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The map label for this gene is kynU [H]

Identifier: 157963733

GI number: 157963733

Start: 4770233

End: 4771348

Strand: Reverse

Name: kynU [H]

Synonym: Spea_3922

Alternate gene names: 157963733

Gene position: 4771348-4770233 (Counterclockwise)

Preceding gene: 157963734

Following gene: 157963731

Centisome position: 92.21

GC content: 49.1

Gene sequence:

>1116_bases
ATGCAGGACTTCAAAGCAGACTTTAGCTTAGCAAGCGGCAGTTATCTGCTTAATCACTCCGTTGGCAGGCCACTGAAGAG
CGCCGAACAGGTTCTTGCTCAGCAGTTTTTTGCACCTTGGCAAGACTCTAACGTCGAGCCTTGGCAGCAGTGGCTAAAGG
TCGTCGATCTCTTCTGTCTTAATCTGGCTAAATTATTTAATGGCCGGGTCGAAGAGTTTTGTCCTCAGGTGAATCTCTCC
AGTGCACTGACAAAACTGGTTATGTCGCTAGATGCACTTGGCGATAAAAATGCCGTGGTACTTATGAGTGAGATCGATTT
TCCCAGCATGGGGTTTGCGCTGAAAAAAGCGCTGCCACAAGGCTGCGTGTTGCGATTTATTCCTAAGTCACTCGATATTA
CCGATCCCGCCGTTTGGCAGTCCCATATCAAGGCTGATGTGGATTTGGTATTTGTCAGTCATGTCTATTCCAACACCGGG
CAGTTGGCACCAGTCAATGACATCGTCGAGGCTGCAAAGTCTAAGGCTGCGCTAACGCTTATCGATGTAGCGCAATCTGC
TGGCATAGTGCCGCTAGACTTAGGTCATCTACAGCCAGACTTTATGATAGGGTCGAGCGTAAAATGGCTTTGTGGCGGGC
CAGGGTCTGCTTACTTGTGGGTGAACTCGAAGCATATTGAGGGCTGTCAGCCTAAAGATGTGGGCTGGTTCAGCCACGAA
AATCCTTTCGAGTTTGATATTCATCACTTTCGTTATCATCCGACGGCGCTTAAGTTTTGGGGCGGCACACCATCGATTGC
GCCCTATGCCATAGCGGCCCATAGCATAGGTTATTTTACCGATATCGGTTCCCATAAACTGCGTTCGCATAATCAGCGCT
TAATCGATGCTGTGGCTGAGCAGCTGGGGGAGGCGTTCGTGTCGCCCATGCAAGAATCAAGGCGCAGCGGCACGATGATC
TTGGATTTCGGTGCTAAGCAGCAACAGGTAATGGCGGCTTTGCAGCGGGCTAATGTGAGTGTGGATCTGCGTAGTGAAGG
TATTCGGGTGTCACCGCATATCTATAATGATATGGCTGATATTGAAAACTTAATTACAGCTGTTAAGGGGATATAA

Upstream 100 bases:

>100_bases
GAGAAGTTGCGTGATAGACGAGCCGCAGCTAAGCGCAGTGATATTCGTACTCGCTATGAAGATATTCAATCGCTGCTCGC
GAGTATGGAGGCGTAATAGT

Downstream 100 bases:

>100_bases
AAATTACCGCTACAGGCTGGTAGCCTGTAGCGAAATCAAAGAGCTTAAGGCTGAACGGCTCTTAAGTGAACTTTTCGGTA
ATCATACTTCTGGTTGATGC

Product: class V aminotransferase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MQDFKADFSLASGSYLLNHSVGRPLKSAEQVLAQQFFAPWQDSNVEPWQQWLKVVDLFCLNLAKLFNGRVEEFCPQVNLS
SALTKLVMSLDALGDKNAVVLMSEIDFPSMGFALKKALPQGCVLRFIPKSLDITDPAVWQSHIKADVDLVFVSHVYSNTG
QLAPVNDIVEAAKSKAALTLIDVAQSAGIVPLDLGHLQPDFMIGSSVKWLCGGPGSAYLWVNSKHIEGCQPKDVGWFSHE
NPFEFDIHHFRYHPTALKFWGGTPSIAPYAIAAHSIGYFTDIGSHKLRSHNQRLIDAVAEQLGEAFVSPMQESRRSGTMI
LDFGAKQQQVMAALQRANVSVDLRSEGIRVSPHIYNDMADIENLITAVKGI

Sequences:

>Translated_371_residues
MQDFKADFSLASGSYLLNHSVGRPLKSAEQVLAQQFFAPWQDSNVEPWQQWLKVVDLFCLNLAKLFNGRVEEFCPQVNLS
SALTKLVMSLDALGDKNAVVLMSEIDFPSMGFALKKALPQGCVLRFIPKSLDITDPAVWQSHIKADVDLVFVSHVYSNTG
QLAPVNDIVEAAKSKAALTLIDVAQSAGIVPLDLGHLQPDFMIGSSVKWLCGGPGSAYLWVNSKHIEGCQPKDVGWFSHE
NPFEFDIHHFRYHPTALKFWGGTPSIAPYAIAAHSIGYFTDIGSHKLRSHNQRLIDAVAEQLGEAFVSPMQESRRSGTMI
LDFGAKQQQVMAALQRANVSVDLRSEGIRVSPHIYNDMADIENLITAVKGI
>Mature_371_residues
MQDFKADFSLASGSYLLNHSVGRPLKSAEQVLAQQFFAPWQDSNVEPWQQWLKVVDLFCLNLAKLFNGRVEEFCPQVNLS
SALTKLVMSLDALGDKNAVVLMSEIDFPSMGFALKKALPQGCVLRFIPKSLDITDPAVWQSHIKADVDLVFVSHVYSNTG
QLAPVNDIVEAAKSKAALTLIDVAQSAGIVPLDLGHLQPDFMIGSSVKWLCGGPGSAYLWVNSKHIEGCQPKDVGWFSHE
NPFEFDIHHFRYHPTALKFWGGTPSIAPYAIAAHSIGYFTDIGSHKLRSHNQRLIDAVAEQLGEAFVSPMQESRRSGTMI
LDFGAKQQQVMAALQRANVSVDLRSEGIRVSPHIYNDMADIENLITAVKGI

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17550466, Length=394, Percent_Identity=23.6040609137056, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 40905; Mature: 40905

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDFKADFSLASGSYLLNHSVGRPLKSAEQVLAQQFFAPWQDSNVEPWQQWLKVVDLFCL
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
NLAKLFNGRVEEFCPQVNLSSALTKLVMSLDALGDKNAVVLMSEIDFPSMGFALKKALPQ
HHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCC
GCVLRFIPKSLDITDPAVWQSHIKADVDLVFVSHVYSNTGQLAPVNDIVEAAKSKAALTL
CHHHHHCCCCCCCCCHHHHHHHHHCCHHEEEEEHHHCCCCCCCCHHHHHHHHHCCCHHHE
IDVAQSAGIVPLDLGHLQPDFMIGSSVKWLCGGPGSAYLWVNSKHIEGCQPKDVGWFSHE
EEHHHHCCCCEEECCCCCCCEEECCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCC
NPFEFDIHHFRYHPTALKFWGGTPSIAPYAIAAHSIGYFTDIGSHKLRSHNQRLIDAVAE
CCCEECCEEEEECCCEEEECCCCCCCCHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHH
QLGEAFVSPMQESRRSGTMILDFGAKQQQVMAALQRANVSVDLRSEGIRVSPHIYNDMAD
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHH
IENLITAVKGI
HHHHHHHHHCC
>Mature Secondary Structure
MQDFKADFSLASGSYLLNHSVGRPLKSAEQVLAQQFFAPWQDSNVEPWQQWLKVVDLFCL
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
NLAKLFNGRVEEFCPQVNLSSALTKLVMSLDALGDKNAVVLMSEIDFPSMGFALKKALPQ
HHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCC
GCVLRFIPKSLDITDPAVWQSHIKADVDLVFVSHVYSNTGQLAPVNDIVEAAKSKAALTL
CHHHHHCCCCCCCCCHHHHHHHHHCCHHEEEEEHHHCCCCCCCCHHHHHHHHHCCCHHHE
IDVAQSAGIVPLDLGHLQPDFMIGSSVKWLCGGPGSAYLWVNSKHIEGCQPKDVGWFSHE
EEHHHHCCCCEEECCCCCCCEEECCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCC
NPFEFDIHHFRYHPTALKFWGGTPSIAPYAIAAHSIGYFTDIGSHKLRSHNQRLIDAVAE
CCCEECCEEEEECCCEEEECCCCCCCCHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHH
QLGEAFVSPMQESRRSGTMILDFGAKQQQVMAALQRANVSVDLRSEGIRVSPHIYNDMAD
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHH
IENLITAVKGI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA