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The map label for this gene is ddc [H]

Identifier: 157963682

GI number: 157963682

Start: 4715680

End: 4717122

Strand: Reverse

Name: ddc [H]

Synonym: Spea_3871

Alternate gene names: 157963682

Gene position: 4717122-4715680 (Counterclockwise)

Preceding gene: 157963683

Following gene: 157963681

Centisome position: 91.16

GC content: 49.13

Gene sequence:

>1443_bases
ATGTCACATCATTTTAAAGATTACCGCGGTTCACTTGAGCGTTCTTTAGAGCATGCTGTCTCGTACCTTGAGTCGCTAGA
TGAACGACCTGTCGCTAAAGAGATCACGTCGCAGCAACTACGAGATTTAATTGCGGGTGAAATGCCACAGCAAGCTACAG
CGCCAGAGCAGGTTATCGATGAAATGGCATATGCGCTCGATGCGGGTCTTGTCGCCTCTGGTGGACCGAGATTTTTTGGT
TATGCCATCGGCGGGACGTTCCCTGCGGCATTAGCTGCAGACTGGCTAGTCAGTGCGTGGGATCAAAATGTGCCCTACTA
CGTGTCGAGCCCAGCAATGGCTGTTGCCGAAGAAACGGCAGCCGAGTGGATGGTAGAGTTACTTGGCTTGACTAAGGGCT
CTGCGGTTGGTTTTACTTCAGGCGCTCAAGAAGCGATTTATACCTCGTTAATCACCGCGCGTAATTCACTGCTAGAAAAT
GCAGGATGGGATGTGGCCACTAAAGGCCTGTATGGCGCGCCACAGGTGAATGTGGTCGTCAGTGATCAAATTCACTCAAC
CATTAAGCGCGCGCTTTCGATGATAGGTTTGGGGATTGAAACCATAGTTAAGGTGCCGACTGACGATAATCTTCGCCTTA
TTCCACAAGAGCTTGAGCGGGTATTAGCCGACATTAACGGCCCAACACTGGTTTGTGCCCAAGCGGGTTGTATCGATTCA
GGGGCATTCGATCCTTTCGATGAGATTGCAGATGCCGTTGCTAATCATGGTAATGCTTGGCTACATGTGGATGGCGCAAT
CGGTCTGTGGGCCGCTGCGAGCGACAAGCAGAAGCATCTATTAAAAGGGATTGAGCGAGCGGATTCCATCGATACCGACG
GCCATAAGTGGTTCAACATGCCTTATGACTGCGGCATGGTGATAGTGAAAGATCCTGCCAAGATCACCTCGGCAATGGGG
GGCGGAAACATGGGGGATTACCTTAATGATGCGATGGAGAAGCCTGATCGTAACGCGATTAACTTTGGTATTGCCGCATC
GAGACGTGCCCGTGGCCTGCCTGTATACGCCGCGTTTAAGTCGCTTGGTAAGCAAGGCATCGTTGACCATTTAGATAACT
GCTGCGCCTTAGCCAAACGCATGGCGGATATTTTGAGAGAAGTAGAGGGCATCACAATTCTTAATGATGTGGTATCGAAT
CGATTCTCTGCGCAATTTGGCACAGGTGATGTCGAGTATCGCAACGAGCTAACAGCCCGTGTGGTACATAGACTGCAGCA
AGAGGGTTACCTTTACCCCTCTACATCTGGATACAAGGGCTTAAAGACCATGCTGTTTTCAGTGCTGAATTATCACACAT
CGATAGAGGATATTGATAATTCAGCGATGAAAATTATTGAAGCTTTTAACACTGAAAAAGCGATATTTGTTAAGCCGGCT
TAA

Upstream 100 bases:

>100_bases
TTGCAGGTGTTCGCTTTTGTTTTGGCTGTCACCAAATGGCCATTTTATAAAAATATTGCTGGTATATTAGACGGACATTC
CTACTTGAAGAGTATTAAAC

Downstream 100 bases:

>100_bases
CGATATGAACTCAACGAGCAAAGAGAGTGGAGGAAGTATGACTCAGCAACGATTTGTAGGTTATAGCCTAGCGGTATTGG
TTTATTTAACTGTGCTCAAT

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSHHFKDYRGSLERSLEHAVSYLESLDERPVAKEITSQQLRDLIAGEMPQQATAPEQVIDEMAYALDAGLVASGGPRFFG
YAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEETAAEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLEN
AGWDVATKGLYGAPQVNVVVSDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPQELERVLADINGPTLVCAQAGCIDS
GAFDPFDEIADAVANHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNMPYDCGMVIVKDPAKITSAMG
GGNMGDYLNDAMEKPDRNAINFGIAASRRARGLPVYAAFKSLGKQGIVDHLDNCCALAKRMADILREVEGITILNDVVSN
RFSAQFGTGDVEYRNELTARVVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDNSAMKIIEAFNTEKAIFVKPA

Sequences:

>Translated_480_residues
MSHHFKDYRGSLERSLEHAVSYLESLDERPVAKEITSQQLRDLIAGEMPQQATAPEQVIDEMAYALDAGLVASGGPRFFG
YAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEETAAEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLEN
AGWDVATKGLYGAPQVNVVVSDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPQELERVLADINGPTLVCAQAGCIDS
GAFDPFDEIADAVANHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNMPYDCGMVIVKDPAKITSAMG
GGNMGDYLNDAMEKPDRNAINFGIAASRRARGLPVYAAFKSLGKQGIVDHLDNCCALAKRMADILREVEGITILNDVVSN
RFSAQFGTGDVEYRNELTARVVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDNSAMKIIEAFNTEKAIFVKPA
>Mature_479_residues
SHHFKDYRGSLERSLEHAVSYLESLDERPVAKEITSQQLRDLIAGEMPQQATAPEQVIDEMAYALDAGLVASGGPRFFGY
AIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEETAAEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLENA
GWDVATKGLYGAPQVNVVVSDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPQELERVLADINGPTLVCAQAGCIDSG
AFDPFDEIADAVANHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNMPYDCGMVIVKDPAKITSAMGG
GNMGDYLNDAMEKPDRNAINFGIAASRRARGLPVYAAFKSLGKQGIVDHLDNCCALAKRMADILREVEGITILNDVVSNR
FSAQFGTGDVEYRNELTARVVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDNSAMKIIEAFNTEKAIFVKPA

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=363, Percent_Identity=30.0275482093664, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI194294551, Length=366, Percent_Identity=27.5956284153005, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI197276620, Length=331, Percent_Identity=26.2839879154079, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4503875, Length=331, Percent_Identity=26.2839879154079, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI58331246, Length=350, Percent_Identity=27.1428571428571, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI92110055, Length=475, Percent_Identity=24.8421052631579, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4503281, Length=412, Percent_Identity=26.4563106796117, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI132814448, Length=412, Percent_Identity=26.4563106796117, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17534817, Length=470, Percent_Identity=25.3191489361702, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17534819, Length=470, Percent_Identity=25.3191489361702, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71993058, Length=371, Percent_Identity=26.1455525606469, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17555682, Length=366, Percent_Identity=26.2295081967213, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71993062, Length=332, Percent_Identity=26.2048192771084, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28573972, Length=468, Percent_Identity=26.4957264957265, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24585139, Length=484, Percent_Identity=24.7933884297521, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221476190, Length=484, Percent_Identity=24.7933884297521, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585143, Length=484, Percent_Identity=24.7933884297521, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24652373, Length=496, Percent_Identity=25.6048387096774, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24586044, Length=484, Percent_Identity=26.0330578512397, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17136190, Length=485, Percent_Identity=24.5360824742268, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24657193, Length=356, Percent_Identity=25.561797752809, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24657185, Length=356, Percent_Identity=25.561797752809, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24657188, Length=356, Percent_Identity=25.561797752809, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24585135, Length=486, Percent_Identity=23.8683127572016, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17136594, Length=362, Percent_Identity=25.1381215469613, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21356415, Length=372, Percent_Identity=22.8494623655914, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52041; Mature: 51910

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHHFKDYRGSLERSLEHAVSYLESLDERPVAKEITSQQLRDLIAGEMPQQATAPEQVID
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
EMAYALDAGLVASGGPRFFGYAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEETA
HHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
AEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLENAGWDVATKGLYGAPQVNVVV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
SDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPQELERVLADINGPTLVCAQAGCIDS
CHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCC
GAFDPFDEIADAVANHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNM
CCCCCHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEECC
PYDCGMVIVKDPAKITSAMGGGNMGDYLNDAMEKPDRNAINFGIAASRRARGLPVYAAFK
CCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHH
SLGKQGIVDHLDNCCALAKRMADILREVEGITILNDVVSNRFSAQFGTGDVEYRNELTAR
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDNSAMKIIEAFNTEKAIFVKPA
HHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
SHHFKDYRGSLERSLEHAVSYLESLDERPVAKEITSQQLRDLIAGEMPQQATAPEQVID
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
EMAYALDAGLVASGGPRFFGYAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEETA
HHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
AEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLENAGWDVATKGLYGAPQVNVVV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
SDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPQELERVLADINGPTLVCAQAGCIDS
CHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCC
GAFDPFDEIADAVANHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNM
CCCCCHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEECC
PYDCGMVIVKDPAKITSAMGGGNMGDYLNDAMEKPDRNAINFGIAASRRARGLPVYAAFK
CCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHH
SLGKQGIVDHLDNCCALAKRMADILREVEGITILNDVVSNRFSAQFGTGDVEYRNELTAR
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDNSAMKIIEAFNTEKAIFVKPA
HHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]