGGTTCGGGAACAACGATCCGCTCCGATGCCTTGAGCACGACAGGCTCAATGAGAGTGGGCCCAAGCCGCTCG
ACACGAGGGATGAAGGCCGC

Downstream 100 bases:

>100_bases
GATTGTCCGTTGGTAGCTAGTTGGGTGCCGCCGCCGCCTCTCACAACGGCGGCGGCGGCACCTACGTGCCGACGCGACGC
GCGGGTCCGGAACGCACGCG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MSHTRLLPLLPLDDAVVLPGMVVPLDLSDAGTRAAVDAARGGRPDSTPDARAPGISSRSFQRTAEILLVPRVDGDLADMG
VLAVVDQIGRLPNGGTAALVRAVSRARVGTAPTPPGAADAGVVWAEATPVEPVLPAGFTGTISATATAGAPGATGDPDGP
TARLVELAREYRTLVTGVLRARGVGQVADTVEAIENPDTLADTAGYSSYLSTAQKLELLRTVDVTARLELLVPWTREHAA
EVDVAETIRRDVQEGVDRQQREFLLRRQLEAVRKELAELDGSPASSEQEDYRARVEAADLPEKVRAAALKEVDKLERTAE
SSPEVGWIRTWLDTVLELPWNEHAEDTYDIASARAVLDADHAGLSDVKDRIVEYLAVRRRRADAGLGVVGGRRSGAVLAL
AGPPGVGKTSLGESVARAMGRRFARVALGGVRDEAEIRGHRRTYVGAQPGRIVRAIREAGSMNPVILLDEVDKVGSDYRG
DPTAALLEVLDPAQNHTFRDHYLEVELDLSDVLFLATANVLESIPAPLLDRMELILLDGYTEEEKVTIARDHLLPRQLER
AGLTPDDVTVDDAALRLLAGEYTREAGVRDLERATARVLRKVVAKVALDETALPVTIGAGDLAGYLGRPRHTPESAERTA
LPGVATGLAVTGAGGDVLFVEASLADPETGASGVTLTGQLGDVMKESAQIALSYLRSRGVELELPVGDLRDRGVHIHVPA
GAVPKDGPSAGVTMTTALASLLSGRPVRADVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGIATVLLPARNGPDLDDVPAA
VREALTVHLVADVREVLELALEPAFDTTHTHAVAA

Sequences:

>Translated_835_residues
MSHTRLLPLLPLDDAVVLPGMVVPLDLSDAGTRAAVDAARGGRPDSTPDARAPGISSRSFQRTAEILLVPRVDGDLADMG
VLAVVDQIGRLPNGGTAALVRAVSRARVGTAPTPPGAADAGVVWAEATPVEPVLPAGFTGTISATATAGAPGATGDPDGP
TARLVELAREYRTLVTGVLRARGVGQVADTVEAIENPDTLADTAGYSSYLSTAQKLELLRTVDVTARLELLVPWTREHAA
EVDVAETIRRDVQEGVDRQQREFLLRRQLEAVRKELAELDGSPASSEQEDYRARVEAADLPEKVRAAALKEVDKLERTAE
SSPEVGWIRTWLDTVLELPWNEHAEDTYDIASARAVLDADHAGLSDVKDRIVEYLAVRRRRADAGLGVVGGRRSGAVLAL
AGPPGVGKTSLGESVARAMGRRFARVALGGVRDEAEIRGHRRTYVGAQPGRIVRAIREAGSMNPVILLDEVDKVGSDYRG
DPTAALLEVLDPAQNHTFRDHYLEVELDLSDVLFLATANVLESIPAPLLDRMELILLDGYTEEEKVTIARDHLLPRQLER
AGLTPDDVTVDDAALRLLAGEYTREAGVRDLERATARVLRKVVAKVALDETALPVTIGAGDLAGYLGRPRHTPESAERTA
LPGVATGLAVTGAGGDVLFVEASLADPETGASGVTLTGQLGDVMKESAQIALSYLRSRGVELELPVGDLRDRGVHIHVPA
GAVPKDGPSAGVTMTTALASLLSGRPVRADVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGIATVLLPARNGPDLDDVPAA
VREALTVHLVADVREVLELALEPAFDTTHTHAVAA
>Mature_834_residues
SHTRLLPLLPLDDAVVLPGMVVPLDLSDAGTRAAVDAARGGRPDSTPDARAPGISSRSFQRTAEILLVPRVDGDLADMGV
LAVVDQIGRLPNGGTAALVRAVSRARVGTAPTPPGAADAGVVWAEATPVEPVLPAGFTGTISATATAGAPGATGDPDGPT
ARLVELAREYRTLVTGVLRARGVGQVADTVEAIENPDTLADTAGYSSYLSTAQKLELLRTVDVTARLELLVPWTREHAAE
VDVAETIRRDVQEGVDRQQREFLLRRQLEAVRKELAELDGSPASSEQEDYRARVEAADLPEKVRAAALKEVDKLERTAES
SPEVGWIRTWLDTVLELPWNEHAEDTYDIASARAVLDADHAGLSDVKDRIVEYLAVRRRRADAGLGVVGGRRSGAVLALA
GPPGVGKTSLGESVARAMGRRFARVALGGVRDEAEIRGHRRTYVGAQPGRIVRAIREAGSMNPVILLDEVDKVGSDYRGD
PTAALLEVLDPAQNHTFRDHYLEVELDLSDVLFLATANVLESIPAPLLDRMELILLDGYTEEEKVTIARDHLLPRQLERA
GLTPDDVTVDDAALRLLAGEYTREAGVRDLERATARVLRKVVAKVALDETALPVTIGAGDLAGYLGRPRHTPESAERTAL
PGVATGLAVTGAGGDVLFVEASLADPETGASGVTLTGQLGDVMKESAQIALSYLRSRGVELELPVGDLRDRGVHIHVPAG
AVPKDGPSAGVTMTTALASLLSGRPVRADVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGIATVLLPARNGPDLDDVPAAV
REALTVHLVADVREVLELALEPAFDTTHTHAVAA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=661, Percent_Identity=43.267776096823, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=675, Percent_Identity=40.7407407407407, Blast_Score=501, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=824, Percent_Identity=41.1407766990291, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17505831, Length=667, Percent_Identity=37.1814092953523, Blast_Score=443, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17556486, Length=634, Percent_Identity=38.01261829653, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=673, Percent_Identity=38.3358098068351, Blast_Score=472, Evalue=1e-134,
Organism=Drosophila melanogaster, GI221513036, Length=645, Percent_Identity=41.0852713178295, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24666867, Length=645, Percent_Identity=41.0852713178295, Blast_Score=506, Evalue=1e-143,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88275; Mature: 88144

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00630 IMP_2 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTRLLPLLPLDDAVVLPGMVVPLDLSDAGTRAAVDAARGGRPDSTPDARAPGISSRSF
CCCCCEEEECCCCCCEECCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHH
QRTAEILLVPRVDGDLADMGVLAVVDQIGRLPNGGTAALVRAVSRARVGTAPTPPGAADA
HCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
GVVWAEATPVEPVLPAGFTGTISATATAGAPGATGDPDGPTARLVELAREYRTLVTGVLR
CEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ARGVGQVADTVEAIENPDTLADTAGYSSYLSTAQKLELLRTVDVTARLELLVPWTREHAA
HCCCCHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHH
EVDVAETIRRDVQEGVDRQQREFLLRRQLEAVRKELAELDGSPASSEQEDYRARVEAADL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
PEKVRAAALKEVDKLERTAESSPEVGWIRTWLDTVLELPWNEHAEDTYDIASARAVLDAD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
HAGLSDVKDRIVEYLAVRRRRADAGLGVVGGRRSGAVLALAGPPGVGKTSLGESVARAMG
CCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
RRFARVALGGVRDEAEIRGHRRTYVGAQPGRIVRAIREAGSMNPVILLDEVDKVGSDYRG
HHHHHHHHCCCCCHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHCCCCCCC
DPTAALLEVLDPAQNHTFRDHYLEVELDLSDVLFLATANVLESIPAPLLDRMELILLDGY
CHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHCCEEEEECCC
TEEEKVTIARDHLLPRQLERAGLTPDDVTVDDAALRLLAGEYTREAGVRDLERATARVLR
CCCCCEEHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KVVAKVALDETALPVTIGAGDLAGYLGRPRHTPESAERTALPGVATGLAVTGAGGDVLFV
HHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCCHHHHCCCCHHHCEEEECCCCCEEEE
EASLADPETGASGVTLTGQLGDVMKESAQIALSYLRSRGVELELPVGDLRDRGVHIHVPA
EEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCEEEEECC
GAVPKDGPSAGVTMTTALASLLSGRPVRADVAMTGEVSLTGRVLPIGGVKQKLLAAHRAG
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCEEECCEEEECCCHHHHHHHHHHCC
IATVLLPARNGPDLDDVPAAVREALTVHLVADVREVLELALEPAFDTTHTHAVAA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure 
SHTRLLPLLPLDDAVVLPGMVVPLDLSDAGTRAAVDAARGGRPDSTPDARAPGISSRSF
CCCCEEEECCCCCCEECCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHH
QRTAEILLVPRVDGDLADMGVLAVVDQIGRLPNGGTAALVRAVSRARVGTAPTPPGAADA
HCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
GVVWAEATPVEPVLPAGFTGTISATATAGAPGATGDPDGPTARLVELAREYRTLVTGVLR
CEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ARGVGQVADTVEAIENPDTLADTAGYSSYLSTAQKLELLRTVDVTARLELLVPWTREHAA
HCCCCHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHH
EVDVAETIRRDVQEGVDRQQREFLLRRQLEAVRKELAELDGSPASSEQEDYRARVEAADL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
PEKVRAAALKEVDKLERTAESSPEVGWIRTWLDTVLELPWNEHAEDTYDIASARAVLDAD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
HAGLSDVKDRIVEYLAVRRRRADAGLGVVGGRRSGAVLALAGPPGVGKTSLGESVARAMG
CCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
RRFARVALGGVRDEAEIRGHRRTYVGAQPGRIVRAIREAGSMNPVILLDEVDKVGSDYRG
HHHHHHHHCCCCCHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHCCCCCCC
DPTAALLEVLDPAQNHTFRDHYLEVELDLSDVLFLATANVLESIPAPLLDRMELILLDGY
CHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHCCEEEEECCC
TEEEKVTIARDHLLPRQLERAGLTPDDVTVDDAALRLLAGEYTREAGVRDLERATARVLR
CCCCCEEHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KVVAKVALDETALPVTIGAGDLAGYLGRPRHTPESAERTALPGVATGLAVTGAGGDVLFV
HHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCCHHHHCCCCHHHCEEEECCCCCEEEE
EASLADPETGASGVTLTGQLGDVMKESAQIALSYLRSRGVELELPVGDLRDRGVHIHVPA
EEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCEEEEECC
GAVPKDGPSAGVTMTTALASLLSGRPVRADVAMTGEVSLTGRVLPIGGVKQKLLAAHRAG
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCEEECCEEEECCCHHHHHHHHHHCC
IATVLLPARNGPDLDDVPAAVREALTVHLVADVREVLELALEPAFDTTHTHAVAA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA