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The map label for this gene is pbpA [H]

Identifier: 158312943

GI number: 158312943

Start: 1299075

End: 1300901

Strand: Direct

Name: pbpA [H]

Synonym: Franean1_1089

Alternate gene names: 158312943

Gene position: 1299075-1300901 (Clockwise)

Preceding gene: 158312942

Following gene: 158312944

Centisome position: 14.46

GC content: 75.48

Gene sequence:

>1827_bases
GTGCCTCTCACTCCGACGGGGTTCAGCCCGTCCATGTCACGCCGCCGGGGCCGGGGCCGGCGTAACGCACTCATCGTCGC
GCTCGTTGTGGTCCTGCTGGCGGTCGGCGGCGGGGTGGCCTACTGGTTGAAGTCCCGCTCCGACGCGCGTGAGGCCGACC
GCCGGGTGGCCGCGGTCGCTCACGCCTACCTGGACGCCTGGAAGACGCTGACGACCGCGCCGGCCGCCGAGGAACCGGCG
GCGGGTGACCCGGGCGGCGGCACCGCGGGCGCGCCGGCGACGGCCGCACCGACAGCATCGGCCGCACCGGCCGCACCGGC
AGCTGCCGGGCAGGGCGCACAGCCTGCTGCCGGGCAGGTCCGGGAGCGGGCGGGCGCCGCCGTGACGGCCCTCAGCACCG
ACGGCGACATCCCGGTCGGTGCCCTTGTCGGGCTGATGGGCGACGTGCGCGACCGGCTCTCGGTGACCGGGGCCGAGCTC
GTCCCCGGCGGGCTGACCCGGTCGGGCACGAGCGCCACCGTCCCGTACACCGCGAAGCTGACGCTCGCCGGTTTCGCCGA
GCCGCTGGCCTACATGGGTGAGCTGGCCCTCGTCGACACCGGCGACGGGCAGTGGAAGGTGCGGGCCCGGCCGTCCTCGG
TGCACCCGTCCCTCAAGCCCGGCCTGCGCCTCGACCGCGCCGCGTCCACCGGCGAGCGCGGCGCCCTGCTCGACGTCAAC
GGGCGGCCGCTGGACGGCAGCCCCGAGCTCGCCGGGAACCTCGTCGGCCGGGTCGATCCGGCGTCCGGCCTGCAGCGGGT
GTACGACGCCAGGCTGCGGCCGCAGGGCGGCTCGGTGGTGGTGCGCACCGACGGCAACGAGACCGTCGAGACCCTCAAGA
CCTACCCGAGCAGCAACGGCGAGGAGATCCGCACCACCATCAACCTGGACGTCCAGCGCGCGGGGGAGGCGGCGCTGGGG
ACCGCGTCGCGCCCCAACGGGGCCCTCGTCGCGATCGACACCCGTACCGGCGGGGTGCTGGCGGCGGTGAACCACCCGCT
CAACGGCTACGGCCGGGCGGTGCGCGGCTCCTACCCGCCGGGCTCCACCTTCAAGATCGTGACGGCTACCGCGGCGCTGA
TGAGTGGCAAGGCCGCCGACACCATGATCGACTGTACGCAGACGGTGAGCGTCGGCGGGCGCGAGTTCCAGAACGCCGAG
GCGGAGCAGTTCGGGGCCATCCCGCTGCGGACGGTCTTCGCCAAGAGCTGCAACACCGCCTTCATCCGGCTCGAGCAGTC
GCTGCCCGACGACGCGCTCGAGCGGGCCGCGAAGCTCTACGGGTTCGACAGCTCCGAGCCGTTGCCGATCGCCAGCGTGG
GCGGCTCGTTCCCGACCCCGCGCGACGCCGTCGAGTCGGCGTCCGCCTCGATCGGGCAGGGGCGGGTGGCCGCGTCGCCG
CTGCAGATGGCGAGCGTCGCCGCGGCGGTGGCCAGCGGCACCTGGCACCAGCCGTTCGTCGTCGGAGAGTCGCCGCGCAG
CAACCCGCTCCCGACCGAGGTGCTGGCGCCGCTGCGGGACTTCATGCGCGCGGTGGTCACCGAGGGGACCGCGGCCGGCG
TCCCGATGCCCGGCGACGTCCACGGCAAGACGGGCACGGCCGAGTACGCCGACGGCAACCCGCCGCCCACGCACGGCTGG
TTCGTCGCCTACCGCGGCGACGTGGCCGTCGCGGTGGTGATCGAGGACGGCGGGTTCGGCGCCGAGTCCGCCGCGCCGGT
GGTGTCGGCGTTCTACACCGCCCTCGACGGCGGCCAGGTCGGCGGCCCGCCCGCCGCGGCCGGCTGA

Upstream 100 bases:

>100_bases
CGGCGCGTCGGATGCGGAGCGGGTTAGCCGTTCGTAGGGTGTGGTCGGGCCGCACGGTCCTGTCAGGCGGTTCTCCGAGC
GAGGGGGGAGGCGAGCCGTC

Downstream 100 bases:

>100_bases
TCGGTTCCCTTCCACCCCGCCGGCATCGACCGAACCATGATCACATGGCCGTCGCCGGCGGGGTGGCGCATGCTTGTCTG
GCGTCCCGGCGGGCGGCGCG

Product: penicillin-binding protein transpeptidase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPLTPTGFSPSMSRRRGRGRRNALIVALVVVLLAVGGGVAYWLKSRSDAREADRRVAAVAHAYLDAWKTLTTAPAAEEPA
AGDPGGGTAGAPATAAPTASAAPAAPAAAGQGAQPAAGQVRERAGAAVTALSTDGDIPVGALVGLMGDVRDRLSVTGAEL
VPGGLTRSGTSATVPYTAKLTLAGFAEPLAYMGELALVDTGDGQWKVRARPSSVHPSLKPGLRLDRAASTGERGALLDVN
GRPLDGSPELAGNLVGRVDPASGLQRVYDARLRPQGGSVVVRTDGNETVETLKTYPSSNGEEIRTTINLDVQRAGEAALG
TASRPNGALVAIDTRTGGVLAAVNHPLNGYGRAVRGSYPPGSTFKIVTATAALMSGKAADTMIDCTQTVSVGGREFQNAE
AEQFGAIPLRTVFAKSCNTAFIRLEQSLPDDALERAAKLYGFDSSEPLPIASVGGSFPTPRDAVESASASIGQGRVAASP
LQMASVAAAVASGTWHQPFVVGESPRSNPLPTEVLAPLRDFMRAVVTEGTAAGVPMPGDVHGKTGTAEYADGNPPPTHGW
FVAYRGDVAVAVVIEDGGFGAESAAPVVSAFYTALDGGQVGGPPAAAG

Sequences:

>Translated_608_residues
MPLTPTGFSPSMSRRRGRGRRNALIVALVVVLLAVGGGVAYWLKSRSDAREADRRVAAVAHAYLDAWKTLTTAPAAEEPA
AGDPGGGTAGAPATAAPTASAAPAAPAAAGQGAQPAAGQVRERAGAAVTALSTDGDIPVGALVGLMGDVRDRLSVTGAEL
VPGGLTRSGTSATVPYTAKLTLAGFAEPLAYMGELALVDTGDGQWKVRARPSSVHPSLKPGLRLDRAASTGERGALLDVN
GRPLDGSPELAGNLVGRVDPASGLQRVYDARLRPQGGSVVVRTDGNETVETLKTYPSSNGEEIRTTINLDVQRAGEAALG
TASRPNGALVAIDTRTGGVLAAVNHPLNGYGRAVRGSYPPGSTFKIVTATAALMSGKAADTMIDCTQTVSVGGREFQNAE
AEQFGAIPLRTVFAKSCNTAFIRLEQSLPDDALERAAKLYGFDSSEPLPIASVGGSFPTPRDAVESASASIGQGRVAASP
LQMASVAAAVASGTWHQPFVVGESPRSNPLPTEVLAPLRDFMRAVVTEGTAAGVPMPGDVHGKTGTAEYADGNPPPTHGW
FVAYRGDVAVAVVIEDGGFGAESAAPVVSAFYTALDGGQVGGPPAAAG
>Mature_607_residues
PLTPTGFSPSMSRRRGRGRRNALIVALVVVLLAVGGGVAYWLKSRSDAREADRRVAAVAHAYLDAWKTLTTAPAAEEPAA
GDPGGGTAGAPATAAPTASAAPAAPAAAGQGAQPAAGQVRERAGAAVTALSTDGDIPVGALVGLMGDVRDRLSVTGAELV
PGGLTRSGTSATVPYTAKLTLAGFAEPLAYMGELALVDTGDGQWKVRARPSSVHPSLKPGLRLDRAASTGERGALLDVNG
RPLDGSPELAGNLVGRVDPASGLQRVYDARLRPQGGSVVVRTDGNETVETLKTYPSSNGEEIRTTINLDVQRAGEAALGT
ASRPNGALVAIDTRTGGVLAAVNHPLNGYGRAVRGSYPPGSTFKIVTATAALMSGKAADTMIDCTQTVSVGGREFQNAEA
EQFGAIPLRTVFAKSCNTAFIRLEQSLPDDALERAAKLYGFDSSEPLPIASVGGSFPTPRDAVESASASIGQGRVAASPL
QMASVAAAVASGTWHQPFVVGESPRSNPLPTEVLAPLRDFMRAVVTEGTAAGVPMPGDVHGKTGTAEYADGNPPPTHGWF
VAYRGDVAVAVVIEDGGFGAESAAPVVSAFYTALDGGQVGGPPAAAG

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=392, Percent_Identity=25, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 61674; Mature: 61543

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTPTGFSPSMSRRRGRGRRNALIVALVVVLLAVGGGVAYWLKSRSDAREADRRVAAVA
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCHHHHHHHHHHHHH
HAYLDAWKTLTTAPAAEEPAAGDPGGGTAGAPATAAPTASAAPAAPAAAGQGAQPAAGQV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
RERAGAAVTALSTDGDIPVGALVGLMGDVRDRLSVTGAELVPGGLTRSGTSATVPYTAKL
HHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCEEEEE
TLAGFAEPLAYMGELALVDTGDGQWKVRARPSSVHPSLKPGLRLDRAASTGERGALLDVN
EHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCCCCCCCEECCCCCCCCCCEEEECC
GRPLDGSPELAGNLVGRVDPASGLQRVYDARLRPQGGSVVVRTDGNETVETLKTYPSSNG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCC
EEIRTTINLDVQRAGEAALGTASRPNGALVAIDTRTGGVLAAVNHPLNGYGRAVRGSYPP
CEEEEEEEEEHHHCCCHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCC
GSTFKIVTATAALMSGKAADTMIDCTQTVSVGGREFQNAEAEQFGAIPLRTVFAKSCNTA
CCCEEEHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHCCCHHHHHHHHCCCEE
FIRLEQSLPDDALERAAKLYGFDSSEPLPIASVGGSFPTPRDAVESASASIGQGRVAASP
EEEEECCCCHHHHHHHHHHHCCCCCCCCEEHCCCCCCCCCHHHHHHHHHCCCCCCCCCCH
LQMASVAAAVASGTWHQPFVVGESPRSNPLPTEVLAPLRDFMRAVVTEGTAAGVPMPGDV
HHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HGKTGTAEYADGNPPPTHGWFVAYRGDVAVAVVIEDGGFGAESAAPVVSAFYTALDGGQV
CCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCC
GGPPAAAG
CCCCCCCC
>Mature Secondary Structure 
PLTPTGFSPSMSRRRGRGRRNALIVALVVVLLAVGGGVAYWLKSRSDAREADRRVAAVA
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCHHHHHHHHHHHHH
HAYLDAWKTLTTAPAAEEPAAGDPGGGTAGAPATAAPTASAAPAAPAAAGQGAQPAAGQV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
RERAGAAVTALSTDGDIPVGALVGLMGDVRDRLSVTGAELVPGGLTRSGTSATVPYTAKL
HHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCEEEEE
TLAGFAEPLAYMGELALVDTGDGQWKVRARPSSVHPSLKPGLRLDRAASTGERGALLDVN
EHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCCCCCCCEECCCCCCCCCCEEEECC
GRPLDGSPELAGNLVGRVDPASGLQRVYDARLRPQGGSVVVRTDGNETVETLKTYPSSNG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCC
EEIRTTINLDVQRAGEAALGTASRPNGALVAIDTRTGGVLAAVNHPLNGYGRAVRGSYPP
CEEEEEEEEEHHHCCCHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCC
GSTFKIVTATAALMSGKAADTMIDCTQTVSVGGREFQNAEAEQFGAIPLRTVFAKSCNTA
CCCEEEHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHCCCHHHHHHHHCCCEE
FIRLEQSLPDDALERAAKLYGFDSSEPLPIASVGGSFPTPRDAVESASASIGQGRVAASP
EEEEECCCCHHHHHHHHHHHCCCCCCCCEEHCCCCCCCCCHHHHHHHHHCCCCCCCCCCH
LQMASVAAAVASGTWHQPFVVGESPRSNPLPTEVLAPLRDFMRAVVTEGTAAGVPMPGDV
HHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HGKTGTAEYADGNPPPTHGWFVAYRGDVAVAVVIEDGGFGAESAAPVVSAFYTALDGGQV
CCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCC
GGPPAAAG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA