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The map label for this gene is moeA [H]

Identifier: 157963909

GI number: 157963909

Start: 4981869

End: 4983668

Strand: Direct

Name: moeA [H]

Synonym: Spea_4098

Alternate gene names: 157963909

Gene position: 4981869-4983668 (Clockwise)

Preceding gene: 157963908

Following gene: 157963910

Centisome position: 96.28

GC content: 50.56

Gene sequence:

>1800_bases
ATGAGCATACCTTTTACTAATCCGTTACCTATTCCTGTACTCGGATTCTGTGCCTACAGTGGCACAGGCAAGACCACATT
ATTGAAGCAATTAATCCCAGAGCTTAATCGCCGCGGTGTGCGACTCGCAGTCATTAAGCATGCTCATCATAACTTCGATG
TCGATATTCCCGGTAAAGATAGCTACGAGATGCGTAAAGCAGGCGCAAAGCAGATGCTGGTTGCTTCTCATGTACGCTGG
GCGTTAATGACCGAAGACGCCAAAGATGGCGACCCTGAACTACCACATTTGCTAAAACAGATAGAAGCCGACAAGGTCGA
TATCGTCCTCGTTGAAGGTTTCAAAAAGCTCGAACTCCCCAAGATAGAACTGCACCGCGCCGCTCACGGCAAGCCTTTCA
TCCACACTCATGATGACAATATCCAAGCTATCGCCTGCTGTGATGACACCGAGCTACCAAGCGAACTACGCCGTTTAGAT
ATCAACAATGTAGAGCAAATCGCCGACTACGTTGGTGAATACATTGCCGCGTGGAAGCCTTGCCCAATCGATCTACCTAT
GGCACCCACTTGTGGCTGCGAACTGGATAACAGCAGTACGCTGTCAGTGCGCCAAGGTATCGACAAGATCCTATCTTACG
TCAACCCAATCAGCGCGACAGAGTCTGTCGAGCTCGATGAGCTTGAGAACCGCGTATTAGCTAGCGATGCCATCTCTCCG
GTTGACGTGCCACAACACACCAATTCAGCGATGGACGGTTACGCGTTTAAATTAAATGACCAGCCAGACGCCTCATACAA
GATGGTTGGCGAAGTGATGGCCGGCCATGCTTATGCTGGCACTATCCAAGCGGGCGAAGCGGTACGCATTATGACTGGCG
CACCAGTGCCAGCAGGTGCAGATACTATTCAGCTACGTGAGCTTGCCAACGAGCAGGACGGTGAAGTTCGTTTCGAAGGT
GAGATGAGCCTAGGGCAACACATTCGCCTAGCTGGTGAAGACATTGCCCAAGGCGCAACAGCCTTAGCCGCACATTCACG
CCTACACGCCGCCGAACAAGGCCTGTTAGCCTCATTAGGTTTTGGTGAGTTACCGGTATTTAAGCGTCCAAAAGTAGCCG
TATTTTCAACAGGCGACGAAGTTTGTCAGCCAGGCGAGCCGTTAAAAGCCAACTGCATTTTCGACTCTAACCGCTACACC
ATTAAATCGATGGCGAAGAAGTTAGGCTGTGAAGTGATCGATTTAGGCATCATTCAAGATTCAGAAGCCGCACTAGCGCA
AGCGCTAAAAGATGGCGCAGCACAGGCCGATATCGTCATCAGTTCAGGCGGTGTATCTGTTGGTGACGCCGACTATATCA
AGACGGTACTAGAGCAAGTGGGCCAGATAAACTTCTGGCGTATCAACATGCGCCCGGGTCGCCCGTTAGCTTTCGGTCAA
ATCGATGATGCATTATTCTTCGGTTTACCGGGTAACCCAGTAGCGGTTATGGTGTCGTTCTTACAGTTTGTGCAGCCAGC
GATTCGTAAACTTGCAGGCGAACAGAACTGGGCACCGACTATGGTGCCAGCAATTACCGACAAGCCACTGCGCAGCCGTA
CAGGCCGCACAGAATTTACCCGTGGCATGTATCACTTAGGTGCTGACGGCAAGCTACATGTAACCACAACCGGTGCTCAG
GGCTCAGGGATGCTTAGCTCTATGGTAAAAGGAAACTGTCTCATCGTGATTGGCGAGAAAGATGATCAGTTAAATCCAGG
TGACACAGTTTACATTCAACCTTTTGCCGACCTCCTTTAG

Upstream 100 bases:

>100_bases
TTTCCGATCAGCCAAATGCGTTTGTAAACGTGAACACACCAGAACAAAAGCAGCAGCTAGGCGAAGCCATAGCTAATGAA
GAAAATCACTAGAGGTGTAA

Downstream 100 bases:

>100_bases
AGGCCGTGTAGGTAGCTAGCATGAGTTTAATCGTTGACACTTTTGGTCGCACGGTAGAATACCTGCGACTATCCGTTACT
GATCGCTGCGATTTTCGCTG

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MSIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKDSYEMRKAGAKQMLVASHVRW
ALMTEDAKDGDPELPHLLKQIEADKVDIVLVEGFKKLELPKIELHRAAHGKPFIHTHDDNIQAIACCDDTELPSELRRLD
INNVEQIADYVGEYIAAWKPCPIDLPMAPTCGCELDNSSTLSVRQGIDKILSYVNPISATESVELDELENRVLASDAISP
VDVPQHTNSAMDGYAFKLNDQPDASYKMVGEVMAGHAYAGTIQAGEAVRIMTGAPVPAGADTIQLRELANEQDGEVRFEG
EMSLGQHIRLAGEDIAQGATALAAHSRLHAAEQGLLASLGFGELPVFKRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYT
IKSMAKKLGCEVIDLGIIQDSEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
IDDALFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFTRGMYHLGADGKLHVTTTGAQ
GSGMLSSMVKGNCLIVIGEKDDQLNPGDTVYIQPFADLL

Sequences:

>Translated_599_residues
MSIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKDSYEMRKAGAKQMLVASHVRW
ALMTEDAKDGDPELPHLLKQIEADKVDIVLVEGFKKLELPKIELHRAAHGKPFIHTHDDNIQAIACCDDTELPSELRRLD
INNVEQIADYVGEYIAAWKPCPIDLPMAPTCGCELDNSSTLSVRQGIDKILSYVNPISATESVELDELENRVLASDAISP
VDVPQHTNSAMDGYAFKLNDQPDASYKMVGEVMAGHAYAGTIQAGEAVRIMTGAPVPAGADTIQLRELANEQDGEVRFEG
EMSLGQHIRLAGEDIAQGATALAAHSRLHAAEQGLLASLGFGELPVFKRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYT
IKSMAKKLGCEVIDLGIIQDSEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
IDDALFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFTRGMYHLGADGKLHVTTTGAQ
GSGMLSSMVKGNCLIVIGEKDDQLNPGDTVYIQPFADLL
>Mature_598_residues
SIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKDSYEMRKAGAKQMLVASHVRWA
LMTEDAKDGDPELPHLLKQIEADKVDIVLVEGFKKLELPKIELHRAAHGKPFIHTHDDNIQAIACCDDTELPSELRRLDI
NNVEQIADYVGEYIAAWKPCPIDLPMAPTCGCELDNSSTLSVRQGIDKILSYVNPISATESVELDELENRVLASDAISPV
DVPQHTNSAMDGYAFKLNDQPDASYKMVGEVMAGHAYAGTIQAGEAVRIMTGAPVPAGADTIQLRELANEQDGEVRFEGE
MSLGQHIRLAGEDIAQGATALAAHSRLHAAEQGLLASLGFGELPVFKRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYTI
KSMAKKLGCEVIDLGIIQDSEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQI
DDALFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFTRGMYHLGADGKLHVTTTGAQG
SGMLSSMVKGNCLIVIGEKDDQLNPGDTVYIQPFADLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=36.0201511335013, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=36.0201511335013, Blast_Score=209, Evalue=6e-54,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=46.4102564102564, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=51.2048192771084, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=340, Percent_Identity=30.8823529411765, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=340, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136978, Length=350, Percent_Identity=33.1428571428571, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24638841, Length=350, Percent_Identity=33.1428571428571, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 64804; Mature: 64673

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKD
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCCC
SYEMRKAGAKQMLVASHVRWALMTEDAKDGDPELPHLLKQIEADKVDIVLVEGFKKLELP
CHHHHHCCHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
KIELHRAAHGKPFIHTHDDNIQAIACCDDTELPSELRRLDINNVEQIADYVGEYIAAWKP
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
CPIDLPMAPTCGCELDNSSTLSVRQGIDKILSYVNPISATESVELDELENRVLASDAISP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
VDVPQHTNSAMDGYAFKLNDQPDASYKMVGEVMAGHAYAGTIQAGEAVRIMTGAPVPAGA
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEECEEECCCEEEEEECCCCCCCC
DTIQLRELANEQDGEVRFEGEMSLGQHIRLAGEDIAQGATALAAHSRLHAAEQGLLASLG
CHHHHHHHCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEECC
FGELPVFKRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYTIKSMAKKLGCEVIDLGIIQD
CCCCCCCCCCCEEEEECCHHHCCCCCCCEEEEEECCCCEEHHHHHHHHCCEEEEEEEECC
SEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
CHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCC
IDDALFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFT
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCHHH
RGMYHLGADGKLHVTTTGAQGSGMLSSMVKGNCLIVIGEKDDQLNPGDTVYIQPFADLL
CCCEEECCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCHHHCC
>Mature Secondary Structure 
SIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKD
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCCC
SYEMRKAGAKQMLVASHVRWALMTEDAKDGDPELPHLLKQIEADKVDIVLVEGFKKLELP
CHHHHHCCHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
KIELHRAAHGKPFIHTHDDNIQAIACCDDTELPSELRRLDINNVEQIADYVGEYIAAWKP
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
CPIDLPMAPTCGCELDNSSTLSVRQGIDKILSYVNPISATESVELDELENRVLASDAISP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
VDVPQHTNSAMDGYAFKLNDQPDASYKMVGEVMAGHAYAGTIQAGEAVRIMTGAPVPAGA
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEECEEECCCEEEEEECCCCCCCC
DTIQLRELANEQDGEVRFEGEMSLGQHIRLAGEDIAQGATALAAHSRLHAAEQGLLASLG
CHHHHHHHCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEECC
FGELPVFKRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYTIKSMAKKLGCEVIDLGIIQD
CCCCCCCCCCCEEEEECCHHHCCCCCCCEEEEEECCCCEEHHHHHHHHCCEEEEEEEECC
SEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
CHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCC
IDDALFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFT
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCHHH
RGMYHLGADGKLHVTTTGAQGSGMLSSMVKGNCLIVIGEKDDQLNPGDTVYIQPFADLL
CCCEEECCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]