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The map label for this gene is gmk [H]

Identifier: 158313549

GI number: 158313549

Start: 2048222

End: 2048800

Strand: Direct

Name: gmk [H]

Synonym: Franean1_1713

Alternate gene names: 158313549

Gene position: 2048222-2048800 (Clockwise)

Preceding gene: 158313548

Following gene: 158313550

Centisome position: 22.8

GC content: 73.23

Gene sequence:

>579_bases
ATGGGACTGACCGTGTTGTCGGGGCCGTCCGGAGTGGGGAAGGGCACGGTCGTCGCCGCCGTCCGCCGGCTGCACCCCGA
GGTGTGGGTGTCGGTGAGCGTGACGACGCGAGCGCCGCGGCCGGGCGAGACGGACGGCGTCGAGTACCACTTCGCCGACG
CGGAGGAGTTCGCCCACATGGTCAAGGTGGGGGAGTTCGTCGAGCACGCGATGTTCGCGGGGCACGCCTACGGCACTCCT
CGGGGACCGCTCGAGGAGCGGCTGGCACAGGGCGTTCCCTGCCTGCTGGAGATCGAGCTGCAGGGCGCCCGGCAGGTCCG
GTCGGCAATGCCGGGCGCCCGGTTCGTCTTCCTGGCCCCGCCCACCTGGGACGAGCTCGTCCGTCGCCTGACCGGTCGGG
GCACGGAGGCGCCTGATGTGATCCGCCGGCGCCTCGACCGGGCCCGCATCGAGCTGGCGGCCGAGACGGAGTTCGACGAG
GTCGTCGTGAACGACGAGGTCACGGCCGCCGCCGCGAAGCTGGTGGGGCTGATGACCGGTCGCCCGCGGGACGCGCACCG
CGCTGCGGACGTCCCGTGA

Upstream 100 bases:

>100_bases
ACGGCGGGCGCCGGGGGGCGCCGGGCCGGCCGTCGCCGGCGTGGCCCGCCCGCCCCGCCTGAACCTGCGTGACCCCGTGG
AGGGGCTCTAAGGTGTCGGG

Downstream 100 bases:

>100_bases
CCGGCGGCTCGGCGCTCCACCTCCCGGGGACGCGTGATCTTCGGGGCACCCACGGCCCGGCGGCGAACGGCTCGGTGACG
GGCTGTACCGGTTGCGGCTG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MGLTVLSGPSGVGKGTVVAAVRRLHPEVWVSVSVTTRAPRPGETDGVEYHFADAEEFAHMVKVGEFVEHAMFAGHAYGTP
RGPLEERLAQGVPCLLEIELQGARQVRSAMPGARFVFLAPPTWDELVRRLTGRGTEAPDVIRRRLDRARIELAAETEFDE
VVVNDEVTAAAAKLVGLMTGRPRDAHRAADVP

Sequences:

>Translated_192_residues
MGLTVLSGPSGVGKGTVVAAVRRLHPEVWVSVSVTTRAPRPGETDGVEYHFADAEEFAHMVKVGEFVEHAMFAGHAYGTP
RGPLEERLAQGVPCLLEIELQGARQVRSAMPGARFVFLAPPTWDELVRRLTGRGTEAPDVIRRRLDRARIELAAETEFDE
VVVNDEVTAAAAKLVGLMTGRPRDAHRAADVP
>Mature_191_residues
GLTVLSGPSGVGKGTVVAAVRRLHPEVWVSVSVTTRAPRPGETDGVEYHFADAEEFAHMVKVGEFVEHAMFAGHAYGTPR
GPLEERLAQGVPCLLEIELQGARQVRSAMPGARFVFLAPPTWDELVRRLTGRGTEAPDVIRRRLDRARIELAAETEFDEV
VVNDEVTAAAAKLVGLMTGRPRDAHRAADVP

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=34.7593582887701, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=34.7593582887701, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=34.7593582887701, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4505237, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI262118255, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI262118263, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI262118259, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI21361598, Length=179, Percent_Identity=28.4916201117318, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=27.1186440677966, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=27.1276595744681, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI21389483, Length=181, Percent_Identity=25.414364640884, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=26.9938650306748, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=178, Percent_Identity=42.1348314606742, Blast_Score=150, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=39.1061452513966, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=39.1061452513966, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320662, Length=179, Percent_Identity=42.4581005586592, Blast_Score=146, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356141, Length=187, Percent_Identity=33.1550802139037, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI116007136, Length=185, Percent_Identity=26.4864864864865, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724806, Length=185, Percent_Identity=26.4864864864865, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554489, Length=185, Percent_Identity=26.4864864864865, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554481, Length=185, Percent_Identity=26.4864864864865, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640542, Length=185, Percent_Identity=26.4864864864865, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161077626, Length=185, Percent_Identity=26.4864864864865, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330162, Length=163, Percent_Identity=28.8343558282209, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221330166, Length=163, Percent_Identity=28.8343558282209, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221330164, Length=159, Percent_Identity=28.9308176100629, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 20827; Mature: 20696

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLTVLSGPSGVGKGTVVAAVRRLHPEVWVSVSVTTRAPRPGETDGVEYHFADAEEFAHM
CCCEEECCCCCCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCHHHHHHH
VKVGEFVEHAMFAGHAYGTPRGPLEERLAQGVPCLLEIELQGARQVRSAMPGARFVFLAP
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEEECCHHHHHHHCCCCEEEEECC
PTWDELVRRLTGRGTEAPDVIRRRLDRARIELAAETEFDEVVVNDEVTAAAAKLVGLMTG
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCC
RPRDAHRAADVP
CCCCCCCCCCCC
>Mature Secondary Structure 
GLTVLSGPSGVGKGTVVAAVRRLHPEVWVSVSVTTRAPRPGETDGVEYHFADAEEFAHM
CCEEECCCCCCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCHHHHHHH
VKVGEFVEHAMFAGHAYGTPRGPLEERLAQGVPCLLEIELQGARQVRSAMPGARFVFLAP
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEEECCHHHHHHHCCCCEEEEECC
PTWDELVRRLTGRGTEAPDVIRRRLDRARIELAAETEFDEVVVNDEVTAAAAKLVGLMTG
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCC
RPRDAHRAADVP
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA