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The map label for this gene is mprA [H]

Identifier: 158317067

GI number: 158317067

Start: 6395674

End: 6396414

Strand: Reverse

Name: mprA [H]

Synonym: Franean1_5311

Alternate gene names: 158317067

Gene position: 6396414-6395674 (Counterclockwise)

Preceding gene: 158317068

Following gene: 158317066

Centisome position: 71.21

GC content: 71.79

Gene sequence:

>741_bases
GTGCGAGTACTGGTGGTGGACGACGACGCGGCTGTCCGCGAGTCGCTGGAGCGGTCGCTGAGGTTCGAGGGCTACGAGGT
GCGCACGGCGCCCGACGGGGTCGCCGCGCTGGAGGTGGTGGCGCGCGACCAGCCGGACATCGTCGTGCTCGACGTGATGA
TGCCGAGGATGGACGGCCTGGAGACCTGCCGCCGTCTGCGGGCGCGCGGTGACGACGTCCCCGTCCTCATGCTGACGGCC
CGTGACGGGCTGGCCGACCGGGTCAGCGGCCTCGACGTGGGCGCCGACGACTACCTGGTGAAGCCCTTCGCGTTGGAGGA
GCTGTTCGCCCGGCTGCGGGCGCTGATCCGGCGGTCCACCCTCGTGACACGGGCCGGCGTGGGCCACGGCCCCGCGCACG
GCGCCGAGCCGGGCCATGGTGTCCCCGCCGCGCTGTCGTACGCGGGGGTGGCGCTCGACCCGGCGAGCCGCCAGGTCCTG
CGGGAGGGCCGGGAGCTGACGCTGACCAAGACCGAGTTCGAGCTGCTCGAGCTGTTCCTGACCCATCCGCGCCAGGTCCT
CTCCCGATCGATGATCATGGAGAAAGTCTGGGGCTACGACTTCGGACCCTCCTCGAACTCCCTGGAGGTGTTCGTGAGCT
ACCTGCGGCGCAAGCTCGAGGCCGGCGGTGAGCCACGGCTGCTGCACACGGTGCGCGGGGTGGGTTACGTCCTGCGTGAA
CCCGCCGCCGACCGGGTGTGA

Upstream 100 bases:

>100_bases
CGGGCATAGCGCCTGAAGCGGGGCTGAGGATCGGACAAGGTCTTGCTGAGATGCGCGTCCGGAGCATGGAACTGTCGGGC
GAGCGGGGCAGACTGGAGCC

Downstream 100 bases:

>100_bases
GCCCGCTGCCGCTGTCAGTGCCGACGACGCCGACGAAACTGGCCAGGTCGAAGAGGCCGGTAAGGCCGGTAAGGCCGACA
ACGCCGACGAGGTCGGTGTG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MRVLVVDDDAAVRESLERSLRFEGYEVRTAPDGVAALEVVARDQPDIVVLDVMMPRMDGLETCRRLRARGDDVPVLMLTA
RDGLADRVSGLDVGADDYLVKPFALEELFARLRALIRRSTLVTRAGVGHGPAHGAEPGHGVPAALSYAGVALDPASRQVL
REGRELTLTKTEFELLELFLTHPRQVLSRSMIMEKVWGYDFGPSSNSLEVFVSYLRRKLEAGGEPRLLHTVRGVGYVLRE
PAADRV

Sequences:

>Translated_246_residues
MRVLVVDDDAAVRESLERSLRFEGYEVRTAPDGVAALEVVARDQPDIVVLDVMMPRMDGLETCRRLRARGDDVPVLMLTA
RDGLADRVSGLDVGADDYLVKPFALEELFARLRALIRRSTLVTRAGVGHGPAHGAEPGHGVPAALSYAGVALDPASRQVL
REGRELTLTKTEFELLELFLTHPRQVLSRSMIMEKVWGYDFGPSSNSLEVFVSYLRRKLEAGGEPRLLHTVRGVGYVLRE
PAADRV
>Mature_246_residues
MRVLVVDDDAAVRESLERSLRFEGYEVRTAPDGVAALEVVARDQPDIVVLDVMMPRMDGLETCRRLRARGDDVPVLMLTA
RDGLADRVSGLDVGADDYLVKPFALEELFARLRALIRRSTLVTRAGVGHGPAHGAEPGHGVPAALSYAGVALDPASRQVL
REGRELTLTKTEFELLELFLTHPRQVLSRSMIMEKVWGYDFGPSSNSLEVFVSYLRRKLEAGGEPRLLHTVRGVGYVLRE
PAADRV

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=241, Percent_Identity=38.5892116182573, Blast_Score=173, Evalue=8e-45,
Organism=Escherichia coli, GI1789809, Length=238, Percent_Identity=36.9747899159664, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786599, Length=237, Percent_Identity=36.2869198312236, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI87082012, Length=236, Percent_Identity=33.8983050847458, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789402, Length=240, Percent_Identity=40.4166666666667, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1790552, Length=238, Percent_Identity=38.2352941176471, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI2367329, Length=239, Percent_Identity=37.6569037656904, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1786911, Length=235, Percent_Identity=35.3191489361702, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=239, Percent_Identity=34.3096234309623, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1787375, Length=238, Percent_Identity=30.672268907563, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=28.8135593220339, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=30.5084745762712, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=243, Percent_Identity=31.6872427983539, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=30.8333333333333, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=40.7407407407407, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=40.9090909090909, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=40.5660377358491, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=38.2608695652174, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=34.7107438016529, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788192, Length=106, Percent_Identity=36.7924528301887, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788905, Length=121, Percent_Identity=31.404958677686, Blast_Score=60, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=112, Percent_Identity=29.4642857142857, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27158; Mature: 27158

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVDDDAAVRESLERSLRFEGYEVRTAPDGVAALEVVARDQPDIVVLDVMMPRMDGL
CEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEHHCCCCHH
ETCRRLRARGDDVPVLMLTARDGLADRVSGLDVGADDYLVKPFALEELFARLRALIRRST
HHHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHH
LVTRAGVGHGPAHGAEPGHGVPAALSYAGVALDPASRQVLREGRELTLTKTEFELLELFL
HHHHCCCCCCCCCCCCCCCCCCHHHHHCCEEECHHHHHHHHCCCCEEEEHHHHHHHHHHH
THPRQVLSRSMIMEKVWGYDFGPSSNSLEVFVSYLRRKLEAGGEPRLLHTVRGVGYVLRE
HCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
PAADRV
CCCCCC
>Mature Secondary Structure
MRVLVVDDDAAVRESLERSLRFEGYEVRTAPDGVAALEVVARDQPDIVVLDVMMPRMDGL
CEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEHHCCCCHH
ETCRRLRARGDDVPVLMLTARDGLADRVSGLDVGADDYLVKPFALEELFARLRALIRRST
HHHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHH
LVTRAGVGHGPAHGAEPGHGVPAALSYAGVALDPASRQVLREGRELTLTKTEFELLELFL
HHHHCCCCCCCCCCCCCCCCCCHHHHHCCEEECHHHHHHHHCCCCEEEEHHHHHHHHHHH
THPRQVLSRSMIMEKVWGYDFGPSSNSLEVFVSYLRRKLEAGGEPRLLHTVRGVGYVLRE
HCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
PAADRV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA