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The map label for this gene is accC [H]

Identifier: 158315737

GI number: 158315737

Start: 4721200

End: 4722546

Strand: Reverse

Name: accC [H]

Synonym: Franean1_3949

Alternate gene names: 158315737

Gene position: 4722546-4721200 (Counterclockwise)

Preceding gene: 158315738

Following gene: 158315736

Centisome position: 52.58

GC content: 72.98

Gene sequence:

>1347_bases
GTGATCAAGAAGGTCCTGATCGCGAACCGCGGGGAGATCGCGCTGCGGGTCGCGCGCACCTGCCGCGAGCTGGGCATCGC
CACCGTGGCCGCCCACTCGTCGGCGGACCGGGACTCCGCCGTCGTCTCCTTCGCCGACGAGTCCGTCCAGATCGGCCCGG
GGCCGTCCCGGGACAGCTACCTCAACATCCCGGCGGTCGTCGAGGCCGCCCGTATCCGCGGCGCCGACGCCGTCCACCCC
GGGTACGGGTTCCTCTCCGAGAATCCCGACTTCGCCGAGATCTGCGCGGCCGAGGGCCTGACGTTCATCGGCCCGCCGGC
CGAGGTGATGGCCCGCCTCGGTGACAAGGCTGTCGCCCGTCGGATCATGTCCGAGGCCGGGCTGCCCCTGCTGCCCGGCA
GCCGGGACACTCCCGACCACCCCGAACAGGCCGCGCAGGTGGCGGCCGAGATCGGCTACCCGGTCATCATCAAGGCGGCG
GCCGGCGGCGGCGGGCGCGGGATGAGCGTCGTGCACGATCCGGACGGCTTCGAGCGCGCCTACCGGCACACCCGCTCCAC
CGCCCAGGCGGTGTTCGGGGACGGCCGCCTGTACGTCGAGCGTTACCTGGCCTCGGCACGGCACGTCGAGGTCCAGGTGC
TCGCCGATGCGCACGGCGCGGCCGTCCACCTGGGCGCCCGGGACTGCTCGCTGCAGCGCCGGCACCAGAAGCTGGTCGAG
GAGACTCCGGCGCCGGCCCTGCCAGCCGAGATCGTCGAGCCGCTGTGTGCGGCCGCCGTCCGCGGCACCCTGGCCAGCGG
GTATGTCGGCGCGGGCACCTTCGAGTTCCTCGTCGACGGCGAGGGCCGGTTCTACTTCATGGAGGTCAACTGCCGGCTGC
AGGTGGAGCACCCGGTCACCGAGATGGTCACCGGGCTCGACCTGGTCGCCGAGCAGATCCGGATCGCCGCGGGCGAGCCG
CTGGGCTACGGCCAGGACGACGTCGACCCGCGCGGGGTGTCGATCGAGTGCCGGATCAACGCCGAGGACCCGCGTCGTGA
CTTCGCCCCCGCGCCGGGTTCGCTCACCGAGTTCACCGTCCCGGCCGGCCCGTTCGTCCGCGTCGACACGCACGCCGCCC
CCGGGTACCGCATCCCGGCCTACTACGACTCACTGGTCGCGAAAGTGGTTGTCTGGGCCCCGGACCGCCCCCGGGCCCTG
GCCCGGATGCGCCGCGCCCTCGACGAGCTGCACGCCGACGGGCCCGGCGTCGTCACCACCGCCGGCTTCCTGCGCGAACT
GCTCGACCACCCCCGGTTCATCGCCGCCGAACACGACACCGTCCTGATCGAGTCCATGACCCACTAA

Upstream 100 bases:

>100_bases
GTGGGCGGGTCCGGGAGATCCTGGTCGCCGACACCACCCCGGTGGAGTACGGCGAACCGCTGCTCACCCTTGACGTCGCC
ACGTCCACCGGCGGGGCCTC

Downstream 100 bases:

>100_bases
GCCTTTGCCGACCTGGCTGACCGCGGGTGGGGGCGAGGCAGGGGCTGGGTGCGGAACGAGGTGAAGCTCCTGGTAGATCG
GTTGTCGACCAAGAGCAACC

Product: carbamoyl-phosphate synthase L chain ATP-binding

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MIKKVLIANRGEIALRVARTCRELGIATVAAHSSADRDSAVVSFADESVQIGPGPSRDSYLNIPAVVEAARIRGADAVHP
GYGFLSENPDFAEICAAEGLTFIGPPAEVMARLGDKAVARRIMSEAGLPLLPGSRDTPDHPEQAAQVAAEIGYPVIIKAA
AGGGGRGMSVVHDPDGFERAYRHTRSTAQAVFGDGRLYVERYLASARHVEVQVLADAHGAAVHLGARDCSLQRRHQKLVE
ETPAPALPAEIVEPLCAAAVRGTLASGYVGAGTFEFLVDGEGRFYFMEVNCRLQVEHPVTEMVTGLDLVAEQIRIAAGEP
LGYGQDDVDPRGVSIECRINAEDPRRDFAPAPGSLTEFTVPAGPFVRVDTHAAPGYRIPAYYDSLVAKVVVWAPDRPRAL
ARMRRALDELHADGPGVVTTAGFLRELLDHPRFIAAEHDTVLIESMTH

Sequences:

>Translated_448_residues
MIKKVLIANRGEIALRVARTCRELGIATVAAHSSADRDSAVVSFADESVQIGPGPSRDSYLNIPAVVEAARIRGADAVHP
GYGFLSENPDFAEICAAEGLTFIGPPAEVMARLGDKAVARRIMSEAGLPLLPGSRDTPDHPEQAAQVAAEIGYPVIIKAA
AGGGGRGMSVVHDPDGFERAYRHTRSTAQAVFGDGRLYVERYLASARHVEVQVLADAHGAAVHLGARDCSLQRRHQKLVE
ETPAPALPAEIVEPLCAAAVRGTLASGYVGAGTFEFLVDGEGRFYFMEVNCRLQVEHPVTEMVTGLDLVAEQIRIAAGEP
LGYGQDDVDPRGVSIECRINAEDPRRDFAPAPGSLTEFTVPAGPFVRVDTHAAPGYRIPAYYDSLVAKVVVWAPDRPRAL
ARMRRALDELHADGPGVVTTAGFLRELLDHPRFIAAEHDTVLIESMTH
>Mature_448_residues
MIKKVLIANRGEIALRVARTCRELGIATVAAHSSADRDSAVVSFADESVQIGPGPSRDSYLNIPAVVEAARIRGADAVHP
GYGFLSENPDFAEICAAEGLTFIGPPAEVMARLGDKAVARRIMSEAGLPLLPGSRDTPDHPEQAAQVAAEIGYPVIIKAA
AGGGGRGMSVVHDPDGFERAYRHTRSTAQAVFGDGRLYVERYLASARHVEVQVLADAHGAAVHLGARDCSLQRRHQKLVE
ETPAPALPAEIVEPLCAAAVRGTLASGYVGAGTFEFLVDGEGRFYFMEVNCRLQVEHPVTEMVTGLDLVAEQIRIAAGEP
LGYGQDDVDPRGVSIECRINAEDPRRDFAPAPGSLTEFTVPAGPFVRVDTHAAPGYRIPAYYDSLVAKVVVWAPDRPRAL
ARMRRALDELHADGPGVVTTAGFLRELLDHPRFIAAEHDTVLIESMTH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=46.7268623024831, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=46.1538461538462, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=46.1538461538462, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=46.1538461538462, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=45.3125, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=45.3125, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=45.3125, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI38679960, Length=499, Percent_Identity=33.6673346693387, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679974, Length=499, Percent_Identity=33.6673346693387, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679971, Length=499, Percent_Identity=33.6673346693387, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679977, Length=499, Percent_Identity=33.6673346693387, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI38679967, Length=499, Percent_Identity=33.6673346693387, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=32.8063241106719, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1789654, Length=416, Percent_Identity=53.8461538461538, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=46.27539503386, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=46.2053571428571, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17567343, Length=432, Percent_Identity=43.0555555555556, Blast_Score=341, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI133931226, Length=483, Percent_Identity=27.1221532091097, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=28.4584980237154, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=502, Percent_Identity=28.8844621513944, Blast_Score=181, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=449, Percent_Identity=42.5389755011136, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=44.097995545657, Blast_Score=335, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=44.3207126948775, Blast_Score=321, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6323863, Length=444, Percent_Identity=34.4594594594595, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6324343, Length=500, Percent_Identity=32.2, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.9662921348315, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=47.5446428571429, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=45.9259259259259, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=33.8, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=33.8, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=33.8, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=33.8, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 47994; Mature: 47994

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLIANRGEIALRVARTCRELGIATVAAHSSADRDSAVVSFADESVQIGPGPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCEEECCCCCCCCE
LNIPAVVEAARIRGADAVHPGYGFLSENPDFAEICAAEGLTFIGPPAEVMARLGDKAVAR
ECCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCHHHHHHHHCHHHHHH
RIMSEAGLPLLPGSRDTPDHPEQAAQVAAEIGYPVIIKAAAGGGGRGMSVVHDPDGFERA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHH
YRHTRSTAQAVFGDGRLYVERYLASARHVEVQVLADAHGAAVHLGARDCSLQRRHQKLVE
HHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
ETPAPALPAEIVEPLCAAAVRGTLASGYVGAGTFEFLVDGEGRFYFMEVNCRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEEEEEECCCHH
EMVTGLDLVAEQIRIAAGEPLGYGQDDVDPRGVSIECRINAEDPRRDFAPAPGSLTEFTV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEC
PAGPFVRVDTHAAPGYRIPAYYDSLVAKVVVWAPDRPRALARMRRALDELHADGPGVVTT
CCCCEEEEECCCCCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHH
AGFLRELLDHPRFIAAEHDTVLIESMTH
HHHHHHHHCCCCEEEECCCEEEEEECCC
>Mature Secondary Structure
MIKKVLIANRGEIALRVARTCRELGIATVAAHSSADRDSAVVSFADESVQIGPGPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCEEECCCCCCCCE
LNIPAVVEAARIRGADAVHPGYGFLSENPDFAEICAAEGLTFIGPPAEVMARLGDKAVAR
ECCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCHHHHHHHHCHHHHHH
RIMSEAGLPLLPGSRDTPDHPEQAAQVAAEIGYPVIIKAAAGGGGRGMSVVHDPDGFERA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHH
YRHTRSTAQAVFGDGRLYVERYLASARHVEVQVLADAHGAAVHLGARDCSLQRRHQKLVE
HHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
ETPAPALPAEIVEPLCAAAVRGTLASGYVGAGTFEFLVDGEGRFYFMEVNCRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEEEEEECCCHH
EMVTGLDLVAEQIRIAAGEPLGYGQDDVDPRGVSIECRINAEDPRRDFAPAPGSLTEFTV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEC
PAGPFVRVDTHAAPGYRIPAYYDSLVAKVVVWAPDRPRALARMRRALDELHADGPGVVTT
CCCCEEEEECCCCCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHH
AGFLRELLDHPRFIAAEHDTVLIESMTH
HHHHHHHHCCCCEEEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]