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The map label for this gene is coaBC [H]

Identifier: 158313551

GI number: 158313551

Start: 2049351

End: 2050625

Strand: Direct

Name: coaBC [H]

Synonym: Franean1_1715

Alternate gene names: 158313551

Gene position: 2049351-2050625 (Clockwise)

Preceding gene: 158313550

Following gene: 158313552

Centisome position: 22.82

GC content: 74.82

Gene sequence:

>1275_bases
ATGCGCGGCGGTGGTTCGGCCGGGGCGGCGCGGCGGCCGCGGGTCGTGCTCGGCGTGTCCGGCGGCATCGCCTCGTACAA
GGCCGTCGAGGTGCTGCGCCAGCTGACCGAGTCCGGCCACGACGTCCGCGTCGTGCCGACGGCCGCGGCGCTGCGTTTCG
TCGGCGAGGTCACCTGGGCGGCGCTGTCCGGCCAGCCGGTGGTGACCGACCTGTTCACCGACGCCGAGGACGTGGCGCAC
GTCCGGGTCGGGCGCGAGGCCGACCTGGTGCTGATCGTGCCCGCCACCGCGGACCTGATGGCGCGGGCCGCGGCGGGCCG
GGCGGACGACCTGCTCACCGGCACGTTGCTCACAGCCACCTGCCCGGTGCTGTTCGCCCCAGCCATGCACACCGAGATGT
GGCAGCACCCAGCGACCCGCGCCAACGTCGCCCTGCTTCGCGAGCGGGGCGCCCTCGTGCTGGAACCGGCCGTCGGCCGG
CTGACCGGCGCCGACTCCGGGCCGGGCCGGCTGCCGGAACCCATCGAGATCGCCTCGGTCGCCCGGGCGGTTCTCGCCCG
CGGGCGTGACGGCATGCGGCCCGACCTCGCCGGCCGCCACGTGCTCGTCAGCGCCGGTGGCACCCGCGAGTACCTCGATC
CGGTGCGGTTTCTCGGTAACGCCTCCAGCGGCCGGCAGGGATACGCGCTGGCCCGCGCGGCGGTGGCCCGCGGCGCGGCG
GTCACCGTCGTGGCCGCCAACGTCGCCCTGCCCGACGTGGCCGGCGCGACCACGGTGCCGGTGGGCTCGGCCGAACAGCT
GCGGGCGGCCGTGCACGACGCGGCCCCCCGCGCCGACGTCGTGGTCATGGCAGCGGCGGTGGCCGATTTCCGGCCCGCCA
CCGAGCACAAGTACAAGATCAAGAAAGAGTCCGCGGCGCCGGACGCGATCGAGCTGATCCGCAACCCGGACGTCCTGGCC
GAGCTTGTCGCGAACCGCCGTCCCGGGCAGGTGTTGGTCGGGTTCGCGGCGGAGACGGGCGGACCCGACGCCGGGGTCCT
CGACCTCGCCCGGGCGAAGCTCGCCCGCAAGCCGGTGGACCTGCTGGTGGTGAACCGGGTCGGGTCCGGCCTGGGGTTTG
AGGTGGAGCAGAACAGCGCCGTCCTCCTTGACCGTGCGGGCGGGGCCGCGGAGATCGCCCTGACCAGTAAGGATCTTCTT
GCCCACCAGGTGCTCGACCGGATCGTCGACGCGCTGCACGACCGGAAGCCGGCCGGTGCGCGTACCCCTGAGTGA

Upstream 100 bases:

>100_bases
CTGCCGCCGATCTCCTGACCCACGCGGCCTCCGCGGCTCGCGTCCGTCTCGCCGGTCCTGCCCGCCTCGGTTGTTCCGCG
TGACAGGCGGCGGGGCGGGG

Downstream 100 bases:

>100_bases
ACCTCGGTAAACTCCGTCGGTATCAGTCCTGATCTCCCCAGGGGGTAGTCCAGTGGCGACGCGCCTTTTCACGTCCGAGT
CCGTCACGGAAGGACACCCG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MRGGGSAGAARRPRVVLGVSGGIASYKAVEVLRQLTESGHDVRVVPTAAALRFVGEVTWAALSGQPVVTDLFTDAEDVAH
VRVGREADLVLIVPATADLMARAAAGRADDLLTGTLLTATCPVLFAPAMHTEMWQHPATRANVALLRERGALVLEPAVGR
LTGADSGPGRLPEPIEIASVARAVLARGRDGMRPDLAGRHVLVSAGGTREYLDPVRFLGNASSGRQGYALARAAVARGAA
VTVVAANVALPDVAGATTVPVGSAEQLRAAVHDAAPRADVVVMAAAVADFRPATEHKYKIKKESAAPDAIELIRNPDVLA
ELVANRRPGQVLVGFAAETGGPDAGVLDLARAKLARKPVDLLVVNRVGSGLGFEVEQNSAVLLDRAGGAAEIALTSKDLL
AHQVLDRIVDALHDRKPAGARTPE

Sequences:

>Translated_424_residues
MRGGGSAGAARRPRVVLGVSGGIASYKAVEVLRQLTESGHDVRVVPTAAALRFVGEVTWAALSGQPVVTDLFTDAEDVAH
VRVGREADLVLIVPATADLMARAAAGRADDLLTGTLLTATCPVLFAPAMHTEMWQHPATRANVALLRERGALVLEPAVGR
LTGADSGPGRLPEPIEIASVARAVLARGRDGMRPDLAGRHVLVSAGGTREYLDPVRFLGNASSGRQGYALARAAVARGAA
VTVVAANVALPDVAGATTVPVGSAEQLRAAVHDAAPRADVVVMAAAVADFRPATEHKYKIKKESAAPDAIELIRNPDVLA
ELVANRRPGQVLVGFAAETGGPDAGVLDLARAKLARKPVDLLVVNRVGSGLGFEVEQNSAVLLDRAGGAAEIALTSKDLL
AHQVLDRIVDALHDRKPAGARTPE
>Mature_424_residues
MRGGGSAGAARRPRVVLGVSGGIASYKAVEVLRQLTESGHDVRVVPTAAALRFVGEVTWAALSGQPVVTDLFTDAEDVAH
VRVGREADLVLIVPATADLMARAAAGRADDLLTGTLLTATCPVLFAPAMHTEMWQHPATRANVALLRERGALVLEPAVGR
LTGADSGPGRLPEPIEIASVARAVLARGRDGMRPDLAGRHVLVSAGGTREYLDPVRFLGNASSGRQGYALARAAVARGAA
VTVVAANVALPDVAGATTVPVGSAEQLRAAVHDAAPRADVVVMAAAVADFRPATEHKYKIKKESAAPDAIELIRNPDVLA
ELVANRRPGQVLVGFAAETGGPDAGVLDLARAKLARKPVDLLVVNRVGSGLGFEVEQNSAVLLDRAGGAAEIALTSKDLL
AHQVLDRIVDALHDRKPAGARTPE

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=190, Percent_Identity=30.5263157894737, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=40.1496259351621, Blast_Score=238, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43894; Mature: 43894

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGGGSAGAARRPRVVLGVSGGIASYKAVEVLRQLTESGHDVRVVPTAAALRFVGEVTWA
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
ALSGQPVVTDLFTDAEDVAHVRVGREADLVLIVPATADLMARAAAGRADDLLTGTLLTAT
EECCCCEEHHHHCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHH
CPVLFAPAMHTEMWQHPATRANVALLRERGALVLEPAVGRLTGADSGPGRLPEPIEIASV
HHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHH
ARAVLARGRDGMRPDLAGRHVLVSAGGTREYLDPVRFLGNASSGRQGYALARAAVARGAA
HHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCE
VTVVAANVALPDVAGATTVPVGSAEQLRAAVHDAAPRADVVVMAAAVADFRPATEHKYKI
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEE
KKESAAPDAIELIRNPDVLAELVANRRPGQVLVGFAAETGGPDAGVLDLARAKLARKPVD
CCCCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCE
LLVVNRVGSGLGFEVEQNSAVLLDRAGGAAEIALTSKDLLAHQVLDRIVDALHDRKPAGA
EEEEECCCCCCCEEECCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCC
RTPE
CCCC
>Mature Secondary Structure
MRGGGSAGAARRPRVVLGVSGGIASYKAVEVLRQLTESGHDVRVVPTAAALRFVGEVTWA
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
ALSGQPVVTDLFTDAEDVAHVRVGREADLVLIVPATADLMARAAAGRADDLLTGTLLTAT
EECCCCEEHHHHCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHH
CPVLFAPAMHTEMWQHPATRANVALLRERGALVLEPAVGRLTGADSGPGRLPEPIEIASV
HHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHH
ARAVLARGRDGMRPDLAGRHVLVSAGGTREYLDPVRFLGNASSGRQGYALARAAVARGAA
HHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCE
VTVVAANVALPDVAGATTVPVGSAEQLRAAVHDAAPRADVVVMAAAVADFRPATEHKYKI
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEE
KKESAAPDAIELIRNPDVLAELVANRRPGQVLVGFAAETGGPDAGVLDLARAKLARKPVD
CCCCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCE
LLVVNRVGSGLGFEVEQNSAVLLDRAGGAAEIALTSKDLLAHQVLDRIVDALHDRKPAGA
EEEEECCCCCCCEEECCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCC
RTPE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]