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The map label for this gene is yngI [H]

Identifier: 158314505

GI number: 158314505

Start: 3171682

End: 3173265

Strand: Direct

Name: yngI [H]

Synonym: Franean1_2681

Alternate gene names: 158314505

Gene position: 3171682-3173265 (Clockwise)

Preceding gene: 158314504

Following gene: 158314506

Centisome position: 35.31

GC content: 71.21

Gene sequence:

>1584_bases
ATGACGGGCACGGGGCTGACCGACTCCTACTGGCCTGCACACGACGAGCTGCCCCTGCTCGCCGGGTCGATCGGCACATT
GCTGCGTGAGCGAGCCGCAGACCAGGGTGACCGCGTCGCGCTGCTTTGGCCGGACGGCGAGCGGATCGGGCGGATGAGCT
ACGCCGACCTTCGCGACCGAGCGGAGCGGACCGCGCGGTCCCTGCTGCGCGCCGCCGCGCCGGGCCACCGGGTCGCGGTC
TGGTCGCGCAACAGTCTCGACTGGGTGGTGCTGCAGTATGCCTGCGCGCTGGCCGGACTCGTCCTGACCCCCTTCAACCC
CGCCTGGACCGACCGCGAGCTCGAGCACGCCATCGCGCTGACCGCGCCCTCCCTGATCTTCAGCGGTCTGGATGGCCGCG
GCGTGGACCTCCACGACCGAGCCTGTGCGCTCGACAGCCCCGCGCCGACGCTCCGCCTGCACGAGCTTGGCACGCTCGCG
GACGACGACGGACCCCTGCCCGAGGTGGGGGCCGAAGCGCCGTTTTTGATCCAGTTCACCTCCGGCACCACGGGCCGGGC
CAAAGGGGCGCTGCTGAGCCACCGGGCCGCGCTGCATAGCGGCTACTTCCGCGCCCGCAACGGACACGCCGGGCCGCACG
ACGTGTGGCTGAACCCGGTGCCGCTCCACCACGTCGGCGGGTCGTGCGTAATGGTGCTCGGCGCACTCAGCGTCGGCGGC
GCCTACGTCGTCATGGACCGGTTCGACGTCGACGCCCTCGTCGGTCTGCTCCGACCGACCGGTGCGACCCGCATCGGCGG
TGTCCCGACCATGCTCTACGCCCTGCTGGACCATCCGCGGATCGCCGAAGCGGCCGGCGGCGTCGTCGGGGTAGGGCTCG
GGGGTGCCAGCGTGCCGCCGGCGCTCGTCGACCGCGTGCGCATCGAGCTCGCCGCCGTCCCGTCCATCGGTTACGGACAG
TCGGAATGTCCGCTGATCACCAGCACGGACGCCGACGACGACGCGATGACGATCGCGATGACCGTCGGGCGTCCCGTGCC
GCACACCACAGTGAAGATCGTCCATGTAGGGTCCGGCGAGGTCGTCCCGGTCGGCACCATCGGCGAGGTGTGCGTGCGCT
CCCCGGTCATGATGGACGGCTACGTCGCGATGCCCGCGGCCACCGCCGACGTGCTTGACCCCGAGGGGTTCCTGCACACC
GGCGACCTCGGCTCCATGGACACCGCCGGCGTCATCACCATTCACGGCCGCGCCCGCGAAGTGATCATCCGCAAGGGCGA
GAACATCTACCCGATCGAGGTCGAGGACGCGCTGCTGCGCCATCAGGCCGTGGCCGCCGCCGCCGTGCTCGGTGTCCTCG
ACGAACGCGACGGCCAGACCGTCGCGGCGGCCGTCCAGCTCGCGCCAGGCAGCACGGCGACCGCCGAGGAGCTGGAAGCC
TTCGTGGCAACCCGGATCGCCCACTACAAGGTGCCCCGGATCTGGTGTCTGGTCGAACACCTGCCCCTCACGGCGTCCGG
CAAGGTCCGCAAGCTCGACCTGGCCGATCTGTTCGACGGGCCTGGAGTACGACCGCATGACTGA

Upstream 100 bases:

>100_bases
ACGGCCCCGGCGGCACCGAGCGGCTCACCGGCCGCGCGGTACATGAGTGGGGCACGCAGGCGGGAAACTTTCCCTTCCTC
ACGGCAACTCCCGAGCGGCC

Downstream 100 bases:

>100_bases
CTTCCGCGCGGTGGGACGCGAGCTGTCGAACTGGGGCCGGTGGGGAGCCGACGACGAGCTCGGCACGCTCAACCTGATCA
CCGACGCGCGGGTAGCCGCG

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTGTGLTDSYWPAHDELPLLAGSIGTLLRERAADQGDRVALLWPDGERIGRMSYADLRDRAERTARSLLRAAAPGHRVAV
WSRNSLDWVVLQYACALAGLVLTPFNPAWTDRELEHAIALTAPSLIFSGLDGRGVDLHDRACALDSPAPTLRLHELGTLA
DDDGPLPEVGAEAPFLIQFTSGTTGRAKGALLSHRAALHSGYFRARNGHAGPHDVWLNPVPLHHVGGSCVMVLGALSVGG
AYVVMDRFDVDALVGLLRPTGATRIGGVPTMLYALLDHPRIAEAAGGVVGVGLGGASVPPALVDRVRIELAAVPSIGYGQ
SECPLITSTDADDDAMTIAMTVGRPVPHTTVKIVHVGSGEVVPVGTIGEVCVRSPVMMDGYVAMPAATADVLDPEGFLHT
GDLGSMDTAGVITIHGRAREVIIRKGENIYPIEVEDALLRHQAVAAAAVLGVLDERDGQTVAAAVQLAPGSTATAEELEA
FVATRIAHYKVPRIWCLVEHLPLTASGKVRKLDLADLFDGPGVRPHD

Sequences:

>Translated_527_residues
MTGTGLTDSYWPAHDELPLLAGSIGTLLRERAADQGDRVALLWPDGERIGRMSYADLRDRAERTARSLLRAAAPGHRVAV
WSRNSLDWVVLQYACALAGLVLTPFNPAWTDRELEHAIALTAPSLIFSGLDGRGVDLHDRACALDSPAPTLRLHELGTLA
DDDGPLPEVGAEAPFLIQFTSGTTGRAKGALLSHRAALHSGYFRARNGHAGPHDVWLNPVPLHHVGGSCVMVLGALSVGG
AYVVMDRFDVDALVGLLRPTGATRIGGVPTMLYALLDHPRIAEAAGGVVGVGLGGASVPPALVDRVRIELAAVPSIGYGQ
SECPLITSTDADDDAMTIAMTVGRPVPHTTVKIVHVGSGEVVPVGTIGEVCVRSPVMMDGYVAMPAATADVLDPEGFLHT
GDLGSMDTAGVITIHGRAREVIIRKGENIYPIEVEDALLRHQAVAAAAVLGVLDERDGQTVAAAVQLAPGSTATAEELEA
FVATRIAHYKVPRIWCLVEHLPLTASGKVRKLDLADLFDGPGVRPHD
>Mature_526_residues
TGTGLTDSYWPAHDELPLLAGSIGTLLRERAADQGDRVALLWPDGERIGRMSYADLRDRAERTARSLLRAAAPGHRVAVW
SRNSLDWVVLQYACALAGLVLTPFNPAWTDRELEHAIALTAPSLIFSGLDGRGVDLHDRACALDSPAPTLRLHELGTLAD
DDGPLPEVGAEAPFLIQFTSGTTGRAKGALLSHRAALHSGYFRARNGHAGPHDVWLNPVPLHHVGGSCVMVLGALSVGGA
YVVMDRFDVDALVGLLRPTGATRIGGVPTMLYALLDHPRIAEAAGGVVGVGLGGASVPPALVDRVRIELAAVPSIGYGQS
ECPLITSTDADDDAMTIAMTVGRPVPHTTVKIVHVGSGEVVPVGTIGEVCVRSPVMMDGYVAMPAATADVLDPEGFLHTG
DLGSMDTAGVITIHGRAREVIIRKGENIYPIEVEDALLRHQAVAAAAVLGVLDERDGQTVAAAVQLAPGSTATAEELEAF
VATRIAHYKVPRIWCLVEHLPLTASGKVRKLDLADLFDGPGVRPHD

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=518, Percent_Identity=31.0810810810811, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI42544132, Length=518, Percent_Identity=26.2548262548263, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI187761345, Length=542, Percent_Identity=25.830258302583, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI187761343, Length=542, Percent_Identity=25.830258302583, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI122937307, Length=515, Percent_Identity=26.9902912621359, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI38505220, Length=514, Percent_Identity=27.2373540856031, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI40807491, Length=478, Percent_Identity=23.8493723849372, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI57165410, Length=474, Percent_Identity=24.4725738396624, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI57165412, Length=474, Percent_Identity=24.0506329113924, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI115511026, Length=518, Percent_Identity=25.0965250965251, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI157311624, Length=527, Percent_Identity=25.8064516129032, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI157311622, Length=527, Percent_Identity=25.8064516129032, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI58082049, Length=522, Percent_Identity=25.6704980842912, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI42794756, Length=477, Percent_Identity=24.3186582809224, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI42794760, Length=477, Percent_Identity=24.3186582809224, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI42794758, Length=477, Percent_Identity=24.3186582809224, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI27477105, Length=512, Percent_Identity=21.484375, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI145693145, Length=470, Percent_Identity=30.8510638297872, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1788107, Length=358, Percent_Identity=31.8435754189944, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI221142682, Length=511, Percent_Identity=24.6575342465753, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786810, Length=528, Percent_Identity=28.5984848484849, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788595, Length=319, Percent_Identity=29.7805642633229, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=560, Percent_Identity=30.5357142857143, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71994690, Length=561, Percent_Identity=31.0160427807487, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71994694, Length=560, Percent_Identity=30.5357142857143, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17560308, Length=569, Percent_Identity=30.9314586994728, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI32563687, Length=514, Percent_Identity=26.4591439688716, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=509, Percent_Identity=28.0943025540275, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=521, Percent_Identity=26.1036468330134, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17557194, Length=523, Percent_Identity=26.0038240917782, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17559526, Length=519, Percent_Identity=26.0115606936416, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=460, Percent_Identity=24.5652173913043, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=517, Percent_Identity=23.21083172147, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI25141359, Length=505, Percent_Identity=22.5742574257426, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=435, Percent_Identity=25.0574712643678, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71996755, Length=503, Percent_Identity=22.8628230616302, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17510401, Length=514, Percent_Identity=22.1789883268482, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17556552, Length=491, Percent_Identity=23.4215885947047, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17564090, Length=315, Percent_Identity=26.3492063492064, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=344, Percent_Identity=29.3604651162791, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24581924, Length=550, Percent_Identity=30, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI18859661, Length=451, Percent_Identity=27.9379157427938, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24653035, Length=473, Percent_Identity=26.8498942917548, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24648260, Length=444, Percent_Identity=28.6036036036036, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355181, Length=522, Percent_Identity=24.7126436781609, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356947, Length=477, Percent_Identity=25.5765199161426, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356441, Length=458, Percent_Identity=25.1091703056769, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161076582, Length=446, Percent_Identity=26.2331838565022, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24648253, Length=451, Percent_Identity=24.1685144124169, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21358303, Length=463, Percent_Identity=24.8380129589633, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648255, Length=451, Percent_Identity=24.390243902439, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281365686, Length=460, Percent_Identity=25.2173913043478, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666501, Length=453, Percent_Identity=25.60706401766, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666497, Length=453, Percent_Identity=25.60706401766, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281366413, Length=474, Percent_Identity=25.3164556962025, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648257, Length=453, Percent_Identity=23.3995584988962, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656500, Length=504, Percent_Identity=24.4047619047619, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130357, Length=464, Percent_Identity=22.6293103448276, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3

Molecular weight: Translated: 55531; Mature: 55400

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTGLTDSYWPAHDELPLLAGSIGTLLRERAADQGDRVALLWPDGERIGRMSYADLRDR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCHHHHHHH
AERTARSLLRAAAPGHRVAVWSRNSLDWVVLQYACALAGLVLTPFNPAWTDRELEHAIAL
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHH
TAPSLIFSGLDGRGVDLHDRACALDSPAPTLRLHELGTLADDDGPLPEVGAEAPFLIQFT
CCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEC
SGTTGRAKGALLSHRAALHSGYFRARNGHAGPHDVWLNPVPLHHVGGSCVMVLGALSVGG
CCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
AYVVMDRFDVDALVGLLRPTGATRIGGVPTMLYALLDHPRIAEAAGGVVGVGLGGASVPP
EEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCEEEECCCCCCCCH
ALVDRVRIELAAVPSIGYGQSECPLITSTDADDDAMTIAMTVGRPVPHTTVKIVHVGSGE
HHHHHHEEEEEECCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCEEEEEEECCCC
VVPVGTIGEVCVRSPVMMDGYVAMPAATADVLDPEGFLHTGDLGSMDTAGVITIHGRARE
EEEECCHHHHHHCCCCEECCEEECCCCHHHCCCCCCCEEECCCCCCCCCCEEEECCCCEE
VIIRKGENIYPIEVEDALLRHQAVAAAAVLGVLDERDGQTVAAAVQLAPGSTATAEELEA
EEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHH
FVATRIAHYKVPRIWCLVEHLPLTASGKVRKLDLADLFDGPGVRPHD
HHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEHHHHCCCCCCCCCC
>Mature Secondary Structure 
TGTGLTDSYWPAHDELPLLAGSIGTLLRERAADQGDRVALLWPDGERIGRMSYADLRDR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCHHHHHHH
AERTARSLLRAAAPGHRVAVWSRNSLDWVVLQYACALAGLVLTPFNPAWTDRELEHAIAL
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHH
TAPSLIFSGLDGRGVDLHDRACALDSPAPTLRLHELGTLADDDGPLPEVGAEAPFLIQFT
CCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEC
SGTTGRAKGALLSHRAALHSGYFRARNGHAGPHDVWLNPVPLHHVGGSCVMVLGALSVGG
CCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
AYVVMDRFDVDALVGLLRPTGATRIGGVPTMLYALLDHPRIAEAAGGVVGVGLGGASVPP
EEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCEEEECCCCCCCCH
ALVDRVRIELAAVPSIGYGQSECPLITSTDADDDAMTIAMTVGRPVPHTTVKIVHVGSGE
HHHHHHEEEEEECCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCEEEEEEECCCC
VVPVGTIGEVCVRSPVMMDGYVAMPAATADVLDPEGFLHTGDLGSMDTAGVITIHGRARE
EEEECCHHHHHHCCCCEECCEEECCCCHHHCCCCCCCEEECCCCCCCCCCEEEECCCCEE
VIIRKGENIYPIEVEDALLRHQAVAAAAVLGVLDERDGQTVAAAVQLAPGSTATAEELEA
EEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHH
FVATRIAHYKVPRIWCLVEHLPLTASGKVRKLDLADLFDGPGVRPHD
HHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; long-chain carboxylic acid; CoA

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]