Click here to switch to the map view.

The map label for this gene is ilvB [H]

Identifier: 158315510

GI number: 158315510

Start: 4397016

End: 4398722

Strand: Reverse

Name: ilvB [H]

Synonym: Franean1_3715

Alternate gene names: 158315510

Gene position: 4398722-4397016 (Counterclockwise)

Preceding gene: 158315515

Following gene: 158315509

Centisome position: 48.97

GC content: 68.66

Gene sequence:

>1707_bases
ATGCCGGTAAAAGTCTACGAGCGCATCCTCCAGTTGTTCGAAGCCGAGGGCATCAAGACGATCTTCGGTATTCCCGACCC
GAACTTCGTGCACATGTTCCACCTCGCCGAGGAACGCGGCTGGACCGTGGTCTCACCGCACCATGAGGAGTCCGCCGGGT
TCATGGCGGAGGCGGTGTCCCGGATGACCGGCAAGGCCGCGGTGGCGATCGGCACCCTGGGCCCGGGTGTCGCGAACCTG
GCCGGGGCGATGATGTGCGCCAAGGTCGAGAACTCGCCGGTCATCTTCCTCGGCGGGCAGCGTGCCCGGATCACCGAGCA
GCGGGTGCGGCGCGGCCGGATCCAGTTCGTGCGGCAGGCGGGCCTGTTCGAGCCGTCGGTGAAGTACTGCGCCAGCATCG
AGTACGCCGACCAGACCGACGAGGTCATCCGCGAGGGCCTGCGCAAGGCCCTGTCCGGCACCCCGGGCCCGGTCTACATC
GAGTACCCCTCCCACATCATCCAGGAGGAGCTCGACGTTCCCCCGCCGCTGCCGCCGGCGGCGTACCGGCTGGTGAACCA
GACCGCCGGCCCCGACAGGATCGCCGAAGCCGTGCAGTACATCCGCGCGGCCAAGCAGCCGGTCCTGCTCGTCGGGCACG
GTGTGCACACCTCCCGCGCGGGAGAGTCCGTCCGCGCCCTCGCGGAGGCGATGGCCTGCCCGGTCATCCAGACCTCCGGC
GGCACCTCCTTCATCAAGGGCCTGGAGGACCGCACCTTCCCCTACGGCTTCTCCGCGGCGGCCGTGGAGGCCGTCGTGGA
GTCAGATCTCTGTCTCGCCATCGGCACCGAAATCGGGGAGCCGGTCCACTACGGCCGCGGCCGGCACTGGGTCGCGAACG
AGGCCAACCGCAAGTGGATCCTCATCGAGCAGGACCCCGAGGCCATCGGGGTGAACCGGTCGATCGACGTGCCCCTCGTC
GGTGACCTGCGCGCGGTCGTCCCGCAGCTCGTCGACGCCCTCAAGGACACCCCGCGCACGCCGACCCCCCGGCTTGAGGC
CTGGGTGACGCAGGAGGCAGCCCGGTTGGCGGAACTGGCGGAGACGGCCCTATCCGGCATGTCACCCGTGCACCCTGCAC
GGCTCATCGTCGAGGCCACCAAGGCCTTTCCCGCCGACGGCATCATGGTGCGCGACGGCGGCGCGATCACCATTTTCGGC
TGGACGTACTCGCAGGCCAAGCCGCACGACGTGATCTGGAACCAGAACTTCGGCCACCTCGGGACCGGGCTCCCCTACGC
CGTCGGCGCCTCGGTGGCGGATGGCGGGAAACGGCCCGTCATGCTCATCACCGGGGACTCGTCCTTCCAGTTCCACATCG
CCGAGCTGGAGACCGCCGCCCGACTGAACCTCCCGCTGGTCTGCGTGGTCAGCGTGGACTACGCCTGGGGCCTCGAGGTC
GGCGTCTACAAGCGCACTTTCGGCCAGGGCTCGCTGGAGACCGGCGTCCACTGGAGTGAAGACGTCCGGCTCAACAAGGT
CGCCGAGGGCTTCGGCTGTTACGGCGAGTACGTCGAGCGCGACGAGGACATCGCCCCCGCCATCAAGCGCGCCTACGCCA
GCGGAAAGACCGCCGTCATCCACGTCGCCGTCGACCCGAAGGCCAACTCGGAGGAAATGCCGAACTACGACGAGTTCCGG
ACCTGGTACGCAGAGGGAATGCAGTAG

Upstream 100 bases:

>100_bases
GACGAGCGCGGTGGGCGTCCAGGCCGTCCCGCCCGCATCGCGAACCAGGCAGGTTGACGGCATCCGTGGCGGATTCGCGA
TTATTGCCGAAAGGACGAAT

Downstream 100 bases:

>100_bases
GGAATGCAATGGCTCCCGGGAGCACGGCGACCGGGAGCAAGCGAGAGGAGGCGGGAAGGATGACCGCGATCACTACGAGA
AAACTGAACGATTATGTCGG

Product: thiamine pyrophosphate binding domain-containing protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MPVKVYERILQLFEAEGIKTIFGIPDPNFVHMFHLAEERGWTVVSPHHEESAGFMAEAVSRMTGKAAVAIGTLGPGVANL
AGAMMCAKVENSPVIFLGGQRARITEQRVRRGRIQFVRQAGLFEPSVKYCASIEYADQTDEVIREGLRKALSGTPGPVYI
EYPSHIIQEELDVPPPLPPAAYRLVNQTAGPDRIAEAVQYIRAAKQPVLLVGHGVHTSRAGESVRALAEAMACPVIQTSG
GTSFIKGLEDRTFPYGFSAAAVEAVVESDLCLAIGTEIGEPVHYGRGRHWVANEANRKWILIEQDPEAIGVNRSIDVPLV
GDLRAVVPQLVDALKDTPRTPTPRLEAWVTQEAARLAELAETALSGMSPVHPARLIVEATKAFPADGIMVRDGGAITIFG
WTYSQAKPHDVIWNQNFGHLGTGLPYAVGASVADGGKRPVMLITGDSSFQFHIAELETAARLNLPLVCVVSVDYAWGLEV
GVYKRTFGQGSLETGVHWSEDVRLNKVAEGFGCYGEYVERDEDIAPAIKRAYASGKTAVIHVAVDPKANSEEMPNYDEFR
TWYAEGMQ

Sequences:

>Translated_568_residues
MPVKVYERILQLFEAEGIKTIFGIPDPNFVHMFHLAEERGWTVVSPHHEESAGFMAEAVSRMTGKAAVAIGTLGPGVANL
AGAMMCAKVENSPVIFLGGQRARITEQRVRRGRIQFVRQAGLFEPSVKYCASIEYADQTDEVIREGLRKALSGTPGPVYI
EYPSHIIQEELDVPPPLPPAAYRLVNQTAGPDRIAEAVQYIRAAKQPVLLVGHGVHTSRAGESVRALAEAMACPVIQTSG
GTSFIKGLEDRTFPYGFSAAAVEAVVESDLCLAIGTEIGEPVHYGRGRHWVANEANRKWILIEQDPEAIGVNRSIDVPLV
GDLRAVVPQLVDALKDTPRTPTPRLEAWVTQEAARLAELAETALSGMSPVHPARLIVEATKAFPADGIMVRDGGAITIFG
WTYSQAKPHDVIWNQNFGHLGTGLPYAVGASVADGGKRPVMLITGDSSFQFHIAELETAARLNLPLVCVVSVDYAWGLEV
GVYKRTFGQGSLETGVHWSEDVRLNKVAEGFGCYGEYVERDEDIAPAIKRAYASGKTAVIHVAVDPKANSEEMPNYDEFR
TWYAEGMQ
>Mature_567_residues
PVKVYERILQLFEAEGIKTIFGIPDPNFVHMFHLAEERGWTVVSPHHEESAGFMAEAVSRMTGKAAVAIGTLGPGVANLA
GAMMCAKVENSPVIFLGGQRARITEQRVRRGRIQFVRQAGLFEPSVKYCASIEYADQTDEVIREGLRKALSGTPGPVYIE
YPSHIIQEELDVPPPLPPAAYRLVNQTAGPDRIAEAVQYIRAAKQPVLLVGHGVHTSRAGESVRALAEAMACPVIQTSGG
TSFIKGLEDRTFPYGFSAAAVEAVVESDLCLAIGTEIGEPVHYGRGRHWVANEANRKWILIEQDPEAIGVNRSIDVPLVG
DLRAVVPQLVDALKDTPRTPTPRLEAWVTQEAARLAELAETALSGMSPVHPARLIVEATKAFPADGIMVRDGGAITIFGW
TYSQAKPHDVIWNQNFGHLGTGLPYAVGASVADGGKRPVMLITGDSSFQFHIAELETAARLNLPLVCVVSVDYAWGLEVG
VYKRTFGQGSLETGVHWSEDVRLNKVAEGFGCYGEYVERDEDIAPAIKRAYASGKTAVIHVAVDPKANSEEMPNYDEFRT
WYAEGMQ

Specific function: Catalyzes The Condensation Of Two Molecules Of Glyoxylate To Give 2-Hydroxy-3-Oxopropanoate (Also Termed Tartronate Semialdehyde). [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=566, Percent_Identity=24.2049469964664, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI21361361, Length=564, Percent_Identity=25.354609929078, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1786717, Length=552, Percent_Identity=28.9855072463768, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081685, Length=472, Percent_Identity=25.4237288135593, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790104, Length=550, Percent_Identity=24.9090909090909, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788716, Length=553, Percent_Identity=24.7739602169982, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787096, Length=561, Percent_Identity=21.2121212121212, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17542570, Length=564, Percent_Identity=26.5957446808511, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17531299, Length=582, Percent_Identity=25.085910652921, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17531301, Length=582, Percent_Identity=25.085910652921, Blast_Score=128, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320816, Length=575, Percent_Identity=23.6521739130435, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323755, Length=571, Percent_Identity=24.3432574430823, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922626, Length=573, Percent_Identity=24.956369982548, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61763; Mature: 61632

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVYERILQLFEAEGIKTIFGIPDPNFVHMFHLAEERGWTVVSPHHEESAGFMAEAVS
CCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEHHHCCCEEECCCCCCHHHHHHHHHH
RMTGKAAVAIGTLGPGVANLAGAMMCAKVENSPVIFLGGQRARITEQRVRRGRIQFVRQA
HHCCCEEEEEECCCCCHHHHHHHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
GLFEPSVKYCASIEYADQTDEVIREGLRKALSGTPGPVYIEYPSHIIQEELDVPPPLPPA
CCCCCCHHHHEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCHH
AYRLVNQTAGPDRIAEAVQYIRAAKQPVLLVGHGVHTSRAGESVRALAEAMACPVIQTSG
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEECC
GTSFIKGLEDRTFPYGFSAAAVEAVVESDLCLAIGTEIGEPVHYGRGRHWVANEANRKWI
CHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEECCCCCCEEE
LIEQDPEAIGVNRSIDVPLVGDLRAVVPQLVDALKDTPRTPTPRLEAWVTQEAARLAELA
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ETALSGMSPVHPARLIVEATKAFPADGIMVRDGGAITIFGWTYSQAKPHDVIWNQNFGHL
HHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCEEECCCCCCC
GTGLPYAVGASVADGGKRPVMLITGDSSFQFHIAELETAARLNLPLVCVVSVDYAWGLEV
CCCCCHHHCCCCCCCCCCCEEEEECCCCCEEEEEEHHHHHHCCCCEEEEEEECCCCCCEE
GVYKRTFGQGSLETGVHWSEDVRLNKVAEGFGCYGEYVERDEDIAPAIKRAYASGKTAVI
EHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHCCCCEEEE
HVAVDPKANSEEMPNYDEFRTWYAEGMQ
EEEECCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
PVKVYERILQLFEAEGIKTIFGIPDPNFVHMFHLAEERGWTVVSPHHEESAGFMAEAVS
CHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEHHHCCCEEECCCCCCHHHHHHHHHH
RMTGKAAVAIGTLGPGVANLAGAMMCAKVENSPVIFLGGQRARITEQRVRRGRIQFVRQA
HHCCCEEEEEECCCCCHHHHHHHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
GLFEPSVKYCASIEYADQTDEVIREGLRKALSGTPGPVYIEYPSHIIQEELDVPPPLPPA
CCCCCCHHHHEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCHH
AYRLVNQTAGPDRIAEAVQYIRAAKQPVLLVGHGVHTSRAGESVRALAEAMACPVIQTSG
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEECC
GTSFIKGLEDRTFPYGFSAAAVEAVVESDLCLAIGTEIGEPVHYGRGRHWVANEANRKWI
CHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEECCCCCCEEE
LIEQDPEAIGVNRSIDVPLVGDLRAVVPQLVDALKDTPRTPTPRLEAWVTQEAARLAELA
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ETALSGMSPVHPARLIVEATKAFPADGIMVRDGGAITIFGWTYSQAKPHDVIWNQNFGHL
HHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCEEECCCCCCC
GTGLPYAVGASVADGGKRPVMLITGDSSFQFHIAELETAARLNLPLVCVVSVDYAWGLEV
CCCCCHHHCCCCCCCCCCCEEEEECCCCCEEEEEEHHHHHHCCCCEEEEEEECCCCCCEE
GVYKRTFGQGSLETGVHWSEDVRLNKVAEGFGCYGEYVERDEDIAPAIKRAYASGKTAVI
EHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHCCCCEEEE
HVAVDPKANSEEMPNYDEFRTWYAEGMQ
EEEECCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]