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The map label for this gene is moaA [H]

Identifier: 158313105

GI number: 158313105

Start: 1510365

End: 1511351

Strand: Direct

Name: moaA [H]

Synonym: Franean1_1253

Alternate gene names: 158313105

Gene position: 1510365-1511351 (Clockwise)

Preceding gene: 158313100

Following gene: 158313106

Centisome position: 16.82

GC content: 74.57

Gene sequence:

>987_bases
ATGCGGTTGACCGATTCCCACGGGCGGGTCGCCACCGACCTTCGGGTGTCGCTGACCGACCGGTGCAACCTCCGCTGCAG
CTACTGCATGCCCGCCGAGGGGCTCGACTGGCTGCCGAATCCGCTGCTCCTCACCGACGACGAGATCCTGCGGCTGGTCA
CGATCGCGGTGGCCCGGCTGGGCGTCACCGAGATCCGGCTGACCGGCGGCGAGCCCACGCTGCGTCCGGGGCTGGTGCGC
CTGGTCGAGCGGATGGCGGCGCTCTCGCCCCGGCCCGAGCTCTCGCTCACCACCAACGGCCTGCGCCTGGCCGGCCTGGC
CGGCCCGCTCGCCGCCGCCGGCCTGGACCGCGTCAACGTCTCTCTGGACACGCTTCGCCCGGAGCGCTTCGCCCGGATCA
CCCGCCGGAACCGGCTCGACGACGTCCTGGCCGGCCTCGCCGCCGCGGCCGACGCCGGGCTGATCCCGGTGAAGGTGAAC
GCGGTGCTCCTCCGTGGCCTGAACGACGACGAGGCCGCGCCGCTGCTGCGCTGGTGCCTCGCGCGCGGCTACGAGCTGCG
CTTCATCGAACAGATGCCGCTGGACGCCCAGCACGGCTGGCGCCGCACCGAGATGATCACGGCCGGCGAGATCCTGACCC
GGCTGGAGGCGGAGTTCGTCCTGACCGCGTTGCCGGGGCGGGGGAGCGCACCCGCCGAGCTGTTCGCCGTCGACGGGGGG
CCGGGCACCGTCGGGGTGATCGGCTCGGTGTCCGCGCCGTTCTGCGCGGCCTGCGACCGGGTCCGGCTCACCGCGGACGG
GCAGGTCCGCAACTGCCTGTTCGCCCGGGACGAATCCGACCTGCGCGGCCCGATGCGGTCCGGCGCCACCGACGACGACC
TCGCCGACCGCTGGGTCCGCGCGGTGTGGGGGAAACACGCCGGCCACGGCATCGACGCGCCGGGCTTCCACCAGCCAGCC
CGGCCGATGTCGGCGATCGGCGGGTGA

Upstream 100 bases:

>100_bases
CTCCGGCGGACGTCCATGCCGCTCCAGGCGGGGCCGGAGATCGCCCGGGGTGGGCCGGACAACGCGTGTGTCCTGTTCTG
AGGGCACCTACTCTGATGAG

Downstream 100 bases:

>100_bases
CACCACTCTCGCCGTCGCCGTCGCCGTCGGGGGAGCTGGGCGATCCGTGGGACGCGCTGGTCCTCGCCGGCGGCCACTCC
CGGCGGCTCGGCGGCCAGGA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRLTDSHGRVATDLRVSLTDRCNLRCSYCMPAEGLDWLPNPLLLTDDEILRLVTIAVARLGVTEIRLTGGEPTLRPGLVR
LVERMAALSPRPELSLTTNGLRLAGLAGPLAAAGLDRVNVSLDTLRPERFARITRRNRLDDVLAGLAAAADAGLIPVKVN
AVLLRGLNDDEAAPLLRWCLARGYELRFIEQMPLDAQHGWRRTEMITAGEILTRLEAEFVLTALPGRGSAPAELFAVDGG
PGTVGVIGSVSAPFCAACDRVRLTADGQVRNCLFARDESDLRGPMRSGATDDDLADRWVRAVWGKHAGHGIDAPGFHQPA
RPMSAIGG

Sequences:

>Translated_328_residues
MRLTDSHGRVATDLRVSLTDRCNLRCSYCMPAEGLDWLPNPLLLTDDEILRLVTIAVARLGVTEIRLTGGEPTLRPGLVR
LVERMAALSPRPELSLTTNGLRLAGLAGPLAAAGLDRVNVSLDTLRPERFARITRRNRLDDVLAGLAAAADAGLIPVKVN
AVLLRGLNDDEAAPLLRWCLARGYELRFIEQMPLDAQHGWRRTEMITAGEILTRLEAEFVLTALPGRGSAPAELFAVDGG
PGTVGVIGSVSAPFCAACDRVRLTADGQVRNCLFARDESDLRGPMRSGATDDDLADRWVRAVWGKHAGHGIDAPGFHQPA
RPMSAIGG
>Mature_328_residues
MRLTDSHGRVATDLRVSLTDRCNLRCSYCMPAEGLDWLPNPLLLTDDEILRLVTIAVARLGVTEIRLTGGEPTLRPGLVR
LVERMAALSPRPELSLTTNGLRLAGLAGPLAAAGLDRVNVSLDTLRPERFARITRRNRLDDVLAGLAAAADAGLIPVKVN
AVLLRGLNDDEAAPLLRWCLARGYELRFIEQMPLDAQHGWRRTEMITAGEILTRLEAEFVLTALPGRGSAPAELFAVDGG
PGTVGVIGSVSAPFCAACDRVRLTADGQVRNCLFARDESDLRGPMRSGATDDDLADRWVRAVWGKHAGHGIDAPGFHQPA
RPMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=40.6727828746177, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=40.6727828746177, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI1786999, Length=333, Percent_Identity=34.5345345345345, Blast_Score=174, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=328, Percent_Identity=38.109756097561, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=38.6706948640483, Blast_Score=213, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI32566331, Length=321, Percent_Identity=36.7601246105919, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI28574490, Length=324, Percent_Identity=44.1358024691358, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI28574488, Length=328, Percent_Identity=43.9024390243902, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35313; Mature: 35313

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTDSHGRVATDLRVSLTDRCNLRCSYCMPAEGLDWLPNPLLLTDDEILRLVTIAVARL
CCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCEEECHHHHHHHHHHHHHHC
GVTEIRLTGGEPTLRPGLVRLVERMAALSPRPELSLTTNGLRLAGLAGPLAAAGLDRVNV
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCHHHHCCCCCEEE
SLDTLRPERFARITRRNRLDDVLAGLAAAADAGLIPVKVNAVLLRGLNDDEAAPLLRWCL
EHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCHHHHHHHHHH
ARGYELRFIEQMPLDAQHGWRRTEMITAGEILTRLEAEFVLTALPGRGSAPAELFAVDGG
HCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCC
PGTVGVIGSVSAPFCAACDRVRLTADGQVRNCLFARDESDLRGPMRSGATDDDLADRWVR
CCCEEEEECCCCCHHHHCCCEEEECCCCHHHHEEECCCHHHCCHHHCCCCCHHHHHHHHH
AVWGKHAGHGIDAPGFHQPARPMSAIGG
HHHCCCCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MRLTDSHGRVATDLRVSLTDRCNLRCSYCMPAEGLDWLPNPLLLTDDEILRLVTIAVARL
CCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCEEECHHHHHHHHHHHHHHC
GVTEIRLTGGEPTLRPGLVRLVERMAALSPRPELSLTTNGLRLAGLAGPLAAAGLDRVNV
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCHHHHCCCCCEEE
SLDTLRPERFARITRRNRLDDVLAGLAAAADAGLIPVKVNAVLLRGLNDDEAAPLLRWCL
EHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCHHHHHHHHHH
ARGYELRFIEQMPLDAQHGWRRTEMITAGEILTRLEAEFVLTALPGRGSAPAELFAVDGG
HCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCC
PGTVGVIGSVSAPFCAACDRVRLTADGQVRNCLFARDESDLRGPMRSGATDDDLADRWVR
CCCEEEEECCCCCHHHHCCCEEEECCCCHHHHEEECCCHHHCCHHHCCCCCHHHHHHHHH
AVWGKHAGHGIDAPGFHQPARPMSAIGG
HHHCCCCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]