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The map label for this gene is cobD [H]

Identifier: 158316627

GI number: 158316627

Start: 5836690

End: 5837688

Strand: Reverse

Name: cobD [H]

Synonym: Franean1_4864

Alternate gene names: 158316627

Gene position: 5837688-5836690 (Counterclockwise)

Preceding gene: 158316628

Following gene: 158316626

Centisome position: 64.99

GC content: 80.58

Gene sequence:

>999_bases
GTGAGCCGCGCCCGCACGGTGGGGCTCGTCCTCGGCGCGGCCCTCGACGCGGTGCTCGCCGACCCTGCCCGCGGCCATCC
CGTGGCCGGTTTCGGGCGGGTCGCCGGCGGCCTCGAGCGGGCCGTCCACCGTGACAGCCGGCTGGTCGGCGCGGCGTACG
CCACGGTCCTCGTCGCCGGCACGGGCGCCGCGGCCGCCGGCGCGGAACGGGCGCTGGCCGGCCGGCACCCGGGACGGCGG
GCCGCGCTGGCCCGCGCGGGCCTGACCGCCGCCACGACCTGGACGGTGCTCGGCGGCACCTCGCTGCGGCGCCAGGGCCG
GGCCCTCGGCGGCGAGCTGGAACGCCGCGACCTGCGCGCGGCCCGGACGCGGCTGCCGTCGCTGTGCGGGCGGGACCCGT
CGGCCCTCGACGCCGGCGGGCTCGCGCGTGCCGGGGTGGAGTCGGTGGCGGAGAACACCTCGGACGCCGTCGTCGCCCCG
CTGCTGTGGGGGGCCGTCGCCGGGCTGCCCGGGCTGGTGGCCTACCGCGCGGCGAACACCCTCGACGCGATGGTCGGCTA
CCGCGACGCCCGGCACGGCCGGTTCGGCTGGGCCGTGGCCCGGACCGACGACGCGGCGAACCTGCTGCCGGCCCGGATGT
GCGCGCTGCTCACCTGCGCCTGCGCCCCGGTCGTCGGCGGTTCCCCGGCGGAGGCGTTCCGGGTGATGCGCCGCGACGGC
CGATCGCATCCGAGCCCGAACGCGGGCGTGGTCGAGGCCGCGTTCGCCGGTGCGCTCGGCCTGCGTCTCGGTGGTGAGCT
GCGGTACCCGCACGGGGTCGAGCACCGTCCCGAGCTGGGGTCCGGGCGTCCGGCCGAAGCCGGCGACCTGGCGGCGGCGG
CCCGTCTTTCCGGCGCGGTCAGCGCGGCCTCGGTCGTGGTGTGCGCCGGTGCGGTCGCCGCCCTCGACACGTTGCGGGCG
CGCCGGGCGGGCTCCCGCGGCCCGCGGGAGGCGGGATGA

Upstream 100 bases:

>100_bases
GGGTGCTGAGCCCGGCGCCGGCACCGGCGCGCCAGGCCGGCACCGTCGCCCGCGCGGACGAGACCCGCGCCTCCAGCCAG
GCCACGGCGCCGTCGGCCGG

Downstream 100 bases:

>100_bases
CGCGCCCGGCCGCGGGCGGGGCACTGCTGGTGGCGGGAACCGCCTCGGACGCGGGTAAGAGCGTCCTGACCGCCGGCCTG
TGCCGCTGGCTGGCCCGCGA

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSRARTVGLVLGAALDAVLADPARGHPVAGFGRVAGGLERAVHRDSRLVGAAYATVLVAGTGAAAAGAERALAGRHPGRR
AALARAGLTAATTWTVLGGTSLRRQGRALGGELERRDLRAARTRLPSLCGRDPSALDAGGLARAGVESVAENTSDAVVAP
LLWGAVAGLPGLVAYRAANTLDAMVGYRDARHGRFGWAVARTDDAANLLPARMCALLTCACAPVVGGSPAEAFRVMRRDG
RSHPSPNAGVVEAAFAGALGLRLGGELRYPHGVEHRPELGSGRPAEAGDLAAAARLSGAVSAASVVVCAGAVAALDTLRA
RRAGSRGPREAG

Sequences:

>Translated_332_residues
MSRARTVGLVLGAALDAVLADPARGHPVAGFGRVAGGLERAVHRDSRLVGAAYATVLVAGTGAAAAGAERALAGRHPGRR
AALARAGLTAATTWTVLGGTSLRRQGRALGGELERRDLRAARTRLPSLCGRDPSALDAGGLARAGVESVAENTSDAVVAP
LLWGAVAGLPGLVAYRAANTLDAMVGYRDARHGRFGWAVARTDDAANLLPARMCALLTCACAPVVGGSPAEAFRVMRRDG
RSHPSPNAGVVEAAFAGALGLRLGGELRYPHGVEHRPELGSGRPAEAGDLAAAARLSGAVSAASVVVCAGAVAALDTLRA
RRAGSRGPREAG
>Mature_331_residues
SRARTVGLVLGAALDAVLADPARGHPVAGFGRVAGGLERAVHRDSRLVGAAYATVLVAGTGAAAAGAERALAGRHPGRRA
ALARAGLTAATTWTVLGGTSLRRQGRALGGELERRDLRAARTRLPSLCGRDPSALDAGGLARAGVESVAENTSDAVVAPL
LWGAVAGLPGLVAYRAANTLDAMVGYRDARHGRFGWAVARTDDAANLLPARMCALLTCACAPVVGGSPAEAFRVMRRDGR
SHPSPNAGVVEAAFAGALGLRLGGELRYPHGVEHRPELGSGRPAEAGDLAAAARLSGAVSAASVVVCAGAVAALDTLRAR
RAGSRGPREAG

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 33475; Mature: 33343

Theoretical pI: Translated: 11.64; Mature: 11.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRARTVGLVLGAALDAVLADPARGHPVAGFGRVAGGLERAVHRDSRLVGAAYATVLVAG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
TGAAAAGAERALAGRHPGRRAALARAGLTAATTWTVLGGTSLRRQGRALGGELERRDLRA
CCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHEEECCCHHHHHHHHHHCCHHHHHHHHH
ARTRLPSLCGRDPSALDAGGLARAGVESVAENTSDAVVAPLLWGAVAGLPGLVAYRAANT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
LDAMVGYRDARHGRFGWAVARTDDAANLLPARMCALLTCACAPVVGGSPAEAFRVMRRDG
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
RSHPSPNAGVVEAAFAGALGLRLGGELRYPHGVEHRPELGSGRPAEAGDLAAAARLSGAV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SAASVVVCAGAVAALDTLRARRAGSRGPREAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SRARTVGLVLGAALDAVLADPARGHPVAGFGRVAGGLERAVHRDSRLVGAAYATVLVAG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
TGAAAAGAERALAGRHPGRRAALARAGLTAATTWTVLGGTSLRRQGRALGGELERRDLRA
CCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHEEECCCHHHHHHHHHHCCHHHHHHHHH
ARTRLPSLCGRDPSALDAGGLARAGVESVAENTSDAVVAPLLWGAVAGLPGLVAYRAANT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
LDAMVGYRDARHGRFGWAVARTDDAANLLPARMCALLTCACAPVVGGSPAEAFRVMRRDG
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
RSHPSPNAGVVEAAFAGALGLRLGGELRYPHGVEHRPELGSGRPAEAGDLAAAARLSGAV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SAASVVVCAGAVAALDTLRARRAGSRGPREAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]