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The map label for this gene is fadA [H]

Identifier: 158314761

GI number: 158314761

Start: 3462238

End: 3463449

Strand: Direct

Name: fadA [H]

Synonym: Franean1_2943

Alternate gene names: 158314761

Gene position: 3462238-3463449 (Clockwise)

Preceding gene: 158314760

Following gene: 158314762

Centisome position: 38.55

GC content: 68.4

Gene sequence:

>1212_bases
GTGAGCGCTGAAGCCTTCGTCTACGATGCCGTTCGCACGCCCCGTGGGCGTGGCCGGAAGGGATCACTGCACGGGACCAA
GCCGATCGACCTGGTGGTCAGCCTCGTGGACGCCCTACGCAAGCGCAACCCCACCCTTGACCCCGAGCGGATCGACGACC
TCGTCCTGGGGGTCGTCACCCCCATCGGCGACCAGGGATCGGACATCGCACGTACCGCCGTGCTGGCCTCGGGCCTGCCC
GACACGGTCGGAGGCGTACAGCTGAACCGGTTCTGTTCCTCGGGTCTGGAGGCAGTCAACACCGCCGCGCAGAAGGTGCG
CTCGGGATGGGAATGCCTGGTGGTCGCCGGTGGAGTCGAGTCCATGTCCCGGGTCCCGATGGCATCGGACGGCGGTGCGT
GGGCCCTGGACCCGTGGACGAATCTCACGACGTCGTTCGTGCCGCAGGGCGTCAGCGCCGACCTCATCGCGACGATCGAG
GGGTTTGACCGGGAGGCGGTCGACTCCTATGCCGTCCGTTCTCAGGGGCTCGCGGCCAAGGCGTGGGCCGGGGGCTACTT
CGAGCGATCTGTGGTCCCGGTCGTGGATCGCAACGGGCTGACCGTCCTCGACCGCGACGAGCACATGCGGCCCGAGACGA
CCCTCGAGAGCCTCGCCGCGCTCAACCCGTCCTTCGCAGCGGTAGGCGAGCAGGGCGGCTTCGACGCGGTGGCGCTGCAG
AAGTACCACTGGGTCGAGCGCATCGAACACGTCCACCACGCCGGCAACTCCTCCGGCGTAGTCGACGGCGCCGCCCTGGT
GGTCGTGGGGAACGAGGAGATCGGACGCGACCTGGGACTGACACCGCGAGCTCGCATCGTGGCCACGGCGACCAGCGGCG
CGGACTCGACGATCATGCTGACCGGCCCGACACCCGCGACCCTCAAGGTGCTGACAAAGGCGGGGCTGACACCCGACGAC
ATCGACCTGTTCGAGATCAACGAGGCGTTCGCGTCGGTCGTCCTGAAGTACCAGAAGGACCTGCGAATTCCGGACGAGAA
GCTCAACGTCAACGGCGGCGCGATCGCGATGGGTCATCCGCTCGGGGCCACCGGTGCCATGATCCTCGGCACCGTGGTCG
ACGAGCTCGAACGCCGTGAGGCCCGACGGGGTCTGGTCACCTTGTGCGTCGGCGGTGGGATGGGCGTGGCCACCGTGGTC
GAGCGCGTCTGA

Upstream 100 bases:

>100_bases
TCGTGTCCAGCGGATCTACGCCGGAGCGAACGAAGTCATGAAGGAACTCATTAGCCGCTCGCTGTGAGTGGCCAGGCCGG
TAATGGAAGGAACCCCGCAC

Downstream 100 bases:

>100_bases
CTCTCCCTCCTACCCGAACCCTCTGACAGAGAGAAACAAGAATTCCATGAGCGACGCGAGCACCGGCCAGTCAATGATTC
GTTGGGAGCAGCGCCCGAAC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSAEAFVYDAVRTPRGRGRKGSLHGTKPIDLVVSLVDALRKRNPTLDPERIDDLVLGVVTPIGDQGSDIARTAVLASGLP
DTVGGVQLNRFCSSGLEAVNTAAQKVRSGWECLVVAGGVESMSRVPMASDGGAWALDPWTNLTTSFVPQGVSADLIATIE
GFDREAVDSYAVRSQGLAAKAWAGGYFERSVVPVVDRNGLTVLDRDEHMRPETTLESLAALNPSFAAVGEQGGFDAVALQ
KYHWVERIEHVHHAGNSSGVVDGAALVVVGNEEIGRDLGLTPRARIVATATSGADSTIMLTGPTPATLKVLTKAGLTPDD
IDLFEINEAFASVVLKYQKDLRIPDEKLNVNGGAIAMGHPLGATGAMILGTVVDELERREARRGLVTLCVGGGMGVATVV
ERV

Sequences:

>Translated_403_residues
MSAEAFVYDAVRTPRGRGRKGSLHGTKPIDLVVSLVDALRKRNPTLDPERIDDLVLGVVTPIGDQGSDIARTAVLASGLP
DTVGGVQLNRFCSSGLEAVNTAAQKVRSGWECLVVAGGVESMSRVPMASDGGAWALDPWTNLTTSFVPQGVSADLIATIE
GFDREAVDSYAVRSQGLAAKAWAGGYFERSVVPVVDRNGLTVLDRDEHMRPETTLESLAALNPSFAAVGEQGGFDAVALQ
KYHWVERIEHVHHAGNSSGVVDGAALVVVGNEEIGRDLGLTPRARIVATATSGADSTIMLTGPTPATLKVLTKAGLTPDD
IDLFEINEAFASVVLKYQKDLRIPDEKLNVNGGAIAMGHPLGATGAMILGTVVDELERREARRGLVTLCVGGGMGVATVV
ERV
>Mature_402_residues
SAEAFVYDAVRTPRGRGRKGSLHGTKPIDLVVSLVDALRKRNPTLDPERIDDLVLGVVTPIGDQGSDIARTAVLASGLPD
TVGGVQLNRFCSSGLEAVNTAAQKVRSGWECLVVAGGVESMSRVPMASDGGAWALDPWTNLTTSFVPQGVSADLIATIEG
FDREAVDSYAVRSQGLAAKAWAGGYFERSVVPVVDRNGLTVLDRDEHMRPETTLESLAALNPSFAAVGEQGGFDAVALQK
YHWVERIEHVHHAGNSSGVVDGAALVVVGNEEIGRDLGLTPRARIVATATSGADSTIMLTGPTPATLKVLTKAGLTPDDI
DLFEINEAFASVVLKYQKDLRIPDEKLNVNGGAIAMGHPLGATGAMILGTVVDELERREARRGLVTLCVGGGMGVATVVE
RV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=410, Percent_Identity=36.8292682926829, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI167614485, Length=410, Percent_Identity=34.6341463414634, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI148539872, Length=409, Percent_Identity=36.1858190709046, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=30.6024096385542, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4504327, Length=445, Percent_Identity=31.0112359550562, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI194353979, Length=91, Percent_Identity=54.9450549450549, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=40.661938534279, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI48994986, Length=411, Percent_Identity=39.4160583941606, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1788554, Length=412, Percent_Identity=39.0776699029126, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082165, Length=413, Percent_Identity=37.5302663438257, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=28.1030444964871, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=413, Percent_Identity=39.225181598063, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI25147385, Length=412, Percent_Identity=30.5825242718447, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17535921, Length=415, Percent_Identity=30.6024096385542, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=445, Percent_Identity=29.6629213483146, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17535917, Length=403, Percent_Identity=27.7915632754342, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=34, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=423, Percent_Identity=28.8416075650118, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24655093, Length=416, Percent_Identity=37.7403846153846, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17648125, Length=373, Percent_Identity=34.5844504021448, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24640423, Length=417, Percent_Identity=30.2158273381295, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17137578, Length=416, Percent_Identity=31.0096153846154, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42396; Mature: 42264

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEAFVYDAVRTPRGRGRKGSLHGTKPIDLVVSLVDALRKRNPTLDPERIDDLVLGVVT
CCCCCEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
PIGDQGSDIARTAVLASGLPDTVGGVQLNRFCSSGLEAVNTAAQKVRSGWECLVVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
SMSRVPMASDGGAWALDPWTNLTTSFVPQGVSADLIATIEGFDREAVDSYAVRSQGLAAK
HHHCCCCCCCCCCEEECCHHCCHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCEEE
AWAGGYFERSVVPVVDRNGLTVLDRDEHMRPETTLESLAALNPSFAAVGEQGGFDAVALQ
HHCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCHHCCCCCCCCCHHHHH
KYHWVERIEHVHHAGNSSGVVDGAALVVVGNEEIGRDLGLTPRARIVATATSGADSTIML
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHCCCCCCCCCCEEEEEECCCCCCEEEE
TGPTPATLKVLTKAGLTPDDIDLFEINEAFASVVLKYQKDLRIPDEKLNVNGGAIAMGHP
ECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCC
LGATGAMILGTVVDELERREARRGLVTLCVGGGMGVATVVERV
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
SAEAFVYDAVRTPRGRGRKGSLHGTKPIDLVVSLVDALRKRNPTLDPERIDDLVLGVVT
CCCCEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
PIGDQGSDIARTAVLASGLPDTVGGVQLNRFCSSGLEAVNTAAQKVRSGWECLVVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
SMSRVPMASDGGAWALDPWTNLTTSFVPQGVSADLIATIEGFDREAVDSYAVRSQGLAAK
HHHCCCCCCCCCCEEECCHHCCHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCEEE
AWAGGYFERSVVPVVDRNGLTVLDRDEHMRPETTLESLAALNPSFAAVGEQGGFDAVALQ
HHCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCHHCCCCCCCCCHHHHH
KYHWVERIEHVHHAGNSSGVVDGAALVVVGNEEIGRDLGLTPRARIVATATSGADSTIML
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHCCCCCCCCCCEEEEEECCCCCCEEEE
TGPTPATLKVLTKAGLTPDDIDLFEINEAFASVVLKYQKDLRIPDEKLNVNGGAIAMGHP
ECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCC
LGATGAMILGTVVDELERREARRGLVTLCVGGGMGVATVVERV
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]