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The map label for this gene is cysK [H]

Identifier: 157963465

GI number: 157963465

Start: 4443930

End: 4445042

Strand: Reverse

Name: cysK [H]

Synonym: Spea_3653

Alternate gene names: 157963465

Gene position: 4445042-4443930 (Counterclockwise)

Preceding gene: 157963466

Following gene: 157963464

Centisome position: 85.9

GC content: 49.6

Gene sequence:

>1113_bases
ATGTCCGCTTCCTCATTTTCTTCAAATTCCGAACGCCCATTACCTGCTACCGATGGCATTGCCAACAATATTACCGAGCT
TATCGGCAATACCGATCTGCTGCGGATCAATAGTCTGAGTGATTTGACGGGTTGTGAGATCTTACTTAAGTGCGAGCAAC
AAAACCCTGGTGGTTCGATTAAAGATCGCGCCGCGTTGCAGATGGTGCAAGATGCGATCGCTGAGGGTAAGTTAACCCCC
GGGATGACTATCGTTGAAGGCACTGCGGGGAATACCGGTATAGGACTCGCGTTAGTTGCCAAGGCGCTGGGATTCAAGAT
GTTGGTGGTGATGCCTAGGGGGCAGGCGCGTGAAAAAGAGCTGATGATCACTCTGTTTGACGCCGAACTTAAGCTAGTCG
ATGCCTGCCCGTTTGCTGATCCCGATCATTTTTATCATACGGCTAAGCGGCTAGGTGAGGCTAATGATAACTATTGGTGG
GCGGATCAATTTGAAAATATCAGTAATAGCAAGGCTCACTTTATTCATACTGGACCAGAGATCTGGCAACAAACTCAAGG
CAAAATTGATGCCCTAGTCTCGGTTGCGGGGACTGGTGGCACCATAGCGGGGAACTCGCGTTATTTATCAGAGCAAAATC
CACAGTTACAAACTTGGCTGGTGGATCCCGATGGTTCAGGGATCTATGCCTATTTAAAGGATGGAAAATACAGCGCCTCG
GGTAGCTCGTTTACCGAAGGGATCGGTATCATGCGCTTGGTAGAAAATTTCCGTCAGGCCAAGATCGATAAAGCCATAAC
CTTGCCGGATCTCGACCTAGTGGCCATTGCTCGCCATGTGCAGGAGCACGACGGTATAGTGCTTGGCAGCAGTGCAGCAC
TTAATGTCGCGGGGGCATTGTACGCCGCAGCTAAAATGGGCCAAGGCAAAACCATAGTGACCTTTTATTGCGATCTTCCC
GAGCGCTCAGCATGCAAACTTTACAATGAGCAGTTTCTTACCGATAAAGGTTTCAGCGGTGACAGTGAAGCCATAGCGGC
AATGTTTGCTCGCTATCAAGCAGAATCGGCATCAAAAGTTGTCTCAGTTGATGCCCGCGACAGGCTTGAGTAG

Upstream 100 bases:

>100_bases
TTGTTACCTTAAAACTCTCATCTGCCTAAATTTAGTGACTTGGCTTAAATTAGAACTGTGCCTAATATTGAATGAGTATC
TGCAACAGAGATTATATTCT

Downstream 100 bases:

>100_bases
CTTATAAAAGAGCATTCTGGATAATATTTTCCGTAAACTGTACTTTCCGAGAGCTTACTCGCTCTGTATTACCTTGGATT
ACCAGTCACTTCAGGCCGTA

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSASSFSSNSERPLPATDGIANNITELIGNTDLLRINSLSDLTGCEILLKCEQQNPGGSIKDRAALQMVQDAIAEGKLTP
GMTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAREKELMITLFDAELKLVDACPFADPDHFYHTAKRLGEANDNYWW
ADQFENISNSKAHFIHTGPEIWQQTQGKIDALVSVAGTGGTIAGNSRYLSEQNPQLQTWLVDPDGSGIYAYLKDGKYSAS
GSSFTEGIGIMRLVENFRQAKIDKAITLPDLDLVAIARHVQEHDGIVLGSSAALNVAGALYAAAKMGQGKTIVTFYCDLP
ERSACKLYNEQFLTDKGFSGDSEAIAAMFARYQAESASKVVSVDARDRLE

Sequences:

>Translated_370_residues
MSASSFSSNSERPLPATDGIANNITELIGNTDLLRINSLSDLTGCEILLKCEQQNPGGSIKDRAALQMVQDAIAEGKLTP
GMTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAREKELMITLFDAELKLVDACPFADPDHFYHTAKRLGEANDNYWW
ADQFENISNSKAHFIHTGPEIWQQTQGKIDALVSVAGTGGTIAGNSRYLSEQNPQLQTWLVDPDGSGIYAYLKDGKYSAS
GSSFTEGIGIMRLVENFRQAKIDKAITLPDLDLVAIARHVQEHDGIVLGSSAALNVAGALYAAAKMGQGKTIVTFYCDLP
ERSACKLYNEQFLTDKGFSGDSEAIAAMFARYQAESASKVVSVDARDRLE
>Mature_369_residues
SASSFSSNSERPLPATDGIANNITELIGNTDLLRINSLSDLTGCEILLKCEQQNPGGSIKDRAALQMVQDAIAEGKLTPG
MTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAREKELMITLFDAELKLVDACPFADPDHFYHTAKRLGEANDNYWWA
DQFENISNSKAHFIHTGPEIWQQTQGKIDALVSVAGTGGTIAGNSRYLSEQNPQLQTWLVDPDGSGIYAYLKDGKYSASG
SSFTEGIGIMRLVENFRQAKIDKAITLPDLDLVAIARHVQEHDGIVLGSSAALNVAGALYAAAKMGQGKTIVTFYCDLPE
RSACKLYNEQFLTDKGFSGDSEAIAAMFARYQAESASKVVSVDARDRLE

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=36.6459627329193, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=36.6459627329193, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=36.6459627329193, Blast_Score=185, Evalue=5e-47,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=34.5394736842105, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788754, Length=282, Percent_Identity=34.0425531914894, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562970, Length=323, Percent_Identity=34.0557275541796, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=34.1137123745819, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=34.6801346801347, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=35.5987055016181, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=33.4426229508197, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=349, Percent_Identity=32.0916905444126, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25147552, Length=302, Percent_Identity=33.7748344370861, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32566672, Length=239, Percent_Identity=30.5439330543933, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17539800, Length=328, Percent_Identity=27.4390243902439, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=35.258358662614, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321594, Length=310, Percent_Identity=33.5483870967742, Blast_Score=142, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=34.2592592592593, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=34.2592592592593, Blast_Score=161, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39865; Mature: 39734

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00144 ASN_GLN_ASE_1 ; PS00165 DEHYDRATASE_SER_THR ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSFSSNSERPLPATDGIANNITELIGNTDLLRINSLSDLTGCEILLKCEQQNPGGSI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
KDRAALQMVQDAIAEGKLTPGMTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAREKE
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCE
LMITLFDAELKLVDACPFADPDHFYHTAKRLGEANDNYWWADQFENISNSKAHFIHTGPE
EEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCEEEECCHH
IWQQTQGKIDALVSVAGTGGTIAGNSRYLSEQNPQLQTWLVDPDGSGIYAYLKDGKYSAS
HHHHHCCCEEEEEEECCCCCEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCEECCC
GSSFTEGIGIMRLVENFRQAKIDKAITLPDLDLVAIARHVQEHDGIVLGSSAALNVAGAL
CCCHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHH
YAAAKMGQGKTIVTFYCDLPERSACKLYNEQFLTDKGFSGDSEAIAAMFARYQAESASKV
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
VSVDARDRLE
EEECCHHCCC
>Mature Secondary Structure 
SASSFSSNSERPLPATDGIANNITELIGNTDLLRINSLSDLTGCEILLKCEQQNPGGSI
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
KDRAALQMVQDAIAEGKLTPGMTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAREKE
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCE
LMITLFDAELKLVDACPFADPDHFYHTAKRLGEANDNYWWADQFENISNSKAHFIHTGPE
EEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCEEEECCHH
IWQQTQGKIDALVSVAGTGGTIAGNSRYLSEQNPQLQTWLVDPDGSGIYAYLKDGKYSAS
HHHHHCCCEEEEEEECCCCCEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCEECCC
GSSFTEGIGIMRLVENFRQAKIDKAITLPDLDLVAIARHVQEHDGIVLGSSAALNVAGAL
CCCHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHH
YAAAKMGQGKTIVTFYCDLPERSACKLYNEQFLTDKGFSGDSEAIAAMFARYQAESASKV
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
VSVDARDRLE
EEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA