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The map label for this gene is hemK [H]

Identifier: 158312865

GI number: 158312865

Start: 1193479

End: 1194483

Strand: Direct

Name: hemK [H]

Synonym: Franean1_1011

Alternate gene names: 158312865

Gene position: 1193479-1194483 (Clockwise)

Preceding gene: 158312864

Following gene: 158312866

Centisome position: 13.29

GC content: 76.12

Gene sequence:

>1005_bases
GTGACAGGCCCGGCCGCGTCCACGACGCGGGCCGACCACGCGGACGCCACGCTCGCCGTCGAGCTCGCCGCCGCGACGGC
CCGGCTGGCCGCGGCCGGTGTCGCCAGCCCCCGCGGCGACGCCGAGCAGCTGGCGGCGCACGTGCTCGGGGTGTCGCGCG
GCCGGCTCGCGCTGGTCACCCGGGTCGAACCGGCCGCGGCCGGCGAGCTGCGCGCGCTGGTGGAACGGCGGGCGAGCCGG
GTCCCACTGCAGCACCTGACCGGCCTCGCCGGCTTCCGCCACCTGGACATCGCCGTCGGGCCCGGAGTGTTCATCCCCCG
CCCGGAGACCGAGTGGGTGGCCGAGTGGGCGATCGCGGCCCTGCGATCGCCCGACGCGGTCGTGGCTGGACGTCCAATCT
GTGTTGATCTTTGTGCGGGTTCGGGGGCGATCGCCCTGTCGGTGGCCGACGAGGTGCCGAACGCCGAGGTGCACGCGGTG
GAGCTGGAGCCGGCGGCGCTCGGCTGGCTGCGCCGCAACGTCGAGCGCACGGGCCTGCCGGTGCGGGTGCACCAGGCCGA
CGTCGGCATCCCGCGGTCGCCAACAGACGCGGGCAGGCCGGTCGCGCCGGTCGGCACGGTCCTGACTGACCTCGCGGGAC
GGGCCGACGTCGTCATCAGCAACCCGCCGTATCTGCCCGATCATGAACGGCCGAGGGTCGAGCCCGAGGTCGGCCGGCAC
GACCCGCCAGCGGCCCTGTGGGGCGGGCCCGACGGCCTGGACGGGCCGCGCGCGGTCGTGGCCGCCGCCGGGGGACTCTT
GCGGCCAGGCGGTTTACTGGTCATGGAACACGCGGACGGACATGGCCAGACGGTGCCCGCGCTGCTCGCCGGTGAGGGCT
GGTGGGCTGGTTCGTGGTCCGAAATCGTGGATCATCCCGATCTCGCCGGGCGGGACCGGTTCGTCACCGCCCGCTGGAAC
CCGCCGGGGCCGCGCCCGCCGCGCGGCGCCGGAGAGGACGTGTGA

Upstream 100 bases:

>100_bases
ACAAGGCGCACAACCTGGAGGCCGTGCTGGACGGCGACCTCGACGCCGTGATCGAGGCCCTGACCGAGGCGGACCTGGAA
TCCCGGATGGCGGCCACGCC

Downstream 100 bases:

>100_bases
TGCAGGTTTTCGACTGCTCCGACGAGGGGCAGCGCAAGGCAGGGCTGGACGCCGCCACCGACGCGGTGGGCCGCGGCAAG
CTCGTCGTGCTGCCGACCGA

Product: HemK family modification methylase

Products: NA

Alternate protein names: M.MtuHHemKP [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTGPAASTTRADHADATLAVELAAATARLAAAGVASPRGDAEQLAAHVLGVSRGRLALVTRVEPAAAGELRALVERRASR
VPLQHLTGLAGFRHLDIAVGPGVFIPRPETEWVAEWAIAALRSPDAVVAGRPICVDLCAGSGAIALSVADEVPNAEVHAV
ELEPAALGWLRRNVERTGLPVRVHQADVGIPRSPTDAGRPVAPVGTVLTDLAGRADVVISNPPYLPDHERPRVEPEVGRH
DPPAALWGGPDGLDGPRAVVAAAGGLLRPGGLLVMEHADGHGQTVPALLAGEGWWAGSWSEIVDHPDLAGRDRFVTARWN
PPGPRPPRGAGEDV

Sequences:

>Translated_334_residues
MTGPAASTTRADHADATLAVELAAATARLAAAGVASPRGDAEQLAAHVLGVSRGRLALVTRVEPAAAGELRALVERRASR
VPLQHLTGLAGFRHLDIAVGPGVFIPRPETEWVAEWAIAALRSPDAVVAGRPICVDLCAGSGAIALSVADEVPNAEVHAV
ELEPAALGWLRRNVERTGLPVRVHQADVGIPRSPTDAGRPVAPVGTVLTDLAGRADVVISNPPYLPDHERPRVEPEVGRH
DPPAALWGGPDGLDGPRAVVAAAGGLLRPGGLLVMEHADGHGQTVPALLAGEGWWAGSWSEIVDHPDLAGRDRFVTARWN
PPGPRPPRGAGEDV
>Mature_333_residues
TGPAASTTRADHADATLAVELAAATARLAAAGVASPRGDAEQLAAHVLGVSRGRLALVTRVEPAAAGELRALVERRASRV
PLQHLTGLAGFRHLDIAVGPGVFIPRPETEWVAEWAIAALRSPDAVVAGRPICVDLCAGSGAIALSVADEVPNAEVHAVE
LEPAALGWLRRNVERTGLPVRVHQADVGIPRSPTDAGRPVAPVGTVLTDLAGRADVVISNPPYLPDHERPRVEPEVGRHD
PPAALWGGPDGLDGPRAVVAAAGGLLRPGGLLVMEHADGHGQTVPALLAGEGWWAGSWSEIVDHPDLAGRDRFVTARWNP
PGPRPPRGAGEDV

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=309, Percent_Identity=30.7443365695793, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1787463, Length=270, Percent_Identity=31.4814814814815, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082085, Length=206, Percent_Identity=30.5825242718447, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24582226, Length=309, Percent_Identity=30.0970873786408, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 34620; Mature: 34489

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPAASTTRADHADATLAVELAAATARLAAAGVASPRGDAEQLAAHVLGVSRGRLALVT
CCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEE
RVEPAAAGELRALVERRASRVPLQHLTGLAGFRHLDIAVGPGVFIPRPETEWVAEWAIAA
ECCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEECCCEECCCCCHHHHHHHHHHH
LRSPDAVVAGRPICVDLCAGSGAIALSVADEVPNAEVHAVELEPAALGWLRRNVERTGLP
HCCCCCEECCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHCCCC
VRVHQADVGIPRSPTDAGRPVAPVGTVLTDLAGRADVVISNPPYLPDHERPRVEPEVGRH
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCC
DPPAALWGGPDGLDGPRAVVAAAGGLLRPGGLLVMEHADGHGQTVPALLAGEGWWAGSWS
CCCCEECCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCHH
EIVDHPDLAGRDRFVTARWNPPGPRPPRGAGEDV
HHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGPAASTTRADHADATLAVELAAATARLAAAGVASPRGDAEQLAAHVLGVSRGRLALVT
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEE
RVEPAAAGELRALVERRASRVPLQHLTGLAGFRHLDIAVGPGVFIPRPETEWVAEWAIAA
ECCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEECCCEECCCCCHHHHHHHHHHH
LRSPDAVVAGRPICVDLCAGSGAIALSVADEVPNAEVHAVELEPAALGWLRRNVERTGLP
HCCCCCEECCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHCCCC
VRVHQADVGIPRSPTDAGRPVAPVGTVLTDLAGRADVVISNPPYLPDHERPRVEPEVGRH
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCC
DPPAALWGGPDGLDGPRAVVAAAGGLLRPGGLLVMEHADGHGQTVPALLAGEGWWAGSWS
CCCCEECCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCHH
EIVDHPDLAGRDRFVTARWNPPGPRPPRGAGEDV
HHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]