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The map label for this gene is apt

Identifier: 158316896

GI number: 158316896

Start: 6161377

End: 6161931

Strand: Reverse

Name: apt

Synonym: Franean1_5140

Alternate gene names: 158316896

Gene position: 6161931-6161377 (Counterclockwise)

Preceding gene: 158316897

Following gene: 158316895

Centisome position: 68.6

GC content: 72.61

Gene sequence:

>555_bases
ATGACAAGCGTCGACAGCCAGCCGGACCTGAGCGCGGCCGAGGCCGTGCTGGGCGCCCACGTGCGCGACGTCATGGACTT
CCCCAAGCCGGGAGTCGTCTTCAAGGACATCACCCCGCTGCTCTCGACTCCGGCCGCCTTCGGAGTGGTCGTCGGTGCGC
TGGCGGACCTCGCCCGCGGGCTGGGCGCCACCACGATCGCCGGCATCGAGGCGCGTGGCTTCCTGCTGGCCGCCCCGGTC
GCCGACCGGGTCGGCGCCGGCATCGTCCCGATCCGCAAGCAGGGCAAGCTGCCCGGCCGGACCCGCAGCGAGGCGTACGC
GCTGGAGTACGGGACGGCCGTCCTGGAGATCCATGAGGACGCCGTCCCGACGGGTGAGCGGGTCCTGATCGTCGACGACG
TGCTCGCTACCGGCGGCACCGCGGCGGCCGCGCACACCCTGCTGCGCGGGTGCGGCGCCGACGTGGTGGGGCTGGCGGTG
CTGATGGAGCTGACCTTCCTCTCCGGGCGCGACCGGACCGGCACGCTCGACGTCACCTCGATCATGAAGATCTGA

Upstream 100 bases:

>100_bases
CAGAGGCAGAACCACGATCGACAGAACCACGACCGGCACGACATCGGCGCGAACCGCCGCCCGCGGGGCGGCGACAACGA
AGATCGGAGAGGTCACCACG

Downstream 100 bases:

>100_bases
CCGTGTCCGGTGCGTCGCCCGTGTCCGGTCACGGTTCGTGACCGGCGCTCGGCATTGACGCGACCGGCCTGCCCGCCGGC
CTCCGGCGCGCCCCTGGCCG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MTSVDSQPDLSAAEAVLGAHVRDVMDFPKPGVVFKDITPLLSTPAAFGVVVGALADLARGLGATTIAGIEARGFLLAAPV
ADRVGAGIVPIRKQGKLPGRTRSEAYALEYGTAVLEIHEDAVPTGERVLIVDDVLATGGTAAAAHTLLRGCGADVVGLAV
LMELTFLSGRDRTGTLDVTSIMKI

Sequences:

>Translated_184_residues
MTSVDSQPDLSAAEAVLGAHVRDVMDFPKPGVVFKDITPLLSTPAAFGVVVGALADLARGLGATTIAGIEARGFLLAAPV
ADRVGAGIVPIRKQGKLPGRTRSEAYALEYGTAVLEIHEDAVPTGERVLIVDDVLATGGTAAAAHTLLRGCGADVVGLAV
LMELTFLSGRDRTGTLDVTSIMKI
>Mature_183_residues
TSVDSQPDLSAAEAVLGAHVRDVMDFPKPGVVFKDITPLLSTPAAFGVVVGALADLARGLGATTIAGIEARGFLLAAPVA
DRVGAGIVPIRKQGKLPGRTRSEAYALEYGTAVLEIHEDAVPTGERVLIVDDVLATGGTAAAAHTLLRGCGADVVGLAVL
MELTFLSGRDRTGTLDVTSIMKI

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=47.0588235294118, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=51.2, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=46.3414634146341, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=177, Percent_Identity=40.1129943502825, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=38.3233532934132, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=156, Percent_Identity=37.8205128205128, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136334, Length=169, Percent_Identity=39.0532544378698, Blast_Score=110, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_FRASN (A8KZE2)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001509404.1
- ProteinModelPortal:   A8KZE2
- GeneID:   5673474
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_5140
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   FSP1855:FRANEAN1_5140-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18858; Mature: 18727

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVDSQPDLSAAEAVLGAHVRDVMDFPKPGVVFKDITPLLSTPAAFGVVVGALADLARG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHC
LGATTIAGIEARGFLLAAPVADRVGAGIVPIRKQGKLPGRTRSEAYALEYGTAVLEIHED
CCCHHEECCCCCCEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHCCEEEEEECC
AVPTGERVLIVDDVLATGGTAAAAHTLLRGCGADVVGLAVLMELTFLSGRDRTGTLDVTS
CCCCCCEEEEEECHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHH
IMKI
HHCC
>Mature Secondary Structure 
TSVDSQPDLSAAEAVLGAHVRDVMDFPKPGVVFKDITPLLSTPAAFGVVVGALADLARG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHC
LGATTIAGIEARGFLLAAPVADRVGAGIVPIRKQGKLPGRTRSEAYALEYGTAVLEIHED
CCCHHEECCCCCCEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHCCEEEEEECC
AVPTGERVLIVDDVLATGGTAAAAHTLLRGCGADVVGLAVLMELTFLSGRDRTGTLDVTS
CCCCCCEEEEEECHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHH
IMKI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA