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The map label for this gene is cobB1 [H]

Identifier: 158314325

GI number: 158314325

Start: 2972366

End: 2973214

Strand: Direct

Name: cobB1 [H]

Synonym: Franean1_2495

Alternate gene names: 158314325

Gene position: 2972366-2973214 (Clockwise)

Preceding gene: 158314311

Following gene: 158314326

Centisome position: 33.09

GC content: 75.62

Gene sequence:

>849_bases
ATGGTCTTCGCCCGGTTGCGTGATCTTGTCGCCGGCGGTGGCGTCGCGGTGCTCACCGGAGCGGGGATGTCGACCGACTC
GGGAATCCCTGACTATCGGGGGCCGAACGGCTCGCTGCGCCAGCACACGCCGATGACCTACCAGCAGTTCAACCGGGACC
AGGCGGCCCGGCGCCGGTACTGGGCGCGCAGCCACCTCGGCTGGCGCCACGTCGCCGGGGCGCGCCCCAACACCGGGCAC
CGCGCTCTGGCGGAACTGGAGGCCGCGGGCCTGCTCGACGGCGTCATCACCCAGAACGTCGACGGGCTGCACCGGGCCGC
CGGGTCGCTCCGGGTCATCGACCTGCACGGCGAGCTCGCCCGGGTCCGCTGCCGGGCCTGCGGGGCGCTCAGCGCGCGGG
CCGAGCTCGACCGCCGCCTGCGCGCGGCGAACCCGGGCTTCGCTGCCGGGGTGGCCGCCGCGTCGCCGCTCGGCGCCGAG
GTCAATCCGGACGGCGACGTCACCCTCCCCGACGAGGCGATCGACGGTTTCGTCGTAGTGGGGTGCACCGGCTGCGGGGG
CGACCTGGAGCCCGACGTGGTCTTCTTCGGCGCCACGGTGCCGCCGGCGCGGCTGGCGTCCGCGGTCGCGCTGGTCGAGA
ACGCCCGCGGGCTGCTCGTGCTCGGCTCGTCGCTGGCCGTCATGTCGGGCTACCGGTTCGTACTGCGGGCGGGAGAGCTC
GGCATCCCGGTCGGGATCGTGAACCAGGGCCCGACCCGCGGCGACGCGCGGGCGGAGTTCACCGTCGACTCGCCACTGGG
CGCCGTCCTGCCCCGCCTCGCCGCCGAGCTGCTCGGCGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
TAACGGTACGTCTGTGGTGTGGGCGGCACCACCGGGCGCCGCGGGGCGCCTCGCCGGCACCCGGCCGCCTCGTCCGGGCG
GCGGGCCATACCCTCGAGGC

Downstream 100 bases:

>100_bases
TGGCCACTGATGCGGATCACCCCGTCGGGGATCGCGCGGAGCTGACCCTGCGCGCCGCCGGGCCGGGTGACGTCGCCGCG
CTTGTCGAGCTGATCGAGTC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MVFARLRDLVAGGGVAVLTGAGMSTDSGIPDYRGPNGSLRQHTPMTYQQFNRDQAARRRYWARSHLGWRHVAGARPNTGH
RALAELEAAGLLDGVITQNVDGLHRAAGSLRVIDLHGELARVRCRACGALSARAELDRRLRAANPGFAAGVAAASPLGAE
VNPDGDVTLPDEAIDGFVVVGCTGCGGDLEPDVVFFGATVPPARLASAVALVENARGLLVLGSSLAVMSGYRFVLRAGEL
GIPVGIVNQGPTRGDARAEFTVDSPLGAVLPRLAAELLGAAA

Sequences:

>Translated_282_residues
MVFARLRDLVAGGGVAVLTGAGMSTDSGIPDYRGPNGSLRQHTPMTYQQFNRDQAARRRYWARSHLGWRHVAGARPNTGH
RALAELEAAGLLDGVITQNVDGLHRAAGSLRVIDLHGELARVRCRACGALSARAELDRRLRAANPGFAAGVAAASPLGAE
VNPDGDVTLPDEAIDGFVVVGCTGCGGDLEPDVVFFGATVPPARLASAVALVENARGLLVLGSSLAVMSGYRFVLRAGEL
GIPVGIVNQGPTRGDARAEFTVDSPLGAVLPRLAAELLGAAA
>Mature_282_residues
MVFARLRDLVAGGGVAVLTGAGMSTDSGIPDYRGPNGSLRQHTPMTYQQFNRDQAARRRYWARSHLGWRHVAGARPNTGH
RALAELEAAGLLDGVITQNVDGLHRAAGSLRVIDLHGELARVRCRACGALSARAELDRRLRAANPGFAAGVAAASPLGAE
VNPDGDVTLPDEAIDGFVVVGCTGCGGDLEPDVVFFGATVPPARLASAVALVENARGLLVLGSSLAVMSGYRFVLRAGEL
GIPVGIVNQGPTRGDARAEFTVDSPLGAVLPRLAAELLGAAA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=268, Percent_Identity=43.2835820895522, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI6912664, Length=281, Percent_Identity=30.9608540925267, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI300795542, Length=280, Percent_Identity=30.3571428571429, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13787215, Length=268, Percent_Identity=30.9701492537313, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI300797577, Length=278, Percent_Identity=27.3381294964029, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI300797597, Length=170, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI308199517, Length=276, Percent_Identity=29.7101449275362, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990482, Length=260, Percent_Identity=41.1538461538462, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71990487, Length=262, Percent_Identity=40.8396946564886, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17567771, Length=260, Percent_Identity=40.3846153846154, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17541892, Length=223, Percent_Identity=27.3542600896861, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571445, Length=274, Percent_Identity=44.1605839416058, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI28571443, Length=225, Percent_Identity=43.5555555555556, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571441, Length=225, Percent_Identity=43.5555555555556, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 29198; Mature: 29198

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFARLRDLVAGGGVAVLTGAGMSTDSGIPDYRGPNGSLRQHTPMTYQQFNRDQAARRRY
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHH
WARSHLGWRHVAGARPNTGHRALAELEAAGLLDGVITQNVDGLHRAAGSLRVIDLHGELA
HHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCHHH
RVRCRACGALSARAELDRRLRAANPGFAAGVAAASPLGAEVNPDGDVTLPDEAIDGFVVV
HHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEECCHHHCCCEEEE
GCTGCGGDLEPDVVFFGATVPPARLASAVALVENARGLLVLGSSLAVMSGYRFVLRAGEL
EEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHCCEEEEEECCC
GIPVGIVNQGPTRGDARAEFTVDSPLGAVLPRLAAELLGAAA
CCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVFARLRDLVAGGGVAVLTGAGMSTDSGIPDYRGPNGSLRQHTPMTYQQFNRDQAARRRY
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHH
WARSHLGWRHVAGARPNTGHRALAELEAAGLLDGVITQNVDGLHRAAGSLRVIDLHGELA
HHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCHHH
RVRCRACGALSARAELDRRLRAANPGFAAGVAAASPLGAEVNPDGDVTLPDEAIDGFVVV
HHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEECCHHHCCCEEEE
GCTGCGGDLEPDVVFFGATVPPARLASAVALVENARGLLVLGSSLAVMSGYRFVLRAGEL
EEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHCCEEEEEECCC
GIPVGIVNQGPTRGDARAEFTVDSPLGAVLPRLAAELLGAAA
CCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]