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The map label for this gene is hisC [H]

Identifier: 158313752

GI number: 158313752

Start: 2298308

End: 2299669

Strand: Direct

Name: hisC [H]

Synonym: Franean1_1917

Alternate gene names: 158313752

Gene position: 2298308-2299669 (Clockwise)

Preceding gene: 158313751

Following gene: 158313753

Centisome position: 25.59

GC content: 75.4

Gene sequence:

>1362_bases
ATGACCGGGAACATCAGCGGAGCGGGTGACGGCGCCCCCTCGGGCGACAGCCCCGGCCTGGGCGACAGCCCCGGCCTGGG
TGACGGCGCCGGCCTGGGTGACGGCGCAGGTCCCAGCGGGGTGCTCCCGGGGGCGCCGGCCGGCCAGGGCGCGCCCGTCG
GTGGCCGCGGGCGGCTGCGCTCCGCTGCGGCCACCCCGGCCGACCGTGCCCCGTGGCGGCCCGTCACCCTGGACGACCTG
CCCCTGCGTGACGACCTGCGGGGGATGTCGCCCTACGGCGCGCCCCAGATCGACGTCCCGGTGCGGCTGAACACCAACGA
GAACCCGCACCCGCCGTCCGCCGGGCTCGTGGACGCGCTCGGCAAGGCCGCGACCCTCGCCGCGACCGAGGCCAACCGCT
ATCCCGACCGGGAGGCCGAGGCTCTGCGCGCCGATCTGGCGTACTACCTGACCCCGGACGCCGGTTTCGGCGTGCACGCG
GCCCAGGTGTGGGCGGCCAACGGGTCGAACGAGATCCTCCAGCAGCTCTGCCAGGCGTTCGGCGGTCCGGGGCGGGTGGC
GGTGGGCTTCGAGCCGTCCTACTCGATGCACCGGCTGATCGCGCTGGCGACCGCCACCGGCTGGGTCGCCGAGTCCCGCG
CGGCGGACTTCACCCTCGACGCCGACCGGGTCACCGCCGCGATCCGCCGGTACCGCCCGGCGCTGCTGTTCCTGTGCTCG
CCGAACAACCCCACCGCCACCGCGCTCGGCGCGGAGGTCATCGCGGCCGCCTGCGACGCCATGGCCGAGGTCGGCTCGGG
TGTCGTCGTGGTCGACGAGGCCTACGGCGAGTTCCGCCGGGCCGGCGTCCCCAGCGCGCTCACCCTGCTGCCCGACCACC
CTCGGCTGGTCGTCACCCGGACGATGAGCAAGGCGTTCGCGTTGGCCGGCGCCAGGGTCGGCTACCTCGCGGCGCATCCG
GCGGTTGTCGACGCGCTGCAGCTCGTCCGCCTGCCCTACCACCTGTCGTCGTTCACCCAGGCGGTCGCGCGCACCGCGCT
CGCCCACGCCGACGAGCTGCTCGGCACAGTGGACGCGGTGAAGGCACAGCGCGACCTGCTCGTCCGGTCCCTGCCGGAGT
TCGGCTGCGTGACCGCTCCGAGCGACGCCAACTTCGTGCTGTTCGGCCACTTCACCGACCAGCGCGCCGTGTGGCAGGGC
CTGCTCGACGCCGGCGTGCTCGTCCGCGACGTCGGCCTCGACGGCTGGCTGCGGGTGACGGCCGGCCTGCCGAACGAGAC
AGAGTCCTTCCTCGACGCGCTGCGCCGGGTGCTGACCGCCCGCCCGGCCCTCCTGCGCGCCGCCGCGGAGATCAGCTCCT
GA

Upstream 100 bases:

>100_bases
GCGGCCCCGAGGCGCTCGCCGACGTCGCGCCCCGCATCGCCGCGCTCGGCGGAGCCGAGGACCTGATCGCCCACGTCGAC
GCGGTGGAGGTACGGGCCCG

Downstream 100 bases:

>100_bases
CCGACCGGGCCGGACCGACCCGACCCGACCCGAACATCCGGACCGACCCGAACATCCGGACCGGTACGACCGCCCGGACC
GACCAAACAGCCAGCCGGCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTGNISGAGDGAPSGDSPGLGDSPGLGDGAGLGDGAGPSGVLPGAPAGQGAPVGGRGRLRSAAATPADRAPWRPVTLDDL
PLRDDLRGMSPYGAPQIDVPVRLNTNENPHPPSAGLVDALGKAATLAATEANRYPDREAEALRADLAYYLTPDAGFGVHA
AQVWAANGSNEILQQLCQAFGGPGRVAVGFEPSYSMHRLIALATATGWVAESRAADFTLDADRVTAAIRRYRPALLFLCS
PNNPTATALGAEVIAAACDAMAEVGSGVVVVDEAYGEFRRAGVPSALTLLPDHPRLVVTRTMSKAFALAGARVGYLAAHP
AVVDALQLVRLPYHLSSFTQAVARTALAHADELLGTVDAVKAQRDLLVRSLPEFGCVTAPSDANFVLFGHFTDQRAVWQG
LLDAGVLVRDVGLDGWLRVTAGLPNETESFLDALRRVLTARPALLRAAAEISS

Sequences:

>Translated_453_residues
MTGNISGAGDGAPSGDSPGLGDSPGLGDGAGLGDGAGPSGVLPGAPAGQGAPVGGRGRLRSAAATPADRAPWRPVTLDDL
PLRDDLRGMSPYGAPQIDVPVRLNTNENPHPPSAGLVDALGKAATLAATEANRYPDREAEALRADLAYYLTPDAGFGVHA
AQVWAANGSNEILQQLCQAFGGPGRVAVGFEPSYSMHRLIALATATGWVAESRAADFTLDADRVTAAIRRYRPALLFLCS
PNNPTATALGAEVIAAACDAMAEVGSGVVVVDEAYGEFRRAGVPSALTLLPDHPRLVVTRTMSKAFALAGARVGYLAAHP
AVVDALQLVRLPYHLSSFTQAVARTALAHADELLGTVDAVKAQRDLLVRSLPEFGCVTAPSDANFVLFGHFTDQRAVWQG
LLDAGVLVRDVGLDGWLRVTAGLPNETESFLDALRRVLTARPALLRAAAEISS
>Mature_452_residues
TGNISGAGDGAPSGDSPGLGDSPGLGDGAGLGDGAGPSGVLPGAPAGQGAPVGGRGRLRSAAATPADRAPWRPVTLDDLP
LRDDLRGMSPYGAPQIDVPVRLNTNENPHPPSAGLVDALGKAATLAATEANRYPDREAEALRADLAYYLTPDAGFGVHAA
QVWAANGSNEILQQLCQAFGGPGRVAVGFEPSYSMHRLIALATATGWVAESRAADFTLDADRVTAAIRRYRPALLFLCSP
NNPTATALGAEVIAAACDAMAEVGSGVVVVDEAYGEFRRAGVPSALTLLPDHPRLVVTRTMSKAFALAGARVGYLAAHPA
VVDALQLVRLPYHLSSFTQAVARTALAHADELLGTVDAVKAQRDLLVRSLPEFGCVTAPSDANFVLFGHFTDQRAVWQGL
LDAGVLVRDVGLDGWLRVTAGLPNETESFLDALRRVLTARPALLRAAAEISS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=375, Percent_Identity=30.4, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322075, Length=386, Percent_Identity=24.6113989637306, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 46864; Mature: 46733

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNISGAGDGAPSGDSPGLGDSPGLGDGAGLGDGAGPSGVLPGAPAGQGAPVGGRGRLR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAAATPADRAPWRPVTLDDLPLRDDLRGMSPYGAPQIDVPVRLNTNENPHPPSAGLVDAL
HHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
GKAATLAATEANRYPDREAEALRADLAYYLTPDAGFGVHAAQVWAANGSNEILQQLCQAF
CCHHEEEEHHCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHH
GGPGRVAVGFEPSYSMHRLIALATATGWVAESRAADFTLDADRVTAAIRRYRPALLFLCS
CCCCEEEEECCCCHHHHHHHHHHHHHCHHHHCCCCCEEECHHHHHHHHHHCCCEEEEEEC
PNNPTATALGAEVIAAACDAMAEVGSGVVVVDEAYGEFRRAGVPSALTLLPDHPRLVVTR
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCCEEEECCCCCCEEEEH
TMSKAFALAGARVGYLAAHPAVVDALQLVRLPYHLSSFTQAVARTALAHADELLGTVDAV
HHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQRDLLVRSLPEFGCVTAPSDANFVLFGHFTDQRAVWQGLLDAGVLVRDVGLDGWLRVT
HHHHHHHHHHCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCEEEEE
AGLPNETESFLDALRRVLTARPALLRAAAEISS
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCC
>Mature Secondary Structure 
TGNISGAGDGAPSGDSPGLGDSPGLGDGAGLGDGAGPSGVLPGAPAGQGAPVGGRGRLR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAAATPADRAPWRPVTLDDLPLRDDLRGMSPYGAPQIDVPVRLNTNENPHPPSAGLVDAL
HHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
GKAATLAATEANRYPDREAEALRADLAYYLTPDAGFGVHAAQVWAANGSNEILQQLCQAF
CCHHEEEEHHCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHH
GGPGRVAVGFEPSYSMHRLIALATATGWVAESRAADFTLDADRVTAAIRRYRPALLFLCS
CCCCEEEEECCCCHHHHHHHHHHHHHCHHHHCCCCCEEECHHHHHHHHHHCCCEEEEEEC
PNNPTATALGAEVIAAACDAMAEVGSGVVVVDEAYGEFRRAGVPSALTLLPDHPRLVVTR
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCCEEEECCCCCCEEEEH
TMSKAFALAGARVGYLAAHPAVVDALQLVRLPYHLSSFTQAVARTALAHADELLGTVDAV
HHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQRDLLVRSLPEFGCVTAPSDANFVLFGHFTDQRAVWQGLLDAGVLVRDVGLDGWLRVT
HHHHHHHHHHCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCEEEEE
AGLPNETESFLDALRRVLTARPALLRAAAEISS
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA