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The map label for this gene is inhA [H]

Identifier: 158314059

GI number: 158314059

Start: 2662749

End: 2663522

Strand: Direct

Name: inhA [H]

Synonym: Franean1_2226

Alternate gene names: 158314059

Gene position: 2662749-2663522 (Clockwise)

Preceding gene: 158314058

Following gene: 158314063

Centisome position: 29.65

GC content: 71.96

Gene sequence:

>774_bases
ATGAGCGGACTTCTCGAAGGCAAGCGCGTTCTCGTCACCGGTGTCCTGACCGAGGCGTCCATCGCGTTCAGTGTTGCCCG
CATCGCCCAGGAGCAGGGTGCTTCCGTGGTGCTCACCGGGTTTGGCCGCGGCCTGTCCCTCACCCGCCGGATCGCGCGCC
GCCTGCCCACCGAGCCGCCGGTCGTCGAGCTCGACGTGACTGACGAGGAGCATCTCGCCGAGCTCTCCGCGAAGGTCCTC
GAGCACGTCGACGGCCTCGACGGGGTGATGCACGCGATCGGGTTCGCGCCGGAATCGGTGCTGGGCGGCAAGCCGTTCGT
CGAGGCGGCCTGGTCGGAGGTCGGTACCGCGCTTCAGGTCTCCACCTGGTCGCTCGCGTCCCTGACCCGCGCGACCATGC
CGCTGTTCGGCGAGCGCGCCAGCATCGTCGGCCTGGACTTCGACGCCTCGGTCGCCTGGCCGTCCTACGACTGGATGGGG
GTCGCCAAGGCGGGGCTCGCCTCCGCCGCCCGCTACCTGGCCCGGGACCTCGGCCCCAGCGGAGTGCGGGTGAATCTGGT
CGCCGCCGGCCCGCTGCGCACGATGGCGGCCAAGAGCATCCCCGGGTTCAGCAAGTTCGAGGAGGTCTGGGGCACCCGGG
CACCGCTCGGCTGGGACATCGCGGACACCACGCCCGCGGCGCGCGCCTGCGTCGCCCTCCTCTCGGACTGGTTCCCCGCG
ACGACGGGCGAGATCGTGCACGTCGACGGCGGCTTCCACGCGGTCGGCGCCTGA

Upstream 100 bases:

>100_bases
GCCTTGCCGCGGGCCGTGTGACCCGCGGCTGGGTGCCGGCGCGCGAATCTCGGCCGGGCTGGCGGGATTCACCCGGCGAT
GTTTGGCAGGATGACGCTCC

Downstream 100 bases:

>100_bases
CCTCCGGGCGGCGTCCCACGCAGCCCTGGCCGGCCCCTGAAACCACAGCCCGGCCGCGGGGCCTTTGAAACCGCGGCCCG
GCGGTGGGCATCGGAATTCC

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSGLLEGKRVLVTGVLTEASIAFSVARIAQEQGASVVLTGFGRGLSLTRRIARRLPTEPPVVELDVTDEEHLAELSAKVL
EHVDGLDGVMHAIGFAPESVLGGKPFVEAAWSEVGTALQVSTWSLASLTRATMPLFGERASIVGLDFDASVAWPSYDWMG
VAKAGLASAARYLARDLGPSGVRVNLVAAGPLRTMAAKSIPGFSKFEEVWGTRAPLGWDIADTTPAARACVALLSDWFPA
TTGEIVHVDGGFHAVGA

Sequences:

>Translated_257_residues
MSGLLEGKRVLVTGVLTEASIAFSVARIAQEQGASVVLTGFGRGLSLTRRIARRLPTEPPVVELDVTDEEHLAELSAKVL
EHVDGLDGVMHAIGFAPESVLGGKPFVEAAWSEVGTALQVSTWSLASLTRATMPLFGERASIVGLDFDASVAWPSYDWMG
VAKAGLASAARYLARDLGPSGVRVNLVAAGPLRTMAAKSIPGFSKFEEVWGTRAPLGWDIADTTPAARACVALLSDWFPA
TTGEIVHVDGGFHAVGA
>Mature_256_residues
SGLLEGKRVLVTGVLTEASIAFSVARIAQEQGASVVLTGFGRGLSLTRRIARRLPTEPPVVELDVTDEEHLAELSAKVLE
HVDGLDGVMHAIGFAPESVLGGKPFVEAAWSEVGTALQVSTWSLASLTRATMPLFGERASIVGLDFDASVAWPSYDWMGV
AKAGLASAARYLARDLGPSGVRVNLVAAGPLRTMAAKSIPGFSKFEEVWGTRAPLGWDIADTTPAARACVALLSDWFPAT
TGEIVHVDGGFHAVGA

Specific function: Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide [H]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=253, Percent_Identity=33.596837944664, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR016040 [H]

Pfam domain/function: NA

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 26964; Mature: 26833

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLEGKRVLVTGVLTEASIAFSVARIAQEQGASVVLTGFGRGLSLTRRIARRLPTEPP
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCC
VVELDVTDEEHLAELSAKVLEHVDGLDGVMHAIGFAPESVLGGKPFVEAAWSEVGTALQV
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHCCEEEE
STWSLASLTRATMPLFGERASIVGLDFDASVAWPSYDWMGVAKAGLASAARYLARDLGPS
ECHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GVRVNLVAAGPLRTMAAKSIPGFSKFEEVWGTRAPLGWDIADTTPAARACVALLSDWFPA
CEEEEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
TTGEIVHVDGGFHAVGA
CCCCEEEECCCEEECCC
>Mature Secondary Structure 
SGLLEGKRVLVTGVLTEASIAFSVARIAQEQGASVVLTGFGRGLSLTRRIARRLPTEPP
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCC
VVELDVTDEEHLAELSAKVLEHVDGLDGVMHAIGFAPESVLGGKPFVEAAWSEVGTALQV
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHCCEEEE
STWSLASLTRATMPLFGERASIVGLDFDASVAWPSYDWMGVAKAGLASAARYLARDLGPS
ECHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GVRVNLVAAGPLRTMAAKSIPGFSKFEEVWGTRAPLGWDIADTTPAARACVALLSDWFPA
CEEEEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
TTGEIVHVDGGFHAVGA
CCCCEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8284673; 7623658; 12788972 [H]