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The map label for this gene is glmS [H]

Identifier: 157964045

GI number: 157964045

Start: 5146047

End: 5147876

Strand: Reverse

Name: glmS [H]

Synonym: Spea_4234

Alternate gene names: 157964045

Gene position: 5147876-5146047 (Counterclockwise)

Preceding gene: 157964046

Following gene: 157964038

Centisome position: 99.48

GC content: 47.27

Gene sequence:

>1830_bases
ATGTGTGGAATCGTAGGCGCTGTAGCGCAAAGAGATGTAGCTGAAATTCTTGTGGAAGGCCTAAGACGCCTAGAATACCG
TGGTTATGATTCAGCGGGTGTAGCGGTACTTAATAACGGTGAGTTAAACAGAACTCGCCGTGTAGGTAAGGTGCAAGAAT
TGTCTGCTGCGCTTGATGCTGCACCTTTAGCTGGTGGTACGGGTATCGCTCACACGCGTTGGGCGACTCACGGTGAGCCA
AGTGAGCGAAACGCGCATCCACATTTATCTGAAGGTGATATCGCCGTTGTACATAACGGGATTATCGAAAACCACAATAA
ACTACGTGAGATGCTAAAAGGCTTAGGTTATAGCTTTGCGTCAGACACTGACACAGAGGTGATTTGCCACTTAGTTCACC
ACAAGTTAAAAACTCATGACACGTTACTTGCAGCAGTTCAAGCAAGCGTTAAGCAGCTTGAAGGTGCTTACGGTACAGTG
GTTATCGACCGTACTGACAGCGAACGCATGATCGTGGCTCGCTCTGGCAGCCCGTTGGTTATTGGTTATGGTCTTGGTGA
GAACTTTGTTGCCTCAGATCAGTTGGCATTACTGCCAGTGACTCGTTCATTCGCTTTCTTAGAAGAGGGCGATGTGGCTG
AAGTGACTCGCCGTGAAGTGAACATTTATGATGTTGACGGTAATGCAGTTGAGCGTGAAGTTAAAGAGTCTGAAGTGACT
CATGACGCCGGTGATAAAGGTGAATACCGTCACTACATGCTAAAAGAGATCTACGAGCAGCCAACAGCTATCGCGCGCAC
GCTTGAAGGTCGTATTGCAGGTGGTAAAGTATTAGATACTGCTTTTGGTGATAACGCAGCCGAATTCTTAAAAGACATTA
AGCACGTACAGATTATTGCTTGTGGTACCAGTTACCATGCGGGTATGGCTGCGCGTTACTGGCTAGAAGATTGGGCTGGG
GTGTCTTGTAACGTCGAAATCGCATCTGAGTTCCGTTACCGCAAATCGCACCTGTTCCCAAATAGCCTGTTAGTCACTAT
TTCACAATCAGGTGAAACAGCCGATACCTTGGCAGCAATGCGTTTGGCTAAAGAGATGGGCTACAAGGCGACACTGACAA
TCTGTAACGCACCGGGTTCATCGCTAGTACGTGAATCAGATATGGCTTACATGATGAAAGCTGGCGCCGAGATTGGTGTA
GCTTCGACTAAAGCCTTTACTGTGCAACTAGCAGGTCTATTGATGCTGACTACGGCAATTGGCCGTTACAACGGTATGTC
TGACGAGATGCAAGCGGCGATTACTCAGAGCCTGCAGTCTATGCCTGCTAAAGTAGAGCAAGCGCTAGGCCTAGACGATG
CTATCGCAGAGCTCGCAGAAGACTTCGCCGATAAGCACAACGCACTATTTTTAGGTCGCGGTGATCAATATCCAATCGCG
ATGGAAGGTGCACTAAAGCTTAAAGAGATCTCTTATATTCACGCTGAAGCTTATGCTTCTGGTGAACTTAAGCATGGTCC
ACTAGCGCTTATCGATGCCGATATGCCCGTTATCGTGGTTGCGCCAAACAACGAGCTATTAGAGAAACTTAAATCTAACG
TAGAAGAAGTGCGTGCTCGTGGCGGCTTGATGTATGTGTTTGCAGATAAAGATGCCGAGTTTGAATCAGATGACACCATG
AAGGTGATCCCTGTGCCGCATTGTGATGAGTTTATGGCACCACTTATCTATACTATCCCACTACAATTGCTTTCTTATCA
TGTGGCCTTGATTAAAGGTACCGACGTTGACCAGCCACGTAACTTGGCTAAGTCAGTTACTGTTGAGTAA

Upstream 100 bases:

>100_bases
TATGCAGGGTAATGATTACAAGCACGTGGCTTGATGAACTATCCATTTCAAATTCAATTTTTAACTTTAACTCTCAAAGA
GAGAAGCTAGGTAACTAAAT

Downstream 100 bases:

>100_bases
GTATTTAATTGGCAATGAGTGAAACAATAAACGGCTACCTAGGTAGCCGTTTTTATATTTAATCAGTTAAGGTGATACTT
ATTTAAAGCTTATTAAATAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVLNNGELNRTRRVGKVQELSAALDAAPLAGGTGIAHTRWATHGEP
SERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYSFASDTDTEVICHLVHHKLKTHDTLLAAVQASVKQLEGAYGTV
VIDRTDSERMIVARSGSPLVIGYGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRREVNIYDVDGNAVEREVKESEVT
HDAGDKGEYRHYMLKEIYEQPTAIARTLEGRIAGGKVLDTAFGDNAAEFLKDIKHVQIIACGTSYHAGMAARYWLEDWAG
VSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAMRLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGV
ASTKAFTVQLAGLLMLTTAIGRYNGMSDEMQAAITQSLQSMPAKVEQALGLDDAIAELAEDFADKHNALFLGRGDQYPIA
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRARGGLMYVFADKDAEFESDDTM
KVIPVPHCDEFMAPLIYTIPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVLNNGELNRTRRVGKVQELSAALDAAPLAGGTGIAHTRWATHGEP
SERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYSFASDTDTEVICHLVHHKLKTHDTLLAAVQASVKQLEGAYGTV
VIDRTDSERMIVARSGSPLVIGYGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRREVNIYDVDGNAVEREVKESEVT
HDAGDKGEYRHYMLKEIYEQPTAIARTLEGRIAGGKVLDTAFGDNAAEFLKDIKHVQIIACGTSYHAGMAARYWLEDWAG
VSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAMRLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGV
ASTKAFTVQLAGLLMLTTAIGRYNGMSDEMQAAITQSLQSMPAKVEQALGLDDAIAELAEDFADKHNALFLGRGDQYPIA
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRARGGLMYVFADKDAEFESDDTM
KVIPVPHCDEFMAPLIYTIPLQLLSYHVALIKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVLNNGELNRTRRVGKVQELSAALDAAPLAGGTGIAHTRWATHGEP
SERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYSFASDTDTEVICHLVHHKLKTHDTLLAAVQASVKQLEGAYGTV
VIDRTDSERMIVARSGSPLVIGYGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRREVNIYDVDGNAVEREVKESEVT
HDAGDKGEYRHYMLKEIYEQPTAIARTLEGRIAGGKVLDTAFGDNAAEFLKDIKHVQIIACGTSYHAGMAARYWLEDWAG
VSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAMRLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGV
ASTKAFTVQLAGLLMLTTAIGRYNGMSDEMQAAITQSLQSMPAKVEQALGLDDAIAELAEDFADKHNALFLGRGDQYPIA
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRARGGLMYVFADKDAEFESDDTM
KVIPVPHCDEFMAPLIYTIPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=36.8421052631579, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=36.9565217391304, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI29570798, Length=266, Percent_Identity=25.5639097744361, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=68.6885245901639, Blast_Score=863, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=228, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=39.5833333333333, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=39.3518518518519, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=39.3518518518519, Blast_Score=285, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=722, Percent_Identity=36.2880886426593, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=30.8584686774942, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=37.7450980392157, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=164, Percent_Identity=29.8780487804878, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=35.7558139534884, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI28573187, Length=139, Percent_Identity=31.6546762589928, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66218; Mature: 66218

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVLNNGELNRTRRVGKVQELSAALDA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHC
APLAGGTGIAHTRWATHGEPSERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYSFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHCCCCCC
SDTDTEVICHLVHHKLKTHDTLLAAVQASVKQLEGAYGTVVIDRTDSERMIVARSGSPLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEE
IGYGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRREVNIYDVDGNAVEREVKESEVT
EEECCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHCEEEEEECCCHHHHHHHHHHHCC
HDAGDKGEYRHYMLKEIYEQPTAIARTLEGRIAGGKVLDTAFGDNAAEFLKDIKHVQIIA
CCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHCCEEEEEE
CGTSYHAGMAARYWLEDWAGVSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAM
ECCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGVASTKAFTVQLAGLLMLTTAI
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRYNGMSDEMQAAITQSLQSMPAKVEQALGLDDAIAELAEDFADKHNALFLGRGDQYPIA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEE
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRAR
ECCCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGLMYVFADKDAEFESDDTMKVIPVPHCDEFMAPLIYTIPLQLLSYHVALIKGTDVDQPR
CCEEEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVLNNGELNRTRRVGKVQELSAALDA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHC
APLAGGTGIAHTRWATHGEPSERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYSFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHCCCCCC
SDTDTEVICHLVHHKLKTHDTLLAAVQASVKQLEGAYGTVVIDRTDSERMIVARSGSPLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEE
IGYGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRREVNIYDVDGNAVEREVKESEVT
EEECCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHCEEEEEECCCHHHHHHHHHHHCC
HDAGDKGEYRHYMLKEIYEQPTAIARTLEGRIAGGKVLDTAFGDNAAEFLKDIKHVQIIA
CCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHCCEEEEEE
CGTSYHAGMAARYWLEDWAGVSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAM
ECCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGVASTKAFTVQLAGLLMLTTAI
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRYNGMSDEMQAAITQSLQSMPAKVEQALGLDDAIAELAEDFADKHNALFLGRGDQYPIA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEE
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRAR
ECCCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGLMYVFADKDAEFESDDTMKVIPVPHCDEFMAPLIYTIPLQLLSYHVALIKGTDVDQPR
CCEEEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]