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The map label for this gene is hemE [H]

Identifier: 158316931

GI number: 158316931

Start: 6210539

End: 6211621

Strand: Reverse

Name: hemE [H]

Synonym: Franean1_5175

Alternate gene names: 158316931

Gene position: 6211621-6210539 (Counterclockwise)

Preceding gene: 158316939

Following gene: 158316930

Centisome position: 69.16

GC content: 73.59

Gene sequence:

>1083_bases
ATGTCCCTCGGAAGTACCGCCGTTGCGCCGCCTCGCCCCGGGGTCTCGCCCCGACGTCCAGGTCTCGCCGCGACTTCGCC
GTTCCTGCGCGCCGCCGCCGGGGACCGCCCCGACAGCGTGCCCGTGTGGTTCATGCGGCAGGCCGGCCGGGTGCTTCCCG
AGTACCGCGCCCTGCGCGCCACCACCGCCATGCTCGATTCCTGCCGCAACGCCGACATGGTCACCGAGATCACCCTGCAG
CCGGTGCGCCGTTTCCGGCCCGACGCCGCGATCTTCTTCTCGGACATCGTCCTGCCGCTCGCGGCCGTCGGGGTGGACGT
CGACATCGTCGCCGGGGTCGGGCCCGTGGTGGCCCATCCCGTCCGGGCGCCGTCCGACCTGGACGTGCTGCGCCCGCTGG
AGCCCGGTGACGTGCCCTACGTGAGCGAGGCGGTGGCCTCCCTGGTCCGCGAGCTCGGGCAGACGCCGCTGATCGGTTTC
GCCGGCGCGCCGTTCACCCTGGCCAGCTATCTGATCGAAGGCGGGCCGAGCCGCAACCACACCCGCACGAAGGCGCTCAT
GTACGCCGAGCCGGCGCTGTGGCACGACCTGCTCGGCCGGCTCGCCGACATCACGGCCGCCTTCCTGCGGGTGCAGGTCG
ACGCCGGCGCCGACGCCATCCAGCTGTTCGACTCGTGGGCGGGCGCGCTCAGCGAGGACGACTACCTGCGCTACGTGGCT
CCGCACAGCACCCGGGTTCTCGCGGCGTTCGCCGACGACGGCATCCCGCGCATCCACTTCGGGGTGAACACCGGGGAGCT
GCTCGGCGCGATGGGCGCGGCCGGCGCGGACGTCGTCGGGGTCGACTGGCGCGTCCCGCTGGACGAGGCCGCCCGCCGGG
TCGGCCCCGGTCGTGCCGTGCAGGGCAACCTCGACCCGGCCGCGGTCTTCGCCCCGTCCGACGTGCTCGCGGCGAAGGTC
CGCGACGTCTGCCGCCGGGGTGCGGCCGCTCCCGGGCACATCTTCAACTTCGGGCACGGCGTGCTTCCGGAGAGTGATCC
GGGCGTGCTGGCGCACATCGTGGACCTCGTCCACCAGTTCTGA

Upstream 100 bases:

>100_bases
GACGCGTTCTCCAGCCTGACTTCTACTGCGAGTAGAAGATATCGCACACAGTCGTGTGCCCTGCGCGGCATCTGTCCGCC
GGGCGTGCAACGATCGGGCC

Downstream 100 bases:

>100_bases
CAGCGGGGGGGCGGCAGCCACCGACTCGCCAGGCCCGCGCACGGGGCCGTAGGCCGGTCCGGGGCCGCTCGGCGGTGCCC
GCCACCGGCGTGGCACGGCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSLGSTAVAPPRPGVSPRRPGLAATSPFLRAAAGDRPDSVPVWFMRQAGRVLPEYRALRATTAMLDSCRNADMVTEITLQ
PVRRFRPDAAIFFSDIVLPLAAVGVDVDIVAGVGPVVAHPVRAPSDLDVLRPLEPGDVPYVSEAVASLVRELGQTPLIGF
AGAPFTLASYLIEGGPSRNHTRTKALMYAEPALWHDLLGRLADITAAFLRVQVDAGADAIQLFDSWAGALSEDDYLRYVA
PHSTRVLAAFADDGIPRIHFGVNTGELLGAMGAAGADVVGVDWRVPLDEAARRVGPGRAVQGNLDPAAVFAPSDVLAAKV
RDVCRRGAAAPGHIFNFGHGVLPESDPGVLAHIVDLVHQF

Sequences:

>Translated_360_residues
MSLGSTAVAPPRPGVSPRRPGLAATSPFLRAAAGDRPDSVPVWFMRQAGRVLPEYRALRATTAMLDSCRNADMVTEITLQ
PVRRFRPDAAIFFSDIVLPLAAVGVDVDIVAGVGPVVAHPVRAPSDLDVLRPLEPGDVPYVSEAVASLVRELGQTPLIGF
AGAPFTLASYLIEGGPSRNHTRTKALMYAEPALWHDLLGRLADITAAFLRVQVDAGADAIQLFDSWAGALSEDDYLRYVA
PHSTRVLAAFADDGIPRIHFGVNTGELLGAMGAAGADVVGVDWRVPLDEAARRVGPGRAVQGNLDPAAVFAPSDVLAAKV
RDVCRRGAAAPGHIFNFGHGVLPESDPGVLAHIVDLVHQF
>Mature_359_residues
SLGSTAVAPPRPGVSPRRPGLAATSPFLRAAAGDRPDSVPVWFMRQAGRVLPEYRALRATTAMLDSCRNADMVTEITLQP
VRRFRPDAAIFFSDIVLPLAAVGVDVDIVAGVGPVVAHPVRAPSDLDVLRPLEPGDVPYVSEAVASLVRELGQTPLIGFA
GAPFTLASYLIEGGPSRNHTRTKALMYAEPALWHDLLGRLADITAAFLRVQVDAGADAIQLFDSWAGALSEDDYLRYVAP
HSTRVLAAFADDGIPRIHFGVNTGELLGAMGAAGADVVGVDWRVPLDEAARRVGPGRAVQGNLDPAAVFAPSDVLAAKVR
DVCRRGAAAPGHIFNFGHGVLPESDPGVLAHIVDLVHQF

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=342, Percent_Identity=40.0584795321637, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=40, Blast_Score=246, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=36.7521367521368, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI19921920, Length=341, Percent_Identity=37.5366568914956, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI221330099, Length=341, Percent_Identity=37.5366568914956, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38054; Mature: 37923

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGSTAVAPPRPGVSPRRPGLAATSPFLRAAAGDRPDSVPVWFMRQAGRVLPEYRALRA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHH
TTAMLDSCRNADMVTEITLQPVRRFRPDAAIFFSDIVLPLAAVGVDVDIVAGVGPVVAHP
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCC
VRAPSDLDVLRPLEPGDVPYVSEAVASLVRELGQTPLIGFAGAPFTLASYLIEGGPSRNH
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCC
TRTKALMYAEPALWHDLLGRLADITAAFLRVQVDAGADAIQLFDSWAGALSEDDYLRYVA
CHHHEEEEECHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCEEEEC
PHSTRVLAAFADDGIPRIHFGVNTGELLGAMGAAGADVVGVDWRVPLDEAARRVGPGRAV
CCCCEEEEEECCCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHCCCCCEE
QGNLDPAAVFAPSDVLAAKVRDVCRRGAAAPGHIFNFGHGVLPESDPGVLAHIVDLVHQF
ECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLGSTAVAPPRPGVSPRRPGLAATSPFLRAAAGDRPDSVPVWFMRQAGRVLPEYRALRA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHH
TTAMLDSCRNADMVTEITLQPVRRFRPDAAIFFSDIVLPLAAVGVDVDIVAGVGPVVAHP
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCC
VRAPSDLDVLRPLEPGDVPYVSEAVASLVRELGQTPLIGFAGAPFTLASYLIEGGPSRNH
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCC
TRTKALMYAEPALWHDLLGRLADITAAFLRVQVDAGADAIQLFDSWAGALSEDDYLRYVA
CHHHEEEEECHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCEEEEC
PHSTRVLAAFADDGIPRIHFGVNTGELLGAMGAAGADVVGVDWRVPLDEAARRVGPGRAV
CCCCEEEEEECCCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHCCCCCEE
QGNLDPAAVFAPSDVLAAKVRDVCRRGAAAPGHIFNFGHGVLPESDPGVLAHIVDLVHQF
ECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA