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The map label for this gene is mprB [H]

Identifier: 158317066

GI number: 158317066

Start: 6393672

End: 6395699

Strand: Reverse

Name: mprB [H]

Synonym: Franean1_5310

Alternate gene names: 158317066

Gene position: 6395699-6393672 (Counterclockwise)

Preceding gene: 158317067

Following gene: 158317065

Centisome position: 71.21

GC content: 75.39

Gene sequence:

>2028_bases
GTGAACCCGCCGCCGACCGGGTGTGAGCCCGCTGCCGCTGTCAGTGCCGACGACGCCGACGAAACTGGCCAGGTCGAAGA
GGCCGGTAAGGCCGGTAAGGCCGACAACGCCGACGAGGTCGGTGTGACCGGGCCGGAGCAGCCGGCGAACACGCTGGTCG
AGGGCCGGCGGGTGGGGGGTCCGTCGTCCCAGCCGGCGGCGTCGCGCTGGCCGAGCCGGCTCCCGCGGCTGACGCTGCGG
GCCCGGATGGCGCTGCTCGCCGGGGTGGCCGTCGCCGCCGCGGTCGCCGTCGTGGTCAGCGTCGCCCTCGGCGTCACCCG
GATCGTGCTGAACCAGGCGATCGACGACCAGCTCCTGGAACAGGCCAAGGCGTCGGCCGGCAACCTGCAGGCGAGCCAGA
TCAGCGTCCGGGCCCTGAACTTCGGCATGGAGCTGCAGTTCCTCGACGGCGACGGAGTGCCCCTGGAGAGCGCCTTCCCG
TCGCTGGAGACCTTCGCGATCCCCGTCGACGCGGCCGACGCCGAGGTCGCGCGGGGCCTGCGTGGCAAGAACCTGCGCAC
CGTCACGGTCGAGGGCCAGCGGTACCGGGTGGCCACCGTCCCGCTGCGCTATCCGCCGCCACTCACCGGCACCGGGGCCC
TGCAGCTGGCCCGGTCCACCTCCGACGTGGATCGCACGCTGCGCGATCTCGGGCTGGTGCTGTTCATCGTCGGGCTGGTC
GGCGTGGTCGGCTCGGTGATCGCCGGCCGCCTCGTCGCCCGTGCCTCGCTGAAACCGGTGGACGCCGCGGCGGCCGCGGC
GGAGGAGGTGGCGCGTACCCAGGACCTCTCCGCCCTGATCCCGGTCACCGGCTCGGACGAGATCGCCCGGCTGGCTACCA
GCCTCAACAGCATGCTGCGGGCGCTGGAGGCATCCCGGCTGCGGCAACGCCAGCTCGTCGACGACGCCGCCCACGAGCTG
CGCACGCCGCTGACCAGCCTGCGCACCAACATCGAGCTCCTGATGCGAGCGGAGACGACTCCGAACCGGGCGCTGCCCGC
GGCGGACCGTGACGCGCTGCTGCGCGACGTCGACGCCCAGATGCGCGAGCTGACCGCGCTGGTCAACGAGCTGATCGAGC
TGGCCCGCGACGAGGTGCCCACGGAGGAGATCGAGCGGCTCGACCTCGCCCAGGTCGTGCGGGCCGCCGCGGACCGGGCC
CGGCGCCGGGCGAACACCAAGGGCATCCGGATCGAGGTGAGCGTCGAGCCGTCCCTGGTGGACGGGCGGCCGAGCCTGCT
GGAGCGGGCGGTGACCAACCTGCTGGACAACGCGGTGAAGTTCAGCCCGCCGTCCTCGACCGTGCGGGTGGTCAGCCGGG
CCGGCGAGGTCACCGTCGCCGACGAGGGCCCGGGCATCGCGCCGGCCGACCGGGCCCGCGTCTTCGAGCGCTTCTACCGG
GCCACGGCGGCGCGCAGCCTGCCCGGCTCCGGCCTTGGCCTGGCGATCGTCGCGGACGCCGCGGCGATGCACGGCGGGAC
GGCCGAGGCCGCCGAGTCGCCGTCCGGCGGCGCGCTGCTGCGGATGACATTGCCCTGCGTGGCGGCCTGGGAGCGGGGGG
TTCCCTGGGACGGCGACGATCCCGTCGGGTACGGCGGGTTCGTCTCCGACGGCGGGACCGCCGGCGCGAACGGCTTCCTT
TCGGTAGATGGCCCTCCTCCGATGAGCGGCCCTCTGTCCATGGGCGGCTTCGCTCCGGCGGGCGGAGCCGGGCCCGTGGG
CGTCTCCCCGGCGCGCTCGGGGCCCGCGGCTGCGGACGCGGACTCGCCGTGGCGGCGGCCGGCCGGCGGCTCCGCAGCGG
CCGCCGAAGCGGAGCAGGCGGTGGCCGAGAGAGCGGAGAAGGCAGAACAGACGGCAGAGCGGGCGGCTGGGCAGAAGGCG
GGCGGGGCAGGCACGGGCGGTCCGGCCACGGCGCCCGGCGTTGGCGCGGAGCGGCCCGGGGGGCGTTCGACGGTCCGCCC
GGGGCAGCGGGCAGGATCAGGTCCGTGA

Upstream 100 bases:

>100_bases
AACTCCCTGGAGGTGTTCGTGAGCTACCTGCGGCGCAAGCTCGAGGCCGGCGGTGAGCCACGGCTGCTGCACACGGTGCG
CGGGGTGGGTTACGTCCTGC

Downstream 100 bases:

>100_bases
CATCCGCGCCCGAGCGCCCCGACCAGCCCGCCGCGCCCCCCGCCGCTACCGCGCCGCCTACCACTGCGGCGCCGTCAGCC
GCCGCGCCGTCAGCCGGCGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MNPPPTGCEPAAAVSADDADETGQVEEAGKAGKADNADEVGVTGPEQPANTLVEGRRVGGPSSQPAASRWPSRLPRLTLR
ARMALLAGVAVAAAVAVVVSVALGVTRIVLNQAIDDQLLEQAKASAGNLQASQISVRALNFGMELQFLDGDGVPLESAFP
SLETFAIPVDAADAEVARGLRGKNLRTVTVEGQRYRVATVPLRYPPPLTGTGALQLARSTSDVDRTLRDLGLVLFIVGLV
GVVGSVIAGRLVARASLKPVDAAAAAAEEVARTQDLSALIPVTGSDEIARLATSLNSMLRALEASRLRQRQLVDDAAHEL
RTPLTSLRTNIELLMRAETTPNRALPAADRDALLRDVDAQMRELTALVNELIELARDEVPTEEIERLDLAQVVRAAADRA
RRRANTKGIRIEVSVEPSLVDGRPSLLERAVTNLLDNAVKFSPPSSTVRVVSRAGEVTVADEGPGIAPADRARVFERFYR
ATAARSLPGSGLGLAIVADAAAMHGGTAEAAESPSGGALLRMTLPCVAAWERGVPWDGDDPVGYGGFVSDGGTAGANGFL
SVDGPPPMSGPLSMGGFAPAGGAGPVGVSPARSGPAAADADSPWRRPAGGSAAAAEAEQAVAERAEKAEQTAERAAGQKA
GGAGTGGPATAPGVGAERPGGRSTVRPGQRAGSGP

Sequences:

>Translated_675_residues
MNPPPTGCEPAAAVSADDADETGQVEEAGKAGKADNADEVGVTGPEQPANTLVEGRRVGGPSSQPAASRWPSRLPRLTLR
ARMALLAGVAVAAAVAVVVSVALGVTRIVLNQAIDDQLLEQAKASAGNLQASQISVRALNFGMELQFLDGDGVPLESAFP
SLETFAIPVDAADAEVARGLRGKNLRTVTVEGQRYRVATVPLRYPPPLTGTGALQLARSTSDVDRTLRDLGLVLFIVGLV
GVVGSVIAGRLVARASLKPVDAAAAAAEEVARTQDLSALIPVTGSDEIARLATSLNSMLRALEASRLRQRQLVDDAAHEL
RTPLTSLRTNIELLMRAETTPNRALPAADRDALLRDVDAQMRELTALVNELIELARDEVPTEEIERLDLAQVVRAAADRA
RRRANTKGIRIEVSVEPSLVDGRPSLLERAVTNLLDNAVKFSPPSSTVRVVSRAGEVTVADEGPGIAPADRARVFERFYR
ATAARSLPGSGLGLAIVADAAAMHGGTAEAAESPSGGALLRMTLPCVAAWERGVPWDGDDPVGYGGFVSDGGTAGANGFL
SVDGPPPMSGPLSMGGFAPAGGAGPVGVSPARSGPAAADADSPWRRPAGGSAAAAEAEQAVAERAEKAEQTAERAAGQKA
GGAGTGGPATAPGVGAERPGGRSTVRPGQRAGSGP
>Mature_675_residues
MNPPPTGCEPAAAVSADDADETGQVEEAGKAGKADNADEVGVTGPEQPANTLVEGRRVGGPSSQPAASRWPSRLPRLTLR
ARMALLAGVAVAAAVAVVVSVALGVTRIVLNQAIDDQLLEQAKASAGNLQASQISVRALNFGMELQFLDGDGVPLESAFP
SLETFAIPVDAADAEVARGLRGKNLRTVTVEGQRYRVATVPLRYPPPLTGTGALQLARSTSDVDRTLRDLGLVLFIVGLV
GVVGSVIAGRLVARASLKPVDAAAAAAEEVARTQDLSALIPVTGSDEIARLATSLNSMLRALEASRLRQRQLVDDAAHEL
RTPLTSLRTNIELLMRAETTPNRALPAADRDALLRDVDAQMRELTALVNELIELARDEVPTEEIERLDLAQVVRAAADRA
RRRANTKGIRIEVSVEPSLVDGRPSLLERAVTNLLDNAVKFSPPSSTVRVVSRAGEVTVADEGPGIAPADRARVFERFYR
ATAARSLPGSGLGLAIVADAAAMHGGTAEAAESPSGGALLRMTLPCVAAWERGVPWDGDDPVGYGGFVSDGGTAGANGFL
SVDGPPPMSGPLSMGGFAPAGGAGPVGVSPARSGPAAADADSPWRRPAGGSAAAAEAEQAVAERAEKAEQTAERAAGQKA
GGAGTGGPATAPGVGAERPGGRSTVRPGQRAGSGP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=32.129963898917, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=292, Percent_Identity=28.0821917808219, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786783, Length=350, Percent_Identity=28, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=35.1239669421488, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI1789403, Length=304, Percent_Identity=31.9078947368421, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=31.5126050420168, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1786912, Length=255, Percent_Identity=30.9803921568627, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=32, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788279, Length=299, Percent_Identity=25.4180602006689, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1789808, Length=253, Percent_Identity=29.2490118577075, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=321, Percent_Identity=25.2336448598131, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=28.1512605042017, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=24.6268656716418, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=25.8196721311475, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=23.6947791164659, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787374, Length=282, Percent_Identity=26.9503546099291, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69217; Mature: 69217

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPPTGCEPAAAVSADDADETGQVEEAGKAGKADNADEVGVTGPEQPANTLVEGRRVGG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
PSSQPAASRWPSRLPRLTLRARMALLAGVAVAAAVAVVVSVALGVTRIVLNQAIDDQLLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKASAGNLQASQISVRALNFGMELQFLDGDGVPLESAFPSLETFAIPVDAADAEVARGL
HHHHCCCCCCHHHEEEEEEECCCEEEEECCCCCCHHHHCCCCEEEEEECCCCHHHHHCCC
RGKNLRTVTVEGQRYRVATVPLRYPPPLTGTGALQLARSTSDVDRTLRDLGLVLFIVGLV
CCCCEEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVGSVIAGRLVARASLKPVDAAAAAAEEVARTQDLSALIPVTGSDEIARLATSLNSMLR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHH
ALEASRLRQRQLVDDAAHELRTPLTSLRTNIELLMRAETTPNRALPAADRDALLRDVDAQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHEEEECCCCCCCCCCCCHHHHHHHHHHH
MRELTALVNELIELARDEVPTEEIERLDLAQVVRAAADRARRRANTKGIRIEVSVEPSLV
HHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
DGRPSLLERAVTNLLDNAVKFSPPSSTVRVVSRAGEVTVADEGPGIAPADRARVFERFYR
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHH
ATAARSLPGSGLGLAIVADAAAMHGGTAEAAESPSGGALLRMTLPCVAAWERGVPWDGDD
HHHHHCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCEEEEEHHHHHHHHHCCCCCCCCC
PVGYGGFVSDGGTAGANGFLSVDGPPPMSGPLSMGGFAPAGGAGPVGVSPARSGPAAADA
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DSPWRRPAGGSAAAAEAEQAVAERAEKAEQTAERAAGQKAGGAGTGGPATAPGVGAERPG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GRSTVRPGQRAGSGP
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MNPPPTGCEPAAAVSADDADETGQVEEAGKAGKADNADEVGVTGPEQPANTLVEGRRVGG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
PSSQPAASRWPSRLPRLTLRARMALLAGVAVAAAVAVVVSVALGVTRIVLNQAIDDQLLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKASAGNLQASQISVRALNFGMELQFLDGDGVPLESAFPSLETFAIPVDAADAEVARGL
HHHHCCCCCCHHHEEEEEEECCCEEEEECCCCCCHHHHCCCCEEEEEECCCCHHHHHCCC
RGKNLRTVTVEGQRYRVATVPLRYPPPLTGTGALQLARSTSDVDRTLRDLGLVLFIVGLV
CCCCEEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVGSVIAGRLVARASLKPVDAAAAAAEEVARTQDLSALIPVTGSDEIARLATSLNSMLR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHH
ALEASRLRQRQLVDDAAHELRTPLTSLRTNIELLMRAETTPNRALPAADRDALLRDVDAQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHEEEECCCCCCCCCCCCHHHHHHHHHHH
MRELTALVNELIELARDEVPTEEIERLDLAQVVRAAADRARRRANTKGIRIEVSVEPSLV
HHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
DGRPSLLERAVTNLLDNAVKFSPPSSTVRVVSRAGEVTVADEGPGIAPADRARVFERFYR
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHH
ATAARSLPGSGLGLAIVADAAAMHGGTAEAAESPSGGALLRMTLPCVAAWERGVPWDGDD
HHHHHCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCEEEEEHHHHHHHHHCCCCCCCCC
PVGYGGFVSDGGTAGANGFLSVDGPPPMSGPLSMGGFAPAGGAGPVGVSPARSGPAAADA
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DSPWRRPAGGSAAAAEAEQAVAERAEKAEQTAERAAGQKAGGAGTGGPATAPGVGAERPG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GRSTVRPGQRAGSGP
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA