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The map label for this gene is irtA [H]

Identifier: 158317000

GI number: 158317000

Start: 6305957

End: 6306856

Strand: Direct

Name: irtA [H]

Synonym: Franean1_5244

Alternate gene names: 158317000

Gene position: 6305957-6306856 (Clockwise)

Preceding gene: 158316989

Following gene: 158317004

Centisome position: 70.21

GC content: 64.44

Gene sequence:

>900_bases
GTGCCGCTCAAGCAGGCCCCGATCGTCCTGCTCGACGAGGCGACGGCCACGCTCGACCCGGCAGACGAGTACCTGATCCG
CCGTTCGGTCACCGAGCTGAAGCGCACCTCGACCGTCATCGTCGTGGCGCACACCGCCGCCCTAATCGACGCGGCCGACC
AGGTCGTCGTCCTCGACGGCGGACGGGTCGTCGAGCGCGGCGGCCCGAGCGAGCTCCGCGCGGCCGGCGCGTTCTTCTCC
CTCCTGTGGGGCGACCGCGTACGGTCCTCCGGCTGGCGGCTGGGCGGTAGGCCCGGTCACGGCTTCCCTGGTTCCCCCGC
ATCTGCGACGGTTTTTCCTCAAACTAAGATTATGTTCGTGGTGACACGAGGAGTCCCTTCGATCGCGCCAAACAAGATCA
TTTTTTGGATGCTGATAGGAGCCCTCTCAACTGCTGGCTGCTCAGCGTTGCCCGTCTCATGGCCGGAGGCGGGATGCACG
GACCGGGACAACGAACTTGCCGCAAGGTTGAACAACCTCGCCGTACTCGACCTGCATCCTGCTGGCGCAACGGTCCAAGA
ACAGGGATCTGGCTGCAGCGAAAGCTCCGGCGCAACATATGCGGGGCGCACATACCGGCCGGCGGGTACGACCGATGGAG
TGATGGAGTTCTACCATCGCACCGTGCCCGCGGCCGGCTGGAAGCTGGAGCACGTCGACAATCGCCCGGTCGATCCCGGC
GAACCTATGTACCTTGGATCAAGCCGATGCTACTCCAAGTCCACCGAAGGCAGCACCGTTTTTCTGACCATATGGTTTCC
GGACGACTCCGGTGAGGATGGGAACGACCCGCCAGGACCAGGGATCCGTCACTTCAGATTGGACGTGACGGCGGACAGGG
ACGGCATCTCGACCTGCTGA

Upstream 100 bases:

>100_bases
GCCACGCGACGTCCGCGCCCGGGCCGCTAGCCTGCACCCGTGTCGGGGAGGCGGGTGCACGCCTGTCCAGTGGCGAGCGC
CAGCGGGTGTCGATGCCCGG

Downstream 100 bases:

>100_bases
CACTCTACTTTCGACGCCGACGGAGAACGATGTATACCCTCGTCCCGACAAGCGCGGTCGCCTTTGCCTGCCTGACCGCA
CTACTCAGCGGCTGCGGGTC

Product: multidrug ABC transporter permease-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MPLKQAPIVLLDEATATLDPADEYLIRRSVTELKRTSTVIVVAHTAALIDAADQVVVLDGGRVVERGGPSELRAAGAFFS
LLWGDRVRSSGWRLGGRPGHGFPGSPASATVFPQTKIMFVVTRGVPSIAPNKIIFWMLIGALSTAGCSALPVSWPEAGCT
DRDNELAARLNNLAVLDLHPAGATVQEQGSGCSESSGATYAGRTYRPAGTTDGVMEFYHRTVPAAGWKLEHVDNRPVDPG
EPMYLGSSRCYSKSTEGSTVFLTIWFPDDSGEDGNDPPGPGIRHFRLDVTADRDGISTC

Sequences:

>Translated_299_residues
MPLKQAPIVLLDEATATLDPADEYLIRRSVTELKRTSTVIVVAHTAALIDAADQVVVLDGGRVVERGGPSELRAAGAFFS
LLWGDRVRSSGWRLGGRPGHGFPGSPASATVFPQTKIMFVVTRGVPSIAPNKIIFWMLIGALSTAGCSALPVSWPEAGCT
DRDNELAARLNNLAVLDLHPAGATVQEQGSGCSESSGATYAGRTYRPAGTTDGVMEFYHRTVPAAGWKLEHVDNRPVDPG
EPMYLGSSRCYSKSTEGSTVFLTIWFPDDSGEDGNDPPGPGIRHFRLDVTADRDGISTC
>Mature_298_residues
PLKQAPIVLLDEATATLDPADEYLIRRSVTELKRTSTVIVVAHTAALIDAADQVVVLDGGRVVERGGPSELRAAGAFFSL
LWGDRVRSSGWRLGGRPGHGFPGSPASATVFPQTKIMFVVTRGVPSIAPNKIIFWMLIGALSTAGCSALPVSWPEAGCTD
RDNELAARLNNLAVLDLHPAGATVQEQGSGCSESSGATYAGRTYRPAGTTDGVMEFYHRTVPAAGWKLEHVDNRPVDPGE
PMYLGSSRCYSKSTEGSTVFLTIWFPDDSGEDGNDPPGPGIRHFRLDVTADRDGISTC

Specific function: Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI9955968, Length=80, Percent_Identity=37.5, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI9955966, Length=80, Percent_Identity=37.5, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI45243524, Length=80, Percent_Identity=37.5, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787143, Length=70, Percent_Identity=41.4285714285714, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551501, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45551502, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357851, Length=81, Percent_Identity=39.5061728395062, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR013113
- InterPro:   IPR017927
- InterPro:   IPR017938
- InterPro:   IPR007037 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF08021 FAD_binding_9; PF04954 SIP [H]

EC number: NA

Molecular weight: Translated: 31839; Mature: 31708

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKQAPIVLLDEATATLDPADEYLIRRSVTELKRTSTVIVVAHTAALIDAADQVVVLDG
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHHHHCCCCEEEEEEC
GRVVERGGPSELRAAGAFFSLLWGDRVRSSGWRLGGRPGHGFPGSPASATVFPQTKIMFV
CEEEECCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEE
VTRGVPSIAPNKIIFWMLIGALSTAGCSALPVSWPEAGCTDRDNELAARLNNLAVLDLHP
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEECC
AGATVQEQGSGCSESSGATYAGRTYRPAGTTDGVMEFYHRTVPAAGWKLEHVDNRPVDPG
CCCCHHHCCCCCCCCCCCEECCCEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCC
EPMYLGSSRCYSKSTEGSTVFLTIWFPDDSGEDGNDPPGPGIRHFRLDVTADRDGISTC
CCEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
PLKQAPIVLLDEATATLDPADEYLIRRSVTELKRTSTVIVVAHTAALIDAADQVVVLDG
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHHHHCCCCEEEEEEC
GRVVERGGPSELRAAGAFFSLLWGDRVRSSGWRLGGRPGHGFPGSPASATVFPQTKIMFV
CEEEECCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEE
VTRGVPSIAPNKIIFWMLIGALSTAGCSALPVSWPEAGCTDRDNELAARLNNLAVLDLHP
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEECC
AGATVQEQGSGCSESSGATYAGRTYRPAGTTDGVMEFYHRTVPAAGWKLEHVDNRPVDPG
CCCCHHHCCCCCCCCCCCEECCCEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCC
EPMYLGSSRCYSKSTEGSTVFLTIWFPDDSGEDGNDPPGPGIRHFRLDVTADRDGISTC
CCEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]