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The map label for this gene is ddn [H]

Identifier: 158313866

GI number: 158313866

Start: 2441265

End: 2441642

Strand: Direct

Name: ddn [H]

Synonym: Franean1_2031

Alternate gene names: 158313866

Gene position: 2441265-2441642 (Clockwise)

Preceding gene: 158313860

Following gene: 158313867

Centisome position: 27.18

GC content: 73.02

Gene sequence:

>378_bases
ATGAGACTGACCCGCGGCCGGCTCGGATGGCGGGCCGGCGGCATGCCCGTCCTGGAGCTCACCACGACCGGGCGGCGCAG
CGGCCGGGCACACACCGTCATGCTCACCTCCCCGCTGCGGGATGGCGATGCCATCGTCCTGGTGGCGTCGCGGGCCGGCG
ACGACCGACATCCCGACTGGTACCTGAACATCTGCGCCACCGCGGACGTCGAGGTCCGGGTCAGGGGCGGGTCGTGGCGG
CCGATGCGCGCGCGGGTGGCGACACCGCCGGAACGGGAGCGGCTGTGGCCCCGCGTGGTGGCGGACAGCCGCTGGTACAA
GAGCTATCAGGCCAAGTCGAAGCGGGTGATCCCGCTCGTCCTGCTCGAGCCGCGCTGA

Upstream 100 bases:

>100_bases
CGGGACGGGTCGGCGCGCGGCGGAGCAGCAGGGGATCGGGGGCGAAGCCATGGTGAGCGACCGCAGTCTGAAGACCTTGA
ACGTCACGCACAGGCGCCTG

Downstream 100 bases:

>100_bases
TGCGGCCCGGCGCCCGGGACGCGGGCTGGAGCCTGGCCGACGTGCCGGACCAGCGGGGACGGACCGCCGTCGTCACCGGT
GCGAACAGCGGCATCGGCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MRLTRGRLGWRAGGMPVLELTTTGRRSGRAHTVMLTSPLRDGDAIVLVASRAGDDRHPDWYLNICATADVEVRVRGGSWR
PMRARVATPPERERLWPRVVADSRWYKSYQAKSKRVIPLVLLEPR

Sequences:

>Translated_125_residues
MRLTRGRLGWRAGGMPVLELTTTGRRSGRAHTVMLTSPLRDGDAIVLVASRAGDDRHPDWYLNICATADVEVRVRGGSWR
PMRARVATPPERERLWPRVVADSRWYKSYQAKSKRVIPLVLLEPR
>Mature_125_residues
MRLTRGRLGWRAGGMPVLELTTTGRRSGRAHTVMLTSPLRDGDAIVLVASRAGDDRHPDWYLNICATADVEVRVRGGSWR
PMRARVATPPERERLWPRVVADSRWYKSYQAKSKRVIPLVLLEPR

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 14231; Mature: 14231

Theoretical pI: Translated: 11.91; Mature: 11.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTRGRLGWRAGGMPVLELTTTGRRSGRAHTVMLTSPLRDGDAIVLVASRAGDDRHPDW
CCCCCCCCCEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCE
YLNICATADVEVRVRGGSWRPMRARVATPPERERLWPRVVADSRWYKSYQAKSKRVIPLV
EEEEEEECCEEEEEECCCCCCEEEEECCCCHHHCCCCEEECCCCHHHHHHCCCCCEEEEE
LLEPR
EECCC
>Mature Secondary Structure
MRLTRGRLGWRAGGMPVLELTTTGRRSGRAHTVMLTSPLRDGDAIVLVASRAGDDRHPDW
CCCCCCCCCEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCE
YLNICATADVEVRVRGGSWRPMRARVATPPERERLWPRVVADSRWYKSYQAKSKRVIPLV
EEEEEEECCEEEEEECCCCCCEEEEECCCCHHHCCCCEEECCCCHHHHHHCCCCCEEEEE
LLEPR
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]