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The map label for this gene is hisD [H]

Identifier: 158313751

GI number: 158313751

Start: 2297016

End: 2298311

Strand: Direct

Name: hisD [H]

Synonym: Franean1_1916

Alternate gene names: 158313751

Gene position: 2297016-2298311 (Clockwise)

Preceding gene: 158313749

Following gene: 158313752

Centisome position: 25.57

GC content: 76.31

Gene sequence:

>1296_bases
GTGCTCAGAAGGCTCGATCTGCGCTCCGCGCAGCCCACCATGTCGGACGTCCGTCGGCTCTTCCCGCGGGCGGCCGTGGA
CGTCGACGTCGCGATGGACGCGGTCCGCCCCGTCTGCGACGACGTGCGCGACCGTGGTGACGCGGCCGTCCTCGACGCCG
CGGAGCGCTTCGACCGGGTCCGCCCGGCCGAGCTGCGGGTACCGGCCGACGCGCTCGCGAGCGCGCTCGCGGCCCTCGGC
CCGGCGGTCCGTGACGCGCTGACCGAGGCGATCCGCCGCGCGCGGCTGGTGCACCGGGCCCAGCTCCGGGAGCCGGTGGT
CGTCGAGGTGGCCCCCGGCACGAAGGTCACCGAGCGCTGGATCCCGGTCGGCCGGGTCGGCCTCTACGTGCCGGGCGGGC
GGGTCGCCTACCCCAGCAGCGTGGTCATGAACGTCGTCCCCGCGCAGGAGGCCGGCGTCGCCTCGCTGGCGGTGACCTCG
CCGCCCCAGGTCGACAACGGCGGCCTGCCGCATCCGGTCGTACTGGCCGCCTGCGCCCTGCTCGGGGTCGACGAGGTCTA
CGCGGCCGGCGGCGCCCAGGCCGTCGCGATGTTCGCGCACGGCACCGAGAGCTGCCCGGCCGTCGATGTCGTCACCGGCC
CCGGCAACGTCTACGTCACCGCGGCGAAGCGGCTGCTGCGCGGGCTGGTCGGCGTCGACGCCGAGGCGGGCCCGACCGAG
GTCGCCATTCTCGCCGACGGCTCGGCCCGCCCCGACTTCGTCGCCGCCGACCTGATCGCGCAGGCCGAGCACGACCCGAT
GGCCGCCTGCCTGCTGGTCACGACGTCGCCAGAGCTGGCCGACGCCGTCGACGTCGAGCTCGACAAGCAGGTCCCCGCCA
CCCGGCACCGGGAGCGGGTCACTGAGGCGCTGGCCGGCCAGGGCGCCGTGGCGATCGTCGCCGACGTCGACGCGGGTCTC
GCGGTCGTCGACGCCTGGGCCGCCGAGCACCTGGAGATCCACACCGCGGACGCGGCGGGTGTCGCCGCCCGGGTGCGCAA
CGCGGGCGCGATCTTCGTCGGCGCCTACGCGCCCGTGCCACTCGGGGACTACCTCGCCGGCTCGAACCACGTCCTGCCCA
CCGGCGGCACCGCGCGGCACTCCAGCGGCCTCGCCGTGTCCGCCTTCCAGCGCCAGGTCCATGTCGTCGAGTGCGGCCCC
GAGGCGCTCGCCGACGTCGCGCCCCGCATCGCCGCGCTCGGCGGAGCCGAGGACCTGATCGCCCACGTCGACGCGGTGGA
GGTACGGGCCCGATGA

Upstream 100 bases:

>100_bases
CCGGGTCCCGGTGCCACCGCGCCCCGCGCCGTATCACGGTGTGGTATTCCCAAAGAGTTCCACTGCTCGGACCGGCGGTC
GGGCCGATACGCTCGTGGGC

Downstream 100 bases:

>100_bases
CCGGGAACATCAGCGGAGCGGGTGACGGCGCCCCCTCGGGCGACAGCCCCGGCCTGGGCGACAGCCCCGGCCTGGGTGAC
GGCGCCGGCCTGGGTGACGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLRRLDLRSAQPTMSDVRRLFPRAAVDVDVAMDAVRPVCDDVRDRGDAAVLDAAERFDRVRPAELRVPADALASALAALG
PAVRDALTEAIRRARLVHRAQLREPVVVEVAPGTKVTERWIPVGRVGLYVPGGRVAYPSSVVMNVVPAQEAGVASLAVTS
PPQVDNGGLPHPVVLAACALLGVDEVYAAGGAQAVAMFAHGTESCPAVDVVTGPGNVYVTAAKRLLRGLVGVDAEAGPTE
VAILADGSARPDFVAADLIAQAEHDPMAACLLVTTSPELADAVDVELDKQVPATRHRERVTEALAGQGAVAIVADVDAGL
AVVDAWAAEHLEIHTADAAGVAARVRNAGAIFVGAYAPVPLGDYLAGSNHVLPTGGTARHSSGLAVSAFQRQVHVVECGP
EALADVAPRIAALGGAEDLIAHVDAVEVRAR

Sequences:

>Translated_431_residues
MLRRLDLRSAQPTMSDVRRLFPRAAVDVDVAMDAVRPVCDDVRDRGDAAVLDAAERFDRVRPAELRVPADALASALAALG
PAVRDALTEAIRRARLVHRAQLREPVVVEVAPGTKVTERWIPVGRVGLYVPGGRVAYPSSVVMNVVPAQEAGVASLAVTS
PPQVDNGGLPHPVVLAACALLGVDEVYAAGGAQAVAMFAHGTESCPAVDVVTGPGNVYVTAAKRLLRGLVGVDAEAGPTE
VAILADGSARPDFVAADLIAQAEHDPMAACLLVTTSPELADAVDVELDKQVPATRHRERVTEALAGQGAVAIVADVDAGL
AVVDAWAAEHLEIHTADAAGVAARVRNAGAIFVGAYAPVPLGDYLAGSNHVLPTGGTARHSSGLAVSAFQRQVHVVECGP
EALADVAPRIAALGGAEDLIAHVDAVEVRAR
>Mature_431_residues
MLRRLDLRSAQPTMSDVRRLFPRAAVDVDVAMDAVRPVCDDVRDRGDAAVLDAAERFDRVRPAELRVPADALASALAALG
PAVRDALTEAIRRARLVHRAQLREPVVVEVAPGTKVTERWIPVGRVGLYVPGGRVAYPSSVVMNVVPAQEAGVASLAVTS
PPQVDNGGLPHPVVLAACALLGVDEVYAAGGAQAVAMFAHGTESCPAVDVVTGPGNVYVTAAKRLLRGLVGVDAEAGPTE
VAILADGSARPDFVAADLIAQAEHDPMAACLLVTTSPELADAVDVELDKQVPATRHRERVTEALAGQGAVAIVADVDAGL
AVVDAWAAEHLEIHTADAAGVAARVRNAGAIFVGAYAPVPLGDYLAGSNHVLPTGGTARHSSGLAVSAFQRQVHVVECGP
EALADVAPRIAALGGAEDLIAHVDAVEVRAR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=421, Percent_Identity=35.3919239904988, Blast_Score=250, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319819, Length=409, Percent_Identity=35.6968215158924, Blast_Score=239, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44477; Mature: 44477

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRLDLRSAQPTMSDVRRLFPRAAVDVDVAMDAVRPVCDDVRDRGDAAVLDAAERFDRV
CCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
RPAELRVPADALASALAALGPAVRDALTEAIRRARLVHRAQLREPVVVEVAPGTKVTERW
CCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHC
IPVGRVGLYVPGGRVAYPSSVVMNVVPAQEAGVASLAVTSPPQVDNGGLPHPVVLAACAL
CCCCCEEEEECCCCEECCCHHHEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
LGVDEVYAAGGAQAVAMFAHGTESCPAVDVVTGPGNVYVTAAKRLLRGLVGVDAEAGPTE
HCHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCCCCE
VAILADGSARPDFVAADLIAQAEHDPMAACLLVTTSPELADAVDVELDKQVPATRHRERV
EEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHCCEECCCCCCHHHHHHH
TEALAGQGAVAIVADVDAGLAVVDAWAAEHLEIHTADAAGVAARVRNAGAIFVGAYAPVP
HHHHCCCCCEEEEEECCCCHHHHHHHHHHCEEEEECCHHHHHHHHCCCCEEEEECCCCCC
LGDYLAGSNHVLPTGGTARHSSGLAVSAFQRQVHVVECGPEALADVAPRIAALGGAEDLI
CHHHHCCCCEEECCCCCCCCCCCCEEEEHHCEEEEEECCHHHHHHHHHHHHHCCCHHHHH
AHVDAVEVRAR
HHHHHEEEECC
>Mature Secondary Structure
MLRRLDLRSAQPTMSDVRRLFPRAAVDVDVAMDAVRPVCDDVRDRGDAAVLDAAERFDRV
CCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
RPAELRVPADALASALAALGPAVRDALTEAIRRARLVHRAQLREPVVVEVAPGTKVTERW
CCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHC
IPVGRVGLYVPGGRVAYPSSVVMNVVPAQEAGVASLAVTSPPQVDNGGLPHPVVLAACAL
CCCCCEEEEECCCCEECCCHHHEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
LGVDEVYAAGGAQAVAMFAHGTESCPAVDVVTGPGNVYVTAAKRLLRGLVGVDAEAGPTE
HCHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCCCCE
VAILADGSARPDFVAADLIAQAEHDPMAACLLVTTSPELADAVDVELDKQVPATRHRERV
EEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHCCEECCCCCCHHHHHHH
TEALAGQGAVAIVADVDAGLAVVDAWAAEHLEIHTADAAGVAARVRNAGAIFVGAYAPVP
HHHHCCCCCEEEEEECCCCHHHHHHHHHHCEEEEECCHHHHHHHHCCCCEEEEECCCCCC
LGDYLAGSNHVLPTGGTARHSSGLAVSAFQRQVHVVECGPEALADVAPRIAALGGAEDLI
CHHHHCCCCEEECCCCCCCCCCCCEEEEHHCEEEEEECCHHHHHHHHHHHHHCCCHHHHH
AHVDAVEVRAR
HHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA