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The map label for this gene is dxs

Identifier: 158316940

GI number: 158316940

Start: 6222873

End: 6224825

Strand: Reverse

Name: dxs

Synonym: Franean1_5184

Alternate gene names: 158316940

Gene position: 6224825-6222873 (Counterclockwise)

Preceding gene: 158316941

Following gene: 158316939

Centisome position: 69.3

GC content: 70.35

Gene sequence:

>1953_bases
GTGTCGCTTCTGTCGACGATCGACAGCCCGCAGGACGTCAAGCGCCTCGACCATGAGGAGCTGGTGACGCTCGCGGCTGA
GATCCGTGATTTCCTCATCCACGCGGTTGCCCGCACAGGCGGCCACCTAGGGCCGAATCTGGGCGCTGTAGAACTGACTC
TCGCAATCCACCGAGTGTTCGATTCACCATTCGACCGTGTCCTCTGGGACACGGGCCACCAGTCCTATGTTCACAAGATT
CTGACCGGCCGCCGGGAGCAGTTCGACCGCCTCCGTCAACGCGGCGGGCTCTCCGGCTACCCGAGCCAGGCCGAGTCCGA
GCACGACATCATCGAGAACTCGCACGCCTCCACGGCGCTGTCGTACGCCGACGGGCTGTCCCGCGCCTACGAGCTGCGCG
GGGAGAACCGGGCCGTCGTCGCGGTCGTCGGCGACGGGGCGCTGACCGGCGGAATGTGCTGGGAGGCGCTGAACAACATC
GCCGCCAGCGACCGGCAGGTCGTCATCGTCGTCAACGACAACGGCCGGTCCTACTCACCCACCATCGGCGGCCTCGCCGA
CCACCTCGCGTCGCTGCGCCTGGCGCCCGAGTACGAGCAGGTCCTGGACGTCGTCAAGCAGGTGCTGGGCCGCACCCCGC
TCGTCGGCGCACCGCTGTTCGACGCCCTGCACGGCATCAAGAAGGGCATCAAGGACGTCGTCACCCCGCAGGGCATGTTC
GAGGACCTCGGGCTGAAGTACGTCGGCCCGGTCGACGGCCACGACGTGGTCGCCATGGAGTCGGCGCTGCGCCGGGCCAA
GGACTTCGGCGGCCCGGTGATCGTCCACGCCATGACCCGCAAGGGCTTCGGGTACCCGGCGGCCGAGCAGGACGACGCCG
ACAACTTCCACGCCGTCGGCGTCATCGACCCGGTGACCGGCAAGCCGAAGTCGGCGTCCAAGGGCACCACCTGGACCTCG
ATCTTCTCCGAGGAGATCGTCCGGATCGGCTCCGAGCGGCCCGACGTGGTCACCATGACCGCGGCGATGCTCCAGCCGGT
CGGCCTGAAGTCGTTCGCCAAGGCCTTCCCGGACCGGGTCTTCGACGTCGGCATCGCCGAGCAGCACGCGGTCACCTCGG
CCGCCGGCCTGGCCATGGGCGGTCTCAAGCCCGTTGTGTGCATCTACGCGACGTTCCTGAACCGCGCCTTCGACCAGGTC
CTCATGGACGTCGCCATGCACCGCCAGCCGGTGACCTTCGTGCTCGACCGCGCCGGGATCACCGGCGAGGACGGCGCGTC
CCACAACGGCATGTGGGACATGTCCTTCCTGCAGGTCGTGCCGGGTCTGGCGATCGCCGCCCCGCGTGACGCCGCGACCC
TGCGCGCCGAGCTCGACGAGGCGGTCTCCAACACCGACGGCCCGACGGTCGTGCGTTACCCCAAGGGCAAGGTCGCCGCG
GACTCCCCGGCGATCGACCAGGTCGGCGGGGTCGACGTCCTCTACCGGGCGCCGGCGGCCGCGCGGCACCGCGAGGTGCT
GCTCGTCTCGATCGGCGCGATGGCCCCGACCTGTCTGGACGTCGCCGAGCGTGTCGCCAGCCAGGGCATCGGCATCACCG
TGGTCGACCCGCGGTGGGTCAAGCCGCTCGACCCGGCGCTGGTCGACCTCGCCCGTGACCACGACCTCGTCGTCACCGTC
GAGGACAACGGGCGGGTCGGTGGCGTCGGTGCCTGCGTCGCGCAGCTGCTGCGGGACGCCGACGTCGACGTCCCGGTGCG
TGAGTTCGGGGTCGCCCAGCGCTTCCTCGACCACGGCAAGCGCGACGACGTGCTGGCCGAGGTCGGCCTCGCCCCGCAGG
ACCTGGCCCGCAAGGTGATCGAGGCGGTCGCCAAGCGCCAGCACGCCCTCATGGGCGACGAGGTCGGCGCGGACGAGTCC
AACCAGACCCCCGCCGGCGGCGGTCAGGCCTGA

Upstream 100 bases:

>100_bases
GCAGCTCACATGTCGGGAGCCTGTCTGCGGAGCCCGGGGTGCCCTGCGTAGACTTTGCCGGACCCGGACCGATCCCCTTT
CGGGGGAGGGAGAGCACGCC

Downstream 100 bases:

>100_bases
CCGGCCGGGCCTGACCGGCCGGGCCTGACCGGCCGGGCCTGACCGGCCAGGCCTGACCGGCGCGGCCGGGTCGCGCCCGC
GCCCGGCCCGGCGCGGGTGC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSLLSTIDSPQDVKRLDHEELVTLAAEIRDFLIHAVARTGGHLGPNLGAVELTLAIHRVFDSPFDRVLWDTGHQSYVHKI
LTGRREQFDRLRQRGGLSGYPSQAESEHDIIENSHASTALSYADGLSRAYELRGENRAVVAVVGDGALTGGMCWEALNNI
AASDRQVVIVVNDNGRSYSPTIGGLADHLASLRLAPEYEQVLDVVKQVLGRTPLVGAPLFDALHGIKKGIKDVVTPQGMF
EDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVIVHAMTRKGFGYPAAEQDDADNFHAVGVIDPVTGKPKSASKGTTWTS
IFSEEIVRIGSERPDVVTMTAAMLQPVGLKSFAKAFPDRVFDVGIAEQHAVTSAAGLAMGGLKPVVCIYATFLNRAFDQV
LMDVAMHRQPVTFVLDRAGITGEDGASHNGMWDMSFLQVVPGLAIAAPRDAATLRAELDEAVSNTDGPTVVRYPKGKVAA
DSPAIDQVGGVDVLYRAPAAARHREVLLVSIGAMAPTCLDVAERVASQGIGITVVDPRWVKPLDPALVDLARDHDLVVTV
EDNGRVGGVGACVAQLLRDADVDVPVREFGVAQRFLDHGKRDDVLAEVGLAPQDLARKVIEAVAKRQHALMGDEVGADES
NQTPAGGGQA

Sequences:

>Translated_650_residues
MSLLSTIDSPQDVKRLDHEELVTLAAEIRDFLIHAVARTGGHLGPNLGAVELTLAIHRVFDSPFDRVLWDTGHQSYVHKI
LTGRREQFDRLRQRGGLSGYPSQAESEHDIIENSHASTALSYADGLSRAYELRGENRAVVAVVGDGALTGGMCWEALNNI
AASDRQVVIVVNDNGRSYSPTIGGLADHLASLRLAPEYEQVLDVVKQVLGRTPLVGAPLFDALHGIKKGIKDVVTPQGMF
EDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVIVHAMTRKGFGYPAAEQDDADNFHAVGVIDPVTGKPKSASKGTTWTS
IFSEEIVRIGSERPDVVTMTAAMLQPVGLKSFAKAFPDRVFDVGIAEQHAVTSAAGLAMGGLKPVVCIYATFLNRAFDQV
LMDVAMHRQPVTFVLDRAGITGEDGASHNGMWDMSFLQVVPGLAIAAPRDAATLRAELDEAVSNTDGPTVVRYPKGKVAA
DSPAIDQVGGVDVLYRAPAAARHREVLLVSIGAMAPTCLDVAERVASQGIGITVVDPRWVKPLDPALVDLARDHDLVVTV
EDNGRVGGVGACVAQLLRDADVDVPVREFGVAQRFLDHGKRDDVLAEVGLAPQDLARKVIEAVAKRQHALMGDEVGADES
NQTPAGGGQA
>Mature_649_residues
SLLSTIDSPQDVKRLDHEELVTLAAEIRDFLIHAVARTGGHLGPNLGAVELTLAIHRVFDSPFDRVLWDTGHQSYVHKIL
TGRREQFDRLRQRGGLSGYPSQAESEHDIIENSHASTALSYADGLSRAYELRGENRAVVAVVGDGALTGGMCWEALNNIA
ASDRQVVIVVNDNGRSYSPTIGGLADHLASLRLAPEYEQVLDVVKQVLGRTPLVGAPLFDALHGIKKGIKDVVTPQGMFE
DLGLKYVGPVDGHDVVAMESALRRAKDFGGPVIVHAMTRKGFGYPAAEQDDADNFHAVGVIDPVTGKPKSASKGTTWTSI
FSEEIVRIGSERPDVVTMTAAMLQPVGLKSFAKAFPDRVFDVGIAEQHAVTSAAGLAMGGLKPVVCIYATFLNRAFDQVL
MDVAMHRQPVTFVLDRAGITGEDGASHNGMWDMSFLQVVPGLAIAAPRDAATLRAELDEAVSNTDGPTVVRYPKGKVAAD
SPAIDQVGGVDVLYRAPAAARHREVLLVSIGAMAPTCLDVAERVASQGIGITVVDPRWVKPLDPALVDLARDHDLVVTVE
DNGRVGGVGACVAQLLRDADVDVPVREFGVAQRFLDHGKRDDVLAEVGLAPQDLARKVIEAVAKRQHALMGDEVGADESN
QTPAGGGQA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=259, Percent_Identity=27.4131274131274, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4507521, Length=259, Percent_Identity=27.4131274131274, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI133778974, Length=423, Percent_Identity=27.6595744680851, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI225637459, Length=421, Percent_Identity=25.6532066508314, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI225637461, Length=421, Percent_Identity=25.6532066508314, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637463, Length=423, Percent_Identity=26.241134751773, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=40.3225806451613, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17539652, Length=413, Percent_Identity=24.9394673123487, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666278, Length=267, Percent_Identity=32.2097378277154, Blast_Score=109, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45551847, Length=374, Percent_Identity=28.0748663101604, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550715, Length=374, Percent_Identity=28.0748663101604, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645119, Length=374, Percent_Identity=28.0748663101604, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_FRASN (A8L0K9)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001509448.1
- ProteinModelPortal:   A8L0K9
- SMR:   A8L0K9
- GeneID:   5673518
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_5184
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   FSP1855:FRANEAN1_5184-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69351; Mature: 69220

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLSTIDSPQDVKRLDHEELVTLAAEIRDFLIHAVARTGGHLGPNLGAVELTLAIHRVF
CCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DSPFDRVLWDTGHQSYVHKILTGRREQFDRLRQRGGLSGYPSQAESEHDIIENSHASTAL
CCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHH
SYADGLSRAYELRGENRAVVAVVGDGALTGGMCWEALNNIAASDRQVVIVVNDNGRSYSP
HHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEECC
TIGGLADHLASLRLAPEYEQVLDVVKQVLGRTPLVGAPLFDALHGIKKGIKDVVTPQGMF
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHH
EDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVIVHAMTRKGFGYPAAEQDDADNFHAVG
HHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCCCCCCCEEEEE
VIDPVTGKPKSASKGTTWTSIFSEEIVRIGSERPDVVTMTAAMLQPVGLKSFAKAFPDRV
EECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHCCCCHHHHHHHCCHHH
FDVGIAEQHAVTSAAGLAMGGLKPVVCIYATFLNRAFDQVLMDVAMHRQPVTFVLDRAGI
HCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
TGEDGASHNGMWDMSFLQVVPGLAIAAPRDAATLRAELDEAVSNTDGPTVVRYPKGKVAA
CCCCCCCCCCCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
DSPAIDQVGGVDVLYRAPAAARHREVLLVSIGAMAPTCLDVAERVASQGIGITVVDPRWV
CCCCHHHCCCCCEEECCCCHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCC
KPLDPALVDLARDHDLVVTVEDNGRVGGVGACVAQLLRDADVDVPVREFGVAQRFLDHGK
CCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
RDDVLAEVGLAPQDLARKVIEAVAKRQHALMGDEVGADESNQTPAGGGQA
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLLSTIDSPQDVKRLDHEELVTLAAEIRDFLIHAVARTGGHLGPNLGAVELTLAIHRVF
CHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DSPFDRVLWDTGHQSYVHKILTGRREQFDRLRQRGGLSGYPSQAESEHDIIENSHASTAL
CCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHH
SYADGLSRAYELRGENRAVVAVVGDGALTGGMCWEALNNIAASDRQVVIVVNDNGRSYSP
HHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEECC
TIGGLADHLASLRLAPEYEQVLDVVKQVLGRTPLVGAPLFDALHGIKKGIKDVVTPQGMF
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHH
EDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVIVHAMTRKGFGYPAAEQDDADNFHAVG
HHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCCCCCCCEEEEE
VIDPVTGKPKSASKGTTWTSIFSEEIVRIGSERPDVVTMTAAMLQPVGLKSFAKAFPDRV
EECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHCCCCHHHHHHHCCHHH
FDVGIAEQHAVTSAAGLAMGGLKPVVCIYATFLNRAFDQVLMDVAMHRQPVTFVLDRAGI
HCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
TGEDGASHNGMWDMSFLQVVPGLAIAAPRDAATLRAELDEAVSNTDGPTVVRYPKGKVAA
CCCCCCCCCCCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
DSPAIDQVGGVDVLYRAPAAARHREVLLVSIGAMAPTCLDVAERVASQGIGITVVDPRWV
CCCCHHHCCCCCEEECCCCHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCC
KPLDPALVDLARDHDLVVTVEDNGRVGGVGACVAQLLRDADVDVPVREFGVAQRFLDHGK
CCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
RDDVLAEVGLAPQDLARKVIEAVAKRQHALMGDEVGADESNQTPAGGGQA
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA