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The map label for this gene is livF [H]

Identifier: 158313876

GI number: 158313876

Start: 2453734

End: 2454900

Strand: Direct

Name: livF [H]

Synonym: Franean1_2041

Alternate gene names: 158313876

Gene position: 2453734-2454900 (Clockwise)

Preceding gene: 158313875

Following gene: 158313878

Centisome position: 27.32

GC content: 73.61

Gene sequence:

>1167_bases
GTGACACCGGACGGGAACCCCCTCGACGGATCGCCACTCGAGAACATCGCGCCACTCGAGAACATCGCGCCACTCGAGAA
CATCGCGCCGCTGGAGAACATCTCGCCGGTCGACAGCACGCTCCCGACCGGGAGCACGCCGCCGACCGGGAGCACGCCGC
CGACCGGGAGTGCCTCGCAGGTCGGGAGTGCGCCGCAGGTCGGGAGCGTCTCGGCGTTCAGGAGCACGATTCCGGCCGGG
ACGTTGGTCGACCTGACCGTCCCCGAGCGACCGCTGTTGGACGTGCGCGACGCCGAGGTGGCCTACGGAGCCGTCACCGC
GCTGCGGGGGATCTCGCTGCGGGTGGACCGGGGCGAGGTGGTGGCCCTGCTCGGCGCGAACGGAGCCGGGAAGACCACCA
CCCTGCGGATGATCTCCGGACTCCTCCCGCCCGCTCGCGGCTCGGTCTGGTTCGACGGCGCCCGCCTGGCTGGCACCGGC
AGCGGTACCGGGCTCGGTGGCACTGGCACCGACGGCGGTACCAGTGGGCACGGCGATACCAGCGGGCACGGCGGTGCCGG
TGCCTGGTCCGACGGCACGCGGGACTCACCAGGGCTGCCGGTGCACCGGGTAGCCGCGCTCGGCATCAGCCACGTGCCCG
AGGGACGGCGGATCTTCCCGGCGATGACGGTGGCCGAGAACCTCGCGATGGGCGCCTACACCGACCGCCACCGGGCCTGG
AGCCGTGCCGGCCGCGACGCCCGCCGAGAAGCCCGCCGGGACGTCCGCCGTGGCCTCGACCGCGTGCACGCGCTGTTCCC
ACGCCTCGCCGAGCGGGACCGCCAGCCCGCGGGCACGCTCTCCGGCGGGGAGCAGCAGATGCTGGCGATCGGGCGGGCAC
TGATGGCCCGGCCCCGGCTGGTCCTGCTGGACGAGCCCTCGCTCGGGCTGGCCCCGAAACTGGTCGCGACGATCTTCGAA
GTGATCGAGGAGATCAACGCGGACGGGGTGACCGTCCTGCTGGTGGAGCAGAACGCGGCGGCGGCGCTGCGGATCGCGCA
CCGGGGCTACGTCCTGGACACCGGCCAGGTAGCACTCGCGGGCAGTGCTGACGAGCTGGCCCGCGACCCCCGGGTGCGCG
ACGCCTACCTGGGCAGCCCGAGCGATTCCGACGCCGTGGCACCCTAG

Upstream 100 bases:

>100_bases
TCGGCCGGGTGATCGCCGCGGGACGTCCCGACGAGGTTCGGGCCGACCCCGCCGTCGTCGAGGCCTACCTGGGCGAACCG
GACGAGAGGCGGGACGGGCC

Downstream 100 bases:

>100_bases
ATTCCGACTCCGTGGCACCGAAGTGGCACCGGTGCCGGGGATGTGGCTCGCGGGGCCTGTGGCCGGCGCTTTGGCGAATG
CCCGGGGTGGACTTTGGTGC

Product: ABC transporter-like protein

Products: ADP; phosphate; L-leucine [Cytoplasm]; ADP; L-valine [Cytoplasm]; L-iso-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein F [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTPDGNPLDGSPLENIAPLENIAPLENIAPLENISPVDSTLPTGSTPPTGSTPPTGSASQVGSAPQVGSVSAFRSTIPAG
TLVDLTVPERPLLDVRDAEVAYGAVTALRGISLRVDRGEVVALLGANGAGKTTTLRMISGLLPPARGSVWFDGARLAGTG
SGTGLGGTGTDGGTSGHGDTSGHGGAGAWSDGTRDSPGLPVHRVAALGISHVPEGRRIFPAMTVAENLAMGAYTDRHRAW
SRAGRDARREARRDVRRGLDRVHALFPRLAERDRQPAGTLSGGEQQMLAIGRALMARPRLVLLDEPSLGLAPKLVATIFE
VIEEINADGVTVLLVEQNAAAALRIAHRGYVLDTGQVALAGSADELARDPRVRDAYLGSPSDSDAVAP

Sequences:

>Translated_388_residues
MTPDGNPLDGSPLENIAPLENIAPLENIAPLENISPVDSTLPTGSTPPTGSTPPTGSASQVGSAPQVGSVSAFRSTIPAG
TLVDLTVPERPLLDVRDAEVAYGAVTALRGISLRVDRGEVVALLGANGAGKTTTLRMISGLLPPARGSVWFDGARLAGTG
SGTGLGGTGTDGGTSGHGDTSGHGGAGAWSDGTRDSPGLPVHRVAALGISHVPEGRRIFPAMTVAENLAMGAYTDRHRAW
SRAGRDARREARRDVRRGLDRVHALFPRLAERDRQPAGTLSGGEQQMLAIGRALMARPRLVLLDEPSLGLAPKLVATIFE
VIEEINADGVTVLLVEQNAAAALRIAHRGYVLDTGQVALAGSADELARDPRVRDAYLGSPSDSDAVAP
>Mature_387_residues
TPDGNPLDGSPLENIAPLENIAPLENIAPLENISPVDSTLPTGSTPPTGSTPPTGSASQVGSAPQVGSVSAFRSTIPAGT
LVDLTVPERPLLDVRDAEVAYGAVTALRGISLRVDRGEVVALLGANGAGKTTTLRMISGLLPPARGSVWFDGARLAGTGS
GTGLGGTGTDGGTSGHGDTSGHGGAGAWSDGTRDSPGLPVHRVAALGISHVPEGRRIFPAMTVAENLAMGAYTDRHRAWS
RAGRDARREARRDVRRGLDRVHALFPRLAERDRQPAGTLSGGEQQMLAIGRALMARPRLVLLDEPSLGLAPKLVATIFEV
IEEINADGVTVLLVEQNAAAALRIAHRGYVLDTGQVALAGSADELARDPRVRDAYLGSPSDSDAVAP

Specific function: Component of the leucine-specific transport system [H]

COG id: COG0410

COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI87082268, Length=290, Percent_Identity=41.7241379310345, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1789864, Length=293, Percent_Identity=27.3037542662116, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789593, Length=281, Percent_Identity=29.8932384341637, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081791, Length=292, Percent_Identity=28.0821917808219, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787792, Length=296, Percent_Identity=27.3648648648649, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789672, Length=287, Percent_Identity=25.4355400696864, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787029, Length=279, Percent_Identity=25.8064516129032, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788897, Length=257, Percent_Identity=29.9610894941634, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788225, Length=278, Percent_Identity=28.0575539568345, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790467, Length=292, Percent_Identity=27.7397260273973, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787089, Length=265, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790190, Length=251, Percent_Identity=26.2948207171315, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786872, Length=280, Percent_Identity=24.6428571428571, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790544, Length=283, Percent_Identity=26.1484098939929, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994943, Length=276, Percent_Identity=23.1884057971014, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48995001, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789991, Length=251, Percent_Identity=23.9043824701195, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 40003; Mature: 39872

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00101 HEXAPEP_TRANSFERASES ; PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDGNPLDGSPLENIAPLENIAPLENIAPLENISPVDSTLPTGSTPPTGSTPPTGSASQ
CCCCCCCCCCCCCHHCCCHHHCCCHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCHHH
VGSAPQVGSVSAFRSTIPAGTLVDLTVPERPLLDVRDAEVAYGAVTALRGISLRVDRGEV
CCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCE
VALLGANGAGKTTTLRMISGLLPPARGSVWFDGARLAGTGSGTGLGGTGTDGGTSGHGDT
EEEEECCCCCCHHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCCCCCCCCCCCCCCC
SGHGGAGAWSDGTRDSPGLPVHRVAALGISHVPEGRRIFPAMTVAENLAMGAYTDRHRAW
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHH
SRAGRDARREARRDVRRGLDRVHALFPRLAERDRQPAGTLSGGEQQMLAIGRALMARPRL
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCE
VLLDEPSLGLAPKLVATIFEVIEEINADGVTVLLVEQNAAAALRIAHRGYVLDTGQVALA
EEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHCCEEEECCCEEEE
GSADELARDPRVRDAYLGSPSDSDAVAP
CCHHHHHCCCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TPDGNPLDGSPLENIAPLENIAPLENIAPLENISPVDSTLPTGSTPPTGSTPPTGSASQ
CCCCCCCCCCCCHHCCCHHHCCCHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCHHH
VGSAPQVGSVSAFRSTIPAGTLVDLTVPERPLLDVRDAEVAYGAVTALRGISLRVDRGEV
CCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCE
VALLGANGAGKTTTLRMISGLLPPARGSVWFDGARLAGTGSGTGLGGTGTDGGTSGHGDT
EEEEECCCCCCHHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCCCCCCCCCCCCCCC
SGHGGAGAWSDGTRDSPGLPVHRVAALGISHVPEGRRIFPAMTVAENLAMGAYTDRHRAW
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHH
SRAGRDARREARRDVRRGLDRVHALFPRLAERDRQPAGTLSGGEQQMLAIGRALMARPRL
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCE
VLLDEPSLGLAPKLVATIFEVIEEINADGVTVLLVEQNAAAALRIAHRGYVLDTGQVALA
EEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHCCEEEECCCEEEE
GSADELARDPRVRDAYLGSPSDSDAVAP
CCHHHHHCCCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-leucine [Periplasm]; H2O; ATP; L-valine [Periplasm]; L-iso-leucine [Periplasm] [C]

Specific reaction: ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]