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The map label for this gene is ykoW [H]

Identifier: 158313974

GI number: 158313974

Start: 2568165

End: 2570354

Strand: Direct

Name: ykoW [H]

Synonym: Franean1_2140

Alternate gene names: 158313974

Gene position: 2568165-2570354 (Clockwise)

Preceding gene: 158313973

Following gene: 158313976

Centisome position: 28.59

GC content: 73.33

Gene sequence:

>2190_bases
ATGAGTCGGGCCGTCCGGCGTCTCACCACGCCGGTGGCCCGACGGTGCCAGGAATCACCCGGTTCGACCGCATACAGCGG
TTCGGCAGTGCGTGGCGGCGCGGCTGCGCGCAGCAGTGCCGTGGCGACGGCCGGCGGGGGGAAGACGGCGAGGGCGCAGG
CCACGGTCGCGCACGCCGGAGGGGAAACGTCGGATGCGCCGATGACCTCTCCTGCGATGGCGCACTCGCCGACCACCGGA
GGTTCTCCGACGTTTCCGGAGCTGGAGGTCTCCAGCGCGGGGCGCTCGAGCGGCGGAGACCAGCACGGCCGGAATCGGCC
CTGGGGCGGGCGGCAGCGCGCGGGCGGCCGTGTCGACGAGACCACGACATCCGGTCGGCGGCCCGGCGTCCTCGCGTCTG
CGTCCGTGGTTCTTCTCGTAGGGGTCGTGTCCTGGTGGGCGGCGATCAAGGTGCTGGCCCCGTCCGGCGCGATCACCACA
TCGCTGACGGTGGCGGCGGTGGCGTGCCTGCCGCTGTCCGGACTGGGTGACCGGATGGTCGCGGCGGTCCGTCGCCGCTG
GTACGGCTCGGACGATCTGACTGGCCTGCCAGGTCGTCGCCATTTCGTCGCGACCGCCTCCCGCTGGCTCGGGGGCGGTC
ACCGAGCCCGGGGCTCGGTGTCGGCGGCGCTCATCCTGATCGATCTCGACCGCCTCCGGGACATCAACGGGACGCTCGGC
CACGAGCACGGTGACCACATGCTGGCCACCGTCGGCGCCCGGCTGCGTTCCGTGCTGCGTCCCGCCGACCTGCTCGCGCG
GGTCGACGGCGACGAGTTCGCGGTACTGCTGCGGGACGTCGACCTCGCCGGCGCCGAGGCGGTCGCCCGGCGGATCCGGG
AGGCGCTGAGAATCCCTGTCCGCCTGGATGACCTGCGCGTCCAGGCCGACGTCAGTGTCGGTATCGCCCATGCTCCCGAA
CACGGGCGCGGCATCCTGGAGCTCATGCGGCGGGCGGAGGAGGCGATGTACGCGGCCAAGGGGACCCACACCGGCCAGCG
TGTCTACGACCCTGCCTGCCAGCTCGGCAACCGTGCCCAGCTGGGGCTGCGGGCCGACCTGCGGGAGGCGCTGGACGGCG
GCCAGATCGAACTCCGCTACCAGCCCAAGGCCGAAATGCGCAGCGGCCGGATCAGGGGTGTCGAGGCGCTGGTGCGATGG
CGCCATCCCACCGGCGGGCTCCGTCCGCCGAACATGTTCCTGCCCGAGATGGAACGCGCCGGCCTGATGGGGCGCCTGAC
CCAGCAGGTCCTCGACATCGCCCTCGCCGACTGCGCCCGCTGGCACGCGGCCGGCGCCGCGCTGGCCGTGTCGGTGAACG
TGCCCGCCTCGGTCATCGTCGACCGCGGATTCGTGGACCTGGTGCGCGGTGCGCTGGAGCGCCACGGCCTGCCCGCGTCG
GCGCTGGTCGTCGAAGTCACCGAGGACGGGCTCATCACGGTCCTGGAGCAGGCACAGCGGACCCTCTCCGGCCTGCGTGA
CCACGGTGTGCGGGTCAGCCTCGACGACTACGGCACAGGCCTGTGCTCGCTCGCCTACCTGCGGGAGCTCCCCGCGGACG
AGGTGAAGCTCGACCAGCGGTTCCTGCGCGACATCGACCGCGACTCCTCGGCGGCCGAGATCGTCCGGTCCACGGTTTCC
CTCGCGCACGCGCTCCGGCTGCGCATCGTCGCCGAGGGCGTCGAGACGTCGCGCTCGTGGGCGTCGCTTGCGGCCTGGCA
GTGCGACGAGGTCCAGGGCTACTTCGTCTCCCGCCCGCTGGCGGGGGAGCGGGTGCTGAGCTGGCTGCGCGAATGGGGCG
ACCGGCTCCGGTGGCTGCCCTCCGGGGGGGAGCCTGCGCCGACGGGTCCGATCAGGGTCACCACCGCCTCGCGTGGCGCC
CGAGTGCACTCGGTGGCTACCGCCGCGAACGCCCAGCTCTCCTCGCCCGCAGCAGGAGCGGCGTCCGCCGCGCCGGTCGC
GACGGCGTCGATGATGACTTCGGGTTCGGCGTGCGGCGCCGCGGAGCCGCCCACGGCGGGCAAACCCTCGCTCGCCGTGC
CGTCCAGTCGCCCGGGCCTGCGGTCGATGGGATTCCGCATGTCGCAGCATGCTGAGGCGGGAAGCCGGCGGCCGTCCGGT
CAGCCTGCCCATGATGGGTGGGGAGCCTGA

Upstream 100 bases:

>100_bases
CGGACGGTGCAGGTTCAACTTCGGGGGCAAATCGTATGGTCAGGCAAGACCGTTCTCTGATCGGTTCGGCGGGTGTGGGC
CGATGGTGACGTCATTGCAC

Downstream 100 bases:

>100_bases
CAGGCTAGGCCTGCTGGGTCCGGGCCCCGGTTCGGCGGGGGGCCGCGACGCCCAGGAGGACAGCGAGCAGACGGGTTGGT
GGGTCGAGGGCGGCCTCGAT

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 729; Mature: 728

Protein sequence:

>729_residues
MSRAVRRLTTPVARRCQESPGSTAYSGSAVRGGAAARSSAVATAGGGKTARAQATVAHAGGETSDAPMTSPAMAHSPTTG
GSPTFPELEVSSAGRSSGGDQHGRNRPWGGRQRAGGRVDETTTSGRRPGVLASASVVLLVGVVSWWAAIKVLAPSGAITT
SLTVAAVACLPLSGLGDRMVAAVRRRWYGSDDLTGLPGRRHFVATASRWLGGGHRARGSVSAALILIDLDRLRDINGTLG
HEHGDHMLATVGARLRSVLRPADLLARVDGDEFAVLLRDVDLAGAEAVARRIREALRIPVRLDDLRVQADVSVGIAHAPE
HGRGILELMRRAEEAMYAAKGTHTGQRVYDPACQLGNRAQLGLRADLREALDGGQIELRYQPKAEMRSGRIRGVEALVRW
RHPTGGLRPPNMFLPEMERAGLMGRLTQQVLDIALADCARWHAAGAALAVSVNVPASVIVDRGFVDLVRGALERHGLPAS
ALVVEVTEDGLITVLEQAQRTLSGLRDHGVRVSLDDYGTGLCSLAYLRELPADEVKLDQRFLRDIDRDSSAAEIVRSTVS
LAHALRLRIVAEGVETSRSWASLAAWQCDEVQGYFVSRPLAGERVLSWLREWGDRLRWLPSGGEPAPTGPIRVTTASRGA
RVHSVATAANAQLSSPAAGAASAAPVATASMMTSGSACGAAEPPTAGKPSLAVPSSRPGLRSMGFRMSQHAEAGSRRPSG
QPAHDGWGA

Sequences:

>Translated_729_residues
MSRAVRRLTTPVARRCQESPGSTAYSGSAVRGGAAARSSAVATAGGGKTARAQATVAHAGGETSDAPMTSPAMAHSPTTG
GSPTFPELEVSSAGRSSGGDQHGRNRPWGGRQRAGGRVDETTTSGRRPGVLASASVVLLVGVVSWWAAIKVLAPSGAITT
SLTVAAVACLPLSGLGDRMVAAVRRRWYGSDDLTGLPGRRHFVATASRWLGGGHRARGSVSAALILIDLDRLRDINGTLG
HEHGDHMLATVGARLRSVLRPADLLARVDGDEFAVLLRDVDLAGAEAVARRIREALRIPVRLDDLRVQADVSVGIAHAPE
HGRGILELMRRAEEAMYAAKGTHTGQRVYDPACQLGNRAQLGLRADLREALDGGQIELRYQPKAEMRSGRIRGVEALVRW
RHPTGGLRPPNMFLPEMERAGLMGRLTQQVLDIALADCARWHAAGAALAVSVNVPASVIVDRGFVDLVRGALERHGLPAS
ALVVEVTEDGLITVLEQAQRTLSGLRDHGVRVSLDDYGTGLCSLAYLRELPADEVKLDQRFLRDIDRDSSAAEIVRSTVS
LAHALRLRIVAEGVETSRSWASLAAWQCDEVQGYFVSRPLAGERVLSWLREWGDRLRWLPSGGEPAPTGPIRVTTASRGA
RVHSVATAANAQLSSPAAGAASAAPVATASMMTSGSACGAAEPPTAGKPSLAVPSSRPGLRSMGFRMSQHAEAGSRRPSG
QPAHDGWGA
>Mature_728_residues
SRAVRRLTTPVARRCQESPGSTAYSGSAVRGGAAARSSAVATAGGGKTARAQATVAHAGGETSDAPMTSPAMAHSPTTGG
SPTFPELEVSSAGRSSGGDQHGRNRPWGGRQRAGGRVDETTTSGRRPGVLASASVVLLVGVVSWWAAIKVLAPSGAITTS
LTVAAVACLPLSGLGDRMVAAVRRRWYGSDDLTGLPGRRHFVATASRWLGGGHRARGSVSAALILIDLDRLRDINGTLGH
EHGDHMLATVGARLRSVLRPADLLARVDGDEFAVLLRDVDLAGAEAVARRIREALRIPVRLDDLRVQADVSVGIAHAPEH
GRGILELMRRAEEAMYAAKGTHTGQRVYDPACQLGNRAQLGLRADLREALDGGQIELRYQPKAEMRSGRIRGVEALVRWR
HPTGGLRPPNMFLPEMERAGLMGRLTQQVLDIALADCARWHAAGAALAVSVNVPASVIVDRGFVDLVRGALERHGLPASA
LVVEVTEDGLITVLEQAQRTLSGLRDHGVRVSLDDYGTGLCSLAYLRELPADEVKLDQRFLRDIDRDSSAAEIVRSTVSL
AHALRLRIVAEGVETSRSWASLAAWQCDEVQGYFVSRPLAGERVLSWLREWGDRLRWLPSGGEPAPTGPIRVTTASRGAR
VHSVATAANAQLSSPAAGAASAAPVATASMMTSGSACGAAEPPTAGKPSLAVPSSRPGLRSMGFRMSQHAEAGSRRPSGQ
PAHDGWGA

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=428, Percent_Identity=34.5794392523364, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI87081921, Length=421, Percent_Identity=30.6413301662708, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI226510982, Length=394, Percent_Identity=30.7106598984772, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081845, Length=243, Percent_Identity=35.3909465020576, Blast_Score=137, Evalue=4e-33,
Organism=Escherichia coli, GI1786507, Length=245, Percent_Identity=32.2448979591837, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1790496, Length=245, Percent_Identity=27.7551020408163, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1787055, Length=239, Percent_Identity=31.3807531380753, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788502, Length=250, Percent_Identity=28.8, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI87081743, Length=242, Percent_Identity=28.9256198347107, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082096, Length=241, Percent_Identity=31.5352697095436, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1788849, Length=303, Percent_Identity=30.6930693069307, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI87081980, Length=279, Percent_Identity=29.0322580645161, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1787262, Length=223, Percent_Identity=29.5964125560538, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788381, Length=352, Percent_Identity=26.7045454545455, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1786584, Length=153, Percent_Identity=30.718954248366, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI87081881, Length=151, Percent_Identity=35.0993377483444, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788085, Length=155, Percent_Identity=27.741935483871, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081977, Length=152, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI145693134, Length=173, Percent_Identity=28.9017341040462, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 76820; Mature: 76689

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAVRRLTTPVARRCQESPGSTAYSGSAVRGGAAARSSAVATAGGGKTARAQATVAHAG
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCEEECCCCCCCHHHEEEEECC
GETSDAPMTSPAMAHSPTTGGSPTFPELEVSSAGRSSGGDQHGRNRPWGGRQRAGGRVDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TTTSGRRPGVLASASVVLLVGVVSWWAAIKVLAPSGAITTSLTVAAVACLPLSGLGDRMV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
AAVRRRWYGSDDLTGLPGRRHFVATASRWLGGGHRARGSVSAALILIDLDRLRDINGTLG
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHCCCCCCC
HEHGDHMLATVGARLRSVLRPADLLARVDGDEFAVLLRDVDLAGAEAVARRIREALRIPV
CCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
RLDDLRVQADVSVGIAHAPEHGRGILELMRRAEEAMYAAKGTHTGQRVYDPACQLGNRAQ
EEECEEEEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC
LGLRADLREALDGGQIELRYQPKAEMRSGRIRGVEALVRWRHPTGGLRPPNMFLPEMERA
CCHHHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
GLMGRLTQQVLDIALADCARWHAAGAALAVSVNVPASVIVDRGFVDLVRGALERHGLPAS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHCCCCHH
ALVVEVTEDGLITVLEQAQRTLSGLRDHGVRVSLDDYGTGLCSLAYLRELPADEVKLDQR
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
FLRDIDRDSSAAEIVRSTVSLAHALRLRIVAEGVETSRSWASLAAWQCDEVQGYFVSRPL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCC
AGERVLSWLREWGDRLRWLPSGGEPAPTGPIRVTTASRGARVHSVATAANAQLSSPAAGA
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCC
ASAAPVATASMMTSGSACGAAEPPTAGKPSLAVPSSRPGLRSMGFRMSQHAEAGSRRPSG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCCCCC
QPAHDGWGA
CCCCCCCCC
>Mature Secondary Structure 
SRAVRRLTTPVARRCQESPGSTAYSGSAVRGGAAARSSAVATAGGGKTARAQATVAHAG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCEEECCCCCCCHHHEEEEECC
GETSDAPMTSPAMAHSPTTGGSPTFPELEVSSAGRSSGGDQHGRNRPWGGRQRAGGRVDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TTTSGRRPGVLASASVVLLVGVVSWWAAIKVLAPSGAITTSLTVAAVACLPLSGLGDRMV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
AAVRRRWYGSDDLTGLPGRRHFVATASRWLGGGHRARGSVSAALILIDLDRLRDINGTLG
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHCCCCCCC
HEHGDHMLATVGARLRSVLRPADLLARVDGDEFAVLLRDVDLAGAEAVARRIREALRIPV
CCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
RLDDLRVQADVSVGIAHAPEHGRGILELMRRAEEAMYAAKGTHTGQRVYDPACQLGNRAQ
EEECEEEEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC
LGLRADLREALDGGQIELRYQPKAEMRSGRIRGVEALVRWRHPTGGLRPPNMFLPEMERA
CCHHHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
GLMGRLTQQVLDIALADCARWHAAGAALAVSVNVPASVIVDRGFVDLVRGALERHGLPAS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHCCCCHH
ALVVEVTEDGLITVLEQAQRTLSGLRDHGVRVSLDDYGTGLCSLAYLRELPADEVKLDQR
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
FLRDIDRDSSAAEIVRSTVSLAHALRLRIVAEGVETSRSWASLAAWQCDEVQGYFVSRPL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCC
AGERVLSWLREWGDRLRWLPSGGEPAPTGPIRVTTASRGARVHSVATAANAQLSSPAAGA
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCC
ASAAPVATASMMTSGSACGAAEPPTAGKPSLAVPSSRPGLRSMGFRMSQHAEAGSRRPSG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCCCCC
QPAHDGWGA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]