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The map label for this gene is fadJ [H]

Identifier: 158316936

GI number: 158316936

Start: 6216740

End: 6218908

Strand: Direct

Name: fadJ [H]

Synonym: Franean1_5180

Alternate gene names: 158316936

Gene position: 6216740-6218908 (Clockwise)

Preceding gene: 158316935

Following gene: 158316937

Centisome position: 69.21

GC content: 73.21

Gene sequence:

>2169_bases
ATGAGCAGCGCCGCGATGACCCTGGAGCACCCGGACGAGGTCGTCACGCAGGCCCATGTCCGGTACGCACAACTGTCCGG
CGTGAGCGGCCCGGTCGCGCTCATCACCCTGGACAACGGGCAGGACCACACCCGCCCGAGCACCTTCGGCCCGGGCGGGC
TGCGGTCACTGCTCACCGCCGTCGAGGAGATCGAGGCCCACGACCCGCCGGTGGCGGCGGTGGCGGTGACCGGCAAGCCG
TTCATCTTCTGCGCCGGCGCGGACCTCTCCTACCGGTCGTCGCTGACCGACCCGGCCGAGGTCCGGCCGAAGCTCACCGC
GCTCGGCGAGCTCGGGCACACCGCGCTGCGCCGGGTCGGCGAGGGCCGGCTGGGCGACCGGCGGGTCCCCACCTTCGCGC
TGGTCAACGGCGCCGCGATGGGCGGCGGCCTGGAGCTGGCGCTGCACTGCGACTACCGGGCGATCTCCGCCGGTGCCGCG
CCGATCGCGCTGCCCGAGGTCTTCCTCGGCCTGGTGCCGGCCTGGGGCGGCACCCAGCTGCTGCCGAACCTGGTCGGCCC
GGAGAACGCGGTCACCATCATGATCGACAACGCGCTCAGCCAGAACCGGACGCTGCGCGGCCCCAAGGCGTTCGCGCTCG
GCCTCGGTGACGTCCTGCTGGATGCCGCGGACTTCCTCGAGGAGGCGCTGCACTGGGTCGGCCAGGTGCTGCGGGGCGAG
GTGGACCCGACCAAGGGCCGCCGTCCCGTCGAGCAGGGTGCCGCCTGGGCTGCGGCGCTGGAGCGCGGTCGCGTCCTCGC
GGACGCCCGGCTGCACGGCGCGGCCCCGGCCGCCTACCGCGCGCTCGAGCTGATGGCCCTGGCGGAGACCGCGGACGCCG
ACACGGGGTACGCCGCCGAGACGGCGGCGCTGGCCGATCTCGGGTCCAGCGAGGAACTCGTCGCCGGGCTCTACTCCTTC
GACCTGGTGAACCGGCGCGCCAAGCGGCCGGTCGGCGGGCCCGACCGCTCGCTGGCCCAGGCGGTGACCAAGGTCGGCGT
GGTCGGCGCGGGGCTGATGGCCAGCCAGCTCGGGCTGCTGTTCGCCCAGCGGCTGGAGGTGCCGGTCGTCCTCACCGACC
TCGACCAGGCGCGTCTCGACGCGGGAGTCGCACACGTCCACAGCGAGATCGACAACCTGCTGCTGCGCGGGCGGATCTCC
CACGACCGCGCGAACCGGCTCAAGGCCTCCGTGACCGGCTCACTGACCAAGGACGCGTTCGCCGACGCCGACCTGATCAT
CGAGGCCGTCTTCGAGGACATGTCGGTCAAGAAGGCGGTGCTCGCCGAGCTCGAGTCCGTGGTGAAGCCGGAGACGCTGC
TGCTCACCAACACCTCGGCCCTCTCGGTGACCGAGATGGCCGCCGACCTGACCCATCCGGAGCGGGTCGCCGGGCTGCAC
TTCTTCAACCCGGTGGCGGTGCTGCCCCTGGTCGAGGTCGTCCGCACCCCGCGGACCGACGACACCACGATCGCGACCAC
GCTGCAGGTCGCGAAGCAGCTGAAGAAGAACGCGGTGCTGGTCGCAGACGCGCCGGCCTTCGTGGTGAACCGCCTCCTCA
CCCGGTTCATGGGCGAGGTGCTCGCGGCCACCGAGACCGGAACCCCGATCGAGCAGGCCGACGGCGCGCTCGACCCGCTC
GGACTGCCGATGTCGCCGCTGGTCCTGCTCTCGCTGGTCGGCCCGCCGGTCGCACTGCACGTGGCCCGGACCCTGCACCA
GGCCATGCCCGACCGGTTCCGCACGCCGGACGGCCTGGCGCGGGTCGTGGCCGCCGGGAAGAGCAGCTTCTACACGGCCG
GACCGGGCGGCGAGCAGATCGTCGACCCGGAGGTCGCCGATCTCGTCCGGAGCATGGACGACGGCACCGCGCCGACCGCT
CGGGAGGGTGCGGCGATGACGCCCGAGCAGGTCCGCGAGGCGGCGCTCTCCGCGCTGGCCCAGGAGATAAGGCTCCTGCT
GGACGAGGGCGTCGTGGCCGAGGCGGCGGACGTCGACCTGTGCATGATCCTCGGCGCCGGCTGGCCCTTCCACCTCGGCG
GCATCACCCCGTACCTGGACCGCACCGGCATCAGCGAACGCGTGACCGGTCGCCGTTTCAACCCTCCGGGCGTCGCCACC
GTCGCCTGA

Upstream 100 bases:

>100_bases
CCGAGGTCCGCTACGGGATGACCGCGATGTGCGTGGGCTTCGGCATGGGAGCGACGACGATCTGGGAGAACCCGCACTTC
GGCCGAACGGGAGAAGGAGC

Downstream 100 bases:

>100_bases
TCGGATGAGAACTCCGGGCGGGCGGACGCCGGCACTGCCCGCCCGCCCGGAGTGCCCGTCCGAGGCCGCCGCTCGGATCC
GCCGCGCTCCGGGCCGACAT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MSSAAMTLEHPDEVVTQAHVRYAQLSGVSGPVALITLDNGQDHTRPSTFGPGGLRSLLTAVEEIEAHDPPVAAVAVTGKP
FIFCAGADLSYRSSLTDPAEVRPKLTALGELGHTALRRVGEGRLGDRRVPTFALVNGAAMGGGLELALHCDYRAISAGAA
PIALPEVFLGLVPAWGGTQLLPNLVGPENAVTIMIDNALSQNRTLRGPKAFALGLGDVLLDAADFLEEALHWVGQVLRGE
VDPTKGRRPVEQGAAWAAALERGRVLADARLHGAAPAAYRALELMALAETADADTGYAAETAALADLGSSEELVAGLYSF
DLVNRRAKRPVGGPDRSLAQAVTKVGVVGAGLMASQLGLLFAQRLEVPVVLTDLDQARLDAGVAHVHSEIDNLLLRGRIS
HDRANRLKASVTGSLTKDAFADADLIIEAVFEDMSVKKAVLAELESVVKPETLLLTNTSALSVTEMAADLTHPERVAGLH
FFNPVAVLPLVEVVRTPRTDDTTIATTLQVAKQLKKNAVLVADAPAFVVNRLLTRFMGEVLAATETGTPIEQADGALDPL
GLPMSPLVLLSLVGPPVALHVARTLHQAMPDRFRTPDGLARVVAAGKSSFYTAGPGGEQIVDPEVADLVRSMDDGTAPTA
REGAAMTPEQVREAALSALAQEIRLLLDEGVVAEAADVDLCMILGAGWPFHLGGITPYLDRTGISERVTGRRFNPPGVAT
VA

Sequences:

>Translated_722_residues
MSSAAMTLEHPDEVVTQAHVRYAQLSGVSGPVALITLDNGQDHTRPSTFGPGGLRSLLTAVEEIEAHDPPVAAVAVTGKP
FIFCAGADLSYRSSLTDPAEVRPKLTALGELGHTALRRVGEGRLGDRRVPTFALVNGAAMGGGLELALHCDYRAISAGAA
PIALPEVFLGLVPAWGGTQLLPNLVGPENAVTIMIDNALSQNRTLRGPKAFALGLGDVLLDAADFLEEALHWVGQVLRGE
VDPTKGRRPVEQGAAWAAALERGRVLADARLHGAAPAAYRALELMALAETADADTGYAAETAALADLGSSEELVAGLYSF
DLVNRRAKRPVGGPDRSLAQAVTKVGVVGAGLMASQLGLLFAQRLEVPVVLTDLDQARLDAGVAHVHSEIDNLLLRGRIS
HDRANRLKASVTGSLTKDAFADADLIIEAVFEDMSVKKAVLAELESVVKPETLLLTNTSALSVTEMAADLTHPERVAGLH
FFNPVAVLPLVEVVRTPRTDDTTIATTLQVAKQLKKNAVLVADAPAFVVNRLLTRFMGEVLAATETGTPIEQADGALDPL
GLPMSPLVLLSLVGPPVALHVARTLHQAMPDRFRTPDGLARVVAAGKSSFYTAGPGGEQIVDPEVADLVRSMDDGTAPTA
REGAAMTPEQVREAALSALAQEIRLLLDEGVVAEAADVDLCMILGAGWPFHLGGITPYLDRTGISERVTGRRFNPPGVAT
VA
>Mature_721_residues
SSAAMTLEHPDEVVTQAHVRYAQLSGVSGPVALITLDNGQDHTRPSTFGPGGLRSLLTAVEEIEAHDPPVAAVAVTGKPF
IFCAGADLSYRSSLTDPAEVRPKLTALGELGHTALRRVGEGRLGDRRVPTFALVNGAAMGGGLELALHCDYRAISAGAAP
IALPEVFLGLVPAWGGTQLLPNLVGPENAVTIMIDNALSQNRTLRGPKAFALGLGDVLLDAADFLEEALHWVGQVLRGEV
DPTKGRRPVEQGAAWAAALERGRVLADARLHGAAPAAYRALELMALAETADADTGYAAETAALADLGSSEELVAGLYSFD
LVNRRAKRPVGGPDRSLAQAVTKVGVVGAGLMASQLGLLFAQRLEVPVVLTDLDQARLDAGVAHVHSEIDNLLLRGRISH
DRANRLKASVTGSLTKDAFADADLIIEAVFEDMSVKKAVLAELESVVKPETLLLTNTSALSVTEMAADLTHPERVAGLHF
FNPVAVLPLVEVVRTPRTDDTTIATTLQVAKQLKKNAVLVADAPAFVVNRLLTRFMGEVLAATETGTPIEQADGALDPLG
LPMSPLVLLSLVGPPVALHVARTLHQAMPDRFRTPDGLARVVAAGKSSFYTAGPGGEQIVDPEVADLVRSMDDGTAPTAR
EGAAMTPEQVREAALSALAQEIRLLLDEGVVAEAADVDLCMILGAGWPFHLGGITPYLDRTGISERVTGRRFNPPGVATV
A

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=745, Percent_Identity=27.9194630872483, Blast_Score=253, Evalue=5e-67,
Organism=Homo sapiens, GI68989263, Length=668, Percent_Identity=30.5389221556886, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI261878539, Length=597, Percent_Identity=30.9882747068677, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI296179429, Length=153, Percent_Identity=39.8692810457516, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI296179427, Length=183, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI115430219, Length=208, Percent_Identity=28.8461538461538, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1788682, Length=670, Percent_Identity=30, Blast_Score=231, Evalue=2e-61,
Organism=Escherichia coli, GI1790281, Length=643, Percent_Identity=27.3716951788491, Blast_Score=208, Evalue=9e-55,
Organism=Escherichia coli, GI1787661, Length=255, Percent_Identity=34.9019607843137, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787659, Length=145, Percent_Identity=34.4827586206897, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558304, Length=677, Percent_Identity=29.6898079763663, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17508951, Length=712, Percent_Identity=28.0898876404494, Blast_Score=226, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17508953, Length=712, Percent_Identity=28.0898876404494, Blast_Score=226, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI25144276, Length=635, Percent_Identity=28.0314960629921, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71985923, Length=356, Percent_Identity=26.4044943820225, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=379, Percent_Identity=27.1767810026385, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17549919, Length=281, Percent_Identity=33.8078291814947, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553560, Length=247, Percent_Identity=33.6032388663968, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17563036, Length=201, Percent_Identity=33.8308457711443, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921000, Length=684, Percent_Identity=28.2163742690059, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24583077, Length=684, Percent_Identity=28.2163742690059, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24583079, Length=684, Percent_Identity=28.2163742690059, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI45549573, Length=210, Percent_Identity=29.0476190476191, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653139, Length=175, Percent_Identity=32, Blast_Score=73, Evalue=9e-13,
Organism=Drosophila melanogaster, GI20129971, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653477, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 75768; Mature: 75636

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAMTLEHPDEVVTQAHVRYAQLSGVSGPVALITLDNGQDHTRPSTFGPGGLRSLLTA
CCCCCEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHH
VEEIEAHDPPVAAVAVTGKPFIFCAGADLSYRSSLTDPAEVRPKLTALGELGHTALRRVG
HHHHHCCCCCEEEEEECCCCEEEEECCCCHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHC
EGRLGDRRVPTFALVNGAAMGGGLELALHCDYRAISAGAAPIALPEVFLGLVPAWGGTQL
CCCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHCCCCCHHH
LPNLVGPENAVTIMIDNALSQNRTLRGPKAFALGLGDVLLDAADFLEEALHWVGQVLRGE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VDPTKGRRPVEQGAAWAAALERGRVLADARLHGAAPAAYRALELMALAETADADTGYAAE
CCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
TAALADLGSSEELVAGLYSFDLVNRRAKRPVGGPDRSLAQAVTKVGVVGAGLMASQLGLL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FAQRLEVPVVLTDLDQARLDAGVAHVHSEIDNLLLRGRISHDRANRLKASVTGSLTKDAF
HHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
ADADLIIEAVFEDMSVKKAVLAELESVVKPETLLLTNTSALSVTEMAADLTHPERVAGLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCHHHHHCCH
FFNPVAVLPLVEVVRTPRTDDTTIATTLQVAKQLKKNAVLVADAPAFVVNRLLTRFMGEV
HCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHH
LAATETGTPIEQADGALDPLGLPMSPLVLLSLVGPPVALHVARTLHQAMPDRFRTPDGLA
HHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHCCCCHHHH
RVVAAGKSSFYTAGPGGEQIVDPEVADLVRSMDDGTAPTAREGAAMTPEQVREAALSALA
HHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QEIRLLLDEGVVAEAADVDLCMILGAGWPFHLGGITPYLDRTGISERVTGRRFNPPGVAT
HHHHHHHHCCCEECCCCCCEEEEEECCCCEECCCCCCHHHCCCCCHHCCCCCCCCCCCCC
VA
CC
>Mature Secondary Structure 
SSAAMTLEHPDEVVTQAHVRYAQLSGVSGPVALITLDNGQDHTRPSTFGPGGLRSLLTA
CCCCEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHH
VEEIEAHDPPVAAVAVTGKPFIFCAGADLSYRSSLTDPAEVRPKLTALGELGHTALRRVG
HHHHHCCCCCEEEEEECCCCEEEEECCCCHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHC
EGRLGDRRVPTFALVNGAAMGGGLELALHCDYRAISAGAAPIALPEVFLGLVPAWGGTQL
CCCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHCCCCCHHH
LPNLVGPENAVTIMIDNALSQNRTLRGPKAFALGLGDVLLDAADFLEEALHWVGQVLRGE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VDPTKGRRPVEQGAAWAAALERGRVLADARLHGAAPAAYRALELMALAETADADTGYAAE
CCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
TAALADLGSSEELVAGLYSFDLVNRRAKRPVGGPDRSLAQAVTKVGVVGAGLMASQLGLL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FAQRLEVPVVLTDLDQARLDAGVAHVHSEIDNLLLRGRISHDRANRLKASVTGSLTKDAF
HHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
ADADLIIEAVFEDMSVKKAVLAELESVVKPETLLLTNTSALSVTEMAADLTHPERVAGLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCHHHHHCCH
FFNPVAVLPLVEVVRTPRTDDTTIATTLQVAKQLKKNAVLVADAPAFVVNRLLTRFMGEV
HCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHH
LAATETGTPIEQADGALDPLGLPMSPLVLLSLVGPPVALHVARTLHQAMPDRFRTPDGLA
HHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHCCCCHHHH
RVVAAGKSSFYTAGPGGEQIVDPEVADLVRSMDDGTAPTAREGAAMTPEQVREAALSALA
HHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QEIRLLLDEGVVAEAADVDLCMILGAGWPFHLGGITPYLDRTGISERVTGRRFNPPGVAT
HHHHHHHHCCCEECCCCCCEEEEEECCCCEECCCCCCHHHCCCCCHHCCCCCCCCCCCCC
VA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA