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The map label for this gene is lldD2 [H]

Identifier: 158316435

GI number: 158316435

Start: 5576894

End: 5578150

Strand: Reverse

Name: lldD2 [H]

Synonym: Franean1_4670

Alternate gene names: 158316435

Gene position: 5578150-5576894 (Counterclockwise)

Preceding gene: 158316436

Following gene: 158316434

Centisome position: 62.1

GC content: 75.5

Gene sequence:

>1257_bases
ATGAGGCCCCTGGCGACACTGCGTTCCGTCATGCGGTTCGGCCCGGTCGAGACCAACCGGACCGAGCGGCGGCTGGCCCG
GGCGGCCTCGGTGCACGATCTGCGGCGGCTGGCCCGCCGGCGGCTGCCCGGTGGGGTCTTCGACTACATCGACGGCGCCG
CGGAGGACGAACGCACCCTCGCCGCGAACGAGCGGGCCTACGCCGCCACGACCTTCCGCCCGCGGGTGCTGCGCGGCCTG
CCCGAGGTCTCGGTCGGCACGGAGATCCTCGGTGCGCCGGCGGCGTACCCGCTCGTGCTCGCGCCCACCGGATTCACCCG
CATCGCCGATCCCCAGGGGGAGCTGGCCGTGGCCCGCGCCGCCGCCCGCGCCGGCCTGCCCTACACGCTGTCGACGTTGA
GCACCCGTTCGATCGAGGAGGTCCGCGCGGTCAGCGACGGGCGGCTGTGGTTCCAGGTCTACGCGTGGCGTGACCGCGGC
CTGGTCAAGGAGATGATCGACCGGGCCGCCGCGGCCCGGTACGAGGCGATCGTGCTCACCGTCGACACCGCCGTCTTCGG
CCGCCGCGAGCGCGACGTCCGCCGCGGCTTCTCCCTGCCGCCCACGATCGGTCCGGGCACGATCCTCGACGGCCTGCTGC
ATCCCGGCTGGACCTGGCAGTTCGTCCGCAGCGAACCGATCCGGTTCAGCAACGTCGCGGGCCGCGACGTGGGCGACGGC
GCGTCACCGGTGACGCTGTCCGACTACATCAACACGCAGTTCGACCCCGGCCTGTCCTGGGCGGACCTGACCTGGCTGCG
CTCGGTCTGGGCCGGCCGCGTGGTCGTCAAGGGCATCCAGACCGTCGCGGACGCGAAGCTCGCCGCCGAGGCCGGCGTCG
ACGCGATCGTGCTGTCGAACCACGGCGGCCGGCAGCTGGACGGGGCGCCGGCCACGCTGCCGCTCGTGGCCCCGGTCGCC
GACGCGGTCGGCGGTCGCACCGAGATCATCTGCGACGGCGGCGTCCGGCGCGGCAGCGACATCGTCAAGGCGGTCGCGGC
CGGCGCGACGGCCGCCATGGCCGGCCGCGCCTACCTCTACGCGCTCGGAGCCGCCGGGGAACGCGGGGTCGACCGGCTGC
TCGCCTGGTTCGCCGCCGACATCCACCGCACCCTGGCCCTCCTGGGCGCGGCCGGCGTCGCGGACCTCGGCCGCGACCAC
CTCGACCTTCCCGCCGAGCCGGTCGGCCCGGCCGCACCGCCCCACCCACCCGCCTGA

Upstream 100 bases:

>100_bases
TCCTCGTCCAGGCTCGGGCCCACGGCGCCGCGCCGGCCACCCTGGAAGACCTGCGCGCGCAGCTCGCGCGTGCATCGACC
CTCCGGAGGTACGAGCCGTC

Downstream 100 bases:

>100_bases
CCGCCTGACCGCGCCCGGCCCACCGCCGGTCGCGCTGTCGCCGCCCGAGATCGAGGTCCCATGCCCCCTCGCTGGAACGC
CGCGTTCATCGCCGCCCCGT

Product: L-lactate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRPLATLRSVMRFGPVETNRTERRLARAASVHDLRRLARRRLPGGVFDYIDGAAEDERTLAANERAYAATTFRPRVLRGL
PEVSVGTEILGAPAAYPLVLAPTGFTRIADPQGELAVARAAARAGLPYTLSTLSTRSIEEVRAVSDGRLWFQVYAWRDRG
LVKEMIDRAAAARYEAIVLTVDTAVFGRRERDVRRGFSLPPTIGPGTILDGLLHPGWTWQFVRSEPIRFSNVAGRDVGDG
ASPVTLSDYINTQFDPGLSWADLTWLRSVWAGRVVVKGIQTVADAKLAAEAGVDAIVLSNHGGRQLDGAPATLPLVAPVA
DAVGGRTEIICDGGVRRGSDIVKAVAAGATAAMAGRAYLYALGAAGERGVDRLLAWFAADIHRTLALLGAAGVADLGRDH
LDLPAEPVGPAAPPHPPA

Sequences:

>Translated_418_residues
MRPLATLRSVMRFGPVETNRTERRLARAASVHDLRRLARRRLPGGVFDYIDGAAEDERTLAANERAYAATTFRPRVLRGL
PEVSVGTEILGAPAAYPLVLAPTGFTRIADPQGELAVARAAARAGLPYTLSTLSTRSIEEVRAVSDGRLWFQVYAWRDRG
LVKEMIDRAAAARYEAIVLTVDTAVFGRRERDVRRGFSLPPTIGPGTILDGLLHPGWTWQFVRSEPIRFSNVAGRDVGDG
ASPVTLSDYINTQFDPGLSWADLTWLRSVWAGRVVVKGIQTVADAKLAAEAGVDAIVLSNHGGRQLDGAPATLPLVAPVA
DAVGGRTEIICDGGVRRGSDIVKAVAAGATAAMAGRAYLYALGAAGERGVDRLLAWFAADIHRTLALLGAAGVADLGRDH
LDLPAEPVGPAAPPHPPA
>Mature_418_residues
MRPLATLRSVMRFGPVETNRTERRLARAASVHDLRRLARRRLPGGVFDYIDGAAEDERTLAANERAYAATTFRPRVLRGL
PEVSVGTEILGAPAAYPLVLAPTGFTRIADPQGELAVARAAARAGLPYTLSTLSTRSIEEVRAVSDGRLWFQVYAWRDRG
LVKEMIDRAAAARYEAIVLTVDTAVFGRRERDVRRGFSLPPTIGPGTILDGLLHPGWTWQFVRSEPIRFSNVAGRDVGDG
ASPVTLSDYINTQFDPGLSWADLTWLRSVWAGRVVVKGIQTVADAKLAAEAGVDAIVLSNHGGRQLDGAPATLPLVAPVA
DAVGGRTEIICDGGVRRGSDIVKAVAAGATAAMAGRAYLYALGAAGERGVDRLLAWFAADIHRTLALLGAAGVADLGRDH
LDLPAEPVGPAAPPHPPA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=370, Percent_Identity=35.4054054054054, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=34.9462365591398, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=34.9462365591398, Blast_Score=215, Evalue=7e-56,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=37.4005305039788, Blast_Score=247, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI193208036, Length=374, Percent_Identity=35.0267379679144, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=292, Percent_Identity=34.2465753424658, Blast_Score=171, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6323587, Length=390, Percent_Identity=31.7948717948718, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI78707188, Length=369, Percent_Identity=34.9593495934959, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=34.9593495934959, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=34.9593495934959, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 44518; Mature: 44518

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLATLRSVMRFGPVETNRTERRLARAASVHDLRRLARRRLPGGVFDYIDGAAEDERTL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHH
AANERAYAATTFRPRVLRGLPEVSVGTEILGAPAAYPLVLAPTGFTRIADPQGELAVARA
HCCCCEEEEECCCHHHHHCCCCCCCCHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
AARAGLPYTLSTLSTRSIEEVRAVSDGRLWFQVYAWRDRGLVKEMIDRAAAARYEAIVLT
HHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHEEEEEEE
VDTAVFGRRERDVRRGFSLPPTIGPGTILDGLLHPGWTWQFVRSEPIRFSNVAGRDVGDG
ECHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEECCCCCCCCCCC
ASPVTLSDYINTQFDPGLSWADLTWLRSVWAGRVVVKGIQTVADAKLAAEAGVDAIVLSN
CCCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGGRQLDGAPATLPLVAPVADAVGGRTEIICDGGVRRGSDIVKAVAAGATAAMAGRAYLY
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCHHHHHHCCEEEE
ALGAAGERGVDRLLAWFAADIHRTLALLGAAGVADLGRDHLDLPAEPVGPAAPPHPPA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPLATLRSVMRFGPVETNRTERRLARAASVHDLRRLARRRLPGGVFDYIDGAAEDERTL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHH
AANERAYAATTFRPRVLRGLPEVSVGTEILGAPAAYPLVLAPTGFTRIADPQGELAVARA
HCCCCEEEEECCCHHHHHCCCCCCCCHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
AARAGLPYTLSTLSTRSIEEVRAVSDGRLWFQVYAWRDRGLVKEMIDRAAAARYEAIVLT
HHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHEEEEEEE
VDTAVFGRRERDVRRGFSLPPTIGPGTILDGLLHPGWTWQFVRSEPIRFSNVAGRDVGDG
ECHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEECCCCCCCCCCC
ASPVTLSDYINTQFDPGLSWADLTWLRSVWAGRVVVKGIQTVADAKLAAEAGVDAIVLSN
CCCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGGRQLDGAPATLPLVAPVADAVGGRTEIICDGGVRRGSDIVKAVAAGATAAMAGRAYLY
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCHHHHHHCCEEEE
ALGAAGERGVDRLLAWFAADIHRTLALLGAAGVADLGRDHLDLPAEPVGPAAPPHPPA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]