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The map label for this gene is capL [H]

Identifier: 158313998

GI number: 158313998

Start: 2597490

End: 2598905

Strand: Direct

Name: capL [H]

Synonym: Franean1_2164

Alternate gene names: 158313998

Gene position: 2597490-2598905 (Clockwise)

Preceding gene: 158313997

Following gene: 158313999

Centisome position: 28.92

GC content: 70.55

Gene sequence:

>1416_bases
ATGACTTCTTCGGGAAAGCTGGTGGTGGTCGGCCAGGGGTACGTAGGTCTTCCCGTGGCGATGCGCGCGGTCGAGGTCGA
CTGGCGGGTGGTCGGCGTCGACGTCGACGCCGGGCGGGTCAAGCGGCTGGCCGCCGGCGAGTCGTACGTCGAGGACGTCT
CGCGGGACCGGCTCGCCGCGGCACTCGACTCCGGGCGGTATGAGCCGACGGCCGACTTCGCGGCGGCCGCGGGGTTCGAC
GTCGCGGTCGTCACCGTCCCCACCCCGCTGCGGGAGGGCGCGCCCGATCTGGGTTACGTCGTCGAGGCGGCCCGCAGCCT
GGCGCCGCTGGTGACACCGGGGGCGACGGTGGTGCTGGAGTCGACCACCTATCCGGGGACAACCGAGGAACTGTTCGGGC
CGTTGCTGGAGGAAGGATCCGGGCTCACCGCCGGAGACGACTTCCGGCTCGGCTACTCCCCGGAGCGTATCGACCCGGGA
AACCCGACATGGCGGCTGGAAAACACGCCGAAGGTCGTCTCCGGAGTCAACGGCGCCTCGCTCGAGGCGGTCCGGGCCTT
CTACGACTCGCTGGTGGACCGTACCGTGTCGGTCGCCTCGACGAGGACGGCCGAGCTCACCAAGCTGCTGGAGAACACCT
TCCGGCATGTCAACATCGCCCTGGTCAACGAGCTCGCGATGTTCGCGCACGAGTTGGGGGTGGATGTGTGGGAGGCGATC
GACGCCGCCTCCACCAAACCGTTCGGGTTCATGCCGTTCCGGCCCGGCCCCGGCGCCGGTGGCCATTGCCTGCCCATCGA
CCCGTCGTATCTGTCCTGGCGGGTGCGGCGACGGCTCGGCCGCAGCTTCCGGTTCGTCGAACTGGCCAACGACATCAATG
ACCACATGCCGGACCATGTGGTCCGTCGTGTGATCGACATGCTCAACCGGCGCGGACGCTCGGTGAGTGGCAGCCGCATC
CTTCTACTCGGACTGGCCTACAAGAGGAACACCGGCGACTCCCGTGAGTCGCCTGCCGCGCGAGTGGCCGCGCTGCTGGC
CGATCTCGGTGCCGGGGTCCTCGCAGCCGATCCGCACATCGACCCCGCGCAGGCGCCGGGACGGGTCGCGCTGGTGGACG
CCGACGCGGCGCAGATCGCGGCAGCCGACCTGGTGGTCGTGCTGGTGGACCACGACGCGTTCTGTCGCGACCTGGTGATG
CGTCACGCCACGGCCGTCCTCGACACGCGCCGGTGGCTGCCGGCCGTGTCCACAGGCGCCGCCGGTGCGCCGGTGGATCA
TACGCAGACCGGAATGCCGTCCGGTCCGGCGCGCGCCTCGGTGGTCGACGTGCCGGCGGCGGCTGATCTTCCGGTCGGGG
CGGTTGTCCCGGCGCCTCGTTCCGAGCCGCGCCGCGTCCTCATCGAGTCGCTGTGA

Upstream 100 bases:

>100_bases
GCCCGACCCCCTGCTGCCGACATCGCCTGCCGATCGCGGAGCGTGACACACCGTAATGCTGTTGTGTAGCTGACAGTATT
TAGTGAGTCACAATAGGTTC

Downstream 100 bases:

>100_bases
CCTACGGCGTGCCCGACGCCGAGCCGACTGCCAGCGCGGCTTGACGCCAGGGGCCAGGGGGGTGGATCTCAACCTGTAAC
CGATCGTTCTGGCCGTCATG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTSSGKLVVVGQGYVGLPVAMRAVEVDWRVVGVDVDAGRVKRLAAGESYVEDVSRDRLAAALDSGRYEPTADFAAAAGFD
VAVVTVPTPLREGAPDLGYVVEAARSLAPLVTPGATVVLESTTYPGTTEELFGPLLEEGSGLTAGDDFRLGYSPERIDPG
NPTWRLENTPKVVSGVNGASLEAVRAFYDSLVDRTVSVASTRTAELTKLLENTFRHVNIALVNELAMFAHELGVDVWEAI
DAASTKPFGFMPFRPGPGAGGHCLPIDPSYLSWRVRRRLGRSFRFVELANDINDHMPDHVVRRVIDMLNRRGRSVSGSRI
LLLGLAYKRNTGDSRESPAARVAALLADLGAGVLAADPHIDPAQAPGRVALVDADAAQIAAADLVVVLVDHDAFCRDLVM
RHATAVLDTRRWLPAVSTGAAGAPVDHTQTGMPSGPARASVVDVPAAADLPVGAVVPAPRSEPRRVLIESL

Sequences:

>Translated_471_residues
MTSSGKLVVVGQGYVGLPVAMRAVEVDWRVVGVDVDAGRVKRLAAGESYVEDVSRDRLAAALDSGRYEPTADFAAAAGFD
VAVVTVPTPLREGAPDLGYVVEAARSLAPLVTPGATVVLESTTYPGTTEELFGPLLEEGSGLTAGDDFRLGYSPERIDPG
NPTWRLENTPKVVSGVNGASLEAVRAFYDSLVDRTVSVASTRTAELTKLLENTFRHVNIALVNELAMFAHELGVDVWEAI
DAASTKPFGFMPFRPGPGAGGHCLPIDPSYLSWRVRRRLGRSFRFVELANDINDHMPDHVVRRVIDMLNRRGRSVSGSRI
LLLGLAYKRNTGDSRESPAARVAALLADLGAGVLAADPHIDPAQAPGRVALVDADAAQIAAADLVVVLVDHDAFCRDLVM
RHATAVLDTRRWLPAVSTGAAGAPVDHTQTGMPSGPARASVVDVPAAADLPVGAVVPAPRSEPRRVLIESL
>Mature_470_residues
TSSGKLVVVGQGYVGLPVAMRAVEVDWRVVGVDVDAGRVKRLAAGESYVEDVSRDRLAAALDSGRYEPTADFAAAAGFDV
AVVTVPTPLREGAPDLGYVVEAARSLAPLVTPGATVVLESTTYPGTTEELFGPLLEEGSGLTAGDDFRLGYSPERIDPGN
PTWRLENTPKVVSGVNGASLEAVRAFYDSLVDRTVSVASTRTAELTKLLENTFRHVNIALVNELAMFAHELGVDVWEAID
AASTKPFGFMPFRPGPGAGGHCLPIDPSYLSWRVRRRLGRSFRFVELANDINDHMPDHVVRRVIDMLNRRGRSVSGSRIL
LLGLAYKRNTGDSRESPAARVAALLADLGAGVLAADPHIDPAQAPGRVALVDADAAQIAAADLVVVLVDHDAFCRDLVMR
HATAVLDTRRWLPAVSTGAAGAPVDHTQTGMPSGPARASVVDVPAAADLPVGAVVPAPRSEPRRVLIESL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=412, Percent_Identity=25.7281553398058, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI296040438, Length=304, Percent_Identity=25.9868421052632, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI296040443, Length=245, Percent_Identity=27.3469387755102, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI48994968, Length=407, Percent_Identity=35.1351351351351, Blast_Score=212, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17560350, Length=447, Percent_Identity=25.9507829977629, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17136908, Length=376, Percent_Identity=25.2659574468085, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49904; Mature: 49773

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSGKLVVVGQGYVGLPVAMRAVEVDWRVVGVDVDAGRVKRLAAGESYVEDVSRDRLAA
CCCCCCEEEEECCCCCCCHHHEEEEECEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHH
ALDSGRYEPTADFAAAAGFDVAVVTVPTPLREGAPDLGYVVEAARSLAPLVTPGATVVLE
HHHCCCCCCCHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEE
STTYPGTTEELFGPLLEEGSGLTAGDDFRLGYSPERIDPGNPTWRLENTPKVVSGVNGAS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCH
LEAVRAFYDSLVDRTVSVASTRTAELTKLLENTFRHVNIALVNELAMFAHELGVDVWEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DAASTKPFGFMPFRPGPGAGGHCLPIDPSYLSWRVRRRLGRSFRFVELANDINDHMPDHV
HHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCHHHH
VRRVIDMLNRRGRSVSGSRILLLGLAYKRNTGDSRESPAARVAALLADLGAGVLAADPHI
HHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCC
DPAQAPGRVALVDADAAQIAAADLVVVLVDHDAFCRDLVMRHATAVLDTRRWLPAVSTGA
CCCCCCCEEEEEECCHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AGAPVDHTQTGMPSGPARASVVDVPAAADLPVGAVVPAPRSEPRRVLIESL
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
TSSGKLVVVGQGYVGLPVAMRAVEVDWRVVGVDVDAGRVKRLAAGESYVEDVSRDRLAA
CCCCCEEEEECCCCCCCHHHEEEEECEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHH
ALDSGRYEPTADFAAAAGFDVAVVTVPTPLREGAPDLGYVVEAARSLAPLVTPGATVVLE
HHHCCCCCCCHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEE
STTYPGTTEELFGPLLEEGSGLTAGDDFRLGYSPERIDPGNPTWRLENTPKVVSGVNGAS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCH
LEAVRAFYDSLVDRTVSVASTRTAELTKLLENTFRHVNIALVNELAMFAHELGVDVWEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DAASTKPFGFMPFRPGPGAGGHCLPIDPSYLSWRVRRRLGRSFRFVELANDINDHMPDHV
HHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCHHHH
VRRVIDMLNRRGRSVSGSRILLLGLAYKRNTGDSRESPAARVAALLADLGAGVLAADPHI
HHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCC
DPAQAPGRVALVDADAAQIAAADLVVVLVDHDAFCRDLVMRHATAVLDTRRWLPAVSTGA
CCCCCCCEEEEEECCHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AGAPVDHTQTGMPSGPARASVVDVPAAADLPVGAVVPAPRSEPRRVLIESL
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]