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The map label for this gene is moaA [H]

Identifier: 157963910

GI number: 157963910

Start: 4983689

End: 4984675

Strand: Direct

Name: moaA [H]

Synonym: Spea_4099

Alternate gene names: 157963910

Gene position: 4983689-4984675 (Clockwise)

Preceding gene: 157963909

Following gene: 157963914

Centisome position: 96.31

GC content: 49.65

Gene sequence:

>987_bases
ATGAGTTTAATCGTTGACACTTTTGGTCGCACGGTAGAATACCTGCGACTATCCGTTACTGATCGCTGCGATTTTCGCTG
CGTGTACTGCATGAGTGAAGATCCCTGCTTTTTAGGCCGGGAACATGTACTCAGCCTAGAAGAATTAGCCTGGGTCGCCC
AAGCTTTTACCGAACTAGGCGTTAAGAAGATCCGCTTAACAGGAGGTGAGCCGTTAGTGCGCACCGACTGCGATCAGCTA
GTTAAGCTATTAGGTAAGTTACCGGGCCTTGAAGAGTTGTCGATGACGACCAACGGTTCTCGCTTAACCCGTTTCGCGCA
AGAGATGCATGATTCAGGCTTGAACCGACTCAACATCAGCTTAGATACCTTAAAGCCAGATCTGTTTACCAGTCTTACTC
GTAACGGCAAGGTCGACCGCGTTATTGCCGGTATCGACGCCGCCATTGCAGCAGGTTTTAAAAAGATTAAGATCAACGCG
GTGATTTTACGTGGCCAAAACGATGATGAAGTCTTAGATTTAATCGAGTTTTGCCGCGAACGCGACTTAGATATCGCCTT
TATCGAAGAGATGCCACTAGGCGTGATTGATGAGCGCAAGCGCAGCCGTCACTGCAGCAGTAAAGAAATTCAAGACATCA
TCACTGAGCGTTACCCGCTAATCCAGTCAAACCGCCGTACAGGTGGCCCAGCGCGTTACTTCACCATGCCCGGCAGCGAC
ATACATGTGGGCTTTATCTCGCCCCACAGCAATAACTTCTGCCACGAATGCAATCGCGTCCGCGTCACGGTAGAGGGCAA
ACTGTTACTCTGCCTAGGCAACGAAAACTCAGTGGATCTCAAAGCTATTGTCCGCGAATTCCCCGGTGATATCGAAAGGC
TAAAAACCGCGATTCTAGACGGCATCCAGCACAAACCCAAAGAGCACCATTTCGACCCAAATGGTGAAACGCAGATCTTG
CGCTTTATGAATGCAACGGGTGGCTAA

Upstream 100 bases:

>100_bases
TCATCGTGATTGGCGAGAAAGATGATCAGTTAAATCCAGGTGACACAGTTTACATTCAACCTTTTGCCGACCTCCTTTAG
AGGCCGTGTAGGTAGCTAGC

Downstream 100 bases:

>100_bases
CTGTTGCTTGAACAGTTTTGTCGCTGATGGTGGTCTGGTGTTTTCTGTCACCACAGTGGTTAACTGTTAGCTTGGAGTTA
GCTGTACGCTAGATACATAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSLIVDTFGRTVEYLRLSVTDRCDFRCVYCMSEDPCFLGREHVLSLEELAWVAQAFTELGVKKIRLTGGEPLVRTDCDQL
VKLLGKLPGLEELSMTTNGSRLTRFAQEMHDSGLNRLNISLDTLKPDLFTSLTRNGKVDRVIAGIDAAIAAGFKKIKINA
VILRGQNDDEVLDLIEFCRERDLDIAFIEEMPLGVIDERKRSRHCSSKEIQDIITERYPLIQSNRRTGGPARYFTMPGSD
IHVGFISPHSNNFCHECNRVRVTVEGKLLLCLGNENSVDLKAIVREFPGDIERLKTAILDGIQHKPKEHHFDPNGETQIL
RFMNATGG

Sequences:

>Translated_328_residues
MSLIVDTFGRTVEYLRLSVTDRCDFRCVYCMSEDPCFLGREHVLSLEELAWVAQAFTELGVKKIRLTGGEPLVRTDCDQL
VKLLGKLPGLEELSMTTNGSRLTRFAQEMHDSGLNRLNISLDTLKPDLFTSLTRNGKVDRVIAGIDAAIAAGFKKIKINA
VILRGQNDDEVLDLIEFCRERDLDIAFIEEMPLGVIDERKRSRHCSSKEIQDIITERYPLIQSNRRTGGPARYFTMPGSD
IHVGFISPHSNNFCHECNRVRVTVEGKLLLCLGNENSVDLKAIVREFPGDIERLKTAILDGIQHKPKEHHFDPNGETQIL
RFMNATGG
>Mature_327_residues
SLIVDTFGRTVEYLRLSVTDRCDFRCVYCMSEDPCFLGREHVLSLEELAWVAQAFTELGVKKIRLTGGEPLVRTDCDQLV
KLLGKLPGLEELSMTTNGSRLTRFAQEMHDSGLNRLNISLDTLKPDLFTSLTRNGKVDRVIAGIDAAIAAGFKKIKINAV
ILRGQNDDEVLDLIEFCRERDLDIAFIEEMPLGVIDERKRSRHCSSKEIQDIITERYPLIQSNRRTGGPARYFTMPGSDI
HVGFISPHSNNFCHECNRVRVTVEGKLLLCLGNENSVDLKAIVREFPGDIERLKTAILDGIQHKPKEHHFDPNGETQILR
FMNATGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=310, Percent_Identity=36.4516129032258, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI22027536, Length=310, Percent_Identity=36.4516129032258, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=35.5623100303951, Blast_Score=210, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI32566331, Length=316, Percent_Identity=34.8101265822785, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=35.8306188925081, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=307, Percent_Identity=35.1791530944625, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574490, Length=312, Percent_Identity=40.3846153846154, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28574488, Length=312, Percent_Identity=40.3846153846154, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36959; Mature: 36828

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIVDTFGRTVEYLRLSVTDRCDFRCVYCMSEDPCFLGREHVLSLEELAWVAQAFTELG
CCEEHHHHHHHEEHHEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
VKKIRLTGGEPLVRTDCDQLVKLLGKLPGLEELSMTTNGSRLTRFAQEMHDSGLNRLNIS
CEEEEECCCCCCHHCCHHHHHHHHHCCCCCCHHEECCCCHHHHHHHHHHHHCCCCEEEEE
LDTLKPDLFTSLTRNGKVDRVIAGIDAAIAAGFKKIKINAVILRGQNDDEVLDLIEFCRE
HHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
RDLDIAFIEEMPLGVIDERKRSRHCSSKEIQDIITERYPLIQSNRRTGGPARYFTMPGSD
CCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCE
IHVGFISPHSNNFCHECNRVRVTVEGKLLLCLGNENSVDLKAIVREFPGDIERLKTAILD
EEEEEECCCCCCHHCCCCEEEEEEECEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHH
GIQHKPKEHHFDPNGETQILRFMNATGG
HHHCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SLIVDTFGRTVEYLRLSVTDRCDFRCVYCMSEDPCFLGREHVLSLEELAWVAQAFTELG
CEEHHHHHHHEEHHEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
VKKIRLTGGEPLVRTDCDQLVKLLGKLPGLEELSMTTNGSRLTRFAQEMHDSGLNRLNIS
CEEEEECCCCCCHHCCHHHHHHHHHCCCCCCHHEECCCCHHHHHHHHHHHHCCCCEEEEE
LDTLKPDLFTSLTRNGKVDRVIAGIDAAIAAGFKKIKINAVILRGQNDDEVLDLIEFCRE
HHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
RDLDIAFIEEMPLGVIDERKRSRHCSSKEIQDIITERYPLIQSNRRTGGPARYFTMPGSD
CCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCE
IHVGFISPHSNNFCHECNRVRVTVEGKLLLCLGNENSVDLKAIVREFPGDIERLKTAILD
EEEEEECCCCCCHHCCCCEEEEEEECEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHH
GIQHKPKEHHFDPNGETQILRFMNATGG
HHHCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA