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The map label for this gene is trpC

Identifier: 158313766

GI number: 158313766

Start: 2313797

End: 2314603

Strand: Direct

Name: trpC

Synonym: Franean1_1931

Alternate gene names: 158313766

Gene position: 2313797-2314603 (Clockwise)

Preceding gene: 158313764

Following gene: 158313767

Centisome position: 25.76

GC content: 72.0

Gene sequence:

>807_bases
ATGAACGCTCTCGAGGAGATCCTCGACGGGGTCAGAGCAGATCTGGCCGTCCGTGAGCGGGAAACGTCCCTGGCAGCTCT
GAAACAACGTGTTGAGCGTGTACCCGATCCCCGGGACGCGCTGGCGGTGCTGCGCGCACCGCGGGTTTCGGTGATCGCGG
AGATCAAGCGCCGCTCGCCGTCCAGGGGTGCGCTCGCGACGATCGCCGATCCGGCGGCGCTCGCCTCGCTCTACGAGCAG
GCGGGCGCCGCGGCGGTCAGCGTCCTCACCGAGCAGCGGCGGTTCGGCGGCTCGCTGGCCGATCTGGACGCCGTCCGGGT
GGCCGTCGACATCCCCGTCCTGCGCAAGGACTTCGTGATCTCGCCGTACCAGGTCCTCGAGGCGCGGGCGCATGGCGCCG
ACATGGTCCTGCTGATCGTGGCCGCACTCGATCAGCCGAGGCTGATCGGGCTGCTCGAGCGGGTCGAGTCGCTGGGCATG
ACCGCGCTGGTCGAGGTGCACGACGAGACCGAGATGCTGCGGGCGCTCGACGCGGGCGCCCGGCTGGTCGGGGTCAACGC
CCGCAACCTGCGCACCCTCGAGGTGGACAGGGAGACCTTCGCCCGGCTCGCGCCGATGGTCCCGCAGGGGGTGCTGAAGG
TCGCCGAGTCCGGCGTGCGCGGCCCGCGCGACCTGCTCCAGTACGCGGGTGCCGGGGCGGACGCGGTGCTGGTCGGGGAG
GCCGCCGTGACCGGCGGCGACCCGCGCCAGTTCGTCGCCGATCTCGTGACCGCTGGAACGCATCCCGCCACCCGTATCGC
GCACTGA

Upstream 100 bases:

>100_bases
CGTGACGGCTCGGCGTCGCGGGTGGGGGCGACGGGCCTCGGGCTCGAGACTGCCCTACCATCGGCGGCATGGCAGCCGCG
ACTGGCGCGAGCGCGGGGCG

Downstream 100 bases:

>100_bases
CCCGCCGACCGCTCGGGCGCTGCGGCAGGCGGTCGGCCGAGCGGTCGCCGGCCGGCCCCGCACGGGTGCTCTGTGTTCGG
AGCGTCTCCGGGCGGGGCCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNALEEILDGVRADLAVRERETSLAALKQRVERVPDPRDALAVLRAPRVSVIAEIKRRSPSRGALATIADPAALASLYEQ
AGAAAVSVLTEQRRFGGSLADLDAVRVAVDIPVLRKDFVISPYQVLEARAHGADMVLLIVAALDQPRLIGLLERVESLGM
TALVEVHDETEMLRALDAGARLVGVNARNLRTLEVDRETFARLAPMVPQGVLKVAESGVRGPRDLLQYAGAGADAVLVGE
AAVTGGDPRQFVADLVTAGTHPATRIAH

Sequences:

>Translated_268_residues
MNALEEILDGVRADLAVRERETSLAALKQRVERVPDPRDALAVLRAPRVSVIAEIKRRSPSRGALATIADPAALASLYEQ
AGAAAVSVLTEQRRFGGSLADLDAVRVAVDIPVLRKDFVISPYQVLEARAHGADMVLLIVAALDQPRLIGLLERVESLGM
TALVEVHDETEMLRALDAGARLVGVNARNLRTLEVDRETFARLAPMVPQGVLKVAESGVRGPRDLLQYAGAGADAVLVGE
AAVTGGDPRQFVADLVTAGTHPATRIAH
>Mature_268_residues
MNALEEILDGVRADLAVRERETSLAALKQRVERVPDPRDALAVLRAPRVSVIAEIKRRSPSRGALATIADPAALASLYEQ
AGAAAVSVLTEQRRFGGSLADLDAVRVAVDIPVLRKDFVISPYQVLEARAHGADMVLLIVAALDQPRLIGLLERVESLGM
TALVEVHDETEMLRALDAGARLVGVNARNLRTLEVDRETFARLAPMVPQGVLKVAESGVRGPRDLLQYAGAGADAVLVGE
AAVTGGDPRQFVADLVTAGTHPATRIAH

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=34.6613545816733, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=232, Percent_Identity=43.1034482758621, Blast_Score=166, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_FRASN (A8LGR8)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506274.1
- ProteinModelPortal:   A8LGR8
- SMR:   A8LGR8
- GeneID:   5670332
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1931
- HOGENOM:   HBG540956
- OMA:   VICEVKR
- ProtClustDB:   PRK00278
- BioCyc:   FSP1855:FRANEAN1_1931-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28516; Mature: 28516

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALEEILDGVRADLAVRERETSLAALKQRVERVPDPRDALAVLRAPRVSVIAEIKRRSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCC
SRGALATIADPAALASLYEQAGAAAVSVLTEQRRFGGSLADLDAVRVAVDIPVLRKDFVI
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCC
SPYQVLEARAHGADMVLLIVAALDQPRLIGLLERVESLGMTALVEVHDETEMLRALDAGA
CHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCC
RLVGVNARNLRTLEVDRETFARLAPMVPQGVLKVAESGVRGPRDLLQYAGAGADAVLVGE
EEEECCCCCEEEEEECHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECC
AAVTGGDPRQFVADLVTAGTHPATRIAH
HHCCCCCHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MNALEEILDGVRADLAVRERETSLAALKQRVERVPDPRDALAVLRAPRVSVIAEIKRRSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCC
SRGALATIADPAALASLYEQAGAAAVSVLTEQRRFGGSLADLDAVRVAVDIPVLRKDFVI
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCC
SPYQVLEARAHGADMVLLIVAALDQPRLIGLLERVESLGMTALVEVHDETEMLRALDAGA
CHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCC
RLVGVNARNLRTLEVDRETFARLAPMVPQGVLKVAESGVRGPRDLLQYAGAGADAVLVGE
EEEECCCCCEEEEEECHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECC
AAVTGGDPRQFVADLVTAGTHPATRIAH
HHCCCCCHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA