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The map label for this gene is mhpC [C]

Identifier: 158314326

GI number: 158314326

Start: 2973214

End: 2974509

Strand: Direct

Name: mhpC [C]

Synonym: Franean1_2496

Alternate gene names: 158314326

Gene position: 2973214-2974509 (Clockwise)

Preceding gene: 158314325

Following gene: 158314327

Centisome position: 33.1

GC content: 74.46

Gene sequence:

>1296_bases
ATGGCCACTGATGCGGATCACCCCGTCGGGGATCGCGCGGAGCTGACCCTGCGCGCCGCCGGGCCGGGTGACGTCGCCGC
GCTTGTCGAGCTGATCGAGTCCGCGTACCGGGGCGAGCGCAGCCGGGTTGGCTGGACCACCGAGGCCGACCTGCTGGGCG
GCCAGCGCACCGACCCGGAGATGCTCGCCGCCGCGCTCGCCGAGCCCGACATCCGGATGCTCCTCGCGCTCGGCCCGGCC
GGGGAGCCGGTCGGCTGCTGCCAGCTCCAGCGGCGCCCGGACGGCGCCTACTTCGGCATGTTCGCCGTCCAGCCGGACAT
CCAGGGGCAAGGGATCGGGGACCGTCTGCTCACCGCCGCGGAGGCACTCGCCCGCGACGAGTGGGCGGCGGCCCGGATGG
AGCTGTACGTCATCTCGCTGCGCGCCGAGCTGATCGCCTGGTACGAGCGGCGCGGCTACCGGCGTACGGACCGCCACGAG
CCCTTCCCCTACGGGGACACCCGGTTCGGCGTGCCGCTGCGCGACGACCTGGTCTTCGCCGTCCTGGAGAAGGACCTCGG
CCACCGGGTCGACGTCGGCGGCCTCGCGCTGCACGTCGAGACCTGGACGGGCCAGGCGCACTCATCCACCCCGCTGCTGC
TCCTGCACGGCATCGGTGGGAGCACCAGGGACTGGGCCGGGGTGTCCCGCGAGCTCGCCGGCGCCGTGTCGAGCCGGGTC
GTGGCCTACGACCACCGCGGCCACGGAACCAGCGGGCGGGCGGCCCGCCCGGAGTACACCTTCGACCACCTCGTCCGCGA
TCTCGAGACCGTCGTCGCGACGCTGGAGCTGGCGCCGCTGCACCTGCTGGGGCATTCGATGGGCGGGGTGGTCGCGCTCC
GGTACGCGCTGGCCCACCCCGAGGCCGTCCGGTCGCTGATCCTGATGGACACCGCCGCGGCGCCGGCGGCGGGTGATCAT
CTGCTGTCCCGGCTGGGCATGGGCGCGCTCATGGAGGGCATCGCCGCCGCGACCGCGCTGCTGGGGCACGGGGACCACGC
CGACCCCGCCGCCCTCGCCGCCTTCGGCCACGAGCTCAACGCCTACCCCTCGATGATCGACCGGCTGGGCGAGATCCGCT
GCCCCACGACGGTCATCGTCGGCGAGCGGGACGTCCTGCTGCGTGGTGCCGCGCGGGATCTGGCCGGCGCCATCGAGGGT
GCCCGGCTCGCGGTGATCGCCGGTGCCGATCACAACCCGCAGGCCAGTCACCCACAGGCCTGGCTCAGCGCGGTGGAGCG
GCACGCCGCCTTCTGA

Upstream 100 bases:

>100_bases
GCCCGACCCGCGGCGACGCGCGGGCGGAGTTCACCGTCGACTCGCCACTGGGCGCCGTCCTGCCCCGCCTCGCCGCCGAG
CTGCTCGGCGCGGCCGCCTG

Downstream 100 bases:

>100_bases
GAACCGCGGCCATTCATTTTCCGGCCCGGTGGCGGTGGCCGCGGTTGGCAGTGTCCACGGTCACGGGTTCTTCGCACGCC
AGAATTTAGGACGTACTGAG

Product: alpha/beta hydrolase fold protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MATDADHPVGDRAELTLRAAGPGDVAALVELIESAYRGERSRVGWTTEADLLGGQRTDPEMLAAALAEPDIRMLLALGPA
GEPVGCCQLQRRPDGAYFGMFAVQPDIQGQGIGDRLLTAAEALARDEWAAARMELYVISLRAELIAWYERRGYRRTDRHE
PFPYGDTRFGVPLRDDLVFAVLEKDLGHRVDVGGLALHVETWTGQAHSSTPLLLLHGIGGSTRDWAGVSRELAGAVSSRV
VAYDHRGHGTSGRAARPEYTFDHLVRDLETVVATLELAPLHLLGHSMGGVVALRYALAHPEAVRSLILMDTAAAPAAGDH
LLSRLGMGALMEGIAAATALLGHGDHADPAALAAFGHELNAYPSMIDRLGEIRCPTTVIVGERDVLLRGAARDLAGAIEG
ARLAVIAGADHNPQASHPQAWLSAVERHAAF

Sequences:

>Translated_431_residues
MATDADHPVGDRAELTLRAAGPGDVAALVELIESAYRGERSRVGWTTEADLLGGQRTDPEMLAAALAEPDIRMLLALGPA
GEPVGCCQLQRRPDGAYFGMFAVQPDIQGQGIGDRLLTAAEALARDEWAAARMELYVISLRAELIAWYERRGYRRTDRHE
PFPYGDTRFGVPLRDDLVFAVLEKDLGHRVDVGGLALHVETWTGQAHSSTPLLLLHGIGGSTRDWAGVSRELAGAVSSRV
VAYDHRGHGTSGRAARPEYTFDHLVRDLETVVATLELAPLHLLGHSMGGVVALRYALAHPEAVRSLILMDTAAAPAAGDH
LLSRLGMGALMEGIAAATALLGHGDHADPAALAAFGHELNAYPSMIDRLGEIRCPTTVIVGERDVLLRGAARDLAGAIEG
ARLAVIAGADHNPQASHPQAWLSAVERHAAF
>Mature_430_residues
ATDADHPVGDRAELTLRAAGPGDVAALVELIESAYRGERSRVGWTTEADLLGGQRTDPEMLAAALAEPDIRMLLALGPAG
EPVGCCQLQRRPDGAYFGMFAVQPDIQGQGIGDRLLTAAEALARDEWAAARMELYVISLRAELIAWYERRGYRRTDRHEP
FPYGDTRFGVPLRDDLVFAVLEKDLGHRVDVGGLALHVETWTGQAHSSTPLLLLHGIGGSTRDWAGVSRELAGAVSSRVV
AYDHRGHGTSGRAARPEYTFDHLVRDLETVVATLELAPLHLLGHSMGGVVALRYALAHPEAVRSLILMDTAAAPAAGDHL
LSRLGMGALMEGIAAATALLGHGDHADPAALAAFGHELNAYPSMIDRLGEIRCPTTVIVGERDVLLRGAARDLAGAIEGA
RLAVIAGADHNPQASHPQAWLSAVERHAAF

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0454

COG function: function code KR; Histone acetyltransferase HPA2 and related acetyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI23200008, Length=107, Percent_Identity=33.6448598130841, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI23200012, Length=107, Percent_Identity=33.6448598130841, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081721, Length=250, Percent_Identity=28.4, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640348, Length=156, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 45966; Mature: 45834

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDADHPVGDRAELTLRAAGPGDVAALVELIESAYRGERSRVGWTTEADLLGGQRTDPE
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCHH
MLAAALAEPDIRMLLALGPAGEPVGCCQLQRRPDGAYFGMFAVQPDIQGQGIGDRLLTAA
HHHHHHCCCCEEEEEEECCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
EALARDEWAAARMELYVISLRAELIAWYERRGYRRTDRHEPFPYGDTRFGVPLRDDLVFA
HHHHHHHHHHHHEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHH
VLEKDLGHRVDVGGLALHVETWTGQAHSSTPLLLLHGIGGSTRDWAGVSRELAGAVSSRV
HHHHHCCCEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCE
VAYDHRGHGTSGRAARPEYTFDHLVRDLETVVATLELAPLHLLGHSMGGVVALRYALAHP
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCH
EAVRSLILMDTAAAPAAGDHLLSRLGMGALMEGIAAATALLGHGDHADPAALAAFGHELN
HHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AYPSMIDRLGEIRCPTTVIVGERDVLLRGAARDLAGAIEGARLAVIAGADHNPQASHPQA
HHHHHHHHHHCCCCCEEEEECCCHHEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHH
WLSAVERHAAF
HHHHHHHHCCC
>Mature Secondary Structure 
ATDADHPVGDRAELTLRAAGPGDVAALVELIESAYRGERSRVGWTTEADLLGGQRTDPE
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCHH
MLAAALAEPDIRMLLALGPAGEPVGCCQLQRRPDGAYFGMFAVQPDIQGQGIGDRLLTAA
HHHHHHCCCCEEEEEEECCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
EALARDEWAAARMELYVISLRAELIAWYERRGYRRTDRHEPFPYGDTRFGVPLRDDLVFA
HHHHHHHHHHHHEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHH
VLEKDLGHRVDVGGLALHVETWTGQAHSSTPLLLLHGIGGSTRDWAGVSRELAGAVSSRV
HHHHHCCCEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCE
VAYDHRGHGTSGRAARPEYTFDHLVRDLETVVATLELAPLHLLGHSMGGVVALRYALAHP
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCH
EAVRSLILMDTAAAPAAGDHLLSRLGMGALMEGIAAATALLGHGDHADPAALAAFGHELN
HHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AYPSMIDRLGEIRCPTTVIVGERDVLLRGAARDLAGAIEGARLAVIAGADHNPQASHPQA
HHHHHHHHHHCCCCCEEEEECCCHHEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHH
WLSAVERHAAF
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]