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The map label for this gene is pip [H]

Identifier: 157963719

GI number: 157963719

Start: 4754027

End: 4754959

Strand: Reverse

Name: pip [H]

Synonym: Spea_3908

Alternate gene names: 157963719

Gene position: 4754959-4754027 (Counterclockwise)

Preceding gene: 157963720

Following gene: 157963718

Centisome position: 91.89

GC content: 46.62

Gene sequence:

>933_bases
ATGTCTGCAGTGCAGTCGCCACTCCTTAGCCGAACCTGGCTAGATGTTGGAGATGACCACCAAATATATGTAGCCCAGTA
CGGTAATCCGAACGGGATACCACTGCTGTATTTGCATGGTGGGCCGGGAGCGGGTTGTAGCACAGAAGATTTAAAACTAT
TCGACCTGTCAGTCTATCAGGTTATTTTGCTCGATCAGCGGGGGGCGGGGCGTTCTCGTCCCCGCGGTGAACTTAAGCAT
AATAATTTGCACACTTTACTGGATGATATAGAGCGGGTTCGTTGTTGGCTTAATGTTCCTCAATGGATGCTTGCCGGTGG
CTCATTTGGTGCAACCTTAGCCCTACTTTATTCTGCCTGTTACCCTAATCGAGTGATATCACAAGTGCTGTGGGGCTTGT
TTATCCCTAACCCCGCAGGCATAGAATGGCTCTATGGTAATAGCGGTGCAGCTCGTTTGTTTATAGATGAATATCGCGCT
TTCACTCAGGGTGTTGAATGCCAAGAGCTCGAGGTTTTACTCGCACATTATCGATCAAAGTTAGAGAATGAGTGCCAAGA
AATTCGGCATGATGCTACCGCACACTGGCTCAGTTGGGAAATGGCTTTAGCCTATCCGGGCAGTATGCTCGGCGAGGCCA
ATACACCTTTCAGTCAGTCTCTAGCAAGCATAGAGCTTTATTATGTAGCTAATGATTACTTTGGTGCATTTGAAAAACTC
ATCGTTAAATTGCCTTTGATTCAGTGTCAAACATACGTACTGCAAGGTGAAATGGACTGGGTTTGCCCCTTTAAGGTGTT
ACAAGACTTCTTTAAAGGCAGGGCGAGTCAGTTAGTTAAAGTGACAGAGATTAAAGGCGGGTATCACGCTTTGGCCGATG
TTAAGATGGCTAAAGCGGTAAAGGATGCCATACGGGAAATGGCCAAACAATAA

Upstream 100 bases:

>100_bases
ATGATGGCCCAAATAGTAGCAATGATAGTGGTCAAGACAACGTCAGAGGCAGTGAGAAAACTGATGAGCCAGCCCAAGAT
AAACAGGACAAGCTGGATTA

Downstream 100 bases:

>100_bases
ACAAGGAAATATAGACGCTATGAAAAAACTGATTCTTACAGGCTTAACTATTGGCTTAACTATGGGCCTAACAGCTTGTG
CTTCTACTGAAAAAACAGCA

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSAVQSPLLSRTWLDVGDDHQIYVAQYGNPNGIPLLYLHGGPGAGCSTEDLKLFDLSVYQVILLDQRGAGRSRPRGELKH
NNLHTLLDDIERVRCWLNVPQWMLAGGSFGATLALLYSACYPNRVISQVLWGLFIPNPAGIEWLYGNSGAARLFIDEYRA
FTQGVECQELEVLLAHYRSKLENECQEIRHDATAHWLSWEMALAYPGSMLGEANTPFSQSLASIELYYVANDYFGAFEKL
IVKLPLIQCQTYVLQGEMDWVCPFKVLQDFFKGRASQLVKVTEIKGGYHALADVKMAKAVKDAIREMAKQ

Sequences:

>Translated_310_residues
MSAVQSPLLSRTWLDVGDDHQIYVAQYGNPNGIPLLYLHGGPGAGCSTEDLKLFDLSVYQVILLDQRGAGRSRPRGELKH
NNLHTLLDDIERVRCWLNVPQWMLAGGSFGATLALLYSACYPNRVISQVLWGLFIPNPAGIEWLYGNSGAARLFIDEYRA
FTQGVECQELEVLLAHYRSKLENECQEIRHDATAHWLSWEMALAYPGSMLGEANTPFSQSLASIELYYVANDYFGAFEKL
IVKLPLIQCQTYVLQGEMDWVCPFKVLQDFFKGRASQLVKVTEIKGGYHALADVKMAKAVKDAIREMAKQ
>Mature_309_residues
SAVQSPLLSRTWLDVGDDHQIYVAQYGNPNGIPLLYLHGGPGAGCSTEDLKLFDLSVYQVILLDQRGAGRSRPRGELKHN
NLHTLLDDIERVRCWLNVPQWMLAGGSFGATLALLYSACYPNRVISQVLWGLFIPNPAGIEWLYGNSGAARLFIDEYRAF
TQGVECQELEVLLAHYRSKLENECQEIRHDATAHWLSWEMALAYPGSMLGEANTPFSQSLASIELYYVANDYFGAFEKLI
VKLPLIQCQTYVLQGEMDWVCPFKVLQDFFKGRASQLVKVTEIKGGYHALADVKMAKAVKDAIREMAKQ

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34811; Mature: 34680

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVQSPLLSRTWLDVGDDHQIYVAQYGNPNGIPLLYLHGGPGAGCSTEDLKLFDLSVYQ
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCEEEEHHEEE
VILLDQRGAGRSRPRGELKHNNLHTLLDDIERVRCWLNVPQWMLAGGSFGATLALLYSAC
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHC
YPNRVISQVLWGLFIPNPAGIEWLYGNSGAARLFIDEYRAFTQGVECQELEVLLAHYRSK
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHH
LENECQEIRHDATAHWLSWEMALAYPGSMLGEANTPFSQSLASIELYYVANDYFGAFEKL
HHHHHHHHHHHHHHHHHEEEEHEECCCHHCCCCCCCHHHHHHEEEEEEEECHHHHHHHHH
IVKLPLIQCQTYVLQGEMDWVCPFKVLQDFFKGRASQLVKVTEIKGGYHALADVKMAKAV
HHHCCHHHHHEEEEECCCCCCCHHHHHHHHHCCHHHHEEEEEECCCCHHHHHHHHHHHHH
KDAIREMAKQ
HHHHHHHHCC
>Mature Secondary Structure 
SAVQSPLLSRTWLDVGDDHQIYVAQYGNPNGIPLLYLHGGPGAGCSTEDLKLFDLSVYQ
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCEEEEHHEEE
VILLDQRGAGRSRPRGELKHNNLHTLLDDIERVRCWLNVPQWMLAGGSFGATLALLYSAC
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHC
YPNRVISQVLWGLFIPNPAGIEWLYGNSGAARLFIDEYRAFTQGVECQELEVLLAHYRSK
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHH
LENECQEIRHDATAHWLSWEMALAYPGSMLGEANTPFSQSLASIELYYVANDYFGAFEKL
HHHHHHHHHHHHHHHHHEEEEHEECCCHHCCCCCCCHHHHHHEEEEEEEECHHHHHHHHH
IVKLPLIQCQTYVLQGEMDWVCPFKVLQDFFKGRASQLVKVTEIKGGYHALADVKMAKAV
HHHCCHHHHHEEEEECCCCCCCHHHHHHHHHCCHHHHEEEEEECCCCHHHHHHHHHHHHH
KDAIREMAKQ
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]